• Journal of the Ergonomics Society of Korea
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• v.31 no.6
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• pp.725-731
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• 2012

Objective: The aim of this study is to investigate visual feedback effects and human performance in the foot mouse control. Background: Generally, computer mouse tasks are controlled by visual feedback. In order to understand the characteristics of a foot mouse control, it is important to investigate the patterns of visual feedback involved in foot-mouse control tasks. Human performance of foot mouse control is also an important factor to understand the foot mouse control. Method: Three types of mouse control were determined to investigate visual feedback effects and human performance in the foot mouse control. Visual feedback effects in the foot mouse control were compared with those of a typical hand mouse. The cursor movement speed and mental workload were measured in the three types of tasks and two types of mouses. Results: Mouse control tasks with an element of homing-in to the target were more quickly performed by the hand mouse than the foot mouse. Mental workload was also higher in the foot mouse than the hand mouse. However, in the steering movement, human performance of the foot mouse control was not lower than that of the hand mouse control. Visual feedback in the foot mouse control was less required than in the hand mouse control. Conclusion: The foot mouse was not efficient in the most mouse control tasks, compared to the hand mouse. However, the foot mouse was efficient in the steering movement, moving a cursor within a path with lateral constraints. Application: The results of this study might help to develop the foot mouse.

• Journal of the Ergonomics Society of Korea
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• v.35 no.3
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• pp.175-184
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• 2016

Objective: In this study, two types of foot-controlled mouse devices are compared with a hand mouse in the input tasks requiring repetitively switching between a keyboard and a mouse. Background: Foot-controlled mouse devices have been developed for persons with impairments in the mobility of their hands. However, some researchers insisted that the foot-controlled mouse devices could be effectively used by the persons with no limits to their hand mobility. There are needs to investigate the efficiency of the foot-controlled mouse devices, when they are used by the nondisabled people. Method: Participants conducted the input tasks, requiring repetitive switches between a keyboard and a computer mouse. The used computer mouse devices were two types of foot-controlled mouse and a typical hand mouse. Participants performed three types of input task for five days and three types of task performance were measured; the number of completed input tasks within a given practice time, subjective satisfaction level and the time wasted for the mouse control. Results: For five days, the performance of input tasks sharply increased in input tasks by foot-controlled mouse devices rather than a hand mouse. After five days, the level of satisfaction on the foot-controlled mouse devices approached to about 76% of a hand mouse satisfaction level. The control time of the foot-controlled mouse devices also approached to about 109% of a hand mouse control time. Conclusion: After only five-day practice, the input task performance by foot-controlled mouse devices approached to that of a hand mouse. This result may suggest that the foot-controlled mouse devices can be effectively used as an alternative input device for the nondisabled people, if input tasks are easy and enough practice time is provided. Application: The results of this study might help to design foot-controlled mouse devices and to expend the usage of them.

• IE interfaces
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• v.17 no.1
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• pp.113-120
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• 2004

The increased use of computers has introduced a variety kind of human-computer interfaces. Mouse is one of the useful interface tools to place the cursor on the desired position on the monitor. This paper suggested a foot controlled isotonic mouse which was similar to the ordinary hand-controlled mouse except that positioning was controlled by the right foot and the clicking was performed by the left foot. Experimental results showed that both the index of difficulty(IOD) and the display-control gain(DC gain) varied the total movement time in a target acquisition task on the monitor. The present authors also drew the optimal display-control gain of the foot-controlled isotonic mouse over the index of difficulty of 1.0 to 3.0. The optimal display-control gain, i. e., 0.256, could be used when designing a foot-controlled isotonic mouse.

• Proceedings of the IEEK Conference
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• 2008.06a
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• pp.1107-1108
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• 2008

The purpose of this study is to develope a computer mouse using the head movements and eye blink in order to help the disability persons who can't move the hands or foot because of car accident or cerebral apoplexy. The mouse is composed of two gyro-sensors and photo sensor. The gryo-sensors detect the head horizontal and vertical angular velocities, respectively. The photo sensor detect the eye blink to perform click, double click, and to reset the head position. In the results, we could control the mouse points in real time using the proposed system.

