• 제목/요약/키워드: Dermatomycosis

검색결과 10건 처리시간 0.029초

울릉도의 일개 병원을 내원한 피부 진균증 환자들의 피부 진균증에 대한 인식도에 관한 사례 연구 (Case Control Study of Recognition level for Dermatomycosis of Dermatomycosis Patient to be Treated in Ulleung Hospital of Ulleung island)

  • 배정민;정만진;하동엽;정호건;정기훈
    • 농촌의학ㆍ지역보건
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    • 제30권2호
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    • pp.205-211
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    • 2005
  • 울릉도의 피부 진균증 환자들은 타 지역에 비해 중복 감염율이 높은데, 이는 피부 진균증에 대한 환자들의 인식도가 낮기 때문으로 생각된다. 또한 가족 내 감염율도 타지역 보다 높아서 피부 진균증에 대한 예방 교육이 절실하다. 그러나, 피부 진균증 환자들의 나이가 고령화, 여성화 되고 있어 피부 진균증에 대한 인식을 높이기 위한 보건 교육을 고령 환자들과 여성 환자들에 맞추어 시행할 필요가 있다. 주위 동료들의 감염율도 높으므로 적절한 예방 교육이 이루어 진다면 피부 진균증의 예방 효과는 클 것으로 예상된다. 부족하나마 설문 조사로 피부 진균증 환자들의 피부 진균증에 대한 인식도가 미흡다는 사실은 울릉군 지역의 피부 진균증 예방교육의 필요성을 제시 할 것으로 생각된다. 추후에도 울릉군 지역의 피부 진균증에 대한 여러 가지 방면에서의 연구가 필요할 것으로 생각되며, 인식도 조사도 많은 환자와 주민을 대상으로 시행하여 통계적인 유의성을 찾아야 할 것으로 생각된다.

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Growth Inhibitory Activities of Kalopanaxsaponins A and I against Human Pathogenic Fungi

  • Kim, Dong-Wook;Bang, Kyu-Ho;Rhee, Young-ha;Lee, Kyung-Tae;Park, Hee-Juhn
    • Archives of Pharmacal Research
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    • 제21권6호
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    • pp.688-691
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    • 1998
  • Antifungal activities of the compounds isolated from Kalopanax pictus against representative fungi of dermatomycosis were investigated using paper disc diffusion method. It was found that kalopanaxsaponins A and I were effective in inhibiting the growth of Candida albicans KCTC 1940 and Cryptococcus neoformans KCTC 7224 with minimum inhibitory concentration(MIC) of 25${\mu}g$/ml. It showed that antifungal activity of both compounds have strong selectivity against the fungi of dermatomycosis.

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피부진균증의 원인진균과 발현 빈도에 관한 연구(I) (Mycological Studies of Superficial Fungal Disease : Pathogenic Fungus and Prevalence)

  • 신현성
    • 한국균학회지
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    • 제29권1호
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    • pp.28-33
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    • 2001
  • 피부과환자 105명에서 원인 진균의 발현율을 보기 위하여 연구를 하였다. 피부질환의 병형별 발현율은 족부백선이 44.8%, 완선이 30,5%였으며, 병원성진균의 분리율이 높았던 병형은 안면백선, 체부백선, 조감백선이었다. 병원성진균의 분리율이 높았던 연령군은 $0{\sim}9$세군, $60{\sim}69$세군, $20{\sim}29$세군 이었다. 피부질환의 원인진균으로는 Trichophyton spp.가 43.5%, Candida spp 12.9%. Microsporium spp. 3.2%였다 전체적으로 분리된 진균은 Trichophyton spp. 24.1%, Penicillium spp. 23.2%, Rhizopus spp. 8.0%였다.

