• Journal of Life Science
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• v.32 no.4
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• pp.318-324
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• 2022

PPARγ and C/EBPα are master adipogenic transcription factors (TFs) required for adipose tissue development. They control the induction of many adipocyte genes and the early phase of adipogenesis in the embryonic development of adipose tissue. Adipose tissue continues to expand after birth, which, as a late phase of adipogenesis, requires the lipogenesis of adipocytes. In particular, the liver and adipose tissues are major sites for de novo lipogenesis (DNL), where carbohydrates are primarily converted to fatty acids. Furthermore, fatty acids are esterified with glycerol-3-phosphate to produce triglyceride, a major source of lipid droplets in adipocytes. Hepatic DNL has been actively studied, but the DNL of adipocytes in vivo remains not fully understood. Thus, an understanding of lipogenesis and adipose expansion may provide therapeutic opportunities for obesity, type 2 diabetes, and metabolic diseases. In adipocytes, DNL gene expression is transcriptionally regulated by lipogenesis coactivators, as well as by lipogenic TFs such as ChREBP and SREBP1a. Recent in vivo studies have revealed new insights into the lipogenesis gene expression and adipose expansion. Future detailed molecular mechanism studies will determine how nutrients and metabolism regulate DNL and adipose expansion. This review will summarize recent updates of DNL in adipocytes and adipose expansion in terms of transcriptional regulation.

• Proceedings of the KIEE Conference
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• 1985.07a
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• pp.262-264
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• 1985

• Journal of the Semiconductor & Display Technology
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• v.3 no.4
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• pp.19-27
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• 2004

The characteristic evaluation of A/D converter is to measure the linearity of the converter. The evaluation of the linearity is to measure the DNL, INL, gain error and offset error in the various test parameters of A/D converter. Generally, DNL and INL are to be measured by the Histogram Test Algorithm in the DSP-based ATE environment. And gain error and offset error are to be measured by the calculation equation of the measuring algorithm. It is to propose the new Concurrent Histogram Test Algorithm for the test of the housekeeping A/D converter used in the CDMA cellular phone. Using the proposed method, it is to measure the DNL, INL, gain error and offset error concurrently and to show the measured results.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.35 no.8
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• pp.309-315
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• 1986

We proposed a preliminary Data Flow Machine Model(DNL1) operating on the basis of Node Label. In this model, all the PMs(Processing Modules) were synchronized with the content of LC(Level Counter) and were not implemented dy the processing cability on conditional nodes. This paper presents an architecture of a concurrent multiprocessor system which was developed from DNL1 with two additional types of memories, CF(Control Flag) and ETF (Enabled Token Flag). The CF memory holds the control condition flag ('1' or '0') to be referenced to when a node is fired and the ETF represents the firability of a certain node. Firable nodes are fetched to the PU(Processing Unit) and processed. This Data Flow system can be extended hierarchically by a network of simple modules. The principle working elements of the machine are a set of PMs, each of which performs the execution of the data flow procedures held in a local memory, NTM(Node Token Memory) within the PM.

• Journal of Korean Neurosurgical Society
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• v.50 no.4
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• pp.304-310
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• 2011

Objective : Intrathecal methotrexate (MTX) therapy combined with whole brain radiotherapy (WBRT) is one of the major treatment modalities for leukemia and lymphoma involving the central nervous system (CNS). The purpose of this study was to retrospectively determine the incidences of leukoencephalopathy and disseminated necrotizing leukoencephalopathy (DNL) following intrathecal MTX therapy for CNS lymphoma or leukemia and to assess the potential risk factors. Methods : Between January 2000 and August 2009, 143 patients with CNS lymphoma or leukemia received intrathecal MTX therapy alone or in combination with WBRT at a single institution. Patients were followed up clinically and radiologically at regular two- or three-month intervals. Medical records were reviewed to obtain information regarding the patients' demographics, medical histories, radiologic characteristics, treatments, and clinical courses. Results : On follow-up MR images, leukoencephalopathy was found in 95 of 143 patients (66.4%). The median time to develop leukoencephalopathy was 6.6 months. Among those with leukoencephalopathy, four patients showed seven extensive white-matter changes with strongly enhancing lesions demonstrating DNL. Histological confirmation was done in six lesions of three patients and radiological diagnosis alone in one patient. Four lesions spontaneously disappeared on MR images without any treatment, with a mean duration of 14 months before disappearance of DNL. Conclusion : Leukoencephalopathy is a common phenomenon that occurs following intrathecal MTX therapy; however, DNL occurs at a very low incidence. For newly developed enhancing lesions, consideration for the occurrence of DNL should be taken to avoid unnecessary invasive procedures or therapies.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.21 no.5
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• pp.421-425
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• 2008

