• Title/Summary/Keyword: Differentiation

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The Effects of Intergenerational Transmission of Self-Differentiation on Psychological Adjustment of College Student (자기분화의 세대간 전이가 대학생의 심리적 적응에 미치는 영향)

  • Ha, Sang-Hee;Chung, Hye-Jeong
    • Journal of the Korean Home Economics Association
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    • v.46 no.7
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    • pp.95-108
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    • 2008
  • The major purpose of this study was to investigate the effect of intergenerational transmission of self-differentiation on psychological adjustment of college students. Specifically, the present study endeavored to test the causal model focusing on the effect of the father's and the mother's self-differentiation on college student's psychological adjustment through the student's self-differentiation. The data were collected from 254 male and 293 female college students and their parents by using self-administered questionnaire method. The casual model was tested through structural equation model by using AMOS 7.0 program. The results showed that mother's and father's self-differentiation had direct and indirect effect on student's psychological adjustment. The results showed that both mother's and father's self-differentiation had direct effect on son's self-differentiation level, which directly influenced his psychological adjustment. The test of structural equation model also revealed that daughter's self-differentiation level was positively influenced only by mother's self-differentiation, while father's self-differentiation did not influenced female student's self-differentiation. Both male and female student's psychological adjustment was directly influenced by his or her self-differentiation level.

Identification of anti-adipogenic proteins in adult bovine serum suppressing 3T3-L1 preadipocyte differentiation

  • Park, Jeongho;Park, Jihyun;Nahm, Sang-Soep;Choi, Inho;Kim, Jihoe
    • BMB Reports
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    • v.46 no.12
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    • pp.582-587
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    • 2013
  • Adipocyte differentiation is a complex developmental process forming adipocytes from various precursor cells. The murine 3T3-L1 preadipocyte cell line has been most frequently used in the studies of adipocyte differentiation. Differentiation of 3T3-L1 preadipocytes includes a medium containing fetal bovine serum (FBS) with hormonal induction. In this study, we observed that differentiation medium containing adult bovine serum (ABS) instead of FBS did not support differentiation of preadipocytes. Impaired adipocyte differentiation was due to the presence of a serum protein factor in ABS that suppresses differentiation of preadipocytes. Using a proteomic analysis, alpha-2-macroglobulin and paraoxonase/arylesterase 1, which were previously shown to suppress differentiation of preadipocytes, were identified as anti-adipogenic proteins. Although their functional mechanisms have not yet been elucidated, the anti-adipogenic effects of these proteins are discussed.

Effect of Polyamines on Cellular Differentiation of N. gruberi: Inhibition of Translation of Tubulin mRNA

  • Yoo, Jin-Uk;Kwon, Kyung-Soon;Cho, Hyun-Il;Kim, Dae-Myung;Chung, In-Kwon;Kim, Young-Min;Lee, Tae-Ho;Lee, Joo-Hun
    • Journal of Microbiology
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    • v.35 no.4
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    • pp.315-322
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    • 1997
  • The effects of a polyamine, spermine, on the differentiation of Naegleria gruberi amebas into flagellates were tested. Addition of spermine at early stages of differentiation (until 40 min after the initiation of differentiation) completely inhibited the differentiation. To understand the inhibition mechanism, we examined the effect of spermine treatment on the transcription and translation of differentiation-specific genes during differentiation. Addition of spermine at early stages did not inhibit the accumulation of two differentiation-specific mRNAs, ${\alpha}$-tubulin and Class I mRNA, significantly, but rather prevented the rapid degradation of the mRNAs in later overall protein synthesis partially and gradually. However, translation of the ${\alpha}$-tubulin mRNA was completely inhibited. These data suggest that the inhibition of differentiation of N. gruberi by spermine treatment did not result from the inhibition of transcription of differentiation-specific genes but from the specific inhibition of translation of the mRNAs during the differentiation.

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Comparative Review of Treatment Based on Syndrome Differentiation and Treatment Based on Syndrome Differentiation from Disease - Emphasis on Hypertension and Headache - (변증논치(辨證論治)와 병증변치(病證辨治) 장단점의 비교고찰 - 고혈압과 두통의 예를 중심으로 -)

