• 한국의류학회지
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• 제37권7호
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• pp.874-881
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• 2013

Dansam (Salvia miltiorrhiza Bunge) is a perennial plant that belongs to the Labiatae family and is characterized by red pigment found in the epidermis of its roots. Research on the dyeability of Dansam extract was performed with repeated trials under various conditions such as temperature, time, and mordant treatment. Silk fabrics were dyed with Dansam extract and mordanted with various agents such as Al, Fe, Cu, and Sn to evaluate the dyeability and functionality of Dansam extract; subsequently, the K/S value and the change of surface color were analyzed using a colorimeter. In addition, the dyeability of dyed fabrics (such as color fastness to washing, dry cleaning fastness, rubbing fastness and light fastness) and functionality (such as antibacterial activity and deodorization) were analyzed. The surface colors of all dyed fabrics were recorded and the results showed the presence of mostly YR series of colors; in addition, a GY color series appeared in the Fe pre-mordants of the silk fabric. The highest K/S values were recorded in Fe post-mordants. The washing fastness were Level 3 and Level 4; in addition, the dry-cleaning fastness showed excellent results at Level 4 and Level 5. The rubbing fastness was satisfactory at Level 3 and Level 4 and the light fastness was satisfactory at Level 4. The results of the measurements (that pertained to the antibacterial activity of fabrics dyed with Dansam extract) showed a 99.9% bacteria reduction rate of Staphylococcus aureus and Klebsiella pneumoniae. In regards to deodorization ability, dyed fabrics were found to have higher deodorization rates than those not dyed. The dyed fabric demonstrated exceptional deodorization qualities.

• 대한한방내과학회지
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• 제20권1호
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• pp.143-152
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• 1999

Dansam, the root of Salvia miltiorrhiza Bge, (Labiatae), has a bitter taste and a slightly 'cold' property, and is nontoxic. In the present study, effect of Dansam on nitric oxide (NO) generation from peritoneal macrophags was examined. Dansam had no effect on NO generation by itself, whereas recombinant interferon-${\gamma}\;(rIFN-{\gamma})$ alone had modest activity. When Dansam was used in combination with $rIFN-{\gamma}$, there was a marked cooperative induction of NO generation in a dose-dependent manner, The optimal effect of Dansam on NO generation was shown at 6 hr after treatment with $rIFN-{\gamma}$. Furthermore, the effect of Dansam was mainly dependent on Dansam-induced tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})$ secretion. These results suggest that Dansam induces NO generation from macrophages by the result of Dansam-induced $TNF-{\alpha}$ secretion.

• 한국염색가공학회지
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• 제25권4호
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• pp.314-326
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• 2013

The purpose of this research is to analyze the effects of Dansam and Sappan wood extract to perform combination dyeing on silk fabrics, with respect to color changes, fastness (washing, dry cleaning, perspiration, rubbing and light fastness), and functionality (antibacterial activity and deodorization). Combination dyeing was performed by first combining Dansam with Sappan wood, then Sappan wood with Dansam, in these orders. Given the changes in the combination ratio, pre-mordant treatment was performed. Looking at the surface colors of each dye, Dansam generally produces YR color series, while Sappan wood produces YR, R, and RP color series. The effects of changing the order in which combination dying was performed on the surface colors were as follows. First, combination dyeing (A) was performed by using Dansam before Sappan wood, to produce YR and R color series. Then combination dyeing (B) was performed by using Sappan wood before Dansam, to produce YR, R, and RP color series. By visual inspections, more similar color changes of the combination dyeing were noticed with the post-dyeing material rather than the pre-dyeing material. Therefore, it was presumably confirmed that surface color changes of combination dyeing were greatly influenced by the post-dyeing color. Individual dyeing tests for fastness showed that Dansam was comparatively superior to Sappan wood, which demonstrated lower fastness to washing, dry cleaning, perspiration, and light, relatively. The fastness of combination dyed samples was shown middle, but similar fastness to the post-dye material, The fastness of (B) method was higher than (A) method in the washing and light fastness. This confirms that color fastness from combination dyeing was considerably influenced by the post-dye material. It was found that all dyed samples had a very high bacterial reduction rate of 99.9% and high deodorization rate of 95%.

