• Neonatal Medicine
• /
• 제17권2호
• /
• pp.161-167
• /
• 2010

Acute kidney injury (AKI), formerly referred to as acute renal failure (ARF) is defined as the sudden impairment of kidney function (estimated from the glomerular filtration rate [GFR]) that results in the lack of excretion of waste products. More than 30 definitions of AKI exist in the literature, most of which are based on serum creatinine. Lack of a uniform and multidimensional AKI definition has led to failure to recognize significant renal injury, delays in treatment, and inability to generalize single-study results. The RIFLE criteria were developed to standardize the diagnosis of ARF and in the process the term AKI has been proposed to encompass the entire spectrum of the syndrome from minor changes in renal function to requirement for renal replacement therapy. Large prospective studies are needed to test definitions and to better understand risk factors, incidence, independent outcomes, and mechanisms that lead to poor short- and long-term outcomes. Early biomarkers of AKI need to be explored in critically ill neonates.

• 한국인터넷방송통신학회논문지
• /
• 제12권2호
• /
• pp.233-241
• /
• 2012

프로젝트 관리의 목표는 프로젝트를 성공하기 위함이다. 그러나 프로젝트 수행 결과가 성공이라고 명확히 판단할 수 있는가? 또한 판단 결과에 고객과 개발자 모두 동의하는가? 성공과 실패에 대한 정의와 판단 척도들에 대해 다양하게 제시되고 있으나 명확한 분류 기준이 없다. 본 논문은 개발 성공을 결정하기 위한 판단척도들을 살펴보고, 프로젝트의 성공과 실패에 대해 재정의한다. 이러한 정의에 의해 프로젝트 수행 결과를 판단하는 척도와 기준을 제시한다. 제시된 판단 척도와 기준을 적용할 경우, 성공과 실패를 분류하는데 고객과 개발자간의 불협화음을 줄일 수 있을 것이다.

• Corrosion Science and Technology
• /
• 제4권5호
• /
• pp.201-206
• /
• 2005

Starting with the meaning of the word quality, diverse concepts connoted by the term are examined. Instead of a bathtub curve, the desirable shape of a failure rate covering the entire life of a good product, which might be called hockey-stick line, is introduced. From the hockey-stick line and the definition of reliability, two measurements are extracted. The terms r-reliability (failure rate) and durability (product life) are explained. The conceptual analysis of failure mechanics explains that reliability technology pertains to design area. The desirable shape of hazard rate curve of electronic items, hockey-stick line, clarifies that Mean-Time-to-failure (MTTF) as the inverse of failure rate can be regarded a nominal life. And Bx life, different from MTTF, is explained. Reliability relationships between components and set products are explained. Reshaped definitions of r-reliability and durability are recommended. The procedure to improve reliability and the reasons for failing to identify failure mode are clarified in order to search right solutions. And generalized Life-Stress failure model is recommended for the calculation of acceleration factor.

• 산업공학
• /
• 제1권2호
• /
• pp.67-74
• /
• 1988

MTBF (Mean Time Between Failures) is one of the measures to express the reliability for a repairable system, especially for a military weapon system. But MTBF is meaningless without a clear definition of the system failures. In this paper we discuss two failure definitions, one is defined by US Army Training and Doctrine Command jointly with US Army Materiel Command and the other one is used to M1 Tank.

• Radiation Oncology Journal
• /
• 제35권4호
• /
• pp.359-367
• /
• 2017

Purpose: This study sought to identify potential candidates for adjuvant radiotherapy and patterns of regional failure in patients who underwent curative-intent surgery for gallbladder cancer. Materials and Methods: Records for 70 patients with gallbladder cancer who underwent curative resection at a single institution between 2000 and 2016 were analysed retrospectively. No patients received adjuvant radiotherapy. Initial patterns of failure were evaluated. Regional recurrence was categorized according to the definitions of lymph node stations suggested by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. Results: Median follow-up was 23 months. Locoregional recurrence as any component of first failure occurred in 29 patients (41.4%), with isolated locoregional recurrence in 13 (18.6%). Regional recurrence occurred in 23 patients, and 77 regional recurrences were identified. Commonly involved regional stations were #13, #12a2, #12p2, #12b2, #16a2, #16b1, #9, and #8. Independent prognostic factors for locoregional recurrence were ${\geq}pT2$ disease (hazard ratio [HR], 5.510; 95% confidence interval [CI], 1.260-24.094; p = 0.023) and R1 resection (HR, 6.981; 95% CI, 2.378-20.491; p < 0.001). Conclusion: Patients with pT2 disease or R1 resection after curative surgery for gallbladder cancer may benefit from adjuvant radiotherapy. Our findings on regional recurrence may help physicians construct a target volume for adjuvant radiotherapy.

