• Clinical and Experimental Reproductive Medicine
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• 제47권4호
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• pp.300-305
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• 2020

Objective: The feasibility of a gonadotropin-releasing hormone agonist (GnRHa) trigger in normal responders is still a matter of debate. The aim of this study was to compare the number of mature oocytes, the number of good-quality embryos, and the live birth rate in normal responders triggered by GnRHa alone, GnRHa and human chorionic gonadotropin (hCG; a dual trigger), and hCG alone. Methods: A retrospective cohort study was conducted at the infertility clinic of a university hospital. Data from 200 normal responders who underwent controlled ovarian hyperstimulation and intracytoplasmic sperm injection with a GnRH antagonist protocol between January 2016 and January 2017 were reviewed. The first study group consisted of patients with cycles triggered by GnRHa alone. The second study group consisted of patients with cycles triggered by both GnRHa and low-dose hCG (a dual trigger). The control group consisted of patients with cycles triggered by hCG alone. Results: The groups were comparable in terms of demographics and cycle characteristics. The numbers of total oocytes retrieved and metaphase II oocytes were similar between the groups. The total numbers of top-quality embryos were 3.2±2.9 in the GnRHa group, 4.4±3.2 in the dual-trigger group, and 2.9±2.1 in the hCG group (p=0.014). The live birth rates were 21.4%, 30.5%, and 28.2% in those groups, respectively (p=0.126). Conclusion: In normal responders, a dual-trigger approach appears superior to an hCG trigger alone with regard to the number of top-quality embryos produced. However, no clinical benefit was apparent in terms of live birth rates.

• 대한전기학회논문지:전력기술부문A
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• 제49권7호
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• pp.359-364
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• 2000

This paper is introducing a newly developed spark-gap switch with dual trigger system, into which the current from the voltage source is injected along with the test sequence during the synthetic testing of high voltage circuit-breaker. The currently-used spark gap switch is narrow in operating range due to the use of the method of triggering energy being injected by single way. As a result, the frequent happening of misoperation has greatly reduced the test quality and test efficiency and has required the cost of maintenance excessively. In this study, accordingly, in order to basically remove these problems, another triggering system is installed to the opposite direction on the existing triggering system; attaching the same time and the same rising time of pulse wave as on the existing system, so that at a comparatively trigger gap distance from the main electrode(the gap can be operated at 60% of self-break voltage, while at 80% in the current system), the main electrode has been enabled to be closed by the development of spark gap switch with dual trigger system.

• Clinical and Experimental Reproductive Medicine
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• 제47권4호
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• pp.306-311
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• 2020

Objective: The aim of this study was to determine whether co-administration of a gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (hCG) for final oocyte maturation improved mature oocyte cryopreservation outcomes in young women with decreased ovarian reserve (DOR) compared with hCG alone. Methods: Between January 2016 and August 2019, controlled ovarian stimulation (COS) cycles in women (aged ≤35 years, anti-Müllerian hormone [AMH] <1.2 ng/mL) who underwent elective oocyte cryopreservation for fertility preservation were retrospectively analyzed. Results: A total of 76 COS cycles were triggered with a GnRH agonist and hCG (the dual group) or hCG alone (the hCG group). The mean age and serum AMH levels were comparable between the two groups. The duration of stimulation, total dose of follicle-stimulating hormone used, and total number of oocytes retrieved were similar. However, the number of mature oocytes retrieved and the oocyte maturation rate were significantly higher in the dual group than in the hCG group (p=0.010 and p<0.001). After controlling for confounders, the dual-trigger method remained a significant factor related to the number of mature oocytes retrieved (p=0.016). Conclusion: We showed improved mature oocyte collection and maturation rate with the dual triggering of oocyte maturation in young women with DOR. A dual trigger appears to be more beneficial than hCG alone in terms of mature oocyte cryopreservation for young women with DOR.

