The present study was carried out to investigate the potential acute toxicity of amitraz by a single subcutaneous dose in beagle dogs. The test chemical was administered subcutaneously to male beagle dogs at dose levels of 0, 2, 10, or 50 mg/kg. Mortalities, clinical findings, and body weight changes were monitored for the 14-day period following the administration. At the end of 14-day observation period, hematology, serum biochemistry, and gross postmortem examinations were examined. A single dog in the 50 mg/kg group was found dead on day 3 after treatment and the other two dogs in the group were sacrificed because of the severe clinical signs on day 7 after treatment. Treatment related clinical signs, including anorexia, edema, mass and abscess formation in the injection sites, depression, vomiting, lacrimation, decreased locomotor activity, ataxia, recumbency, paresis in the limbs, and/or moribundity were observed in all treatment groups in a dose-dependent manner. Decreased or suppressed body weight gain was also observed dose-dependently in all treated groups. In autopsy, dead animals in the 50 mg/kg group showed muscular hemorrhage and inflammation in the injection sites and congestion in the liver and kidney. The terminal sacrificed animals in the 10 mg/kg group also exhibited muscular hemorrhage and inflammation in the injection sites. Whereas, no treatment related effects on hematology and serum biochemistry were observed on day 14 after treatment at any dose tested. On the basis of the results, it was concluded that a single subcutaneous injection of amitraz to beagle dogs resulted in increased incidence of abnormal clinical signs and death, decreased body weight, and increased incidence of abnormal gross findings. In the experimental conditions, the $LD_{50}$value of amitraz was 22.3 mg/kg (95% confidence limit not specified) and the no-observed-adverse-effect level (NOAEL) was considered to be below 2 mg/kg for male dogs.
The Korean government embarked upon ambitious economic development plans in the 1960's the goals of development policy at that time were the elimination of absolute poverty and the alleviation of unemployment. With scant natural resources, the government had to push for industrialization based upon borrowed foreign raw materials with surplus local labor. Preoccupation with the economic goals of industrialization and export expansion left little room for considering environmental protection. It is evident that Korea's exported industrialization strategy of the past three decades has been a success in terms of income, production, and other macroeconomic indicators, but it cannot be denied that a host of undesirable side-effects have been created. These include environmental problems. congestion in several large cities, poor wealth distribution, and regional disparities. The environmental problems were recognized even in the early stage of development, but preoccupation with the pending economic goals of industrialization and export expansion left little room for considering environment protection. The perceived and actual seriousness of the problems, however, has reached such a level that further negligence may imperil political stability and developmental problems facing the world arise from a world economic order characterized by ever expanding consumption and production, which exhausts and contaminates natural resources and creates and perpetuates gross inequalities between and within nations. It will be necessary to develop new culture and ethical values, transform economic structures, and reorient, our lifestyles. Changing lifestyles can not be promoted by government policy initiative alone but through self=generated educational efforts and mutual training by people themselves. The citizens group for environment (NGOs) should assume these educational and training responsibilities starting from grass-root level of people. It must be reawakened to the reality that the environmental preservation for better quality of life is based on the development of human relationships, creativity, spirituality, reverance for the natural world and celebration of life, and is not dependent upon increased consumption of non-basic material goods. To carry on such environment education social movements and NGOs should (1) provides educational methodologies, which focus on values clarification and moving beyond clarification and moving beyond blame to constructive action. (2) provide training for leaders of business and industry, government, union and others on consumption and production. (3) initiate and support the training and work of environmental counselor who encourage responsible consumption. (4) cooperative with media to initiate and strengthen educational programs on the social environmental programs on the social environmental impacts of consumption and production and to build awareness of consumer responsibility and potential. Economic and social development can be compatible with environment protection : both can be achieved simultaneously. Effective environmental management depends on the various factors : political will, institutional arrangements, appropriate legislation, and availability of the requistite financial and technological resources, which is possible with a strong public awareness of the importance of environmental preservation.
Journal of Korea Society of Industrial Information Systems
/
v.21
no.4
/
pp.67-78
/
2016
Recently many countries around the world are actively promoting smart city projects to address various urban problems such as traffic congestion, housing shortage, and energy scarcity. Due to development of the Internet of Things (IoT), the development of a smart city with sustainability, convenience, and environment-friendliness was enabled through the effective control and reuse of urban resources. The purpose of this study is to analyze the technical trends of IoT and present a development plan for smart city which is one of the applications of the IoT. To this end, the news articles of the Electronic Times between 2013 and 2015were analyzed using the text mining technique and smart city development cases of other countries were investigated. The analysis results revealed the close relationships of big data, cloud, platforms, and sensors with smart city. For the successful development of a smart city, first, all the interested parties in the city must work together to create new values throughout the entire process of value chain. Second, they must utilize big data and disclose public data more actively than they are doing now. This study has made academic contribution in that it has presented a big data analysis method and stimulated follow-up studies. For the practical contribution, the results of this study provided useful data for the policy making of local governments and administrative agencies for smart city development. This study may have limitations in the incorporation of the total trends because only the news articles of the Electronic Times were selected to analyze the technical trends of the IoT.