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토끼의 피부진균증에 대한 제충국화자비액의 도포치료효과 (Effects of Boiled Solution from Chrysanthemum Cineriaefolium Visiani Inunction Therapy on Dermatomycosis in Rabbits)

  • 장경진;배춘식;조용성
    • 한국임상수의학회지
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    • 제14권2호
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    • pp.172-176
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    • 1997
  • This study was carried out to investigate the anti-fungal effect of Pyrethri Flos Boiled Solution (PFBS) from Chrysanthemum Cinerariaefolium Visiani on Microsporum canis, Microsporum gypseum and Trichophyton Mentagrophytes with 0.5 ml, 1ml, 2 ml. In comparative drugs, on Sabouraud's glucose agar medium to 2 ml respectively and PFBS on the rabbit skin lesions, in vivo experiments, were observed. The results obtained were as follows : PFBS slightly suppresed the growth of the fungi in 0.5 ml and markedly it in 1 ml and 2 ml. In comparative drugs, benzylbenzoate represented similar anti-fungal action in 2 ml compared with PFBS. While, salicylic acid and boric acid represented less suppression of growth of the fungi than PFBS in 0.5 ml. The effects of PFBS on the rabbit skin lesions inoculation with dermatophytes was almost normally recorved about Microsporum gypseum, Trichophyton mentagrophytes except Microsporum canis after 8 days.

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trans-Cinnamaldehyde 유도체의 항진균활성 검색 (Antifungal Activities of trans-Cinnamaldehyde Derivatives)

  • 방규호;조근희;이영하
    • 약학회지
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    • 제45권5호
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    • pp.431-436
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    • 2001
  • Antifungal activities of trans-cinnamaldehyde (CA) derivatives including commercial CA derivatives as well as synthesized CA derivatives against various human pathogenic fungi were investigated. Among the derivatives tested, -chlorocinnamaldehyde, $\alpha$-bromocinnamaldehyde and 7-phenyl-2,4,6-heptatrienal were more potent than CA in antifungal activity, $\alpha$-Bromocinnamaldehyde was the most effective in inhibiting the growth of representative fungi of dermatomycosis with minimum inhibitory cocentration(MIC) of 0.61~9.76$\mu\textrm{g}$/ml . In the structure-activity relationship, introduction of the chlorine and bromine group into the C-2 of CA resulted in the decrease of MIC. Derivative with more double bonds exhibited the increase of antifungal activity against various pathogenic fungi.

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계피로부터 항진균물질 AF-001의 분리.정제 및 특성 (Purification and properties of an antifungal component, AF-001, from Cinnamomi Cortex)

  • 방규호;이영하;민병선
    • 한국균학회지
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    • 제25권4호통권83호
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    • pp.348-353
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    • 1997
  • 계피의 항진균활성을 검색한 결과 에테르 추출물이 우수한 활성을 나타내는 것으로 평가되어 계피 에테르의 추출물로부터 항진균물질 AF-001을 분리 정제하였으며 이를 동정한 결과 trans-cinnamaldehyde로 확인되었다. AF-001은 피부진균증의 원인 균주인 Tricophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Cryptococcus neofomans, Aspergillus niger, Candida albicans와 Penicillium avellaneum에 대해 $38{\sim}79\;{\mu}g/ml$의 최소저지농도를 보였으며 imidazole계의 대표적인 항진균제인 Ketoconazole보다 광범위한 항균 스펙트럼을 보였다.

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Cinnamaldehyde 유도체의 항진균 활성 (Antifungal Activities of Cinnamaldehyde Derivatives)

  • 방규호;민병선;이영하
    • 한국균학회지
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    • 제26권4호통권87호
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    • pp.525-530
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    • 1998
  • Cinnamaldehyde 유도체의 항진균활성을 조사한 결과 ${\alpha}-chlorocinnamadehyde$가 가장 항균활성이 우수한 것으로 평가되었다. ${\alpha}-Chlorocinnamaldehyde$는 피부진균증의 원인균주인 Tricophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Cryptococcus neoformans, Aspergillus niger, Candida albicans와 Penicillium avellaneum에 대해 $9.8{\sim}19.5\;{\mu}g/ml$의 최소저지농도를 보였으나 시판중인 항진균제 clotrimzole보다는 역가가 낮은 것으로 나타났다. ${\alpha}-Chlorocinnamaldehyde$를 제외한 나머지 관련 유도체를 비교한 결과 phenyl기 주위의 유도체 화합물에서는 우수한 항균활성이 관찰되지 않았으며, acrolein기가 항균활성에 중요한 관능기로 작용하는 것으로 나타났다.