  • Gi, Youjong;Shin, Sunjoong;Han, Wonyoung;Kim, Hyundo;Han, Yoochang;Lee, Sundong
    • Journal of Society of Preventive Korean Medicine
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    • v.21 no.1
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    • pp.9-17
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    • 2017
  • Objectives : Comparative review was rendered to evaluate strengths and weaknesses of two common treatment approaches of treatment based on syndrome differentiation and treatment based on syndrome differentiation from disease. A typical symptom of headache from hypertension was chosen for substantial approach of this review. Methods : Pros and cons of two different approaches to disease were evaluated based on literatures and texts focusing treatment based on syndrome differentiation and treatment based on syndrome differentiation from disease. Headache can be correlated with hypertension yet it can be induced by multiple other factors, and headache may/may not accompany hypertension. Hypertension is an example of treatment based on syndrome differentiation from disease and headache can be an example of treatment based on syndrome differentiation. Results : Treatment based on syndrome differentiation can give more autonomy and flexibility in approach to the disease, Intuition, experience, and traditional medical theory can be applied with ease. However, management and eradication of diseases are difficult and standardization of treatment is not easy among practitioners. Treatment based on syndrome differentiation from disease incorporated merits of both eastern and western medicines, achieving more evidence based diagnosis and treatment. Eradication and standardization of disorders are possible with the latter approach. Conclusions : Comparing two systems of treatment based on syndrome differentiation and treatment based on syndrome differentiation from disease with emphasis on hypertension and headache yielded medical values. Treatment based on syndrome differentiation from disease appears to be superior in medical values and effectiveness, but further evaluation and interest are needed to make advancement in Korean traditional medicine.

Relationship of Vertical versus Horizontal Individualism and Collectivism with Self-differentiation among Korean College Students

  • Chung, Hye-Jeong
    • International Journal of Human Ecology
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    • v.10 no.1
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    • pp.47-59
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    • 2009
  • This study investigates the relationship of self-differentiation with individualism and collectivism among college students. Special focus was on whether distinctions between vertical and horizontal individualism and collectivism were more useful in examining the relationship with self-differentiation. The results reveal that different aspects of individualism and collectivism were differently related to self-differentiation, indicating that self-differentiation was negatively associated with all aspects of collectivism and with vertical individualism, but positively with horizontal individualism. This study proved that four distinct constructs were more useful in explaining the effects on self-differentiation. The implications of the findings are discussed for clinicians and future research.

Price Competition in Horizontal and Vertical Differentiation : Focusing on the WiBro and HSDPA (수직적.수평적 차별화 시장에서의 서비스 요금전략 : 와이브로와 HSDPA 서비스를 중심으로)

  • Kim, Dow-Han
    • Korean Management Science Review
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    • v.26 no.3
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    • pp.67-78
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    • 2009
  • In this paper, I analyze the mobile broadband services market characterized by vertical and horizontal differentiation. Vertical differentiation as service quality differentiation is based on the transmission speed of mobile internet service and horizontal differentiation as spatial differentiation is based on the service coverage. Theoretical explanations for the competitive price policy have been developed in the game context of WiBro which represent the high quality within the limited service coverage and HSDPA which represent relatively low quality with nation-wide service. When the WiBro has a mobile broadband service quality advantage and the difference in quality is sufficiently low, the price of WiBro with limited service coverage is relatively lower than that of HSDPA. This occurs because the advantage of WiBro's vertical service differentiation is offset by the disadvantage of horizontal differentiation. The difference in the quality of mobile internet service, however, is not too high, the price of WiBro is relatively higher than that of HSDPA. Moreover, when the service quality of WiBro is sufficiently high, the low quality HSDPA service faces no demand.

The IRF2BP2-KLF2 axis regulates osteoclast and osteoblast differentiation

  • Kim, Inyoung;Kim, Jung Ha;Kim, Kabsun;Seong, Semun;Kim, Nacksung
    • BMB Reports
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    • v.52 no.7
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    • pp.469-474
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    • 2019
  • Kruppel-like factor 2 (KLF2) has been implicated in the regulation of cell proliferation, differentiation, and survival in a variety of cells. Recently, it has been reported that KLF2 regulates the p65-mediated transactivation of $NF-{\kappa}B$. Although the $NF-{\kappa}B$ pathway plays an important role in the differentiation of osteoclasts and osteoblasts, the role of KLF2 in these bone cells has not yet been fully elucidated. In this study, we demonstrated that KLF2 regulates osteoclast and osteoblast differentiation. The overexpression of KLF2 in osteoclast precursor cells inhibited osteoclast differentiation by downregulating c-Fos, NFATc1, and TRAP expression, while KLF2 overexpression in osteoblasts enhanced osteoblast differentiation and function by upregulating Runx2, ALP, and BSP expression. Conversely, the downregulation of KLF2 with KLF2-specific siRNA increased osteoclast differentiation and inhibited osteoblast differentiation. Moreover, the overexpression of interferon regulatory protein 2-binding protein 2 (IRF2BP2), a regulator of KLF2, suppressed osteoclast differentiation and enhanced osteoblast differentiation and function. These effects were reversed by downregulating KLF2. Collectively, our data provide new insights and evidence to suggest that the IRF2BP2/KLF2 axis mediates osteoclast and osteoblast differentiation, thereby affecting bone homeostasis.