• 대한한의학회지
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• 제28권2호통권70호
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• pp.185-199
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• 2007

Objectives : This study was carried out to investigate the inhibitive effect of a combined-herb prescription of Dansam-san (DSS) on formation of foam cells and cytokine. Methods : Experimental formation of foam cells was induced on macrophage RAW 264.7 with ox-LDL. The effect of DSS extract was observed by measuring the changes of CD36, $PPAR-{\Gamma}$, MMP-9, iNOS expression and changes of formation level of foam cells after treating experimentally induced foam cells with DSS extract. Then the antioxidative effect of DSS extract was compared with butylated hydroxyanisole (BHA). Result and Conclusions : Results obtained are as follows: 1. DSS extract showed significant antioxidative effect at 8 mg/ml or more. 2. DSS extract inhibited the formation of foam cells. 3. DSS extract inhibited the creation and revelation of conversion-related material about foam cells. 4. DSS extract prohibited the increase of smooth muscle of vessels.

• 한방재활의학과학회지
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• 제33권2호
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• pp.1-18
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• 2023

Objectives The purpose of this study was to evaluate the antioxidant, anti-inflammatory and wound healing effects of Samul-tang-ga-dansam water extract (SD) in wound-induced mice. Methods The mice were divided into five groups (n=7): the normal group, the control group, the positive control group, the low-dose SD group and the high-dose SD group. The normal group had no wounds and the other groups were wounded on the back with a leather punch. Distilled water was administered to the control group, 200 mg/kg of vitamin E was administered to the positive control group. In the low-dose SD group and the high-dose SD group, 1.23 g/kg and 2.47 g/kg of SD were administered, respectively. Antioxidant and anti-inflammatory protein levels were evaluated using western blot analysis. Skin tissue was analyzed by H&E, Masson's trichrome staining method. Results Oral administration of the SD significantly reduced the visible skin damage and decreased the reactive oxygen species and ONOO^- activity of the serum. It significantly increased heme oxygenase-1, superoxide dismutase, catalase, GPx-1/2, Nrf2 and Keap-1 which are antioxidant-related factors in skin tissue and reduced NF-κB p65, inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor α, interleukin (IL)-1β, IL-6 which are inflammation-related factors. Also, SD significantly decreased NOX2, p22^phox and p47^phox and increased α-smooth muscle actin and COL1A1 protein expression in fibroblasts involved in connective tissue repair. According to histological examination, the thickened epithelial layer was thinned and collagen fibers were increased to accelerate wound healing. Conclusions It is suggested that Samul-tang-ga-dansam has antioxidant and anti-inflammatory effects and promotes wound tissue repair.

• 한국식품영양과학회지
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• 제32권1호
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• pp.22-28
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• 2003

단삼을 건조시켜 분쇄한 후 methanol로 추출하여 여러 용매로 분획하여 식품부패미생물의 증식억제 효과를 검색하고 그 항균성 물질을 분리하였다. 단삼의 chloroform 분획 추출물은 B subtilis, S. aureus, L. monocytogenes. E. coli 및 V, parahaemolyticus에 대해서 가장 낮은 농도인 250 $\mu\textrm{g}$/disc 농도에서 가장 높은 항균활성을 나타내었다. 단삼의 chloroform 추출물을 silica gel coliumn chromatography와 TLC로 monitoring 하여 항균성을 실험하였다. 이 결과 우수한 항균성 을 보인 sub fraction을 재차 분리하여 붉은색 결정의 항균성 물질을 얻었고 이를 GC/MS, $^1$H-NMR, $^{13}$C-NMR 로 구조분석 한 결과 화학식 이 $C_{19}$ H$_{20}$ O$_3$이며 분자량이 296.141 의 cryptotanshinone으로 동정되었다.

