• Biomolecules & Therapeutics
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• 제2권2호
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• pp.185-189
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• 1994

The eight combined products composed of ranitidine.HCI, tripotassium dicitrato bismuthate and sucralfate were prepared with various ratios and studied in therapeutic effects of them on various gastrointestinal diseases. These were induced in rats with the porous ligation, ethanol-HCI, acetic acid and cysteamine method, etc. In all experimental setting, the effect of the combined treating was more pronounced than the effect of each drug alone. Specially, the combined treatment consisted of ranitidine : tripotassium dicitrato bismuthate sucralfate ratio of 1.5 : 2 : 6 showed the most powerful therapeutic effect on acute gastric ulcer model and revealed a significant acceleration of the healing on chronic gastroduodenal ulcer model. And that, therapeutic doses of ranitidine, tripotassium dicitrato bismuthate arid sucralfate given in combination had an additive or, in some case, synergistic effect. From the above results, this combined treatment may useful to heal the gastrointestinal diseases that aren't cured well by treatment of each them alone.

• 한국소음진동공학회논문집
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• 제19권9호
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• pp.960-966
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• 2009

The World Health Organization(WHO) has reported the sleep disturbance as one of the adverse effects of noise. And the effect of combined noise sources on human have been investigated because community noises are seldom heard and are concurrent. Therefore, the effects of combined noise source and its S/N ratio on sleep disturbance were investigated; as a single noise source, road traffic noise was selected, and construction and movie noise were combined with road traffic noise. Tests for sleep disturbance were conducted in bedrooms and the effect on each subjects' sleep was evaluated by questionnaire. The results showed that the rate of awakening increased slightly only when the SPL of construction noise was 10 dB higher than that of road traffic noise. It was also found that the sleep disturbance was affected by the type of combined noise sources and its S/N ratio.

• EDISON SW 활용 경진대회 논문집
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• 제6회(2017년)
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• pp.650-652
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• 2017

the aim of this study was to observe the combined effect of the CRT and LVAD on electromechanical cardiac behavior under LBBB and RBBB conditions computationally. We performed simulation by using advanced electromechanics model of failing ventricle combined with lumped model represents circulatory system, CRT and LVAD. We analyzed seven failing ventricle model including normal sinus rhythm, LBBB, LBBB coupled with CRT, LBBB coupled with CRT and LVAD, RBBB, RBBB coupled with CRT, and RBBB coupled with CRT and LVAD. We compared the effect from CRT and the effect from combined CRT and LVAD to both under LBBB and RBBB conditions. The results showed that the combined CRT and LVAD contributed a better hemodynamic compared to single CRT. This combined system synchronized the electrical activation greatly under LBBB and slightly under RBBB. It also shortened mechanical activation time which resulted short electromechanical delay. More importantly, the combined system produced better mechanical responses under both LBBB and RBBB conditions.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 춘계학술대회
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• pp.93-93
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• 1995

The three combined products were prepared as suspended solutions composed of various ratio of Sucralfate, Hydrotalcite and Neusilin, into which 30% ethanol extracts of Machili cortex, and of Atractylodis rhizoma were added. The efficacy for these products was examined in vivo using a pyrous ligation method in rats. The influence of these products on the intestinal motility was also examined in mice. In all experimental setting, the antisecretory effect of the combined treatment was more pronounced than that of each drug alone. The combined treatment consisted of Sucralfate, Hydrotalcite, Neusilin ratios of 2:2:1 produced the highest inhibitory effect for the gastric secretion. The intestinal motility was not influenced significantly by the treatment of all experimental setting. The above results revealed that the therapeutic dose of Sucralfate, Hydrotalcite, Neusilin given in combination showed a synergistic effect for the inhibition of gastric secretion and little side effect on the intestinal motility. Therefore, the combined product with Sucralfate, Hydrotalcite, Neusilin ratio of 2:2:1 is recommended for the useful drug to heal the gastrointestinal diseases with no side effect on the intestinal motility.

