• Biomedical Science Letters
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• v.29 no.3
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• pp.206-209
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• 2023

Asthma is a chronic and allergic inflammation in the lung, mainly caused by house dust mites (HDM). Recent studies have reported Der p 38 and Der f 38 (Dermatophagoides pteronyssinus and D. farinae, respectively) as crucial allergens of HDMs. This study investigates the different allergic effects of Der p 38 and Der f 38 in an asthma-like mouse model. Lung infiltration of neutrophils was induced by intranasal administration of Der p 38 and Der f 38, with stronger infiltration being observed after exposure to Der p 38. Intranasal and intraperitoneal administration of Der p 38 induced the infiltration of neutrophils and eosinophils in the lung, which was similar to the effect subsequent to Der f 38 administration. Although the number of mast cells was increased, no significant difference was obtained between the effects of both allergens. In TLR4 knockout BALB/c mice, Der p 38 and Der f 38 had no effect on the infiltration of neutrophils, eosinophils, and mast cells. Additionally, allergenicity induced by Der p 38 and Der f 38 in the basophils of Der p38+/Der f 38+ asthmatic subjects was similar, although Der f 38 presented stronger allergenicity in basophils of Der p38+/Der f 38+ allergic patients than Der p 38. These findings contribute to understanding the role of similar allergen components derived from different species in the pathogenesis of allergic diseases.

• Journal of Environmental Health Sciences
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• v.38 no.3
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• pp.204-212
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• 2012

Objectives: The purpose of this study was to determine house dust mite concentrations in living rooms and bedding materials in atopic case-control groups. Methods: Fifty four homes with children suffering atopic diseases as cases and fifty one homes without atopic diseases as controls were selected after diagnosis at three elementary schools in Ulsan City. Dust samples were collected from the living rooms and bedding materials in each home during summer and winter with a vacuum cleaner and analyzed for house dust mites using enzyme-linked immunosorbent assay (ELISA). Environmental factors and family history were surveyed during sampling. Results: Both species of house dust mite Dermatophagoides farina (Der f 1) and Dermatophagoides pteronyssinus (Der p 1) were found in all homes. Derf1 concentrations were much higher than Der P1 concentrations, both in atopic homes (1518.9 vs. 27.0 ng/g. dust, respectively) and non-atopic homes (810.8 vs. 44.3 ng/g. dust, respectively). Der f 1 concentrations were significantly higher in the atopic group than in the non-atopic group (atopic: 1518.9 ng/g.dust, non-atopic: 810.8 ng/g.dust, p = 0.035). However, total house dust mite Der p 1 concentrations were significantly higher in the non-atopic group than in the atopic group (atopic: 27.0 ng/g.dust, non-atopic: 44.3 ng/g.dust, p = 0.035). Multiple regression implied that mothers with family history of atopic diseases (OR = 4.79, 95% CI = 1.81-12.69), Der f 1 concentrations (OR = 1.74, 95% CI = 1.07-2.81), and air freshener use (OR = 4.60, 95% CI = 1.72-12.34) had significant associations with atopic children. Conclusion: House dust mite Der f 1 concentrations were associated with atopic children. This study suggests that parents should reduce house dust mite Der f 1 concentrations through environmental controls.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.8
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• pp.143-173
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• 2003

In dieser Arbeit wird versucht, einen weiteren theoretischen Rahmen $f\"{u}r$ die Farbensymbole(Rot, Gelb und Grun) in der deutschen, englischen und korearischen Sprache, vor allem in Idiomatik weiterzuentwickeln. Rot und Grun sind in diesen Sprachen reichlicher als Gelb vertreten. Die symbolische Bedeutung von Rot ist besonders ambivalent Es ist die Farbe der Gesundheit, aber auch die Farbe des Blutes, Krieges und Todes. Rot ist in den untersuchten Sprachen als 'sehr', 'gut', 'gesund' oder 'schlecht' belegt Rot zeigt aber einzelsprachliche Eigenschaften. Im Koreanischen ist Rot syrnbollisch mit 'Frau', im Englischen mit $'B\"{u}rokratismus'$ verbunden.. Gelb hat auch $widerspr\"{u}chliche$ Symbolbedeutung .Es ist die Farbe der $Fr\'{u}hlingsblumen$, der Sonne und des Lichtes. Aber Gelb kann die Farbe von 'Neid, Eifersucht' oder 'feige, schlecht' sein. Grun ist die wichtigste Farbe der Natur. So ist diese Farbe symbolisch mit 'gut', 'unreif, 'sehr, viel', 'Wachstum und Gedeihen' assozziert. Durch Vergleich und Analyse der Farbensymbole in diesen drei Sprachen und durch Resultat der Antwort auf Fragenbogen an denen 99 Deutschen, 100 Amerikaner und 101 Koreaner teilnahmen, zeichnen sich folgende Ergebnisse ab. Sprachsymbole von dieser Farbe hat auf die Farbenwahrnehmungen von diesen Leuten nicht direkte $Einfl\"{u}sse{\;} ausge\"{u}bt$. Rot assoziert in 89 Koreanern und 5 Amerikanern 'Leidenschaft': Gelb in 52 Amerikanem, 47 Deutschen und 38 Koreanern $'W\"{a}rme'$: Grun in 33 Amerikanern, '37 Deutschen und 11 Koreanern 'Frieden'. Im Englischen und Deutschen zeigt sich die Assoziation von Gelb mit 'Neid, Eifersucht', was mit kulturellen Vorstellungen $\"{u}bereinstimmt$. 38 Deutsche und 4 Amerikaner geben $f\"{u}r$ Gelb die Symbolbedeutung 'Neid' an. Hier bin ich mit sprachlichem Determinismus von Wharf-Hypothese einverstanden: Verschiroene Sprachgemeinschaften erfassen die Wirklichkeit in ganz verschiedener Weise. Sprachsymbol und Kul­tursymbol scheinen an die Farbenwahrnehmungen von untersuchten Leuten $anzukn\"{u}pfen$.

• Environmental Analysis Health and Toxicology
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• v.30
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• pp.8.1-8.8
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• 2015

Objectives Bedding in childcare centers (CCCs) can hold house dust mite (HDM) allergens. This study examined whether HDM allergen levels can be reduced through the distribution of an educational newsletter on bedding control to parents of CCC children in Korea. Methods All 38 CCCs were measured for Der 1 (sum of Der f 1 and Der p 1) concentrations on classroom floors and bedding before the intervention. Educational newsletters on children's bedding control were sent to 21 CCCs by mail, and teachers were asked to distribute the newsletters to the parents of the children (intervention group). The remaining 17 CCCs were not sent newsletters (control group). The measurement of Der 1 concentrations in 38 CCCs was repeated after the intervention. Dust samples were collected with a vacuum cleaner and analyzed using enzyme-linked immunosorbent assay methods. Results The Der 1 concentrations on the bedding were significantly higher than those on the floors in 38 CCCs at baseline (p < 0.05). Although changes of the Der 1 concentrations for the control group (n=17) were not significant, Der 1 concentrations for the intervention group (n=21) decreased significantly from 2077.9 ng/g dust to 963.5 ng/g dust on the floors and from 3683.9 ng/g dust to 610.4 ng/g dust on bedding (p < 0.05). Conclusions The distribution of educational newsletters on bedding control to parents may be an effective means of controlling HDMs in CCCs.