• Safety and Health at Work
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• v.2 no.3
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• pp.273-281
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• 2011

Objectives: Studies examining healthcare workers' exposure to antineoplastic drugs have focused on the drug preparation or drug administration areas. However, such an approach has probably underestimated the overall exposure risk as the drugs need to be delivered to the facility, transported internally and then disposed. The objective of this study is to determine whether drug contamination occurs throughout a facility and, simultaneously, to identify those job categories that are potentially exposed. Methods: This was a multi-site study based in Vancouver, British Columbia. Interviews were conducted to determine the departments where the drugs travel. Subsequent site observations were performed to ascertain those surfaces which frequently came into contact with antineoplastic drugs and to determine the job categories which are likely to contact these surfaces. Wipe samples were collected to quantify surface contamination. Results: Surface contamination was found in all six stages of the hospital medication system. Job categories consistently found to be at risk of exposure were nurses, pharmacists, pharmacy technicians, and pharmacy receivers. Up to 11 job categories per site may be at risk of exposure at some point during the hospital medication system. Conclusion: We found drug contamination on select surfaces at every stage of the medication system, which indicates the existence of an exposure potential throughout the facility. Our results suggest that a broader range of workers are potentially exposed than has been previously examined. These results will allow us to develop a more inclusive exposure assessment encompassing all healthcare workers that are at risk throughout the hospital medication system.

• Journal of the Ergonomics Society of Korea
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• v.10 no.1
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• pp.23-28
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• 1991

A major inhibition of past work in a slip/fall accident study has been due to the lack of a facility and a methodology to experimentally investigate such behavior without expowting human subjects to the natural danger of injury resulting from a fall. In order to carry out a slip/fall research, a unique facility must be created specially to investigate falling and slipping behavior. One component of this facility will be used to focus a research towards experimental investigations of the basic mechanisms involved in falls. Especially, this compo- nent must be designed, developed, and fabricated to provide passive, reactive support at the point of loss of ba- lance. This component must allow both normal and reduced friction surfaces to be designated to investigate human falling in the experimental conditions. This study will address how a fall arresting system was designed and it would be implemented in actual case of a slip/fall study.

• Journal of Microbiology and Biotechnology
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• v.32 no.2
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• pp.238-247
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• 2022

Since the skin covers most surfaces of the body, it is susceptible to damage, which can be fatal depending on the degree of injury to the skin because it defends against external attack and protects internal structures. Various types of artificial skin are being studied for transplantation to repair damaged skin, and recently, the production of replaceable skin using three-dimensional (3D) bioprinting technology has also been investigated. In this study, skin tissue was produced using a 3D bioprinter with human skin cell lines and cells extracted from mouse skin, and the printing conditions were optimized. Gelatin was used as a bioink, and fibrinogen and alginate were used for tissue hardening after printing. Printed skin tissue maintained a survival rate of 90% or more when cultured for 14 days. Culture conditions were established using 8 mM calcium chloride treatment and the skin tissue was exposed to air to optimize epidermal cell differentiation. The skin tissue was cultured for 14 days after differentiation induction by this optimized culture method, and immunofluorescent staining was performed using epidermal cell differentiation markers to investigate whether the epidermal cells had differentiated. After differentiation, loricrin, which is normally found in terminally differentiated epidermal cells, was observed in the cells at the tip of the epidermal layer, and cytokeratin 14 was expressed in the lower cells of the epidermis layer. Collectively, this study may provide optimized conditions for bioprinting and keratinization for three-dimensional skin production.

• Journal of the Korean Institute of Landscape Architecture
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• v.17 no.3
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• pp.1-8
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• 1990

The digital terrain model (DTM) or digital elevation model (DEM) is commonly used in representing the continuous variation of relief over space. One of the most frequent applications is to display the three dimensional view of the landform concerned. In this paper, the altitude matrices-regular grid cell format of the elevation in Mt. Kyeryong National Park were used in developing the three dimensional view software for the first time in Korea. It required the removal of hidden lines or surfaces. To do this, it was necessary to identify those surfaces and line segments that are visible and those that are invisible. Then, only the visible portions of the landform were displayed. The assumption that line segments are used to approximate contour surfaces by polygons was used in developing the three dimensional orthographic view. In order to remove hidden lines, the visibility test and masking algorithms were used. The software was developed in the engineering workstation, SUN 3/280 at the Institute of Space Science and Astronomy using 'C' in UNIX operating system. The software developed in this paper can be used in various fields. Some of them are as follows : (1) Landscape design and planning for identifying viewshed area(line of sight maps) (2) For planning the route selection and the facility location (3) Flight simulation for pilot training (4) Other landscape planning or civil engineering purposes

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2003.11a
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• pp.584-589
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• 2003

The hot cell facility which is designed to permit safe handling of source materials with radioactivity levels up to 1,385 TBq, is planned to be built. To meet this goal, the facility is designed to keep gamma and neutron radiation lower than the recommended dose-rate in normally occupied areas. The calculations performed with QAD-CGGP and MCNP-4C are used to evaluate the proposed engineering design concepts that would provide acceptable dose-rates during a normal operation in hot cell facility. The maximum effective gamma dose-rates on the surfaces of the facility at operation area and at service area calculated by QAD-CGGP are estimated to be $2.10{\times}10^{-3}$, $2.97{\times}10^{-2}$ and $1.01{\times}10^{-1}$ mSv/h, respectively. And those calculated by MCNP-4C are $1.60{\times}10^{-3}$, $2.99{\times}10^{-3}$ and $7.88{\times}10^{-2}$ mSv/h, respectively The dose-rates contributed by neutrons are one order of magnitude less than that of gamma sources, and penetration and toboggan will be partly reinforced by lead shield.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.2012-2017
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• 2003