• Radiation Oncology Journal
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• v.6 no.2
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• pp.155-161
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• 1988

The usefulness of hypertermia for cancer therapy have well been established. The purpose of the present investigation was to ascess the effect of step-up $(42^{\circ}{\rightarrow}44^{\circ}C$ sequence) and step-down $(44^{\circ}{\rightarrow}42^{\circ}C$ sequence) heating on the skin of the hind foot of the mouse. Hyperthermic treatments were given by immersion the hind foot of the mouse in circulating water baths. Skin response was studied by the leg reaction, which was scored according to a numerical scoring system proposed by Urano et al (1980). The results were as follows 1. The skin damage of $44^{\circ}C$ control group was more severe than $42^{\circ}C$ control group (P<0.05), except for 15 min. heating group. 2. The Skin damage of step-down group was more severe than step-up group (P<0.05). 3. The skin damage of $44^{\circ}C$ control group was more severe than step-up group when there is no difference in $44^{\circ}C$ heating time of step-up group from $44^{\circ}C$ control group (P<0.05). 4. In step-down group, the skin damage was more severe than $44^{\circ}C$ control group after preheating 45 min at $44^{\circ}C$ (P<0.05). Therefore, the above findings suggest the normal tissue damage by step-up heating was correlated with heating time of post step-up. The dropping of heating temperature in late phase had more severe damage of the skin than that in early phase during hyperthermia, and so contineous control of satisfactory temperature should be considered as the one of the most important factor for prognosis, complications of clinical hyperthermia

• Asian-Australasian Journal of Animal Sciences
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• v.28 no.2
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• pp.166-170
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• 2015

Foot-and-mouth disease (FMD) is a highly contagious disease affecting cloven-hoofed animals and causes severe economic loss and devastating effect on international trade of animal or animal products. Since FMD outbreaks have recently occurred in some Asian countries, it is important to understand the relationship between diverse immunogenomic structures of host animals and the immunity to foot-and-mouth disease virus (FMDV). We performed genome wide association study based on high-density bovine single nucleotide polymorphism (SNP) chip for identifying FMD resistant loci in Holstein cattle. Among 624532 SNP after quality control, we found that 11 SNPs on 3 chromosomes (chr17, 22, and 15) were significantly associated with the trait at the p.adjust <0.05 after PERMORY test. Most significantly associated SNPs were located on chromosome 17, around the genes Myosin XVIIIB and Seizure related 6 homolog (mouse)-like, which were associated with lung cancer. Based on the known function of the genes nearby the significant SNPs, the FMD resistant animals might have ability to improve their innate immune response to FMDV infection.

• The Korean Journal of Pain
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• v.34 no.2
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• pp.185-192
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• 2021

Background: It is known that some analgesics as well as pain can affect the immune system. The aim of this study was to investigate the analgesic effect and immunomodulation of pregabalin (PGB) in a mouse incisional pain model. Methods: A postoperative pain model was induced by hind paw plantar incision in male BALB/c mice. Mice were randomly divided into four groups (n = 8): a saline-treated incision (incision), PGB-treated incision (PGB-incision), sham controls without incision or drug treatment (control), and a PGB-treated control (PGB-control). In the PGB treated groups, PGB was administered intraperitoneally (IP) 30 minutes before and 1 hour after the plantar incision. Changes of the mechanical nociceptive thresholds following incision were investigated. Mice were euthanized for spleen harvesting 12 hours after the plantar incision, and natural killer (NK) cytotoxicity to YAC 1 cells and lymphocyte proliferation responses to phytohemagglutinin were compared among these four groups. Results: Mechanical nociceptive thresholds were decreased after plantar incision and IP PGB administration recovered these decreased mechanical nociceptive thresholds (P < 0.001). NK activity was increased by foot incision, but NK activity in the PGB-incision group was significantly lower than that in the Incision group (P < 0.001). Incisional pain increased splenic lymphocyte proliferation, but PGB did not alter this response. Conclusions: Incisional pain alters cell immunity of the spleen in BALB/c mice. PGB showed antinocieptive effect on mouse incisional pain and attenuates the activation of NK cells in this painful condition. These results suggest that PGB treatment prevents increases in pain induced NK cell activity.

