• Title/Summary/Keyword: Eye irritation

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Comparison of Eye Irritation Potency with Skin Irritation and Cytotoxicity Potency of Anti-wrinkle Agents (주름방지용 화장품원료의 안점막 자극성과 피부자극성 및 세포독성과의 비교)

  • 이은희;이종권;김주환;정경미;정해관;이선희;정수연;홍진태
    • Toxicological Research
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    • v.17 no.2
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    • pp.143-149
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    • 2001
  • In the present study, we examined eye irritation oj six anti-wrinkle agents (ascorbic acid, glycolic acid, all trans-retinoic acid, ginseng extract, retinol, EB). We also compared eye irritation with skin irritation and cytotoxicity in HaCaT cells by these agents. The highest eye irritation was found in glycolic acid, but all trans-retinoic acid showed the highest skin irritation. The rank of eye irritation was not correlated with the cytotoxicity of agents. This result shows that eye irritation potency by these agents were not correlated with skin irritation potency, and cytotoxicity in HaCaT cells.

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Eye Irritation Test of Fel Ursi Pharmacopuncture Solutions for Eye Drop (점안용 웅담약침액의 안점막자극실험)

  • Seo, Hyeong-Sik
    • Journal of Pharmacopuncture
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    • v.11 no.3
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    • pp.93-97
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    • 2008
  • Objective: This study was done to investigate the safety of Fel Ursi pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods: The eye irritation test of this material was performed according to the Regulation of Korea Food & Drug Administration(2005. 10. 21, KFDA 2005-60). After Fel Ursi pharmacopuncture solution was medicated in the left eye of the rabbits, the author observed eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Results: 1. After Fel Ursi pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn't physical problem at 9 rabbits. 2. After Fel Ursi pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn't eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Conclusions: I suggested that Fel Ursi pharmacopuncture solution didn't induced eye irritation in rabbits.

Eye Irritation Test of Fel Ursi & Bovis Calculus Pharmacopuncture Solutions for Eye Drop (점안용 웅담.우황약침액의 안점막자극실험)

  • Seo, Hyeong-Sik
    • Journal of Pharmacopuncture
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    • v.11 no.3
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    • pp.99-104
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    • 2008
  • Objective: This study was done to investigate the safety of Fel Ursi & Bovis Calculus pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods: The eye irritation test of this material was performed according to the Regulation of Korea Food & Drug Administration(2005. 10. 21, KFDA 2005-60). After Fel Ursi & Bovis Calculus pharmacopuncture solution was medicated in the left eye of the rabbits, the author observed eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Results: 1. After Fel Ursi & Bovis Calculus pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn't physical problem at 9 rabbits. 2. After Fel Ursi & Bovis Calculus pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn't eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Conclusions: I suggested that Fel Ursi & Bovis Calculus pharmacopuncture solution didn't induced eye irritation in rabbits.

Eye Irritation Test of Soyeom Pharmacopuncture Solution for Eye Drop (점안용 소염약침액의 안점막자극실험)

  • Seo, Hyeong-Sik
    • Journal of Pharmacopuncture
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    • v.11 no.2
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    • pp.75-79
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    • 2008
  • Objectives This study was done to investigate the safety of Soyeom pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods The eye irritation test of this material was performed according to the Regulation of Korea Food & Drug Administration(2005. 10. 21, KFDA 2005-60). After Soyeom pharmacopuncture solution was medicated in the left eye of the rabbits, the auther observed eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Results 1. After Soyeom pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn't physical problem at 9 rabbits. 2. After Soyeom pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn't eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Conclusions I suggested that Soyeom pharmacopuncture solution didn't induced eye irritation in rabbits.

Eye Irritation Test of Bovis Calculus Pharmacopuncture Solutions for Eye Drop (점안용 우황약침액의 안점막자극실험)

  • Seo, Hyeong-Sik
    • Journal of Pharmacopuncture
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    • v.11 no.2
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    • pp.81-85
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    • 2008
  • Objective This study was done to investigate the safety of Bovis Calculus pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods The eye irritation test of this material was performed according to the Regulation of Korea Food & Drug Administration (2005. 10. 21, KFDA 2005-60). After Bovis Calculus pharmacopuncture solution was medicated in the left eye of the rabbits, the auther observed eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Results 1. After Bovis Calculus pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn't physical problem at 9 rabbits. 2. After Bovis Calculus pharmacopuncture solutionwas medicated in the left eye of the rabbits, there wasn't eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Conclusions I suggested that Bovis Calculus pharmacopuncture solution didn't induced eye irritation in rabbits.

Dermal and Eye Irritation Studies on Bactonematicide, Photorhabdus temperata Isolated from Heterorhabditis megidis (Nematoda: Heterorhabditidae) in Rabbit (Heterorhabditis megidis (Nematoda: Heterorhabditidae)에서 분리한 Bactonematicide, Photorhabdus temperata의 토끼 피부 및 눈자극 시험)

  • Park, Sun-Han;Chung, Nam-Jun;Choo, Young-Moo;Kim, Young-Joon;Kim, Jin-Ho
    • Korean Journal of Organic Agriculture
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    • v.30 no.3
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    • pp.423-439
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    • 2022
  • The acute dermal and eye irritation tests of Photorhabdus temperata, a symbiotic bacterium of Heterorhabditis megidis Gwangju strain, were carried out in New Zealand white rabbit (Oryctolagus cuniculus), following the guidelines of OECD and Rural Development Administration (RDA) of Korea. In both tests, neither dermal nor eye responses were found from all the P. temperata treated rabbits and the results were classified as non-irritating. That is, erythema, eschar, edema, and any other dermal critical signs were not observed from all the experimental rabbits in the dermal irritation test. In the acute eye irritation test, no clinical signs of cornea, iritis, conjunctiva (redness, edema, lacrima, and chemosis) were observed from all the experimental rabbits. Individual ocular irritation, mean ocular irritation, and acute ocular irritation were calculated as 0.0. The results of dermal and eye irritation studies on P. temperata indicated that this bacterium could be a safe and effective alternative bionematicide against the most serious plant-parasitic root-knot nematodes in the genus Meloidogyne.

