• 경영과정보연구
• /
• 제5권
• /
• pp.33-59
• /
• 2000

Problem definition is as important as problem solving in decision making. Decision makers, however, tend to see problem partly or to define it unclearly. The researchers on decision making tend to lay a focus only on the Process of solving the given problem. This dissertation empirically studied the Problem diagnosis and definition in the decision making process. This study developed three kinds of DSS(Decision Support System) for the research and analyzed the effectiveness of the problem diagnosis and definition using DSS developed in this study. The three kinds of DSS are K-T(Kennel and Tregoe) DSS which is a method of table-styled information Presentation, and F-N(Fact-Net) DSS and C-E(Cause and Effect) DSS which are methods of graphic-styled information presentation. The empirical study was conducted twice; the pilot test and the main test. The samples of experiment are 218 students for the pilot test and 259 students for the main test. The author used K-T DSS and F-N DSS for the pilot test, and the revised K-T DSS and C-E DSS for the main test. A questionnaire survey method was included in the main test process The result of the study shows that the group using DSS in problem diagnosis and definition is more effective than the group not using DSS. A table-styled information presentation DSS, K-T, turns out more effective than a graphic-styled information presentation DSS, F-N, K-T DSS and C-E DSS showed no significant differences in the effectiveness in the main test. These results indicate that the use of DSS in the stage of problem diagnosis and definition is very effective and the methods and types of system design are a significant factors for DSS development.

• 한국식품영양학회지
• /
• 제34권2호
• /
• pp.146-155
• /
• 2021

This study observed the anti-inflammatory effect of the polysaccharide derived from the mycelium of Tremella fuciformis in mice with colitis induced with dextran sulfate sodium (DSS). The experimental groups were normal, DSS, DSS-TFL50, DSS-TFH100, and suflasalazine. Body weights, colon lengths, and organ weights were measured, and the plasma level of pro-inflammatory cytokine and mRNA and protein expression in colon tissue were analyzed. Body weight loss, a symptom of DSS-induced colitis, was suppressed by DSS-TF and the speed of weight recovery proceeded rapidly. In addition, DSS-TF showed a significant inhibitory effect on the decrease of colon length typically caused by colon damage. TNF-α, IL-6 and IL-1β cytokine levels in plasma were reduced in DSS-TF and positive control groups. TNF-α, COX-2 and IL-1β mRNA expression in colon tissue were inhibited in DSS-TF and positive control, and it was significantly different from that of the DSS group. The protein expression of inflammation-related genes (IL-6, TNF-α and COX-2) in the colon tissue was significantly increased by DSS compared to that of the normal group, but by DSS-TFL50, DSS-TFH100 and sulfasalarin decreased. In conclusion, the polysaccharide derived from the mycelium of Tremella fuciformis showed the anti-inflammatory effect on DSS-induced colitis in mice.

• Journal of Nutrition and Health
• /
• 제37권6호
• /
• pp.431-439
• /
• 2004

Scutellariae Radix (Scu.), one of the immune-regulatory substances, is recognized to play the role in the metabolic process of inflammation, allergy and immunity. It has been traditionally used in the Oriental medicine to treat inflammatory bowel diseases (IBD). The purpose of this study was to evaluate the effects of water extracts of Scutellariae Radix on the spleen lymphocyte immune function in the Balb/c female mice treated with dextran sodium sulfate (DSS) to induce colitis. Water extract of Scutellariae Radix (100 mg/kg) and sulfasalazine (50 mg/kg) were administrated orally for 2 weeks of experimental period. Mice were divided into three experimental groups randomly: DSS group (5％ DSS was ad libitum for 5 days) as control group, DSS ＋ Scu. (water extracts of Scutellariae Radix for 2 weeks after 5％ DSS was ad libitum for 5 days) as experimental group, and DSS ＋ Sulfasalazine group (Sulfasalazine for 2 weeks after 5％ DSS was ad libitum for 5 days) as positive control group. Levels of Ig A, Ig E, CD4$^{＋}$, CD8$^{＋}$, TNF-$\alpha$ and other cytokines were measured. Treatment of DSS for 5 days induced bowel inflammation and the treatment with Scu. water exteract and sulfasalazine significantly recovered the damage. The length of intestine of DSS group was significantly shorter than that of other groups. The serum and fecal concentration of Ig A of SS ＋ Scu group was higher than those of DSS group. The contents of CD4$^{＋}$ T cells was higher in the DSS ＋ Scu. group than the other groups and CD8$^{＋}$ T cells was the lowest in DSS ＋ Sulfasalazine group. The Ig A level of cultured supernatant of spleen lymphocyte was the highest, while the Ig E level was the lowest in SS ＋ Scu group. The concentration of TNF-$\alpha$, cytokine secreted from the Th1 cell in the supernatant spleen lymphocyte, was the highest in the DSS group and the lowest in the DSS ＋ Scu. group. The concentration of IFN-${\gamma}$ and ll...-12 was lower in the DSS ＋ Scu. group than those of the other groups. The concentration of IL-4 in the supernatant of spleen lymphocyte was the lowest in the DSS ＋ Scu. group but IL-10 was not significantly different. Based on these findings, water extract of Scutellariae Radix exhibited the inhibitory effect via IL-4 production thereby inhibited the production of Ig E and strengthened immune system, and alleviated injury in DSS- induced colitis mice model.