Prediction of shiver differentiation by the form alteration on the stable condition

  • Kim, Jeong-lae;Kim, Kyu-dong
    • International Journal of Internet, Broadcasting and Communication
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    • v.9 no.4
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    • pp.8-13
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    • 2017
  • Movement technique is comprised of the movement status of the circulation differentiation rate (CDR) and rotation differentiation rate (RDR) on the shiver movement form. Condition of the differentiation rate by the shiver movement form is to be modified the teetering movement system. As to fix the movement of signal on the material of body, we compared a shiver value of the circulation differentiation rate on the circulation state. The concept of rotation differentiation rate was identified the reference of rotation differentiation signal and rotation differentiation signal by the rotation state. For detecting a alteration of the CDR-RDR of the maximum and average in terms of the movement form, and shiver movement value that was a shiver value of the top alteration of the Top-ф$_{MAX-AVG}$ with $12.80{\pm}1.27units$, that was a shiver value of the peripheral alteration of the Per-ф$_{MAX-AVG}$ with $4.38{\pm}1.15units$, that was a shiver value of the limbus alteration of the Lim-ф$_{MAX-AVG}$ with $1.65{\pm}0.25units$, that was a shiver value of the center alteration of the Cen-ф$_{MAX-AVG}$ with $0.25{\pm}0.01units$. The teetering movement will be to assess at the ability of the movement form for the control degree of differentiation rate on the CDR-RDR that was shown the circulation and rotation form by the differentiation rate system. Teetering differentiation system was modified of a form by the special movement and was included a shiver data of teetering movement rate.

The Mediating Effects of Couples Communication on the Relations between Self-Differentiation and Marital Satisfaction among Married Women (기혼여성의 자아분화가 결혼만족에 미치는 영향: 부부의사소통의 매개효과를 중심으로)

  • Kim, Hyang Soon;Kim, Soon Duck;Goo, Myoung Yi
    • Journal of Family Resource Management and Policy Review
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    • v.18 no.3
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    • pp.159-176
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    • 2014
  • This study examined the mediating effects of couple communication on self-differentiation and marital satisfaction among married women. The ANOVA, correlation and the multiple regression analysis were used to figure out the relationships and the mediating effects of those variables. The results revealed that self-differentiation was significantly related to marital satisfaction. Also, couple communication was revealed to be a partial and full mediator between self-differentiation and marital satisfaction. The results were as follows. First, there were differences in couple communication and marital satisfaction. Marital satisfaction showed differences according to socio-economic variables such as educational level, occupation, family income, and the years of married life. Educational level and family income made differences in couple's communication. However, socio-economic variables did not make any difference with regard to self-differentiation. Second, there was a significant correlation among all sub-factors for self-differentiation, whole self-differentiation, married couples' communication, and marital satisfaction. Third, the result shows that the mediating effect of couple communication between self-differentiation and marital satisfaction. Couple communication completely mediated the relationship between cognitive vs. emotional function, family projection, emotional cutoff, and marital satisfaction. It also partially mediated the relationship between family regression and marital satisfaction. In addition, there was a tendency to partially mediate the relationship between general self-differentiation and marital satisfaction. The results suggested that self-differentiation and couples communication should be considered together when explaining marital satisfaction among married women. Also, the results implied the importance of the increased self-differentiation and the better couple communication in women's marital satisfaction. Finally, this research suggested the necessity of counseling services to enhance the self-differentiation as well as couple communication programs for the marital satisfaction of women.

The Analysis of usage of Symptom Differentiation in Clinical Trials in Korean Medicine for Cancer Patients (암 환자 대상 한의약 임상시험에서 변증 활용에 대한 분석)

  • Cheon, Chunhoo;Park, Sunju;Jang, Bo-Hyoung;Shin, Yongcheol;Ko, Seong-Gyu
    • Journal of Society of Preventive Korean Medicine
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    • v.19 no.1
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    • pp.61-70
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    • 2015
  • Objective : The aim of this study is to investigate the features of clinical trial which used symptom differentiation on cancer patients Method : Electronic databases including Ovid-Medline, Ovid-EMBASE, and Cochrane library were searched. Search terms incorporating the concepts of cancer, herbal medicine, clinical trial were used. Articles described using symptom differentiation in methods were selected. Results : Twelve studies used symptom differentiation for prescribing herbal medicine to cancer patients. A total of 36 symptom differentiation were used. The kind of the herbal medicines was varied as much as the kind of symptom differentiation. Conclusion : Most of herbal medicines used for cancer patients focused on quality of life or adverse events rather than tumor size. Symptom differentiation and herbal medicine used in selected studies were too diverse to categorize. To use standardized symptom differentiation, symptom differentiation instrument should be developed and reliability test and validity test are needed.