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건강한 지원자에 있어서 염산테르비나핀 함유 라미실정과 무조날정의 약물동력학적 비교 (Pharmacokinetic Comparison of Lamisil Tablet and Muzonal Tablet Containing Terbinafine HCl in Healthy Volunteers)

  • 최한곤;용철순;이종달;우종수;이경희;유봉규
    • 약학회지
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    • 제49권4호
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    • pp.255-259
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    • 2005
  • Financial standing of National Health Insurance has been experiencing a grave deterioration during the last 4-5 years, and the yearly amount paid by the insurance for drug expense rose up to 4 trillion won recently. Furthermore, the ratio of drug expenses in the total expenditure of the insurance reached about $25\%$, showing the tendency to be levelled off. As a measure to improve the financial deterioration of the insurance and to encourage generic substitution among the health professionals, we compared pharmacokinetic parameters of brand name drug (Lamisil) and generic drug (Muzonal) containing terbinafine HCl in healthy volunteers. The area under the curve (AUC) of the two drugs showed $2220.4\pm784.7\;and\;2143.1\pm861.6hr{\cdot}ng/ml$ in the corresponding order and no statistically significant difference was identified. The peak concentration $(C_{max})$ of the generic drug demonstrated $566.6\pm246.2 ng/ml$ compared to $550.8\pm204.0$ of brand name drug, which was not significantly different either. Time to reach peak concentration showed about 6 minutes difference between the drugs, which has no clinical significance to the treatment of dermatomycosis and dermatophytosis.

소아에서 분리된 피부진균증의 발생경향 (Incidence Trends of Dermatophytoses Isolated in Children)

  • 김수정;방용준
    • 대한임상검사과학회지
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    • 제50권4호
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    • pp.444-448
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    • 2018
  • 2017년 1월 2일부터 12월 30일까지 내원한 검사환자 13,093명 중 소아청소년환자는 691명이며 백선균 분리환자는 179명으로 25.9%가 분리되었다. 분석 결과 전체 소아환자 691명 중 남성은 423명으로 61%이며 여성은 268명으로 39%로 분포하였다. 연령군별 조사에서는 신체변화가 가장 많은 시기인 사춘기(317, 46%)에서 높게 나타났고 다음으로 학령기(203, 29%)와 영유아기(171, 25%)의 순서로 나타났다. 계절별 조사에서는 여름(195, 28%)과 겨울(191, 28%)이 높게 분리되었고 봄(165, 24%)과 가을(140, 20%)의 순으로 분리되었다. 부위별로는 족부백선(353, 51%)로 가장 많았으며 다음 순으로는 몸백선(91, 13%), 조갑백선(77명, 11%), 사타구니백선(55, 8%), 두부백선(39, 6%), 수부백선(29, 4%), 그리고 얼굴백선(22, 3%)의 순으로 분리되었다. 연령별에 따른 부위별 질환은 소아연령 모두에서 족부백선이 가장 많이 분리되었고 다음 순으로는 유아기와 학령기에서는 몸백선, 조갑백선, 수부백선, 그리고 두부백선의 순으로 분리되었다. 사춘기에서는 몸백선, 조갑백선, 그리고 사타구니백선으로 분리되었다. 원인균종은 Trichophyton rubrum이 가장 많이 분리되었다. 본 자료분석을 통해 소아의 발달단계에 따른 백선의 분포와 분리균종을 확인하였으며 향후 지속적인 자료수집을 통해 소아피부진균증의 분포 추이에 도움이 될 것으로 사료된다.