• 정보보호학회지
• /
• 제18권4호
• /
• pp.66-75
• /
• 2008

신용카드 및 직불카드 회사들의 연합체인 PCI SSC(PCI Security Standards Council)는 2004년 가정이나 소매상과 같은 소규모 환경에서 고객들의 금융 정보 유출을 방지하기 위한 목적으로 PCI DSS가 제정되었다. 국내에서는 2007년부터 PCI DSS 보안감사제도가 시행되었으며 유일하게 PCI DSS 보안감사자를 보유한 (주)에이쓰리시큐리티사가 가맹점1) 및 PG/VAN사(社)를 대상으로 PCI DSS 보안감사를 실시하였다. 본 연구에서는 2007년 한 해 동안 국내의 PCI DSS 보안감사를 수행하면서 요구사항에 만족하지 못하는 항목들에 대한 사례를 분석함으로써 국내 PCI DSS 보안감사 도입의 현 주소를 파악하고 이에 대한 개선안을 도출하여 보안감사에 보다 유연하게 대처할 수 있도록 하고자 한다. 2007년 한해 국내 보안감사 실시 결과 PCI DSS 보안감사 대상자의 요구사항 준수율은 평균 81%로 측정되었으며, 전체 233개의 요구사항 중 미적용으로 평가된 항목은 평균 38.7개로 나타났다. 전체적인 평균으로 따져봤을 경우 어느 정도 양호한 수준으로 판단할 수도 있으나 피감사 기업의 업태나 사전준비의 유무에 따라 많은 격차가 있었다. 특히, 기반이 튼튼한 PG사나 VAN사에 비해 신규로 등록되어 사업규모가 작거나 타사에 비해 카드결제산업이 차지하는 사업비중이 작은 곳은 PCI DSS 보안감사의 요구사항을 준수하는데 어려움을 겪고 있는 것으로 나타났다. 따라서, 본 연구에서는 PCI DSS 보안감사를 통해 도출된 미적용 사항 중 가장 많은 미적용율을 나타낸 10가지 항목에 대하여 분석하고 이에 대한 대안을 제시함으로써 향후, PCI DSS의 요구사항을 기업환경에 맞게 적용하기 위해 효율적인 가이드로써 활용되었으면 하는 바램이다.

• 대한의생명과학회지
• /
• 제20권4호
• /
• pp.227-236
• /
• 2014

Ulcerative colitis (UC) is a serious gastrointestinal tract disease characterized by recurrent chronic inflammation and mucosal damage of the gastrointestinal tract. The conventional therapies of choice are anti-inflammatory agents, steroids and anti-TNF-${\alpha}$ therapy. However, inherent limitations in these therapies have steered many UC patients to supplement existing therapies with alternative medicinal products. In the current study, we tested the efficacy of Gingko bilola extract (EGb 761) in abating colonic inflammation in a DSS-induced murine model of colitis. C57BL/6 mice were administered 2% DSS in the drinking water for 7 days, then regular water for 7 days, and then 2% DSS for an additional 7 days. EGb 761 (1 mg/dose) was oral gavaged daily for the duration of the experiment. At the termination of the experiment, mice treated with EGb+DSS showed higher body weight, lower spleen weight and longer colon length compared to mice treated with DSS alone. HE-stained colon tissues also exhibited less histologic inflammation in mice treated with EGb+DSS mice compared to mice treated with DSS alone. The serum levels inflammatory cytokines, KC and TNF-${\alpha}$, were also decreased in mice treated with EGb+DSS compared to mice treated with DSS alone. Finally, addition of EGb 761 to TNF-${\alpha}$ treated colonic cell line (HT29/c1) decreased secretion of IL-8 in vitro. These results collectively suggest that EGb 761 abates induction of colitis in DSS-induced model of colitis in mice.

• 경영과학
• /
• 제18권2호
• /
• pp.39-60
• /
• 2001

This Paper deals with a collaborative decision making procedure of web-based DSS for supply chain management (SCM). The seemingly autonomous DSS dedicated to each of mutually exclusive prob1em domains forms a communication network and cooperates each other for better SCM decision making. We a1so propose a hub-spoke information sharing model for the DSS network. In the hub-spoke model, an information hub at the center facilitates information exchange between DSS\\`s and controls the conversations defined by the series of XML messages between agents of DSS. A product ordering scenario where supply decision is triggered upon customer order is used to demonstrate the SCM decision procedure through a collaboration of the web-based DSS.