• Clinical and Experimental Reproductive Medicine
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• 제50권4호
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• pp.270-276
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• 2023

Objective: This study investigated the clinical and laboratory factors associated with the presence of dysmorphic oocytes in intracytoplasmic sperm injection (ICSI) cycles. Methods: The study involved 200 ICSI cycles, performed from 2020 to 2021, that yielded at least one mature oocyte. Clinical characteristics and ovarian stimulation methods were compared between 68 cycles with at least one dysmorphic oocyte (the dysmorphic group) and 132 cycles with normal-form oocytes only (the non-dysmorphic group). Dysmorphic oocytes were characterized by dark cytoplasm, cytoplasmic granularity, cytoplasmic vacuoles, refractile bodies in the cytoplasm, smooth endoplasmic reticulum in the cytoplasm, an oval shape, an abnormal zona pellucida, a large perivitelline space, debris in the perivitelline space, or an abnormal polar body. Results: The ages of the women, indications for in vitro fertilization, serum anti-Müllerian hormone levels, and rates of current ovarian endometrioma were similar between the dysmorphic and non-dysmorphic groups. In both groups, the three ovarian stimulation regimens, two types of pituitary suppression, and total gonadotropin dose were employed similarly. However, the dual-trigger method was used more frequently in the dysmorphic group (67.6% vs. 50%, p=0.024). The dysmorphic group contained significantly more immature oocytes and exhibited significantly lower oocyte maturity (50% vs. 66.7%, p=0.001) than the non-dysmorphic cycles. Within the dysmorphic group, significantly lower oocyte maturity was found in the cycles using a dual-trigger, but not in those with a human chorionic gonadotropin trigger. Conclusion: ICSI cycles with dysmorphic oocytes are closely associated with reduced oocyte maturity. This association was observed exclusively in dual-trigger cycles.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 C
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• pp.1145-1148
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• 1999

This paper is introducing a newly developed spark gap switch with dual trigger system, into which the current from the voltage source is injected along wi th the test sequence during the synthetic testing of high voltage circuit-breaker.

• 자원ㆍ환경경제연구
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• 제31권4호
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• pp.645-668
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• 2022

발전, 수송, 저장, 산업공정 등 에너지 사용 전반에서 탄소중립의 중요한 수단으로 수소에너지가 부각되고 있다. 연료전지 발전소는 수소 생태계에서 가장 빠르게 보급되고 있으며 2050 탄소중립 구현을 위한 핵심적인 발전원 중 하나이다. 하지만 연료전지 발전소의 수익에 영향을 미치는 전력도매가격(SMP)과 신재생에너지 공급인증서(REC) 가격의 높은 변동성은 잠재적 사업자들의 투자시기를 지연시켜 보급에 걸림돌로 작동하고 있다. 본 연구는 실물옵션 방법론을 적용하여 비가역적인 연료전지 발전소의 투자결정에 있어서 SMP와 REC 가격 이중 불확실성이 투자임계가격 수준에 어떠한 영향을 미치는지 분석하였다. 분석 내용은 다음의 3가지로 요약된다. 첫째, 현행 신재생에너지 공급의무화제도(RPS)하에서 사업자에게 전가되는 이중가격 불확실성은 결정론적 가격 대비 투자임계가격을 상당히 증가시켜 현재 가격 수준에서 경제성이 없는 것으로 나타났다. 둘째, REC 가격 변동성을 현재의 절반으로 경감하는 것은 REC 가중치를 한 단위 추가로 부여하는 것 만큼의 투자임계가격 하락 효과를 유발하였다. 셋째, 기존 부생수소 기반 연료전지와 함께 그레이 수소, 그린 수소 기반 투자임계가격을 분석하였으며, 그레이 수소의 경우 탄소배출권 비용이 적용될 경우 그린 수소와 경제성이 상당 부분 좁혀지는 것을 확인할 수 있었다. 본 연구 결과는 현행 RPS 제도가 연료전지 발전소 보급에 저해요소로 작동하며, 보다 비용 효율적이고 안정적인 수소 생태계 구축을 위해서는 정책보완이 필요함을 시사한다.

