• Journal of Yeungnam Medical Science
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• 제27권2호
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• pp.127-132
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• 2010

Acute hepatitis A is a generally self-limiting disease of the liver. Acute renal failure is rare in patients with acute non-fulminant hepatitis A Acute tubular necrosis is the most common form of renal injury found in such patients. The 215 years old male patient visited our hospital with complaint of general weakness, fatigue, nausea, vomiting and myalgia. He was diagnosed with acute renal failure associated with acute non-fulminant hepatitis A We report here on a case of acute renal failure associated with non-fulminant hepatitis A, and we include a review of the literature.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.297.2-297.2
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• 2003

The roots and rhizome of Acanthopanax koreanum are used as folk medicine to ameliorate hepatitis in Korea. The ability of A. koreanum to protect mice from fulminant hepatitis induced in mice by D-galactosamine and lipopolysaccharide was evaluated. Preparations of A. koreanum used were an ethanol extract, and the ethanol-soluble and ethanol-insoluble components of the water extract. (omitted)

• Tuberculosis and Respiratory Diseases
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• 제63권5호
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• pp.435-439
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• 2007

PZA에 의한 독성 간염은 약 2% 정도 보고되고 있으나 전격성 간염으로 진행하여 사망하는 경우는 드물게 보고되고 있다. 본 증례에서는 항결핵제에 의해 중증 독성 간염을 보였다가 회복된 후 저용량의 PZA을 재투여 하고 전격성 간염으로 진행하는 양상을 보였다. 이번 사례를 통해 저용량의 PZA를 투약시 전격성 간부전으로 진행하는 경우를 경험했고 항결핵제 투여시 면밀한 관찰이 필요하고 항결핵 약제 투여시 신중을 기울여야겠다.

• BMB Reports
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• 제33권3호
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• pp.213-220
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• 2000

A fulminant hepatitis is associated with massive liver cell necrosis and a high mortality rate. But survivors regenerate a normal liver and do not have chronic liver disease. This clinical course suggests that the acutely injured livers release a factor that allows a recovery from chronic hepatitis or cirrhosis. The objective of this study was to isolate and characterize an anti-fibrotic factor from acutely damaged rat livers. The liver cell necrosis was prepared from rat by warm ischemical perfusion and the perfusates were assessed against the growth inhibition of fat-storing cells (FSC). A liver-derived growth inhibitory factor (LDGIF) was purified from ischemically damaged rat livers by chromatographies on Sephacryl S-300, CM Sepharose, hydroxyapatite, and Superose 12. The LDGIF was isolated with an overall purification of 194-fold and 40% recovery. Although LDGIF was identified as the rat liver arginase by Nterminal sequence analysis, LDGIF exists as a monomer and the purified native arginase has a trimer form. Furthermore, LDGIF has a lower enzyme activity on the hydrolysis of L-arginine and a higher inhibitory effect on proliferation of FSC than the normal rat liver arginase. The catalytic activity of LDGIF is ascribed to the monomeric characteristics of the LDGIF. Therefore, the inhibitory action of LDGIF might not be due to the arginine depletion by the catalytic activity of arginase. In conclusion, the presence of the LDGIF could interpret the clinical course that serious fibrosis is not found in the liver of patients recovering from severe hepatic necrosis due to fulminant hepatitis, suggesting that this LDGIF may provide a novel target for the prevention and treatment of hepatic fibrosis.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1977년도 제16차 학술대회
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• pp.89.2-90
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• 1977

• 대한핵의학회지
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• 제32권1호
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• pp.114-119
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• 1998

반복적인 수혈을 받은 급성전격성간염 환자에서 Ga-67 체내분포의 양상을 추적하였다. 급성기에 시행한 갈륨스캔에서 간의 악성종양을 의심하게 하는 간섭취증가와 신장, 뼈섭취증가가 관찰되었다. 간섭취증가는 철운반단백질에 결합하지 않은 Ga-67이 염증이 일어난 간세포에 섭취되었기 때문으로 해석되었다. 신장과 뼈섭취증가는 반복적인 수혈에 의한 철운반단백질의 포화에 따른 Ga-67의 세포내운반저하에 의한 것으로 생각되었다. 10개월 후에 다시 시행한 갈륨스캔에서 간섭취는 더욱 증가되었으며 골수섭취의 증가가 관찰되었다. 반면 신장섭취는 정상화되었다. 이러한 소견은 철결핍성 빈혈에 의한 것으로 해석되었다. 이 증례는 체내 철의 양과 이에 따른 철운반단백질 포화도의 변화에 의한 Ga-67의 체내분포의 변화를 예시해 준다.

• 대한한의학회지
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• 제36권4호
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• pp.114-121
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• 2015

More and more patients suffering from hepatitis A, the number of patients representing symptoms that are uncharacteristic to hepatitis A is also increasing. There are occasions of serious complications among adult hepatitis A patients that can cause fulminant hepatitis or cirrhosis which can be fatal. A 43-year-old male was diagnosed as acute hepatitis A and was treated at a Western hospital over the course of three months, which included two months of hospitalization. However, his symptoms did not improve, so he was admitted to Oriental hospital. We prescribed Chunggan extract (CGX) four times a day. Acupuncture was performed twice a day. From the twenty-fourth day of admission, the total bilirubin fell under 10 mg/dL for the first time and next day he was discharged. Following his discharge, he consistently took CGX three times a day. 21 days after discharge all of his symptoms disappeared. This study demonstrated that traditional Korean medicine (TKM) for acute viral hepatitis with cholestatic hepatitis might be effective and safe with no adverse effects.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제15권2호
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• pp.111-116
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• 2012