• Applied Microscopy
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• v.29 no.2
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• pp.149-162
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• 1999

For investigation of the activated carbon on the mouse kidney treated with Pb, the activated carbon (40 mg/kg) and Pb (30 mg/kg) were treated orally for three and six weeks, respectivelly, and observed by the electron microscope. On the glomerulus of the group with only Pb, the basal membrane thicked, projected, and the foot processes fused. On the proximal convoluted tubules, the number of microvilli were decreased and the number of vacuoles and lysosome increased on the cytoplasm. The mitochondria and endoplasmic reticulum were extended and ribosomes dropped from the ER. On the giomerulus of the group with Pb-activated carbon, the basal membrane and the foot processes were merely changed. On the proximal convoluted tubules, the shapes and number of microvilli were not changed and the number of vacuoles, microbodies, and lysosomes decreased. The shapes of mitochondria and endoplasmic reticulum observed almost similar with control group. Th at is, elongated mitochondria and attached ribosomes to endoplasmic reticulum. As result, the activated carbon has positive effect on reducing toxicity of lead in the mouse kidney in the view of electron microscope.

• Korean Journal of Agricultural Science
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• v.45 no.4
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• pp.725-732
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• 2018

The vaccination for foot-and-mouth disease (FMD) is an effective way to control FMD. However, the injection of FMD vaccine causes abnormalities in pork meat by the incidence of lesions at the injection site. This study was conducted to investigate the inhibition effects of dietary bromelain, a natural protease derived from pineapple stems, on the incidence of lesions at the vaccination site on pigs. A total of 335 pigs (LYD [Landrace ${\times}$ Yorkshire ${\times}$ Duroc]; 7-week-old) were randomly allotted to two dietary treatments: control (basic diet) and bromelain treatment (diet supplemented with bromelain 1 kg/ton). The injection of FMD vaccine was conducted on 56- and 84-day-old pigs. Pigs with the bromelain treatment were fed a diet supplemented with bromelain for 14 days from 5 days before the vaccine injection. After slaughtering the pigs, the number of carcasses that had abnormal meat at the injection site of the vaccine and the amount of abnormal meat, discarded meat, and trimmings were recorded. Pork from the bromelain treated pigs had a lower incidence of abnormal meat caused by vaccine injection as well as a lower amount of abnormal meat, discarded meat, and trimmings than those of the control (p < 0.05). Our result suggests that dietary bromelain could improve the quality of pork meat by inhibiting incidence of lesions at the vaccine injection site.

• Korean Journal of Cognitive Science
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• v.21 no.2
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• pp.309-338
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• 2010

In this paper, we studied the brain-computer interface (BCI). BCIs help severely disabled people to control external devices by analyzing their brain signals evoked from motor imageries. The findings in the field of neurophysiology revealed that the power of $\beta$(14-26 Hz) and $\mu$(8-12 Hz) rhythms decreases or increases in synchrony of the underlying neuronal populations in the sensorymotor cortex when people imagine the movement of their body parts. These are called Event-Related Desynchronization / Synchronization (ERD/ERS), respectively. We implemented a BCI-based mouse interface system which enabled subjects to control a computer mouse cursor into four different directions (e.g., up, down, left, and right) by analyzing brain signal patterns online. Tongue, foot, left-hand, and right-hand motor imageries were utilized to stimulate a human brain. We used a non-invasive EEG which records brain's spontaneous electrical activity over a short period of time by placing electrodes on the scalp. Because of the nature of the EEG signals, i.e., low amplitude and vulnerability to artifacts and noise, it is hard to analyze and classify brain signals measured by EEG directly. In order to overcome these obstacles, we applied statistical machine-learning techniques. We could achieve high performance in the classification of four motor imageries by employing Common Spatial Pattern (CSP) and Linear Discriminant Analysis (LDA) which transformed input EEG signals into a new coordinate system making the variances among different motor imagery signals maximized for easy classification. From the inspection of the topographies of the results, we could also confirm ERD/ERS appeared at different brain areas for different motor imageries showing the correspondence with the anatomical and neurophysiological knowledge.