• 대한한의학회지
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• 제20권1호
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• pp.11-21
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• 1999

Dansam, the root of Salvia miltiorrhiza BGE. (Labiatae), has a bitter and a slightly 'cold' property. and is nontoxic. It has been used for the treatment of diseases such as tumors, bruises, gynecologic diseases, menoxenia, anemia and so forth. As an oriental medicine pathway, anal therapy has many kinds of treatments, Retention enema is one the most useful, advantageous methods of anal therapy. This experiment was performed in order to study the effect of an aqueous extract of Salviae radix root(SRRAE) on Immediate type allergic reaction by Retention enema. The results were obtained as follows, 1. SRRAE inhibited compound 48/80-induced Immediate type allergic reaction 100% with the dose of 0.1g/kg by anal treatment. However, SRRAE showed no significant inhibitory effect on the same reaction by oral treatment. When mice were pretreated with SRRAE at a concentration ranging from 0.001 to 1.0g/kg, by intra-anal treatment, the serum histamine levels were reduced in a dose-dependent manner. 2. SRRAE also inhibited by 79.8% local cutaneous allergic reaction activated by anti-dinitrophenyl (DNP) IgE. 3. SRRAE close-dependently inhibited the histamine release from rat peritoneal mast cells(RPMC) by anti-DNP IgE., but SRRAE not inhibited compound 48/80-induced histamine release. 4. SRRAE dose-dependently inhibited tumor necrosis $factor-\;{\alpha}$ $(TNF-\;{\alpha}$) production from RPMC by anti-DNP IgE. Moreover, the level of cAMP in RPMC, when SRRAE was added, significantly increased compared with that of a normal control. According to the above results, anal therapy(Retention enema) of SRRAE may be beneficial in the treatment of systemic and local Immediate type allergic reactions.

• 동국한의학연구소논문집
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• 제6권1호
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• pp.177-203
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• 1997

산욕기(産褥期) 감염(感染)이란 분만후(分娩後) 생식기(生殖器)의 세균(細菌)에 의한 감염(感染)을 의미(意味)하며, 산후(産後) 체온상승(體溫上昇)의 대부분(大部分)은 골반감염(骨盤感染)에 의한 것으로 산욕기(産褥期) 감염(感染)의 중요(重要)한 지표(指標)가 된다. 한의학에서 산후발열(産後發熱)의 병인병기(病因病機)는 주로 사독감염(邪毒感染), 혈어(血瘀), 외감(外感), 혈허(血虛) 등으로 보았으며, 치료는 일반적(一般的)으로 산후질환(産後疾患)에는 허증(虛證)이 많아 발표공리(發表攻裏)를 과도(過度)하게 하지 않고, 기혈(氣血)과 영위(營衛)의 조화(調和)에 위주로 하나, 외감(外感)과 이실증(裏實證)을 소홀(疏忽)히 하면 안된다. 따라서 산후발열(産後發熱)을 야기(惹起)하는 각종(各種) 원인균(原因菌)에 대(對)한 객관적(客觀的)인 억제효과(抑制效果)의 검증(檢證)은 산후발열(産後發熱)의 치료율(治療率)을 높이는데 중요하다. 그 결과 산욕기감염을 유발하는 각종(各種) 세균(細菌)에 대(對)해 황연(黃連), 오매(烏梅), 오미자(五味子) 등의 수용성(水溶性) 졸출물(拙出物)이 항균활성(抗菌活性)이 상대적(相對的)으로 좋은 효과(效果)를 보였다. 따라서 산욕기(産褥期) 감염(感染)의 치료(治療)에 이들 한약재(韓藥材)를 이용하면 보다 효과적(效果的)일 것으로 생각된다.