• Computers and Concrete
• /
• 제14권4호
• /
• pp.463-477
• /
• 2014

The modelling approach in the case of connections in precast buildings is specific. The assembly of the constitutive parts of the connection requires the inclusion of contact definitions in the model. In addition, the material non-linearity including the influence of the spatial stress distribution should be taken into account where appropriate. Here a complex model of a beam-to-column dowel connection is presented. Experiments on the analysed connection were performed within the framework of the European project SAFECAST (Performance of Innovative Mechanical Connections in Precast Building Structures under Seismic Conditions). Several material and interaction parameters were investigated and the influence of each of them was evaluated. The set of parameters which gave the best match with the experiments was chosen.

• 산업공학
• /
• 제25권4호
• /
• pp.405-415
• /
• 2012

The reliability performance measures for low and high or continuous demand modes of operation of safety instrumented systems(SISs) are examined and compared by analyzing the official definitions in IEC 61508 standard. This paper also presents a status of common cause factor(CCF) models used in IEC 61508 and problems relating CCF modelling are discussed and ideas to solve these ones are suggested. An example with mixed M-out-of-N architecture is carried out to illustrate the proposed methods.

• Tuberculosis and Respiratory Diseases
• /
• 제82권1호
• /
• pp.15-26
• /
• 2019

The pathogen Mycobacterium avium complex (MAC) is the most common cause of nontuberculous mycobacterial pulmonary disease worldwide. The decision to initiate long-term antibiotic treatment is difficult for the physician due to inconsistent disease progression and adverse effects associated with the antibiotic treatment. The prognostic factors for the progression of MAC pulmonary disease are low body mass index, poor nutritional status, presence of cavitary lesion(s), extensive disease, and a positive acid-fast bacilli smear. A regimen consisting of macrolides (clarithromycin or azithromycin) with rifampin and ethambutol has been recommended; this regimen significantly improves the treatment of MAC pulmonary disease and should be maintained for at least 12 months after negative sputum culture conversion. However, the rates of default and disease recurrence after treatment completion are still high. Moreover, treatment failure or macrolide resistance can occur, although in some refractory cases, surgical lung resection can improve treatment outcomes. However, surgical resection should be carefully performed in a well-equipped center and be based on a rigorous risk-benefit analysis in a multidisciplinary setting. New therapies, including clofazimine, inhaled amikacin, and bedaquiline, have shown promising results for the treatment of MAC pulmonary disease, especially in patients with treatment failure or macrolide-resistant MAC pulmonary disease. However, further evidence of the efficacy and safety of these new treatment regimens is needed. Also, a new consensus is needed for treatment outcome definitions as widespread use of these definitions could increase the quality of evidence for the treatment of MAC pulmonary disease.

• 한국재료학회지
• /
• 제17권11호
• /
• pp.580-586
• /
• 2007

To enhance the reliability of a newly designed reciprocating compressor applied in a domestic compressor, accelerated life tests were developed using new definitions of the sample size and the $B_1$ life index. In $1^{st}$ accelerated life testing, the compressor was locked due to the fracture of the suction reed valve. The failure modes and mechanisms of the suction reed valve in the accelerated tests were found to be similar to that of the failed product in the field. The root cause of the failure was the overlap between the suction reed valve and the valve plate in the suction port. The missing parameters in the design phase were modified by expanding the trespan size, introducing tumbling process, changing the material and thickness for the valve, introducing a ball peening and brushing process for the valve plate. In $2^{nd}$ accelerated life testing, the compressor was locked due to the interference between the crank shaft and thrust washer. The corrective plan was to heat treat the crank shaft. The $B_1$ life of the compressor improved from 1.5 to 12.9 years.

• 한국시스템다이내믹스연구
• /
• 제15권1호
• /
• pp.51-74
• /
• 2014

Despite the high efficiency of nuclear power plant, people in Korea do not give approvals and supports the facilities because the risk of the accidents and incidents. In particular, the low level of safety culture is a crucial mechanism that damages the robustness of the NPP. By considering the various definitions of safety culture and analyzing the major reasons of incidents, the conceptual safety culture model is made by using Causal Loop Diagramming. For sustaining development of nuclear power, social supports, incentives and organizational learning are needed. It also requires the coordination of work schedules and the expansion of human resource for protecting the rules and procedures in NPP. Decommissioning aging nuclear power plants will prevent a serious accident. In order to promote the safety culture, Korea Hydro & Nuclear Power Corporation should disclose more information to the public and promote the internal and external communications.