• Journal of the Korean Society of Clothing and Textiles
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• v.42 no.4
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• pp.657-670
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• 2018

This study investigated the wearing of jackets by down-aging middle-aged women in their 40s to 50s who enjoy wearing attire from ladies' apparel brands that target the 20s to 30s age group. As a method of research, a survey was done on middle-aged women in their 40s and 50s as the target age group. Based on the survey results, comparison and analysis was done on the wearing of jackets as well as preferred extra space and fitness of the clothes, with the distinction between the down-aging group and the non down-aging group. The down-aging middle-aged women purchased jackets mainly at department stores, outlets, discount outlets, and internet shopping malls, and showed the highest frequency of wearing the jackets once or twice a week. For the item "importance in selecting a jacket", both groups chose "the design" as the most important aspect; however, the non down-aging group took "size and fitness" and "activity and comfort" more than the down-aging group. Especially regarding the size of the jackets, size S (55) was the most often worn by the down-aging group, whereas size M (66) was the most often worn by the non down-aging group.

• International Journal of Costume and Fashion
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• v.17 no.1
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• pp.59-72
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• 2017

This study aimed to analyze the dilemmas of aging and down-aging by the senior street look, and to examine the styling, psychology, and attitudes of the elderly through socio-cultural discussions. It was conducted through a multidisciplinary literature review and empirical analysis of seniors featured in fashion photos collected from SNS. With respect to seniors' fashion attitudes, firstly, they make personal/social records of dress as a means of recording aging and to reminiscence. Secondly, they attempt to down-age kidult play using mature humor. Thirdly, they try to express a perfect, moderate, and mature beauty to positively adapt themselves to aging. Fourthly, they adopt a regional and ethnic look to escape from the dilemmas accompanying aging and down-aging. This may be regarded as an attitude for repositioning themselves and planning a new life by escaping from a long-standing frame. Finally, they show a desire to stop and enjoy the moment of aging. While recording their cherished everyday lives, they enjoy the present rather than becoming concerned about the past or the future and use styling as a cure for their lives.

• Fashion & Textile Research Journal
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• v.14 no.3
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• pp.423-429
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• 2012

This study investigated purchasing practice and size satisfaction to offer basic data to establish a marketing strategy and produce down-aging clothes for females in their 40s-50s. For the data analysis, crosstabs, factor analysis, and one-way ANOVA were used. The results were as follows; first, middle-aged women were observed to purchase down-aging clothes "to look younger" and not purchase clothes "due to the lack of right sizes." For women who answered to 'not purchase clothes', they also acknowledged that they intended to purchase down-aging clothes in the future if the right size is available. Second, people in their early 40s significantly considered perceptual qualities such as fashion and brand names while people in their late 50s placed the most importance in practicality and wearability. For body shapes, people with overweight body types were found to significantly consider physical performance, practicality, and wearability. Third, the examination of purchase satisfaction levels by age groups showed that younger age groups had high satisfaction level for wear functionality related items that included size and activity however, the late 50s group had the lowest satisfaction level. Middle-aged women purchased clothes to look younger however, they simultaneously wear clothes that are plain and conservative or respectable and graceful. Therefore, the development of products reflect the analysis of designs that can help create a more youthful appearance and women's preferred styles are needed in addition to the establishment of a differentiated sizing system for middle-aged female consumers in the incorporation of the characteristics of middle-aged women's body parts.

• Journal of the Korea Fashion and Costume Design Association
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• v.24 no.4
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• pp.41-56
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• 2022