Since Radix Stemonae was recorded hypothennal and a little toxic in the 'Myngyubelrok (名醫別錄)', it has been recorded as having the same nature in many herbal books. However, the security of Radix Stemonae when used to treat respiratory disease over a long term has not been studied until now. Therefore, the objective of this study is to determine the effects of Radix Stemonae on the main organs if Radix Stemonae is administrated over a long term. In order to investigate the histological changes of the liver and kidneys of rats after oral administration of Radix Stemonae extract, the experimental rats were subdivided into control, 1, 3, 5, 7, 21, 28 and 35 days after administration groups, and 10 rats per group were used in this study. The control group was sufficiently supplied with water and solid forage. The other groups were administrated the reagent at 5mg/kg once a day by oral injection. Several times each day, the experimental groups were carefully observed for any changes of general condition, toxic symptoms, activity, appearance and the number of dead rats. The experimental groups were weighed and narcotized. For the histological observation, the tissues of liver and kidneys of the experimental groups were collected, stained by hematoxylin-eosin stain, and evaluated by observing the changes of gross appearance and by observing microscopic findings. 1. This drug, during the experimental term, did not induce any toxicological effect in mortality, abnormal symptoms or changes of body weight except for the 1 day after administration groups whose body weights were decreased, compared to the control group. 2. No gross changes of the liver and kidneys were observed in this study. 3. No histological changes of the liver were detected in 1 day after administration groups. However, dilation of the central vein was observed in 3, 5 and 7 days after administration groups and chronic passive congestion of the liver was demonstrated in the 21 days after administration groups. In the 28 and 35 days after administration groups, a centrolobular disposition of fatty tissue (adipose cell) was observed. 4. No histological changes of the kidneys were observed in this study. It is evaluated that if Radix Stemonae is administrated for a long term, it induces toxicity in the liver. So, to examine the toxicity of Radix Stemonae on the liver and kidney, it is necessary that the studies of biochemistry and electron microscopic findings about Radix Stemonae be systematically performed.
In order to resolve transportation system focused on vehicles which have led to all sorts of problems such as traffic congestion, air pollution and so on, Korea recently have tended to center around Transit Oriented Development(TOD) which is capable of initiating public traffic demands. It is imperative to develop objective evaluation method which is able to measure pedestrian environment and amenity in order to facilitate green transit. The purpose of this paper is to present evaluation indices and measurement framework of pedestrian environment by analyzing effect on TOD major planning factors such as diversity, density, design, and supply etc. For this, we applied evaluation index with regard to TOD planning factors, investigating connection to pedestrian and employed AHP (Analytic Hierarchy Process) so as to quantify the result of measurement in Jongro 3ga and Hangangjin station. As a result, we presented relationship between travel patterns of pedestrian and each TOD planning factor. More importantly, the proposed framework is expected to make the best of the visualization as well as evaluation method for the pedestrian accessibility, convenience of public transportation, and the mixed land-use patterns in subway area and transit center.
Recent environmental concerns have made interest in environment-friendly transportation means such as walking, biking, and public transportation. However, since it is difficult to move long distance by walking or biking, their scope of application is rather limited. On the other hand, public transportation can solve traffic congestion, a recent social issue, though its usability may depend on its time schedule. Currently available information services on public transportation in the Web do not reflect well such traits of the public transportation; thus, in some cases, they may provide wrong information to end users. To solve such problems and provide information based on timetable of public transportations, this paper proposes a STP(Space Time Point) data model. Unlike existing space-time data models, this model recognizes the bottommost element of an object as a point and structures these points in hierarchical way to define an object. In particular, It can make it possible to implement a variety of dynamic spatial objects changing object information according to time. An objective of this study is to design a STP model for bus and subway based on timetables of public transportation in Daejeon area and builds a system to provide path navigation. With the designed navigation function, a path from the Daejeon National Cemetery to Hannam University was searched by time slot. The result showed that the system provided different paths by time, as the system guided different paths when bus operation was limited in midnight. As existing data model could not provide such results, it is confirmed that the system can provide path navigation based on real-time traffic information. It is expected that based on such functionality, it is possible to provide additional functionalities by applying diverse data models such as real-time transport information or traffic history information.
