• Research in Community and Public Health Nursing
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• v.15 no.1
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• pp.76-83
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• 2004

Purpose: This study was aimed at investigating the relationship between retention of the maternal child health handbook, awareness of DPT additional immunization and DPT additional immunization, and to provide basic information to enhance the DPT additional immunization rate. Method: The study subjects were 312 women whose children were between four and six years old, and residing in six provinces of Gyungsangnam do. Data was collected with a 10 item questionnaire by interviews from July 1st to 30th, 2003, and analyzed with descriptive statistics and X2 test at a significance level of 0.05, by two tailed test. Results: The awareness of DPT additional immunization was significantly higher in the women who retained the maternal child health handbook, than their counterparts. The rate of DPT additional immunization was significantly higher in the women who were aware of the DPT additional immunization or who retained the maternal child health handbook, than their counterpart. Conclusion: The DPT additional immunization rate was related to retention of the maternal child health handbook and awareness of DPT additional immunization. Therefore it is recommended that measures be developed and taken to increase the retention rate of the maternal child health handbook and awareness of DPT additional immunization, to enhance the rate of DPT additional immunization.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.4
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• pp.124-130
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• 2008

Automatic layout decomposition techniques have been developed for double patterning technology (DPT). As CMOS manufacturing process scales down to 45nm and below, lithography resolution needs to be improved. DPT has been proposed to enhance the limitation of conventional lithography, by decomposing the layout design into two masks to relax the minimum spacing requirement. However, it is not always possible to decompose a layout into two masks. We have developed new automatic stitching techniques to resolve this problem. Experimental results show that the suggested techniques are promising in decomposing layouts for DPT.

• Journal of Microbiology and Biotechnology
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• v.32 no.9
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• pp.1103-1109
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• 2022

Deoxypodophyllotoxin (DPT), a naturally occurring flavonolignan, possesses several pharmacological properties, including anticancer property. However, the mechanisms underlying DPT mode of action in oral squamous cell carcinoma (OSCC) remain unknown. This study aimed to investigate the anticancer effects of DPT on OSCC and the underlying mechanisms. Results of the MTT assay revealed that DPT significantly reduced the cell viability in a time- and dose-dependent manner. Flow cytometry analysis revealed that DPT induces apoptosis in OSCC cells in a dose-dependent manner. Moreover, DPT enhanced the production of mitochondrial reactive oxygen species (ROS) in OSCC cells. Mechanistically, DPT induced apoptosis in OSCC cells by suppressing the PI3K/AKT signaling pathway while activating the p38 MAPK signaling to regulate the expression of apoptotic proteins. Treatment with SC79, an AKT activator, reversed the effects of DPT on AKT signaling in OSCC cells. Taken together, these results provide the basis for the use of DPT in combination with conventional chemotherapy for the treatment of oral cancer.

• 한국전산유체공학회:학술대회논문집
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• 2003.10a
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• pp.54-54
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• 2003

• Journal of Korean Tunnelling and Underground Space Association
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• v.15 no.1
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• pp.1-11
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• 2013

Steel fiber-reinforced concrete (SFRC) is widely used for tunnel lining structure such as shot-crete in NATM tunnel and segment in TBM tunnel. In tunnel fire accidents, structural performance of a lining is very important because the lining is the structure that directly exposed to fire. In this study, the effects of high temperatures, mix ratios and types on failure pattern, DPT tensile strength and coefficient of variation were investigated through Double Punch Tests (DPT) of SFRC subjected to high temperatures. In the results, it is confirmed that the residual DPT tensile strength increases as for SFRC and this is more in SFRC with higher mix ratio. But, the equation for evaluation of DPT tensile strength does not involve the number of failure surfaces SFRC specimens subjected to high temperatures, therefore, it is required to investigate more fracture energy in DPT tests.

• Biomolecules & Therapeutics
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• v.16 no.3
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• pp.190-196
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• 2008

Deoxypodophyllotoxin (DPT) is a medicinal herb product isolated from Anthriscus sylvestris. DPT possesses beneficial activities in regulating immediate-type allergic reaction and anti-inflammatory activity through the dual inhibition of cyclooxygenase-2 and 5-lipoxygenase. In the present study, the metabolism of DPT was further characterized in rat liver microsomes isolated from male Sprague Dawley rats. The metabolism of DPT was NADPH-dependent. In addition, when liver microsomes were incubated with SKF-525A, a well-known CYP inhibitor, in the presence of $\beta$-NADPH, the metabolism of DPT was significantly inhibited. Using enriched rat liver microsomes, the anticipated isoforms of cytochrome P450s (CYPs) in the metabolism of DPT were partially characterized. Phenobarbital-induced microsomes increased in the formation of metabolite M1. The metabolite M3 was only produced in the enriched microsomes isolated from dexamethasone-treated rats. The results indicated that the metabolism of DPT would be CYP-dependent and that CYP2B and CYP3A might be important in the metabolism of DPT in rats.