Eye Irritation Test of Fel Ursi, Bovis Calculus & Moschus Pharmacopuncture Solutions for Eye Drop (점안용 웅담.우황.사향 약침액의 안점막자극실험)

  • Seo, Hyeong-Sik
    • Journal of Pharmacopuncture
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    • v.11 no.3
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    • pp.105-111
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    • 2008
  • Objective: The aim of this study is to investigate the safety of Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods: The eye irritation test of this material was performed according to the Regulation of Korea Food & Drug Administration(2005. 10. 21, KFDA 2005-60). After Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution was applied eyewash in the left eye of the rabbits, the author observed eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Results: 1. After Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution was applied eyewash in the left eye of the rabbits, there wasn t physical problem at 9 rabbits. 2. After Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution was applied eyewash in the left eye of the rabbits, there wasn't eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Conclusions: In this study, it was observed that Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution didn't induced eye irritation in rabbits.

A STUDY ON THE RECOMBINANT HUMAN INTERFERON ${\alpha}$A(LBD-007) FOR PRIMARY EYE AND SKIN IRRITATION IN RABBITS

  • Park, Jong-Il;Kim, Sung-Hoon;Han, Sang-Seop;Roh, Jung-Koo
    • Toxicological Research
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    • v.9 no.1
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    • pp.119-123
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    • 1993
  • LBD-007, a newly developed recombinant human interferon ${\alpha}$A, was tested for primary eye and skin irritation in male New Zealand White rabbits. In the primary eye irritation test, 0.1ml of a solution of LBD-007 was instilled into the eye. In rinsing group, the eye was washed with water 30 seconds after instillation. No reaction was observed at the cornea, iris and conjunctivae by LBD-007. In the primary skin irritation test, LBD-007 was applied to the back of rabbits for 24 hours. Primary irritation index was "0" in test and control sites of all animals. Thus LBD-007 was evaluated as a non-irritant on the basis of the criteria of Draize et al.,(1994).

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A Study on Local Irritation Test of Bee Venom for Herb-Acupuncture (약침용(藥鍼用) 봉독액(蜂毒液)의 국소독성시험(局所毒性試驗)에 관(關)한 연구(硏究))

  • Lee, Jong-Seok;Koh, Hyung-Kyun;Kim, Chang-Hwan
    • The Journal of Korean Medicine
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    • v.16 no.1 s.29
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    • pp.227-249
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    • 1995
  • Pursuant to the Medical Product Safety Administration Guidelines for safety assessment of Korean bee vonom for herb-acupuncture, rabbits were used for skin, eye balls, subcutaneous and muscle irritation test. The results were as follows; 1. The skin irritation test of bee venom for herb-acupuncture did not produce any irritation reactions, when the skin was covered with bee venom. 2. The eye irritation test produced moderate to severe stimulating reactions, once the eye mucous membrane was contacted with bee venom. 3. The subcutaneous and muscle irritation test of bee venom showed such local inflammatory reactions as death of cells, infiltration of inflamed cells, dropsical swelling, and congestion, once injected under the skin and in the muscle. As the results of the study on bee venom for herb-acupuncture indicate that severe reactions in such tests as eye balls, subcutancous and muscle irritation exist in the laboratory, more professional caution should be taken in clinical application of the therapy. In addition, further study on subacute, chronic toxicity and allergy reactions should be pursued.

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Dermal and Ocular Irritation Studies of Some Phthalates in Rabbits (Phthalate의 피부자극시험 및 안점막자극시험에 관한 연구)

  • 이종권;김주환;이은희;김용규;홍진태;박기숙;안광수;정수연;이선희
    • Toxicological Research
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    • v.17 no.2
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    • pp.91-96
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    • 2001
  • Phthalates are widely used as plasticizers to impart softness and flexibility to normally rigid polyvinylchloride products. However, there are not much studies jar dermal and ocular irritation toxicity of phthalates. So we investigated the skin or eye irritation effect of some phthalates which was not reported. The primary skin irritation of diethyl phthalate (DEP), diisodecyl phthalate (DIDP), diisononyl phthalate (DINP), dipropyl phthalate (DPP) and dipropyl phthalate (DPrP) was studied. The ocular irritation of dibutyl phthalate(DBP), DIDP, DINP, DPP and DPrP was also studied. DEP, DIDP, DINP, DPP, and DPrP were found to be non-irritating to the skin of the test animals. DBP, DIDP, DINP and DPP were found to be non-irritating to the eye of the rabbits. DPrP caused the slight irritations to the eye in 1 or 2 days after treatment but irritation of the animals was soon recovered.

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