The Journal of The Korea Institute of Intelligent Transport Systems
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v.14
no.6
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pp.77-90
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2015
An increasing number of vehicles is causing various traffic problems such as chronic congestion of highways and air pollution. Local governments have been managing traffic by constructing systems such as Intelligent Transport Systems (ITS) and Advanced Traffic Management Systems (ATMS) to relieve such problems, but construction of an infrastructure-based traffic system is insufficient in resolving chronic traffic problems. A more sophisticated system with enhanced operational management capabilities added to the existing facilities is necessary at this point. As traffic patterns of the urban traffic flow is time-specific due to the different vehicle populations throughout the time of the day, a local network-wide signal operation plan that can manage such situation-specific traffic patterns is deemed to be necessary. Therefore, this study is conducted for the purpose of establishment of a plan for contextual signal control management through signal optimization at the network level after setting the Frame Signal in accordance to the traffic patterns gathered from the short-term traffic forecast data as a means to mitigate the problems with existing standardized signal operations.
The Journal of The Korea Institute of Intelligent Transport Systems
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v.10
no.4
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pp.11-23
/
2011
The objective of this paper is to develop a daily pattern clustering algorithm using historical traffic data that can reliably detect under various traffic flow conditions in urban streets. The developed algorithm in this paper is categorized into two major parts, that is to say a macroscopic and a microscopic points of view. First of all, a macroscopic analysis process deduces a daily peak/non-peak hour and emphasis analysis time zones based on the speed time-series. A microscopic analysis process clusters a daily pattern compared with a similarity between individuals or between individual and group. The name of the developed algorithm in microscopic analysis process is called "Two-step speed clustering (TSC) algorithm". TSC algorithm improves the accuracy of a daily pattern clustering based on the time-series speed variation data. The experiments of the algorithm have been conducted with point detector data, installed at a Ansan city, and verified through comparison with a clustering techniques using SPSS. Our efforts in this study are expected to contribute to developing pattern-based information processing, operations management of daily recurrent congestion, improvement of daily signal optimization based on TOD plans.
The Journal of the Institute of Internet, Broadcasting and Communication
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v.12
no.1
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pp.133-140
/
2012
This paper suggests an algorithm that can shorten the complexity $O(n^2)$ of Dijkstra algorithm that is applied to the shortest path searching in real-time GPS Navigation System into an up-to-date O(n). Dijkstra algorithm manipulates the distance of the minimum length path by visiting all the nodes from the starting node. Hence, it has one disadvantage of not being able to provide the information on the shortest path every second, in a city that consists of sophisticated roads, since it has to execute number of node minus 1. The suggested algorithm, firstly, runs by means of organizing the set of out-neighbourhood nodes at each level of the tree, and root node for departure node. It also uses a method of manipulating the distance of the minimum path of all out-neighborhoods and interior of the out-neighborhoods. On applying the suggested algorithm to two sophisticated graphs consisted of bi-direction and uni-direction, we have succeeded to obtain the distance of the minimum length path, just as same as Dijkstra algorithm. In addition, it has an effect of shortening the time taken 4 times from number of node minus1 to number of level minus 1. The satisfaction of the drivers can be increased by providing the information on shortest path of detour, every second, when occurs any rush hour or any traffic congestion due to car accident, by applying this suggested algorithm to the real-time GPS system.
Journal of the Korean Association of Geographic Information Studies
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v.16
no.2
/
pp.114-128
/
2013
Rapid industrialization and economic growth have led to serious problems including reduced open space, environmental degradation, traffic congestion, and urban sprawl. These problems have been exacerbated by the absence of effective conservation and governance, and have resulted in various social conflicts. In response to these challenges, many scholar and government hope to achieve sustainable development through the establishment and management of environment-friendly planning. For this purpose, we would like to analyze functional change for ecosystem by future land-use/cover changes in South Korea. Toward this goal, we predicted land-use/cover changes from 2010 to 2060 using the future population of Statistics Korea and urban growth probability map created by logistic regression analysis and analyzed ecosystem service value using costanza's coefficient. In the case of scenario 1, ecosystem service value represented 6,783~7,092 million USD. In the case of scenario 2, ecosystem represented 6,775~7,089 million USD, 2.9~7.6 million USD decreased compared by scenario 1. This was the result of area reduction for farmland and wetland which have high environmental value relatively according to urban growth by development point of view. The results of this analysis indicate that environmentally sustainable systems and urban development must be applied to achieve sustainable development and environmental protection. Quantitative analysis of environmental values in accordance with environmental policy can help inform the decisions of policy makers and urban developers. Furthermore, forecasting urban growth based on future demand will provide more precise predictive analysis.
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