• Proceedings of the Ginseng society Conference
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• 1993.09a
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• pp.171-178
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• 1993

The effects of Korean Red Ginseng (KRG) in rats submitted to exhaustion exercise have been studied, by measuring different enzymatic and hematological parameters in plasma and muscle. KRG powder was daily administered to 15 male Wistar rats for a period of two weeks. Another group of 15 rats with the same characteristics were administered physiological saline. Both groups were divided as follows: 5 control. 5 exercised till exhaustion and 5 recovered for 48 h after exhaustion. The following results were obtained for the groups treated with KRG in rapport to those treated with saline: - Higher endurance to running, - Increase of the osmotic resistence of red blood cells and higher presence of reticulocytes. - Lower triglyceride levels in plasma. - Increase non statistically significant of urea levels in plasma, - Lower non statistically significant hypoglycemia after exhaustion exercise. - Decrease of liver glycogen after exercise and faster recovery of the resting - level. - Protective effect on tissular damage produced by exhaustion exercise - Lower LDH activity in all studied muscles. only statistically significant in the WG.

• Journal of Microbiology and Biotechnology
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• v.31 no.4
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• pp.559-569
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• 2021

As one of the major types of lung cancer, non-small cell lung cancer (NSCLC) accounts for the majority of cancer-related deaths worldwide. Treatments for NSCLC includes surgery, chemotherapy, and targeted therapy. Among the targeted therapies, resistance to inhibitors of the epidermal growth factor receptor (EGFR) is common and remains a problem to be solved. MET (hepatocyte growth factor receptor) amplification is one of the major causes of EGFR-tyrosine kinase inhibitor (TKI) resistance. Therefore, there exists a need to find new and more efficacious therapies. Deoxypodophyllotoxin (DPT) extracted from Anthriscus sylvestris roots exhibits various pharmacological activities including anti-inflammation and anti-cancer effects. In this study we sought to determine the anti-cancer effects of DPT on HCC827GR cells, which are resistant to gefitinib (EGFR-TKI) due to regulation of EGFR and MET and their related signaling pathways. To identify the direct binding of DPT to EGFR and MET, we performed pull-down, ATP-binding, and kinase assays. DPT exhibited competitive binding with ATP against the network kinases EGFR and MET and reduced their activities. Also, DPT suppressed the expression of p-EGFR and p-MET as well as their downstreat proteins p-ErbB3, p-AKT, and p-ERK. The treatment of HCC827GR cells with DPT induced high ROS generation that led to endoplasmic-reticulum stress. Accordingly, loss of mitochondrial membrane potential and apoptosis by multi-caspase activation were observed. In conclusion, these results demonstrate the apoptotic effects of DPT on HCC827GR cells and signify the potential of DPT to serve as an adjuvant anti-cancer drug by simultaneously inhibiting EGFR and MET.

• Proceedings of the KIEE Conference
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• 1988.07a
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• pp.439-441
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• 1988

The induced currents on a uniform resistive strip by a H-polarized plane wave are obtained by the iteration method in the spectral domain and compared with the results by the moment method.

• Geomechanics and Engineering
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• v.13 no.1
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• pp.119-139
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• 2017

Static Penetration Test (CPT) and Dynamic Penetration Test (DPT) are commonly used in-situ tests in a routine geotechnical investigation. Besides their use for qualitative investigation (lithology, homogeneity and spatial variability), they are used as practical tools of geotechnical characterization (resistance to the penetration, soil rigidity) and modern foundation design as well. The paper aims at presenting the results of an extensive research work on the evaluation of the 1D primary consolidation settlement of saturated clayey soils on the basis of the CPT or DPT tests. The work is based on an analysis of the correlations between the tip resistance to penetration measured in these tests and the parameters of compressibility measured by the compressibility oedometer test, through a local geotechnical database in the northern Algeria. Such an analysis led to the proposal of two methods of calculation of the settlement, one based on the CPT test and the other one on the DPT. The comparison between the predicted settlements and those computed on the basis of the oedometer test showed a good agreement which demonstrate the possbility to use the CPT and DPT tests as reliable tools of computation of foundation settlements in clayey soils.