This study aims to investigate the actual condition of wearing leggings and the preferred design of down-aging women in their 30s and 40s who have young sensibility, but are starting to enter a middle-aged body type. By analyzing the problems experienced when wearing leggings in this age group, this study intends to provide basic data for the development of a middle-aged female leggings pattern with an improved fit. Therefore, a survey was conducted on 214 women in their 30s and 40s. The results of the survey are as follows. Among down-aging women who want to look younger, leggings are becoming an essential item, but most leggings brands are producing leggings with patterns suitable for women in their 20s. The results of this study also showed that down-aging women in their 30s and 40s mainly purchase and prefer body-fitting leggings. However, they are experiencing discomfort due to 'Y-zone accentuate', 'undergarment accentuate', 'cloth stucking', and 'waist band curling and tightening'. The results indicate that women in their 30s and 40s, who are starting to change to a middle-aged body type, have fit problems. Women in their 20s generally prefer functions that improve the body line, while those in their 30s and 40s prefer functions that improve movement and cover problems caused by the abdomen and the Y-zone area. Therefore, when designing leggings for down-aging women in their 30s and 40s, based on body-fitting leggings, a material with excellent elasticity must be selected. Also develop patterns that solves 'Y-zone accentuate', 'undergarment accentuate', 'cloth stucking', and 'waist band curling and tightening' problems.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.4
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• pp.533-542
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• 2010

Skin aging is a natural phenomenon. There are internal and external factors of skin aging. The internal factor of skin aging is from the wearing down of the body over time. The external factors are more noticeable from habits such as smoking, excessive alcohol, malnutrition, and extended exposure to UV rays. Completely stopping skin from aging is impossible but one can slow down and treat external signs of skin aging. In western medicine, the following methods are used to reduce the appearance of skin aging: applying lotions and creams containing ingredients such as fruit acid, antioxidants, plant exracts, depigmentation, moisturizer, retinoids, and sun block; botulinum toxin injections; chemical peels, laser and other painful methods remove the top layer of skin to promote new skin growth; fillers are injected to increase soft tissue growth; surgery. In oriental medicine, the following methods are used: acupuncture into facial muscles which stimulates acupuncture point; applying topical treatments and cosmetics containing herbs are effective of preventing skin aging and wrinkles. Above all thing, medicine that helps maintain essence and blood in the skin can be fundamental.

• Proceedings of the Korean Society of Life Science Conference
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• 2000.06a
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• pp.9-10
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• 2000

The aging process is multifactorial and results from the combined effects of inherited(genetic) and acquired factors including life style, food habits, physical activity, and diseases. That give rise to the various approaches in aging. We are trying to study biological changes with aging, In detail we are focused on gene and protein function accompanied by normal or abnormal aging process, especially our efforts are aimed at revealing the functional relationship of proteins in aging as a final product of gene. We expect that proteomic approach to the study of protein function involved in aging should give us variety of integrated data to understand biological changes of long lived lives, We have applied expression proteomics to rat liver bred in dietary restriction or in at libitum to elucidate the effects of food habit on aging. Expression proteomics shows us protein profile in a selected tissue or cells as a whole and gives us the information about protein expression level, posttranslational modification and degenerative modification of expressed proteins. Comparative analysis of young and old rat liver by two dimensional gels shows that gene expression of several proteins was down regulated in old rats and some protein expression level is increased with aging. Dietary restriction slows down these changes of gene expression and in some proteins there's no difference in protein expression level at same ages in comparison with rats bred in at libitum. About forty protein was identified by peptide mass fingerprint with MALDI-TOF and rest of the protein of interest is in the course of identification, Also we are trying to make mitochondrial and cytosolic proteom reference map. These suborganelle proteom map will gives us the information about low abundance proteins and cellular localization of proteins. Proteomics is a growing methodology to study biological system. High throughput qualitative and qualitative aspect of this approach will gives us large amount of integrated information and speed up our understanding about biological system

• Journal of Sensor Science and Technology
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• v.26 no.4
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• pp.292-296
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• 2017

It has become ever harder to design reliable circuits with each nanometer technology node under normal operation conditions, a transistor device can be affected by various aging effects resulting in performance degradation and eventually design failure. The reliability (aging) effect has traditionally been the area of process engineers. However, in the future, even the smallest of variations can slow down a transistor's switching speed, and an aging device may not perform adequately at a very low voltage. Because of such dilemmas, the transistor aging is emerging as a circuit designer's problem. Therefore, in this paper, the impact of aging effects on the delay and power dissipation of digital circuits by using nanomneter MOSFET power gating structure has been analyzed.. Based on this analyzed aging models, a reliable digital circuits can be designed.

