• 대한전자공학회논문지
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• 제15권5호
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• pp.25-28
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• 1978

생체로 부터의 전기적인 파형의 관찰 및 기록에 있어서 파형의 포각선이 불명확하여 생체반응의 판단 또는 생체신호의 데이터처리가 곤란한 경우가 많다. 본 논문에서는 이 문제를 다상포각선검파법을 응용하여 종전에는 관측하기 어려됐던 생체신호의 포각선을 관측할 수 있음을 제시하였다.

• Journal of Acupuncture Research
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• 제18권4호
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• pp.91-100
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• 2001

Background and Objective : Most diagnostic method for numbness were invasive and complex. So we need to simplify and objectify diagnostic method for numbness. Some study with EAV which is one of Physiological Signal Measuring Instruments, report significantly result as objective diagnostic method for other clinical symptom. By using EAV, we have obtained some physiological signal data from meridian-acupoints of 58 numbness cases. Objective and Methods : This study researched into the clinical statistics for 58 case who ware in numbness, and they ware treated with oriental medical care at the Dong-shin university oriental hospital during 1 year from April 3 2000 to March 30 2001. The data were analyzed and interpreted to compare with traditional differentiation of symptom-complexes, then further evaluated as the Five Evolutive Phases to make them differentiated. The EAV valus of Five Evolutive Phases were identified with the sequence of wood(木), fire(火), earth(土), steel(金), water(水). Results and Conclusion : These values of physiological signal were identical with standard differentiation of symptom-complexes of numbness which is the main cause of dishannonious flow of Qi and blood of the in the liver and deficiency of Qi and blood of the bladder with stagnancy of dampness. Among Five Evolutive Phases, Earth and wood values were increased, steel, fire and water were decreased significantly. This data imply the possibility of somewhat generalization from measuring instruments.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2002년도 춘계학술대회 논문집
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• pp.177-180
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• 2002

The type of physiological stress involved in driving is probably complex, and a comprehensive study involving recording of physiological signals such as electrocardiogram(ECG), electromyogram(EMG). Changes in relevant Physiological parameters, such as ECG, EMG, reflected changes in driver status. In order to derive the mental and physical load of driving a motor vehicle from driving behaviour alone it is necessary to establish the relationship between changes in a driver's physiological parameters and behavioral parameters. In this study, we choose two different condition and investigated driver's status using HRV analysis method. Many previous studies have shown that increasing driving time causes a variation of HRV signal.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2000년도 하계종합학술대회 논문집(5)
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• pp.113-116
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• 2000

In this paper presents the portable wireless ECG data detection and diagnosis system based on discreet wavelet transform. An algorithm based on wavelet transform suitable for real time implementation has been developed in order to detect ECG characteristics. In particular, QRS complex, S and T waves may be distinguished form noise, baseline drift or artifacts. Proposed telemetry system that a transmitting media using radio frequency(RF) for the middle range measurement of the physiological signals and receiving media using optical for electromagnetic interference problem. A standard hi-directional serial communication interface between the telemetry system and a personal computer or laptop, allows read-time controlling, diagnosing and monitoring of system. A portable telemetry system within a size. of 65${\times}$125${\times}$45mm consists of three parts: a digital signal processing part for physiological signal detect or diagnose, RF transmitter for data transfer and a optical receiver for command receive. Advantages of proposed telemetry system is wireless middle range(50m) FM transmission, reduce electromagnetic interference to a minimum. which enables a comfortable diagnosis system at home.

• Journal of Photoscience
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• 제9권2호
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• pp.275-277
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• 2002

We have recently found that a detergent-resistant raft like membrane (DRM) can be prepared from bovine rod outer segment membranes as a low-density buoyant fraction in sucrose density gradient ultracentrifugation. G protein (transducin) and its effector enzyme (phosphodiesterase: PDE) drastically change their affinities to DRM in the process of phototransduction. We report here that the recruitment of transducin and/or $^2$PDE to DRM has close relationship with their states in signal transduction. Active T$\alpha$/PDE-complex has a high affinity to DRM, whereas inactive transducin, or inactive PDE are excluded from DRM. Active T$\alpha$/PDE-complex seems to bind to a GTPase activating protein (GRS9) in multi- protein complexes localized on DRM. Physiological significance of the multi-protein complex on the raft-like membrane in vertebrate phototransduction would be discussed.

• Journal of Acupuncture Research
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• 제19권1호
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• pp.101-110
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• 2002

Background and Purpose : Most diagnostic method for lumbago were invasive and complex. So we need to simplify and objectify diagnostic method for lumbago. Some study with EAV which is one of Physiological Signal Measuring Instruments, report significantly result as objective diagnostic method for other clinical symptom. By using EAV, we have obtained some physiological signal data from meridian-acupoints of 31 lumbago cases. Objective and Methods : This study researched into the clinical statistics for 31 case who ware in lumbago, and they ware treated with oriental medical care at the Dong-shin university oriental hospital during 6 month from June 1 2001 to November 10 2001. The data were analyzed and interpreted to compare with traditional differentiation of symptom-complexes, then further evaluated as the Five Evolutive Phases to make them differentiated. The EAV valus of Five Evolutive Phases were identified with the sequence of wood(木), fire(火), earth(土)steel(金), water(水). Results and Conclusion : These values of physiological signal were identical with standard differentiation of symptom-complexes of lumbago which is the main cause of deficiency of Qi and blood of the kidney and bladder. Among Five Evolutive Phases, Earth and wood values were increased, steel, fire and water were decreased significantly. This data imply the possibility of somewhat generalization from measuring instruments.