• 한국건축시공학회지
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• 제3권4호
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• pp.79-86
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• 2003

The purpose of study is to offer base data for high fluid concrete mix property, as grasp effect of aggregate to reach much more effect for producing high fluid concrete. For this study, there are three types of combined aggregates, river sand + river aggregate(type A), river sand + crusted aggregate(type B), washed sea sand + crushed aggregate(type C) and take a factor, water-contents, water-binder ratio and S/a. And so, we had following conclusion, resulting application-ability of high fluid mortar by K-slump tester to use a handy consistency measuring instrument. And so, we had following conclusion, resulting application-ability of high fluid concrete by K-slump tester to use a handy consistency measuring instrument. 1) In cafe of regular water binder ratio, high fluid concrete suffered much effect of combined aggregates and water binder ratio. Range of water binder ratio by combined aggregates is w/b 0.4 downward(type A and B), w/b 0.35 downward(type C). 2) Water contents to need for producing high fluid concrete is minimum 170kg/$\textrm{m}^3$ without regard to combined aggregates. 3) The effect of S/a on high fluid concrete by combined aggregates is approximately S/a 50% (type A and B), s/a 50-55% (type C). 4) Consistency measuring of high fluid concrete by K-slump tester is possible and first indication value, high fluid concrete can be produced, is 6~10.5cm.

• 대한한의학회지
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• 제16권2호
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• pp.386-413
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• 1995

In order to prove the antitumor effect of Taraxaci Herba experimentally, studies were done. The antitumor effect against hepatic cancers such as Hep G2. Hep 3B & PLC and also the synergstric action was evaluated in the combined treatment with anticancer drugs using chiefly for liver cancer. such as. The results were obtained as follows: 1.$IC_{50}$ against Hep G2. Hep 3B and PLC was $15.5{\mu}g/ml.\;25.4{\mu}g/ml,\;31.25{\mu}g/ml$ in Mitomycin C(MMC), $92.5{mu}g/ml,\;50.2{\mu}g/ml,\;62.5{\mu}g/ml $in cisplatin(CPT) and 125 in 5-flurouracil(5-FU) respectively. 2. In cytotoxic effect against Hep G2 every fractions showed the anti tumor effect as compared with the data of control but EE fraction of Taraxaci Herba was most effective and also hexane fraction was most effective in the combined treatment with anticancer drugs. 3. In cytotoxic effect against Hep 3B every fractions showed the antitumor effect as compared with the data of control but EE fraction of Taraxaci Herba was most effective and also hexane fraction was most effective in the combined treatment with anticancer drugs. 4. In cytotoxic effect against PLC every fractions showed the anti tumor effect in the concentrations of $10^{-5}g/ml$ above as compared with the data of control and also the combined treatment with MMC was most effective. 5. Fractions of Taraxaci Herba showed the most antitumor effect against Hep 3B and also the combined treatment with MMC was most effective. From the above result it was concluded that ethyl ether fraction of Taraxaci Herba was most effective fraction, every fraction showed more antitumor effect against Hep 3B and Hep G2 than PLC.

• Journal of the Korean Wood Science and Technology
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• 제15권3호
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• pp.44-55
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• 1987

In order to study the effect of sawdustboard combined with plastic chips, 0.5mm($T_1$), 1mm($T_2$), 1.4mm($T_3$) thick nylon fiber. polypropylene rope fiber(RP), and 0.23mm thick moth-proof polypropylene net fiber(NP) were cut into 0.5, 1, 2cm long plastic chips. Thereafter, sawdustboard combined with plastic chips prepared as the above and plastic non-combined sawdustboard(control) were manufactured into 3 types of one-, two-, and three layer with 5 or 10% combination level. By the discussions and results at this study, the significant conclusions of mechanical and physical properties were summarized as follows: 1. The MORs were shown in the order of 3 layer> 2 layer> 1 layer among plastic non-combined boards, and $T_3$ < $T_2$ < $T_1$ < RP (NP(5%) < NP(l0%) among plastic combined boards. In 2cm long plastic chip in 1 layer board, the highest strength through all the composition was recognized. 1 layer board showing the lower strength with 0.5cm plastic chip rendered to the bending strength improvement by 2 or 3 layer board composition. On the other hand, 2 or 3 layer combined with 1, 2cm long polypropylene net fiber chips incurred MOR's conspicuous decrease requiring optimum plastic chip combined level and consideration to combined type. 2. MOE in plastic non-combined 3 layer board exhibited sandwich construction effect by higher resin content application to surface layer in the order of 3layer>1layer>2layer with the highest stiffness of the board combined with polypropylene chip, while nylon chip-combined board had little difference from plastic non-combined board. In relevant to length and layer effect, 3 layer board combined with the 0.5cm long polypropylene net fiber chip in 5% and 10% combined level presented 34-43% and 44-76% stiffness increase against plastic non-combined board(control), respectively. Moreover, in 1 layer board, 30% stiffness increase with 10% against 5% combined level in the 1 and 2cm long polypropylene net fiber chip was obtained. 3. Stress at proportional limit(Spl) showing the fiber relationship (r: 0.81-0.97) between MOR presented in the order of 1 layer<2 layer<3 layer in plastic non-combined board. Correspondingly, combined effect by layer and plastic chip length was similar to MOR's. 4. Differently from previous properties(MOR, MOE, Spl). work to maximum load(Wml) of 2 layer board approached to that of 3 layer board. Conforming the above phenomenon. 2 layer combined with 0.5cm long polypropylene net fiber chip kept the greater work than 1 layer. The polypropylene combined board superior to nylon -and plastic non - combined board seemed to have greater anti - failing capacity. 5. Internal bond strength(IB), in contrast to MOR's tendency. showed in the order of T1

