• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.1
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• pp.216-230
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• 2008

Purpose: The purpose of this study is to analysis on the Stress Response Inventory(SRI) and Heart Rate Variability (HRV) of some dysmenorrhoea patients. Methods: We studied 34 patients visiting OO Medical Center from May 2007 to November 2007. And the severity of dysmenorrhoea were measured by Multidimensional Verbal Rating scale(MVRS), Verbal Rating scale (VRS) and Visual Analog Scale(VAS). And SRI and HRV were recorded. Results: According to comparison of Means of HRV values among the groups, most of them were not statistically significant. But the comparison of Means of SRI, the points of almost all values were kept by order of Severe-Moderate-Mild-None group. Most of them are statistically significant. According to correlation analysis between dysmenorrhoea scale and HRV, most of them were not statistically significant. But the correlation analysis between HRV and SRI, there were some correlations. And the correlation analysis between SRI and dysmenorrhoea scale, most of them were statistically significant. According to General Linear Model of Dysmenorrhoea $scale^{\ast}SRI$ and HRV. Dysmenorrhoea scale and SRI influenced values of HRV. But it is hard to conclude the relationship between Dysmenorrhoea $scale^{\ast}SRI$ and HRV Conclusion: The results suggest that stress is related to dysmenorrhoea. But the relation between dysmenorrhoea and HRV was hard to conclude. We need more study for settling the relation between dysmenorrhoea and HRV.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.164-177
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• 2007

Purpose: The purpose of this study is to analysis on the Heart Rate Variability(HRV) of some dysmenorrhoea patients. Methods : We studied 30 patients visiting Kyung Hee University East-West Neo Medical Center from 7th Febrary 2007 to 22th Febrary 2007. Women with organic disease were excluded from this study. The severity of dysmenorrhoea were measured by Multidimensional Verbal Rating scale(MVRS), Verbal Rating scale (VRS) and Visual Analog Scale(VAS). And HRV was recorded. Results : According to comparison of Means of HRV values among the groups of None, Mild and Moderate, the points of almost all values were kept by order of Moderate group-Mild group-None group. Among these, the statistically significant things are PR, SDNN, Ln (TP), Ln (VLF), Ln (LF). According to correlation analysis between dysmenorrhoea and HRV, specially, there were many correlations in VRS2. Among these, the statistically significant things are LF norm, HF norm, LF/HF ratio(p<0.05L). Conclusion : The results suggest that HRV is related to dysmenorrhoea. We may analyze that dysmenorrhoea is related to, specially, increased activities of sympathetic nerve. We need more study for settling this.

• Advances in Traditional Medicine
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• v.7 no.4
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• pp.372-378
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• 2007

A well known Ayurvedic formulation Ashokarista, used for menstrual disorders has been studied in a single blind randomised placebo controlled clinical trial for the treatment of menorrhagia and dysmenorrhoea. Dysmenorrhoea and menorrhagia patients who were taking Ashokarista (20 ml twice daily) for 10 menstrual cycles had an increase in haemoglobin level. Menorrhagia treated group has shown to reduce the erythrocyte sedimentation rate level that has been increased in the menorrhagia control group. The platelet count, total count and differential count were observed unchanged in the study. The Ashokarista did not affect the SGPT and SGOT level, which signify its lack of toxicity in hepatic function. The treated menorrhagic patients showed an increase in serum albumin content and decrease in blood clotting time, whereas the serum protein content was observed unchanged. There was a significant increase in both serum cholesterol and triglyceride level, which usually associated with the use of oral contraceptives. No major side effects were observed by the clinicians during the study.

• CELLMED
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• v.6 no.1
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• pp.4.1-4.7
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• 2016

Dysmenorrhoea is the most important under diagnosed and undertreated gynaecologic disorder of all menstrual complaints. It affects 50% women of childbearing age and has a major impact on health and societal costs worldwideespecially in developing countries. Therefore, a literary exploration of traditional sources for aetiopathogenesis and clinical features of usr-i-tamth (dysmenorrhoea) were reviewed to correlate with contemporary knowledge.The traditional Unani sources viz., Al Hawi fi'l Tibb (Continens Liber),Tarjuma Kamil al-Sana'a al-Tibbiyya, Al-Qanun fi'l Tibb (Canon of Medicine), Dhakhira Khawarizam Shahi, Tibb-i-Akbar, Iksir-i-A'zam, Kitab al-Kulliyyat, and Kulliyyat-i-Qanun were reviewed. Further, recent studies in the contemporary era were also browsed on the website. The causes of usre-i-tamth as per classical sources are distemperament, uterine diseases (atresia, inflammation, amenorrhoea, cancer, prolapse, ulcer, tenuous morbid matter, and cervical obstruction), psychological disturbances, environmental factors, menstrual irregularities, obesity and young age. Recent studies also prove that obesity, psychological disturbance, menstrual irregularities, environmental factors, uterine diseases and young age lead to dysmenorrhea.Unani classical sources are very much enriched with the informative knowledge related to menstruation and uterine pain/dysmenorrhoea and recent studies in contemporary proves the same. Hence, implementation of the traditional system of medicines in present-day era may play a vital role to restore health in a holistic way.

• Journal of the Korean Chemical Society
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• v.62 no.5
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• pp.352-357
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• 2018

Celecoxib (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) is a cyclooxygenase-2 inhibitor used in the treatment of arthritis, acute pain, and dysmenorrhoea. Celecoxib is a Biopharmaceutics Classification System (BCS) class II compound whose oral bioavailability is highly limited owing to its poor aqueous solubility. Several polymorphs of celecoxib have been identified as Form I, Form II, and Form III with melting points of about $162.8^{\circ}C$, $161.5^{\circ}C$, and $160.8^{\circ}C$, respectively. Form IV was generated from the precipitated suspension in the presence of HPMC (Hydroxypropyl methylcellulose) and Polysorbate 80. A rapid rate of dissolution is useful because the rate of dissolution of a drug typically increases its bioavailability. The aim of this study was to investigate the possibility of production of new crystal form of celecoxib that has higher solubility than Form III. New crystal form of celecoxib (Form A) has been isolated by recrystallization and characterized by differential scanning calorimetry (DSC), thermogravimetric (TG) analysis and powder X-ray diffractometry (PXRD). Form A was dissolved faster than Form III. At 30 minutes, the dissolution of Form A was 97.3%, whereas the dissolution of Form III was 82.2% (p < 0.1). After storage of three months at $20^{\circ}C$, in 24% RH (Relative Humidity), the crystal form was not transformed.