Toxic hepatitis is a rare but devastating disease in children. Herbs are widely used in oriental medicine to treat various symptoms in Korea, however, several herbs have been reported to induce liver injury. We report a case of toxic hepatitis induced by Hovenia dulcis in a 3-year-old boy. He complained of nausea, abdominal discomfort, and jaundice. The patient had consumed water boiled with hovenia dulcis for about 1 year prior to presentation. A diagnosis of toxic hepatitis was made based on his history, laboratory data, viral markers, ultrasonography, and biopsied liver tissue. We administered supportive management for acute fulminant hepatitis but his symptoms and liver function progressed. He was transferred to another hospital for further evaluation and consideration for liver transplantation. Because acute liver failure due to herbs or dietary supplement taken for a long time is often fetal, it is important to make early diagnosis and stop taking the drug as soon as drug induced liver injury is suspected.

• Molecules and Cells
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• 제28권1호
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• pp.49-55
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• 2009

Hepatitis delta virus (HDV) infection causes fulminant hepatitis and liver cirrhosis. To elucidate the molecular mechanism of HDV pathogenesis, we examined the effects of HDV viral proteins, the small hepatitis delta antigen (SHDAg) and the large hepatitis delta antigen (LHDAg), on $NF-{\kappa}B$ signaling pathway. In this study, we demonstrated that $TNF-{\alpha}-induced$ $NF-{\kappa}B$ transcriptional activation was increased by LHDAg but not by SHDAg in both HEK293 and Huh7 cells. Furthermore, LHDAg promoted TRAF2-induced $NF-{\kappa}B$ activation. Using coimmunoprecipitation assays, we demonstrated that both SHDAg and LHDAg interacted with TRAF2 protein. We showed that isoprenylation of LHDAg was not required for the increase of $NF-{\kappa}B$ activity. We further showed that only LHDAg but not SHDAg increased the $TNF-{\alpha}-mediated$ nuclear translocation of p65. This was accomplished by activation of $I{\kappa}B_{\alpha}$ degradation by LHDAg. Finally, we demonstrated that LHDAg augmented the COX-2 expression level in Huh7 cells. These data suggest that LHDAg modulates $NF-{\kappa}B$ signaling pathway and may contribute to HDV pathogenesis.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제8권2호
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• pp.213-221
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• 2005

목 적: 혈구탐식 증후군은 지속적인 고열, 간비종대, 혈구감소증, 고 페리틴혈증, 간과 비장 또는 임파절 등의 망상내피계 전반에 걸쳐 적혈구탐식을 보이는 양성 대식세포의 활성화와 증식을 특징으로 하는 질환으로, 심한 급성간염 또는 전격성 간염으로 발현할 수 있어 소아소화기분과로 처음 의뢰되는 경우가 많은데, 혈구탐식증후군은 조기에 etoposide를 포함하는 항암치료 요법을 시행한 후 필요시 골수이식을 시행함으로써 완치가 가능한 질환이나, 다른 원인의 전격성 간염의 경우에는 간이식이 필요하다는 점에서 정확한 감별이 요구된다. 방 법: 1994년 2월부터 2005년 3월까지 서울아산병원 소아과에서 혈구탐식증후군으로 진단받은 환아 23명 중 중증 급성 간염의 소견으로 발현한 11명의 의무기록을 토대로 후향적으로 인구학적 특징, 임상 양상, 검사 결과 등을 분석하였다. 결 과: 전체 혈구탐식 증후군 환아들 23명 중 중증 급성 간염 소견으로 발현한 예는 모두 11예로 48%였고, 이 중 소아소화기 분과로 처음 의뢰된 환아가 7명(64%)으로 반 이상을 차지하였다. 평균 나이는 50개월이었다. 원인으로 가족력은 없었고 바이러스 감염이 4예(36%)에서 증명되었는데, 골수에서 EBV PCR 양성이었으며, 이 중 1예는 HSV PCR이 동시에 양성이었다. 임상 증상으로는 발열이 10예(91%), 간비종대가 모든 환아(100%)에서 있었고, 황달 10예(91%), 점상출혈 3예(27%), 임파절 비대가 3예(27%), 호흡기 증상은 3예(25%)에서 관찰되었다. 혈액학적 소견으로 빈혈 91%, 혈소판 감소증 91%, 백혈구 감소증이 72%에서 관찰되었다. 고 중성지방혈증은 81%, 저 피브리노겐 혈증은 72%에서, 고 페리틴혈증은 64%에서 있었다. 총 9명의 환아가 etoposide를 포함하는 항암요법을 받았고 사망률은 11명 중 8명으로 72%였는데, 발병시부터 4주 이내에 항암요법을 시작한 경우의 사망률은 50%, 4주 이후에 시작한 경우의 사망률은 80%였다. 2세 미만의 환아의 사망률은 100%였다. 결 론: 상당수의 소아 혈구탐식증후군 환아들이 심한 급성 간염 및 간부전, 전격성 간염 등으로 발현할 수 있으며, 특히 지속적인 고열과 혈구감소증 등이 동반된 경우 혈구탐식증후군을 의심하여 조기에 진단하고 4주 이내에 etoposide를 포함한 항암요법과 필요시 골수이식을 실시하여 완치의 가능성을 추구하여야 하며, 다른 원인에 의한 전격성 간염으로 오진하여 불필요한 간이식을 시행하지 않도록 해야할 것이다.