• Structural Engineering and Mechanics
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• 제33권2호
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• pp.137-158
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• 2009

This paper investigates the behavior of reinforced concrete (RC) circular columns under combined loading including torsion. The main variables considered in this study are the ratio of torsional moment to bending moment (T/M) and the level of detailing for moderate and high seismicity (low and high transverse reinforcement/spiral ratio). This paper presents the results of tests on seven columns subjected to cyclic bending and shear, cyclic torsion, and various levels of combined cyclic bending, shear, and torsion. Columns under combined loading were tested at T/M ratios of 0.2 and 0.4. These columns were reinforced with two spiral reinforcement ratios of 0.73% and 1.32%. Similarly, the columns subjected to pure torsion were tested with two spiral reinforcement ratios of 0.73% and 1.32%. This study examined the significance of proper detailing, and spiral reinforcement ratio and its effect on the torsional resistance under combined loading. The test results demonstrate that both the flexural and torsional capacities are decreased due to the effect of combined loading. Furthermore, they show a significant change in the failure mode and deformation characteristics depending on the spiral reinforcement ratio. The increase in spiral reinforcement ratio also led to significant improvement in strength and ductility.

• 상하수도학회지
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• 제26권6호
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• pp.787-796
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• 2012

The purpose of this study is to investigate CSOs(combined sewer overflows) control in the combined sewer with/without separation wall. There is the high correlation between sewage velocity and suspended solid(SS) loading in the sewer without it. The SS/BOD ratio was about 3 times in the area with it, while it was about 5 times in the area without it. Therefore, the accumulated deposit within the sewer has influenced high SS loading in the sewer without it. This study showed that the separation wall installed acquired an acceptable efficiency in controlling the accumulated deposit in the combined sewer. According to this study, the BOD control effect was about 38 % in the sewer with the separation wall, whereas it showed about 24 % in the sewer without it. In this case, it was anticipated that the high pollutant control effect would be expected if the separation wall was installed in the combined sewer.

• The Korean Journal of Pain
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• 제20권1호
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• pp.8-14
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• 2007

Background: Anticonvulsants and antidepressants are adjuvant analgesic drugs that are used widely for treating chronic neuropathic pain syndromes. The combined analgesic effect of gabapentin and milnacipran was investigated with a rat neuropathic pain model. Methods: The rat neuropathic pain model was made by ligating the spinal nerves (L5 and L6). An intrathecal catheter was inserted into the subarachnoid space. Tactile allodynia was tested with the up-down method using von Frey hair. We determined the antiallodynic effect of intraperitoneal (I.P.) and intrathecal (I.T.) gabapentin. The combined effect of I.P. gabapentin (50 mg/kg) and milnacipran (0, 10 and 30 mg/kg) was investigated. Results: Intraperitoneal and intrathecal administration of gabapentin increased the threshold for tactile allodynia (the ED50 was 60.6 mg/kg and $45.5{\mu}g$, respectively). Co-administration of I.P. milnacipran increased the antiallodynic effect of I.P. gabapentin in a dose-dependent fashion. Conclusion: The combined administration of milnacipran and gabapentin may increase the total analgesic effect during treatment of neuropathic pain.