• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.5
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• pp.535-539
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• 2010

We present a digital dilution chip comprising a $2{\times}6$ array of wells; the chip can be employed to change the dilution ratio as well as to initiate reactions among diluted samples by using the inter-well valve around the well. In previous dilution devices, streams comprising sample and dilution solutions were merged and separated by a branched microchannel. Therefore, the dilution ratio could not be changed until the structure of the branched microchannel was changed. The present device merges and splits the wells filled with sample or dilution solution by controlling inter-well valves around the wells. Thus, it is possible to change the dilution ratio by changing the sequence in which merging and splitting sequence of each well filled with sample or dilution solution. In experiments, we found that the chip could be used to change linear or exponential dilution ratios within an error of 16.7% and to initiate reactions among the samples within a reaction error of 17.7%.

• Biotechnology and Bioprocess Engineering:BBE
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• v.8 no.4
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• pp.233-239
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• 2003

For the quantitative analysis of an unknown sample a calibration curve should be obtained, as analytical instruments give relative, rather than absolute measurements. Therefore, researchers should make standard samples with various known concentrations, measure each standard and the unknown sample, and then determine the concentration of the unknown by comparing the measured value to those of the standards. These procedures are tedious and time-consuming. Therefore, we developed a polymer based microfluidic device from polydimethylsiloxane, which integrates serial dilution and capillary electrophoresis functions in a single device. The integrated microchip can provide a one-step analytical tool, and thus replace the complex experimental procedures. Two plastic syringes, one containing a buffer solution and the other a standard solution, were connected to two inlet holes on a microchip, and pushed by a hydrodynamic force. The standard sample is serially diluted to various concentrations through the microfluidic networks. The diluted samples are sequentially introduced through microchannels by electro-osmotic force, and their laser-induced fluorescence signals measured by capillary electrophoresis. We demonstrate the integrated microchip performance by measuring the fluorescence signals of fluorescein at various concentrations. The calibration curve obtained from the electropherograms showed the expected linearity.

• Journal of the Korean Society of Radiology
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• v.14 no.5
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• pp.603-612
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• 2020

This study has a purpose to look into the effect of the relationship between the Tube current (mA) and SOD(Source to Object Distance), which is a parameter of lower limb angiography examination, and the dilution rate of the contrast medium concentration (300, 320, 350) on the image. To that end, using 3 mm vessel model water phantom, a vessel model custom made in the size of peripheral vessel diameter, this study measured relationships between change of parameters, such as tube current (mA), SOD and varying concentrations (300, 320, 350) of contrast medium dilution into SNR and CNR values while analyzing the coefficients of variance(cv<10). The software used to measure SNR and CNR values was Image J 1.50i from NIH (National Institutes of Health, USA). MPV (mean pixel value) and SD (standard deviation) were used after verifying numerically the image signal for region of interest (ROI) and background on phantom from the DICOM (digital imaging and communications in medicine) 3.0 file transmitted to PACS. As to contrast medium dilution by the change of tube current, when 146 mA and 102 mA were compared, For both SNR and CNR, the coefficient of variation value was less than 10 until the section of CM: N/S dilution (100% ~ 30% : 70%) but CM: N/S dilution rate (20%: 80% ~ 10% : 90%) the coefficient of variation was 10 or more. As to contrast medium dilution by concentration for SOD change, when SOD's (32.5 cm and 22.5 cm) were compared,For both SNR and CNR, the coefficient of variation value was less than 10 until the section of CM: N/S dilution (100% ~ 30% : 70%) but CM: N/S dilution rate (20%: 80% ~ 10% : 90%) the coefficient of variation was 10 or more. As to contrast medium dilution by concentration for SOD change, when SOD's (32.5 cm and 12.5 cm) were compared,For both SNR and CNR, the coefficient of variation value was less than 10 until the section of CM: N/S dilution (100% ~ 30% : 70%) but CM: N/S dilution rate (20%: 80% ~ 10% : 90%) the coefficient of variation was 10 or more. As a result, set a low tube current value in other tests or procedures including peripheral angiography of the lower extremities in the intervention, and make the table as close as possible to the image receiver, and adjust the contrast agent concentration (300) to CM: N/S dilution (30%: 70%). ) Is suggested as the most efficient way to obtain images with an appropriate concentration while simultaneously reducing the burden on the kidney and the burden on exposure.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.36 no.8
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• pp.761-766
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• 2008

This paper analyzes the availability and Dilution Of Precision (DOP) of GPS, widely used in positioning, with and without augmentation using QZSS (Quasi-Zenith Satellite System). Orbit simulator for QZSS is developed using Kepler‘s orbital parameters. Also 3D modeling technique based on three-Dimensional GIS digital map and satellite tracking algorithm for visible satellite simulation system are discussed. Performance improvement of the availability and DOP were achieved by combining GPS with QZSS at urban environment of Seoul.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.35 no.12
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• pp.1095-1100
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• 2007

Visibility of the satellite navigation is related to a environmental condition of a receiver. Obstacles like buildings and trees in urban areas can block signals and have effects on accuracy and reliability of positioning. This paper presents a method of creating 3D analysis model of urban canyon of Seoul using three-Dimensional digital map. Analysis techniques of visible satellites with Ray-Polygon Collision Detection and validation of algorithm through field tests are discussed. We have compared and analyzed the visibility of GPS and Galileo with respect to separate and simultaneous tracking in view of DOP (Dilution of Precision) using the 3D GIS digital map.

