• Safety and Health at Work
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• 제2권3호
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• pp.273-281
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• 2011

Objectives: Studies examining healthcare workers' exposure to antineoplastic drugs have focused on the drug preparation or drug administration areas. However, such an approach has probably underestimated the overall exposure risk as the drugs need to be delivered to the facility, transported internally and then disposed. The objective of this study is to determine whether drug contamination occurs throughout a facility and, simultaneously, to identify those job categories that are potentially exposed. Methods: This was a multi-site study based in Vancouver, British Columbia. Interviews were conducted to determine the departments where the drugs travel. Subsequent site observations were performed to ascertain those surfaces which frequently came into contact with antineoplastic drugs and to determine the job categories which are likely to contact these surfaces. Wipe samples were collected to quantify surface contamination. Results: Surface contamination was found in all six stages of the hospital medication system. Job categories consistently found to be at risk of exposure were nurses, pharmacists, pharmacy technicians, and pharmacy receivers. Up to 11 job categories per site may be at risk of exposure at some point during the hospital medication system. Conclusion: We found drug contamination on select surfaces at every stage of the medication system, which indicates the existence of an exposure potential throughout the facility. Our results suggest that a broader range of workers are potentially exposed than has been previously examined. These results will allow us to develop a more inclusive exposure assessment encompassing all healthcare workers that are at risk throughout the hospital medication system.

• 대한인간공학회지
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• 제10권1호
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• pp.23-28
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• 1991

A major inhibition of past work in a slip/fall accident study has been due to the lack of a facility and a methodology to experimentally investigate such behavior without expowting human subjects to the natural danger of injury resulting from a fall. In order to carry out a slip/fall research, a unique facility must be created specially to investigate falling and slipping behavior. One component of this facility will be used to focus a research towards experimental investigations of the basic mechanisms involved in falls. Especially, this compo- nent must be designed, developed, and fabricated to provide passive, reactive support at the point of loss of ba- lance. This component must allow both normal and reduced friction surfaces to be designated to investigate human falling in the experimental conditions. This study will address how a fall arresting system was designed and it would be implemented in actual case of a slip/fall study.

• Journal of Microbiology and Biotechnology
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• 제32권2호
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• pp.238-247
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• 2022

Since the skin covers most surfaces of the body, it is susceptible to damage, which can be fatal depending on the degree of injury to the skin because it defends against external attack and protects internal structures. Various types of artificial skin are being studied for transplantation to repair damaged skin, and recently, the production of replaceable skin using three-dimensional (3D) bioprinting technology has also been investigated. In this study, skin tissue was produced using a 3D bioprinter with human skin cell lines and cells extracted from mouse skin, and the printing conditions were optimized. Gelatin was used as a bioink, and fibrinogen and alginate were used for tissue hardening after printing. Printed skin tissue maintained a survival rate of 90% or more when cultured for 14 days. Culture conditions were established using 8 mM calcium chloride treatment and the skin tissue was exposed to air to optimize epidermal cell differentiation. The skin tissue was cultured for 14 days after differentiation induction by this optimized culture method, and immunofluorescent staining was performed using epidermal cell differentiation markers to investigate whether the epidermal cells had differentiated. After differentiation, loricrin, which is normally found in terminally differentiated epidermal cells, was observed in the cells at the tip of the epidermal layer, and cytokeratin 14 was expressed in the lower cells of the epidermis layer. Collectively, this study may provide optimized conditions for bioprinting and keratinization for three-dimensional skin production.

• 한국조경학회지
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• 제17권3호
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• pp.1-8
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• 1990

The digital terrain model (DTM) or digital elevation model (DEM) is commonly used in representing the continuous variation of relief over space. One of the most frequent applications is to display the three dimensional view of the landform concerned. In this paper, the altitude matrices-regular grid cell format of the elevation in Mt. Kyeryong National Park were used in developing the three dimensional view software for the first time in Korea. It required the removal of hidden lines or surfaces. To do this, it was necessary to identify those surfaces and line segments that are visible and those that are invisible. Then, only the visible portions of the landform were displayed. The assumption that line segments are used to approximate contour surfaces by polygons was used in developing the three dimensional orthographic view. In order to remove hidden lines, the visibility test and masking algorithms were used. The software was developed in the engineering workstation, SUN 3/280 at the Institute of Space Science and Astronomy using 'C' in UNIX operating system. The software developed in this paper can be used in various fields. Some of them are as follows : (1) Landscape design and planning for identifying viewshed area(line of sight maps) (2) For planning the route selection and the facility location (3) Flight simulation for pilot training (4) Other landscape planning or civil engineering purposes

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2003년도 가을 학술논문집
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• pp.584-589
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• 2003

차세대관리 종합공정 실증시설 핫셀은 최대 1,385 TBq의 선원의 취급시에도 방사선 선량율을 법규에서 규제하는 허용치 이하로 차폐능을 가질 수 있도록 설계되고 있다. 선량 제한 설계치를 만족시키기 위하여 각 구역에 대한 차폐보강 방안이 수립되었으며, 이의 검증을 위하여 QAD-CGGP 및 MCNP-4C 코드를 이용하여 차폐 계산을 수행하여, 핫셀의 차폐 설계에 대한 안전성을 평가하였다. 핫셀 외벽에 대한 차폐 평가를 수행한 결과, QAD-CGGP 코드에 의한 작업구역에 대한 감마선 평가 결과는 $2.10{\times}10^{-3}$, $2.97{\times}10^{-2}$ mSv/h, MCNP-4C 코드는 $1.60{\times}10^{-3}$, $2.99{\times}10^{-3}$ mSv/h 이었으며, 서비스 구역은 $1.01{\times}10^{-2}$, $7.88{\times}10^{-2}$ mSv/h로 평가되었다 중성자에 의한 선량률은 감마선에 의한 선량률의 약 20% 이하치를 나타내는 것을 알 수 있었으며, 차폐벽의 각종 Penetration 및 Toboggan 경우 부분적인 납 차폐보강이 필요하였다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 춘계학술대회
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• pp.2012-2017
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• 2003