• Smart Structures and Systems
• /
• 제26권4호
• /
• pp.533-544
• /
• 2020

Effective bridge maintenance reduces bridge operation costs and extends its service life. The possibility of storing bridge life-cycle data in a 3D parametric model of the bridge through Bridge Information Modeling (BrIM) provides new opportunities to enhance current practices of bridge maintenance management. This study develops a Decision Support System (DSS), namely BrDSS, which employs BrIM and an efficient optimization model for bridge maintenance planning. The BrIM model in BrDSS extracts basic data of elements required for the optimization process and visualizes the inspection data and the optimization results to the user to help in decision makings. In the optimization module of the DSS, the specifically formulated Genetic Algorithm (GA) eliminates the chances of producing infeasible solutions for faster convergence. The practicality of the presented DSS was explored by utilizing the DSS in the maintenance planning of a bridge under operation in the southwest of Iran.

• International Journal of Advanced Culture Technology
• /
• 제6권4호
• /
• pp.97-108
• /
• 2018

The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and combination with herbal medicine on dextran sodium sulfate (DSS)-induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n = 9): group I-normal group, group II-DSS control group, group III-DSS + sulfasalazine (30 mg/kg), group IV-DSS + sulfasalazine (60 mg/kg), group V-DSS + sulfasalazine (30 mg/kg) + Radish Extract mixture (30 mg /kg) (SRE). DSS-treated mice developed symptoms similar to those of human UC, such as severe bloody diarrhea and weight loss. SRE supplementation, as well as sulfasalazine, suppressed colonic length and mucosal inflammatory infiltration. In addition, SRE treatment significantly reduced the expression of pro-inflammatory signaling moleculesthrough suppression both mitogen-activated protein kinases(MAPK) and nuclear factor-kappa B ($NF-{\kappa}B$) signaling pathways, and prevented the apoptosis of colon. Moreover, SRE administration significantly led to the up-regulation of anti-oxidant enzyme including SOD and Catalase. This is the first report that Radish extract mixture combined with sulfasalazine protects against experimental UC via the inhibition of both inflammation and apoptosis, very similar to the standard-of-care sulfasalazine.

• 한국해양공학회지
• /
• 제28권4호
• /
• pp.306-313
• /
• 2014

Super duplex stainless steels (sDSS) are excellent for use under severely corrosive conditions such as offshore and marine applications like pipelines and flanges. sDSS has better mechanical properties and corrosion resistance than the standard duplex stainless steel (DSS) but it is easier for a sigma phase to appear, which depresses the mechanical property and corrosion resistance, compared to DSS, because sDSS has a higher alloy element than DSS. In addition, sDSS has a feeble ductile-brittle transition temperature (DBTT) because it has a 50% ferrite microstructure. In the actual operating environment, sDSS would be thermally affected by welding and a sub-zero temperature environment. This study analyzed how precipitated sDSS behaves at a sub-zero temperature through annealing heat treatment and a sub-zero tensile test. Six types of specimens with annealing times of up to 60 min were tested in a sub-zero chamber. According to the experimental results, an increase in the annealing time reduced the elongation of sDSS, and a decrease in the tensile test temperature raises the flow stress and tensile stress. In particular, the elongation of specimens annealed for 15 min and 30 min was clearly lowered with a decrease in the tensile test temperature because of the increasing sigma phase fraction ratio.

• Journal of Microbiology and Biotechnology
• /
• 제30권11호
• /
• pp.1640-1650
• /
• 2020

Colorectal cancer (CRC) is the leading cause of common malignant neoplasm worldwide. Many studies have analyzed compositions of gut microbiota associated with various diseases such as inflammatory bowel diseases (IBD) and colon cancer. One of the most representative bacteria involved in CRC is enterotoxigenic Bacteroides fragilis (ETBF), a species belonging to phylum Bacteroidetes. We used ETBF colonized mice with azoxymethane (AOM)/dextran sulphate sodium (DSS) and zerumbone, a compound with anti-bacterial effect, to determine whether zerumbone could restore intestinal microbiota composition. Four experimental groups of mice were used: sham, ETBF colonized AOM/DSS group, ETBF colonized AOM/DSS group zerumbone 60 mg kg-1 (ETBF/AOM/DSS + Z (60)), and only zerumbone (60 mg kg^-1)-treated group. We performed reversible dye terminators-based analysis of 16S rRNA gene region V3-V4 for group comparison. Microbiota compositions of ETBF/AOM/DSS + Z (60) group and ETBF colonized AOM/DSS group not given zerumbone were significantly different. There were more Bacteroides in ETBF/AOM/DSS + Z (60) group than those in ETBF colonized AOM/DSS group, suggesting that B. fragilis could be a normal flora activated by zerumbone. In addition, based on linear discriminant analysis of effect size (LEfSe) analysis, microbial diversity decreased significantly in the ETBF colonized AOM/DSS group. However, after given zerumbone, the taxonomic relative abundance was increased. These findings suggest that zerumbone not only influenced the microbial diversity and richness, but also could be helpful for enhancing the balance of gut microbial composition. In this work, we demonstrate that zerumbone could restore the composition of intestinal microbiota.