In this research, a 8-bit CMOS 2 stage folding A/D converter is designed, For low power consumption and small chip size, the A/D converter is designed by using folding and interpolation circuit. Folding circuit is composed of the transistor differential pairs which are connected in parallel. It reduces the number of comparator drastically. The analog block composed of folding block, current interpolation circuit, and three stage current comparator is designed with differential-mode for high speed operation. The simulation in a $0.35\;{\mu}m$ CMOS process. shows DNL and SNDR of 0.5LSB and 47 dB at 250 MHz/s sampling frequency.

• Proceedings of the IEEK Conference
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• 2005.11a
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• pp.1241-1246
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• 2005

This paper described an 8bit, 100Msample/s CMOS D/A converter using a glich-time minimization technique for the high-speed sampling rate of 100MHz level. The proposed DAC was implemented in 0,35um Hynix CMOS technology and adopts a current mode architecture to optimize sampling rate, resolution, chip area. The DAC linear characteristics was similar to the proposed specification the prototype error between DNL and INL is less than ${\pm}0.09LSB$ respectively. Also, fab-out chip was tested, analysed the cause of error operation, and proposed the field considerations for chip test.

• Journal of the Korean Operations Research and Management Science Society
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• v.41 no.4
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• pp.1-13
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• 2016

In response to the government's recent attempts to introduce competition and efficiency criteria in the rural railway service provision, this study is to empirically estimate public service values on continuous operation of two rural railways-Young Dong Line (YDL) and Donghae Nambu Line (DNL)-that will be realized beyond the passengers' use values. Based on a contingent valuation survey conducted on 600 passengers and local residents, YDL respondents were willing to pay significantly higher amount compared to those of DNL respondents. Especially tourists traveling on YDL were willing to pay the highest amount, and local residents of DNL were willing to pay relatively high amount. The results will provide useful information in makings decisions on the selection of PSO railways, the amount of PSO compensation and which railways to close, so on.

• 전자공학회논문지 IE
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• v.43 no.3
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• pp.6-12
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• 2006

This paper described an 8bit, 100Msample/s CMOS D/A converter using a glitch-time minimization technique for the high-speed sampling rate of 100MHz level. The proposed DAC was implemented in $0.35{\mu}m$ Hynix CMOS technology and adopts a current mode architecture to optimize sampling rate, resolution, chip area. The DAC linear characteristics was similar to the proposed specification and the prototype error between DNL and INL is less than $\pm$0.09LSB respectively. Also, the manufactured DAC chip was analyzed the cause of error operation and proposed the field considerations for chip test.

• Development and Reproduction
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• v.27 no.2
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• pp.77-89
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• 2023

Metformin is the most widely used anti-diabetic drug that helps maintain normal blood glucose levels primarily by suppressing hepatic gluconeogenesis in type II diabetic patients. We previously found that metformin induces apoptotic death in H4IIE rat hepatocellular carcinoma cells. Despite its anti-diabetic roles, the effect of metformin on hepatic de novo lipogenesis (DNL) remains unclear. We investigated the effect of metformin on hepatic DNL and apoptotic cell death in H4IIE cells. Metformin treatment stimulated glucose consumption, lactate production, intracellular fat accumulation, and the expressions of lipogenic proteins. It also stimulated apoptosis but reduced autophagic responses. These metformin-induced changes were clearly reversed by compound C, an inhibitor of AMP-activated protein kinase (AMPK). Interestingly, metformin massively increased the production of reactive oxygen species (ROS), which was completely blocked by compound C. Metformin also stimulated the phosphorylation of p38 mitogen-activated protein kinase (p38MAPK). Finally, inhibition of p38MAPK mimicked the effects of compound C, and suppressed the metformin-induced fat accumulation and apoptosis. Taken together, metformin stimulates dysregulated glucose metabolism, intracellular fat accumulation, and apoptosis. Our findings suggest that metformin induces excessive glucose-induced DNL, oxidative stress by ROS generation, activation of AMPK and p38MAPK, suppression of autophagy, and ultimately apoptosis.