• Journal of the Korean Geophysical Society
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• v.9 no.4
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• pp.387-395
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• 2006

Nowadays, various digital maps on a reduced scale were drawn in Korea including the topographic series of a nation. Though these digital maps are drawn and revised by using aerial photograph or satellite image, there are some problems that it is difficult to revise or renew the topography and natural feature immediately which changes frequently. As the countermeasures of these problems we use GPS accumbency method, which provides user with convenience and accumbency accuracy which is required to revise and renew digital maps. But acquiring correct position by using GPS only may cause not a few errors because of environmental effect of satellite signal errors that GPS obtains. Although accumulated errors which is the major problem of existing method was diminished owing to the position signal received from satellite which is about 20,183km above, the area that can not receives the signal is occur such as woods and high-rise buildings space. And because of the GDOP (Geometry Dilution of Precision) of GPS satellite and the periodically changing orbit of the satellite, the position calculating problems occur. For settlement of these problems and accurate position determination, DGPS (Differential GPS) is indispensably needed. So, in this study, by adapting Radio Beacon Receiver for marine position determination which is the most convenience method of DGPS methods, we elevated accuracy of modification and renewal of digital map and, having wide application in various measurements, proposed the rapid measurement method about widespread area. In this study, wewant to propose the work scheme of rapid modification and renewal of digital map by using Beacon GPS which is comparatively cheap of all the DGPS methods and which makes it possible to measure independently.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.11B
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• pp.1618-1623
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• 2010

In this paper, we propose a new assisted global positioning system (A-GPS) using terrestrial digital multimedia broadcasting (T-DMB) data services. Because of the weak signal strength from GPS satellite and the signal blockage, it is difficult for the telematics terminal to determine the position in urban area. Proposed A-GPS system calculates pseudo range (PR) from timing information of GPS satellites and obtains the satellite information such as ephemeris from T-DMB station to determine the current position. Compared to conventional GPS system, the proposed system has better performance in terms of the fast time to first fix (TTFF), low horizontal dilution of precision (HDOP). Experimental results show that the proposed system is a feasible and robust solution.

• Journal of Digital Convergence
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• v.13 no.9
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• pp.431-437
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• 2015

This convergence study analyzed the effectiveness of contrast agent reduction by normal saline solution dilution in the computed tomography of arteries of lower limb. 48 patients of 125 cc contrast agent and 30 patients of the same amount divided at a ratio of 7:3 for the contrast agent and normal saline solution were studied. The average attenuation coefficient(HU) and signal to noise ratio(SNR) of abdominal aorta, femoral artery, popliteal artery and posterior tibial artery at each image were evaluated quantitatively and the four criteria in the five point scale was conducted qualitatively by two radiologists and four radiological technologists. In the quantitative evaluation, both HU and SNR had high average score before dilation but there were no statistical significance by independent t-test(p>0.05). In the qualitative evaluation, there were a little differences in the average scores between 4.86~4.77 of original contrast agent and 4.83~4.67 of dilated contrast agent but there were no statistical significance(p>0.05). In the computed tomography of arteries of lower limb, the dilated contrast agent doesn't influence image quality and reduces overall contrast agent and lowers iodine content per unit of molecular therefore will contribute to decrease side effect of contrast agent.

• Korean Journal of Remote Sensing
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• v.19 no.3
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• pp.181-190
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• 2003

Since the operation of the first satellite-based navigation service, satellite positioning has played an increasing role in both surveying and geodesy, and has become an indispensable tool for precise relative positioning. However, in some situations, e.g. at a low angle of elevation, the use of satellites for navigation is seriously restricted because obstacles like buildings and mountains can block signals. As a mean to resolve this problem, the quasi-zenith satellite system has been proposed as a next-generation satellite navigation system. Quasi-zenith satellite is a system which simultaneously deploys several satellites in a quasi-zenith geostationary orbit so that one of the satellites always stay close to the zenith if viewed from a specific point on the ground of East Asia. Thus, if a position measurement function compatible with CPS is installed in the quasi-zenith and stationary satellites, and these satellites are utilized together with the CPS, four satellites can be accessed simultaneously nearly all day long and a substantial improvement in position measurement, especially in metropolitan areas, can be achieved. The purpose of this paper is to evaluate the effectiveness of quasi-zenith satellite system on positioning accuracy improvement through simulation by using precise orbital information of the satellites and a three-dimensional digital map. Through this developed simulation system, it is possible to calculate the number of simultaneously visible satellites and available area for positioning without the need of actual observation. Furthermore, this system can calculate the Dilution Of Precision (DOP) and the error distribution.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.34 no.1
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• pp.71-78
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• 2016

In the paper, we predict the number of multi-GNSS satellites and visible satellites with the navigation satellite launch plans and their nominal orbit parameters. Based on the methodology, the multi-GNSS navigation performance and DOP (Dilution of Precision) variation from 2015 to 2020 were forecasted by the Matlab simulation. To calculate the position using the multi-GNSS constellation, we determined the time-offset between the two different systems. Two different algorithms were considered for the sake of time-offset determination; that of each was applied to system level and user side. Also, the results from two algorithms were compared for evaluating each performance. For the reality, we applied the 3D map information to the simulation, which is expected to contribute for predicting the future navigation performance in urban canyon.