• Journal of Chest Surgery
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• 제16권4호
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• pp.547-554
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• 1983

Implantation of Dual Chamber Pacemakers Which sense in the Atrium and the Ventricle, and sequentially or synchronously trigger impulses in the both chambers, has led us to the near realization of the ideal "Physiologic Pacing". We have experienced two cases of implantation of Dual chamber pacemaker in September and October, 1983. One patient was a 21-year-old male who had postoperative complete heart block since he was taken Total correction of TOF in May, 1983 . We implanted transvenously a dual chamber pacemaker, VDD type, through the left subclavian vein. In the other patient who came to the emergency room for partial obstruction of small bowels with severe abdominal pain, nausea and vomiting, in whom heart block was found, we implanted a DDD type pacemaker through the left subclavian puncture. The pacemakers have been functioning well postoperatively for more than two months, and the conditions of patient were uneventful.

• Asia pacific journal of information systems
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• 제26권2호
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• pp.268-289
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• 2016

While most of studies have paid attention to the initial adoption of a specific application, research on applications has not focused on an individual's update decision process. This study draws upon both dual information processing and status quo bias perspectives as a comprehensive theoretical lens to explain why individuals do not update their applications. This study assumes that individuals' inertia could be the main reason for their reluctance to update the applications. Based on a survey of 186 smartphone users, this study demonstrated that both habit as an affective trigger of system 1 thinking and sunk cost as a cognitive trigger of system 2 thinking promoted the two types of inertia (i.e., affective and cognitive based inertia) in individuals, which have a negative effect on their willingness to update their applications. By grounding the research model in a theoretical view, such as dual information processing and status quo bias, this study provides a unique theoretical lens from which to view individuals' behaviors, thereby gaining a better understanding of their decision not to update to the current version of applications. This study also investigates the moderating effect of the types of applications on the relationships between affective/cognitive-based inertia and willingness to update. Results show that both habit and sunk cost decrease the willingness to update because they increase both affective and cognitive-based inertia. This study also found that the effects of affective/cognitive based inertia differed depending on the type of applications.

• Clinical and Experimental Reproductive Medicine
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• 제47권3호
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• pp.227-232
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• 2020

Objective: The aim of this study was to compare in vitro fertilization outcomes between fresh day 3 or day 4 embryo transfer cycles with dual progesterone (P) administration (intramuscular and vaginal) and cycles with single intramuscular P administration for luteal support. Methods: We selected 124 cycles from 100 women (under age 40 years) who underwent oocyte pick-up (number of trials ≤ 3, 4-14 oocytes obtained) and transfer of two or three day 3 or day 4 embryos at two infertility centers from January 2014 to June 2019. Dual P (intramuscular P [50 mg] daily+vaginal P) was used in 52 cycles and a single intramuscular administration of P (50 mg daily) was used in 72 cycles. Results: Women's age, infertility factors, number of oocytes retrieved, number of transferred embryos, and mean embryo score were similar between the dual P group and the single P group. Although the number of trial cycles was significantly higher (1.9 vs. 1.5), and the mean endometrial thickness on the trigger day (10.0 mm vs. 11.0 mm) was significantly lower in the dual P group, the implantation rate, clinical pregnancy rate, ongoing pregnancy rate, and miscarriage rate for both day 3 and day 4 transfers were similar between the two groups. Conclusion: In fresh day 3 or day 4 embryo transfer cycles, dual P administration did not demonstrate any clinical advantages. Intramuscular P alone appears to be sufficient for luteal support.

• Molecules and Cells
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• 제27권6호
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• pp.689-695
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• 2009

Chemically synthesized small interfering RNAs (siRNAs) can specifically knock-down expression of target genes via RNA interference (RNAi) pathway. To date, the length of synthetic siRNA duplex has been strictly maintained less than 30 bp, because an early study suggested that double-stranded RNAs (dsRNAs) longer than 30 bp could not trigger specific gene silencing due to the induction of non-specific antiviral interferon responses. Contrary to the current belief, here we show that synthetic dsRNA as long as 38 bp can result in specific target gene silencing without non-specific antiviral responses. Using this longer duplex structure, we have generated dsRNAs, which can simultaneously knock-down expression of two target genes (termed as dual-target siRNAs or dsiRNAs). Our results thus demonstrate the structural flexibility of gene silencing siRNAs, and provide a starting point to construct multifunctional RNA structures. The dsiRNAs could be utilized to develop a novel therapeutic gene silencing strategy against diseases with multiple gene alternations such as viral infection and cancer.