• Nutrition Research and Practice
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• v.14 no.3
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• pp.188-202
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• 2020

BACKGROUND/OBJECTIVES: Brain aging is a major risk factor for severe neurodegenerative diseases. Conversely, L-histidine and L-carnosine are known to exhibit neuroprotective effects. The aim of this study was to examine the potential for L-histidine, L-carnosine, and their combination to mediate anti-brain aging effects in neuronal cells subjected to D-galactose-induced aging. MATERIALS/METHODS: The neuroprotective potential of L-histidine, L-carnosine, and their combination was examined in a retinoic acid-induced neuronal differentiated SH-SY5Y cell line exposed to D-galactose (200 mM) for 48 h. Neuronal cell proliferation, differentiation, and expression of anti-oxidant enzymes and apoptosis markers were subsequently evaluated. RESULTS: Treatment with L-histidine (1 mM), L-carnosine (10 mM), or both for 48 h efficiently improved the proliferation, neurogenesis, and senescence of D-galactose-treated SH-SY5Y cells. In addition, protein expression levels of both neuronal markers (β tubulin-III and neurofilament heavy protein) and anti-oxidant enzymes, glutathione peroxidase-1 and superoxide dismutase-1 were up-regulated. Conversely, protein expression levels of amyloid β (1-42) and cleaved caspase-3 were down-regulated. Levels of mRNA for the pro-inflammatory cytokines, interleukin (IL)-8, IL-1β, and tumor necrosis factor-α were also down-regulated. CONCLUSIONS: To the best of our knowledge, we provide the first evidence that L-histidine, L-carnosine, and their combination mediate anti-aging effects in a neuronal cell line subjected to D-galactose-induced aging. These results suggest the potential benefits of L-histidine and L-carnosine as anti-brain aging agents and they support further research of these amino acid molecules.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.5 no.2
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• pp.13-19
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• 2009

As the operating time in nuclear power plants (NPPs) increases, the integrity of nuclear components may be continually degraded due to aging effects of systems, structures and components. Recently, a number of NPPs are being operated beyond their design life to produce more electricity without shutting down. The critical issue in extending a lifetime is to maintain the level of safety during the extended operation period while satisfying the international regulatory standards. Therefore, it is beneficial to build a monitoring system to measure an aging status. In this paper, the Aging Monitor (AM) based on lots of aging database obtained from the operating plants and research results on the aging effects was developed to monitor, manage and evaluate the aging phenomena systematically and effectively in NPPs. The AM for the CANDU is divided into 6 modules: (1) Aging Alarm/Coloring Monitor, (2) Aging Database, (3) Aging Document, (4) Real-time Integrity Monitor, (5) Surveillance and Inspection Management System, and (6) Continued Operation and Periodic Safety Review (PSR) Safety Evaluation. The proposed system is expected to provide the integrity assessment for the major mechanical components of an NPP under concurrent working environments.

• BMB Reports
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• v.52 no.2
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• pp.111-112
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• 2019

Although many studies have reported that the breakdown of the blood-brain barrier (BBB) represents one of the major pathological changes in aging, the mechanism underlying this process remains relatively unexplored. In this study, we described that acid sphingomyelinase (ASM) derived from endothelial cells plays a critical role in BBB disruption in aging. ASM levels were elevated in the brain endothelium and plasma of aged humans and mice, resulting in BBB leakage through an increase in caveolae-mediated transcytosis. Moreover, ASM caused damage to the caveolae-cytoskeleton via protein phosphatase 1-mediated ezrin/radixin/moesin dephosphorylation in primary mouse brain endothelial cells. Mice overexpressing brain endothelial cell-specific ASM exhibited acceleration of BBB impairment and neuronal dysfunction. However, genetic inhibition and endothelial specific knock-down of ASM in mice improved BBB disruption and neurocognitive impairment during aging. Results of this study revealed a novel role of ASM in the regulation of BBB integrity and neuronal function in aging, thus highlighting the potential of ASM as a new therapeutic target for anti-aging.