This paper reports on the influence of blade surface roughness on turbine efficiency. The performance of a low speed one-stage axial turbine with roughened blade surfaces was evaluated. Sandpaper with equivalent sandgrain roughness ($k_s$) was used to roughen the blades. Efficiency (${\eta}/{\eta}_0$) decreases by 4.5 % with sandgrain size of 400 ${\mu}m$ on the stator suction surface.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2003년도 한국우주과학회보 제12권2호
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• pp.26-26
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• 2003

During fabrication process for the large space optical surfaces, the traditional bound abrasive grinding with bronze bond cupped diamond wheel tools leaves the machine marks and the subsurface damage to be removed by subsequent loose abrasive lapping. We explored a new grinding technique for efficient quantitative control of precision CNC grinding for space optics materials such as Zerodur. The facility used is a NANOFORM-600 diamond turning machine with a custom grinding module and a range of resin bond diamond tools. The machining parameters such as grit number, tool rotation speed, work-piece rotation speed, depth of cut and feed rate were altered while grinding the work-piece surfaces of 20-100 mm in diameter. The input grinding variables and the resulting surface quality data were used to build grinding prediction models using empirical and multi-variable regression analysis methods. The effectiveness of the grinding prediction model was then examined by running a series of precision CNC grinding operation with a set of controlled input variables and predicted output surface quality indicators. The experiment details, the results and implications are presented.

• Wind and Structures
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• 제31권4호
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• pp.335-350
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• 2020

In coastal residential communities, especially along the coastline, flooding is a frequent natural hazard that impacts the area. To reduce the adverse effects of flooding, it is recommended to elevate coastal buildings to a certain safe level. However, post storm damage assessment has revealed severe damages sustained by elevated buildings' components such as roofs, walls, and floors. By elevating a structure and creating air gap underneath the floor, the wind velocity increases and the aerodynamics change. This results in varying wind loading and pressure distribution that are different from their slab on grade counterparts. To fill the current knowledge gap, a large-scale aerodynamic wind testing was conducted at the Wall of Wind experimental facility to evaluate the wind pressure distribution over the surfaces of a low-rise gable roof single-story elevated house. The study considered three different stilt heights. This paper presents the observed changes in local and area averaged peak pressure coefficients for the building surfaces of the studied cases. The aerodynamics of the elevated structures are explained. Comparisons are done with ASCE 7-16 and AS/NZS 1170.2 wind loading standards. For the floor surface, the study suggests a wind pressure zoning and pressure coefficients for each stilt height.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2005년도 춘계 학술대회
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• pp.21-29
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• 2005

30 MW의 연구용 원자로인 하나로는 1995년 2월 초임계에 도달한 이후, 정상적으로 가동하고 있다. 가동 후 약 10년이 경과하여 1차 냉각펌프를 분해 점검하기 위해 펌프에 대한 화학제염이 2004년에 수행되었다. 제염을 수행하기 이전에 4개의 point를 설정하여 방사선량율 및 표면오염도를 측정하였고, 최종제염이 수행된 이후 같은 point에 대하여 방사선량율 및 표면오염도를 재측정 하였다. 펌프 외부는 노출되어 있어 쉽게 제염할 수 있으나 케이싱 내부에는 2중 볼류트가 있어 접근이 용이하지 않았다. 이를 제염하기 위하여 제염장치를 개발하였다. 이 장치는 일정 농도의 제염제 (DX-300)를 케이싱 내부에 담아 밀폐시킨 후 펌프의 임펠러를 저속으로 회전함으로서 제염제가 순환된다. 제염제의 유화작용에 의해 표면의 입자성 방사선 물질이 이완되고, 화학 작용에 의해 부식력과 용해성으로 표면 오염이 제거된다. 이 장치를 이용하여 하나로 1차 냉각펌프의 케이싱 내부를 제염하였다. 그 결과 1차 냉각펌프의 케이싱 내부는 반출허용표면오염도 이하로 낮출 수 있어 성공적으로 제염할 수 있었다.

• 한국자기공명학회논문지
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• 제6권2호
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• pp.94-102
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• 2002

An interesting recent application of intermolecular NOE experiment is the saturation transfer difference NMR(STD-NMR) method that is useful in screening compound libraries to identify bio-active ligands. This technique also identifies the group epitopes of the bound ligand in a reversibly forming protein-ligand complex. We present here a complete relaxation and conformational exchange matrix (CORCEMA) theory (Moseley et al., J. Magn. Reson. B, 108, 243-261 (1995)) applicable for the STD-NMR experiment. Using some ideal model systems we have analyzed the factors that influence the STD intensity changes in the ligand proton NMR spectrum when the resonances from some protons on the receptor protein are saturated. These factors will be discussed and some examples of its application in some model systems will be presented. This CORCEMA theory for STD-NMR and the associated algorithm are useful in a quantitative interpretation of the STD-NMR effects, and are likely to be useful in structure-based drug design efforts. They are also useful in a quantitative characterization of protein-protein (or protein-nucleic acid) contact surfaces from an intermolecular cross-saturation NMR experiment.