직업성 피부질환에 대한 현황 파악 및 관리 대책 수립을 위한 연구 (A Study on the Establishment of Management Methods about Occupational Dermatoses)

  • 임현술;정해관;최병순;김지용;성열오;김양호
    • Journal of Preventive Medicine and Public Health
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    • 제29권3호
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    • pp.617-637
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    • 1996
  • Occupational dermatosis is one of the most prevalent occupational disorders. However, the extent of the occupational dermatoses including incidences and prevalencies of each disease entity, and etiologic materials are not yet welt stated in Korea. Authors reviewed the literatures on the statistic data and reports on the occupational dermatoses, and surveyed on the occupational dermatoses in two factories, and surveyed the physicians responsible to the occupational dermatoses with formed questionnaire. The results are as follows; 1. Among medical journals published since 1964, there were 31 articles on the occupational dermatoses. Of 31 articles, 18 were case reports and all others were review articles. Of 18 case reports, 9 were epidemiologic survey. The Workers' Periodic Health Examinations revealed that prevalence of the occupational dermatoses was highest(4.36 per 10,000 workers) in 1974, but number of the cases reported were decreased sharply since 1978 with some tendency to increase since 1981. There were 2,240 reported cases of occupational dermatoses between 1966 and 1992, which is 1.90% of all the reported occupational diseases. Skin infection and injuries due to chemicals were most frequent and there were 6 cases of skin cancer. 2. In an epidemiological survey on the dermatoses among 995 workers in a metal product manufacturing factory and 225 workers in a coal chemical factory, there were 794 with dermatomycosis, 296 workers with acne, 130 workers with scar, 123 workers with deformity of toe nails. Scars, photosensitivity dermatitis, deformity of finger and toe nails, and acne were more prevalent in the metal product manufacturing factory(p<0.05). In the metal prouct manufacturing factory, workers treating organic solvents and oils had more dermatoses than those without treating the materials(p<0.05). On the skin patch performed on 16 workers in the metal product manufacturing factory, there were 8 cases of irritation dermatitis and 5 cases of contact dermatitis. Prevalence of contact dermatitis in the metal product manufacturing factory was 1.3%. 3. On the questionnaire survey, 34 dermatologists, 29 doctors of preventive medicine, and 22 family physician replied. The proportion of occupational etiology among all dermatoses assumed by the physicians were below 9%, and the most important occupational dermatosis in Korea was contact dermatitis. Main etiologic materials related to the occupational dermatosis were organic solvent, acid and alkali, and metals. The reason for the scarcity of report of occupational dermatoses were difficulty in diagnosis and physician's ignorance of the occupational etiology. They replied that to prevent the occupational dermatoses in the workplace, the use of protective devices was most important, and development of diagnostic criteria on the occupational dermatoses is urgent. Above results shows us that there is many workers with occupational dermatoses, but they are mostly unreported. Measures to prevent and manage the occupational dermatoses are not satisfactory at present. Hence, authors suggest measures for the precise diagnosis, report and prevention of the occupational dermatoses. a. Dermatologist, preventive physician, and industrial hygienist should work as a team to examine the high risk group and establish the preventive measures. b. Disease entities, diagnostic criteria of occupational dermatoses should be listed, criteria for the compensation and job fitting at recruitment should be established, and manual for the proper treatment and effective prevention of each occupational dermatosis should be developed. c. Patch test antigens against each occupational category should be developed and it should be available to any physicians responsible. d. To facilitate the diagnosis of occupational dermatoses by the doctors responsible for the Workersr Periodic Health Examination, development of standardized questionnaire, education on the techniques of the patch test, and cooperation with the dermatologist in diagnosis of occupational dermatoses is essential.

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