• 한국콘텐츠학회논문지
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• 제15권7호
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• pp.591-600
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• 2015

최근 건강에 대한 관심이 높아짐에 따라 운동 프로그램을 스스로 학습하고 즐길 수 있는 능동형 피트니스 시스템에 대한 연구가 활발히 진행되고 있다. 본 논문에서는 운동 참여자의 생체신호에서 획득한 생체상태와 운동 정보를 이용하여 개인 수준에 맞는 스피닝 트레이닝 프로그램을 자기 주도 방식으로 학습 및 체험할 수 있게 하는 능동형 스피닝 트레이닝 시스템을 설계하고 구현하였다. 제안 시스템은 운동 참여자의 뇌파와 맥파 신호를 통해 생체 상태를 분석하고, 골격 동작을 실시간 인식하여 검출된 스피닝 동작 일치율과 운동량을 반영하여 운동 참여자에게 적합한 난이도의 스피닝 프로그램을 제공한다. 또한, 가상 스피닝 강사를 통해 올바른 동작을 제시하고 참여자의 동작 일치율에 따라서 난이도를 조절함으로써 운동 효과를 높일 수 있도록 하였다. 다양한 사용자들에 대한 실험을 통해 제안시스템이 비교적 짧은 시간에 유효한 운동 효과를 얻는데 도움이 됨을 확인할 수 있었다.

• 동의생리병리학회지
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• 제18권4호
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• pp.1154-1158
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• 2004

The classical ABC (avidin-biotin peroxidase complex) method for immunohistochemistry in the paraffin-embedded tissues bring into being disadvantage such as low sensitivity of antigen detection and highly background. The biotinyl-tyramide conjugation recently introduced for sensitive immunohistochemistry was applied to light microscopy in paraffin-embedded pancreatic and liver tissues. The protocol consists of an indirect method in which 4-5㎛ tissue sections are reacted successively within a specific primary antibody, followed by a biotinylated secondary antibody, streptavidin-horseradich peroxidase (HRP), and then finally with biotinyl-tyramide. The labeling obtained for insulin and collagen antigen tested in pancreatic and liver tissues, respectively, was found to be highly specific with the labeling for each antigen confined to its particular cellular compartment. In this study, fish (flounder) serum was specially applied to remove nonspecific binding. Background levels and nospecific deposition of the staining were negligible. This results suggest that super-signal induction method by biotinyl-tyramide conjugate can readily applied to antigen detection of the paraffin-embedded tissues.

• 동의생리병리학회지
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• 제28권6호
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• pp.668-673
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• 2014

Cold and Heat pattern identification(CHPI) in traditional East Asian medicine(TEAM) is one of the major indicator to distinguish characteristics of disease and to determine treatment method. Basic parameters to determine CHPI include the pulse rate, respiration rate, and pulse power. Studies to associate physiological responses of human body by cold stress(CS) with CHPI in TEAM were rarely done so far. This study aims to explore the effects of cold stress on pulse signal via a feasibility study for three subjects and investigate some indices which can reflect autonomic nerve reaction(ANR). We measured radial pulse signals and respiration signal of the investigated subjects before the CS, during the CS which continues for 5 minutes, and immediately after the CS, respectively. Finally, we analyzed the pulse rate (P), respiration rate (R), pulse power, pulse depth, and pulse rate per respiration (P/R ratio). As a result, the P/R ratio showed a consistently decreasing tendency through the CS stimulation process, while other parameters behaved more complex and in subject-specific ways. It implies that, among candidate parameters, the P/R ratio is a simple but the most probable parameter that can be used as the ANR indicator. This result is also consistent with the theory in TEAM scripts, in which the P/R ratio is predicted to be a direct indicator for the CHPI. This pilot study shows that P/R ratio can be more appropriately associated with the ANR than heart rate or respiration rate alone. Extensive studies will be necessary to verify or confirm the P/R ratio as an appropriate and well defined parameter for ANR.

• 한국식물학회:학술대회논문집
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• 한국식물학회 1999년도 제13회 식물생명공학심포지움 New Approaches to Understand Gene Function in Plants and Application to Plant Biotechnology
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• pp.41-44
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• 1999

Magnaporthe grisea (Hebert) Barr (anamorph: Pyricularia grisea) is a typical heterothallic Ascomycete and the causal agent of rice blast, one of the most destructive diseases on rice (Oryza sativa L.) worldwide. The interactions between cells of the pathogen and those of the host involve a complex of biological influences which can lead to blast disease. The early stages of infection process in particular may be viewed as a sequence of discrete and critical events. These include conidial attachment, gemination, and the formation of an appressorium, a dome-shaped and melanized infection structure. Disruption of this process at any point will result in failure of the pathogen to colonize host tissues. This may offer a new avenue for developing innovative crop protection strategies. To recognize and capture such opportunities, understanding the very bases of the pathogenesis at the cellular and molecular level is prerequisite. Much has been learned about environmental cues and endogenous signaling systems for the early infection-related morphogenesis in M. grisea during last several years. The study of signal transduction system in phytopathogenic filamentous fungi offers distinct advantages over traditional mammalian systems. Mammalian systems often contain multiple copies of important genes active in the same tissue under the same physiological processes. Functional redundancy, alternate gene splicing, and specilized isoforms make defining the role of any single gene difficult. Fungi and animals are closely related kingdoms [3], so inferences between these organisms are often justified. For many genes, fungi frequently possess only a single copy, thus phenotype can be attributed directly to the mutation or deletion of any particular gene of interest.