This paper reports on the influence of blade surface roughness on turbine efficiency. The performance of a low speed one-stage axial turbine with roughened blade surfaces was evaluated. Sandpaper with equivalent sandgrain roughness ($k_s$) was used to roughen the blades. Efficiency (${\eta}/{\eta}_0$) decreases by 4.5 % with sandgrain size of 400 ${\mu}m$ on the stator suction surface.

• Bulletin of the Korean Space Science Society
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• 2003.10a
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• pp.26-26
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• 2003

During fabrication process for the large space optical surfaces, the traditional bound abrasive grinding with bronze bond cupped diamond wheel tools leaves the machine marks and the subsurface damage to be removed by subsequent loose abrasive lapping. We explored a new grinding technique for efficient quantitative control of precision CNC grinding for space optics materials such as Zerodur. The facility used is a NANOFORM-600 diamond turning machine with a custom grinding module and a range of resin bond diamond tools. The machining parameters such as grit number, tool rotation speed, work-piece rotation speed, depth of cut and feed rate were altered while grinding the work-piece surfaces of 20-100 mm in diameter. The input grinding variables and the resulting surface quality data were used to build grinding prediction models using empirical and multi-variable regression analysis methods. The effectiveness of the grinding prediction model was then examined by running a series of precision CNC grinding operation with a set of controlled input variables and predicted output surface quality indicators. The experiment details, the results and implications are presented.

• Wind and Structures
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• v.31 no.4
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• pp.335-350
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• 2020

In coastal residential communities, especially along the coastline, flooding is a frequent natural hazard that impacts the area. To reduce the adverse effects of flooding, it is recommended to elevate coastal buildings to a certain safe level. However, post storm damage assessment has revealed severe damages sustained by elevated buildings' components such as roofs, walls, and floors. By elevating a structure and creating air gap underneath the floor, the wind velocity increases and the aerodynamics change. This results in varying wind loading and pressure distribution that are different from their slab on grade counterparts. To fill the current knowledge gap, a large-scale aerodynamic wind testing was conducted at the Wall of Wind experimental facility to evaluate the wind pressure distribution over the surfaces of a low-rise gable roof single-story elevated house. The study considered three different stilt heights. This paper presents the observed changes in local and area averaged peak pressure coefficients for the building surfaces of the studied cases. The aerodynamics of the elevated structures are explained. Comparisons are done with ASCE 7-16 and AS/NZS 1170.2 wind loading standards. For the floor surface, the study suggests a wind pressure zoning and pressure coefficients for each stilt height.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2005.06a
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• pp.21-29
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• 2005

The HANARO, a multi-purpose research reactor of 30 MWth open-tank-in-pool type, has been under normal operation since its initial criticality in February, 1995. Recently, ten years after the initial operation of the HANARO, one of the two primary cooling pumps was decontaminated for overhaul maintenance in 2004. Before decontamination exposure doserate and surface contamination level of primary cooling pump measured at 4 points. After final decontamination exposure doserate and surface contamination level of primary cooling pump remeasured by same method done before. It is easy to decontaminate the out side exposed surfaces of the pump, but it is difficult to approach the inside surface due to double volute installed in the casing. Therefore, a new decontamination facility has been developed to solve this problem. A concentrated de-contaminant (DX-300) is rotated in the closed pump casing by the impeller actuated by a temporary motor. Nuclide particles are removed by the emulsification effect of the de-contaminant and the surface contaminants are chemically removed from the pump by the corrosion and dissolution effect. The inside surfaces of the primary cooling pump have been decontaminated by using the facility. As results, the contamination level of the inside surfaces was maintained below the surface contamination limit.

• Journal of the Korean Magnetic Resonance Society
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• v.6 no.2
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• pp.94-102
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• 2002

An interesting recent application of intermolecular NOE experiment is the saturation transfer difference NMR(STD-NMR) method that is useful in screening compound libraries to identify bio-active ligands. This technique also identifies the group epitopes of the bound ligand in a reversibly forming protein-ligand complex. We present here a complete relaxation and conformational exchange matrix (CORCEMA) theory (Moseley et al., J. Magn. Reson. B, 108, 243-261 (1995)) applicable for the STD-NMR experiment. Using some ideal model systems we have analyzed the factors that influence the STD intensity changes in the ligand proton NMR spectrum when the resonances from some protons on the receptor protein are saturated. These factors will be discussed and some examples of its application in some model systems will be presented. This CORCEMA theory for STD-NMR and the associated algorithm are useful in a quantitative interpretation of the STD-NMR effects, and are likely to be useful in structure-based drug design efforts. They are also useful in a quantitative characterization of protein-protein (or protein-nucleic acid) contact surfaces from an intermolecular cross-saturation NMR experiment.