• Proceedings of the Korean Society of Medical Physics Conference
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• 2004.11a
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• pp.49-52
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• 2004

A few studies have shown that the function of fusiform face area is selectively involved in the perception of faces including a race difference. We investigated the neural substrates of the face-selective region called fusiform face area In the ventral occipital-temporal cortex and same-race memory superiority In the fusiform face area by the event-related fMRI. In our fMRI study, twelve healthy subjects (Oriental-Korean) performed the implicit distinction of the race while they consciously made familiar-judgments, regardless of whether they considered a face as Oriental-Korean or European-American. In the race distinction as an implicit task, the fusiform face areas (FFA) and the right parahippocampal gyrus had a greater response to the presentation of Oriental-Korean than European-American faces, but in the consciously race distinction between Oriental-Korean and European-American faces, any significant difference in the FFA was not observed. These results suggest that different activation in the fusiform regions and right parahippocampal gyrus resulting from same-race memory superiority could be implicitly taken place by the physiological processes of face recognition.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2006.05a
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• pp.351-354
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• 2006

시청각 동영상을 이용하여 정서의 뇌 활성화 영역을 규명하는 뇌 영상 연구들은 심상이나 슬라이드와 같은 정서유발도구를 사용한 연구들이 가지지 못한 장점을 가지고 있다. 그러나 시청각 동영상을 이용하여 정서와 관련된 뇌 활성화 영역을 밝히는 연구들은 미미한 실정이다. 본 연구는 시청각 동영상 자극을 이용하여 부적정서에 해당하는 공포, 분노, 혐오정서의 뇌 활성화 영역을 밝히도록 하겠다. 실험참가자로 11명의 오른손잡이 여대생이 선정되었다. fMRI 실험을 위한 패러다임은 block design으로, 각 정서당 통제자극 30초와 정서자극 1분 30초로 구성되었다. 개발된 공포자극에 의해 유발된 공포정서를 경험하는 동안, 공포자극에서는 우측 Amygdala와 양측 Fusiform Gyrus, 좌측 Middle Occipital Gyrus, 우측 Superior Temporal Gyrus가, 분노자극에서는 좌측 Thalamus와 양측 Anterior Cingulate Gyrus, 혐오자극에서는 좌측 Insula, 우측 Putamen, 우측 Fusiform Gyrus, 우측 Middle Occipital Gyrus, 우측Superior Temporal Gyrus 가 활성화되는 것으로 나타났다. 본 연구 결과에서는 시청각 자극을 사용하여 부적 정서에 따른 뇌 활성화 영역을 규명할 수 있었다.

• Journal of Korean Neurosurgical Society
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• v.54 no.6
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• pp.453-460
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• 2013

Objective : There is a rich literature confirming the default mode network found compatible with task-induced deactivation regions in normal subjects, but few investigations of alterations of the motor deactivation in patients with intracranial lesions. Therefore, we hypothesized that an intracranial lesion results in abnormal changes in a task-induced deactivation region compared with default mode network, and these changes are associated with specific attributes of allocated regions. Methods : Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) during a motor task were obtained from 27 intracranial lesion patients (mean age, 57.3 years; range 15-78 years) who had various kinds of brain tumors. The BOLD fMRI data for each patient were evaluated to obtain activation or deactivation regions. The distinctive deactivation regions from intracranial lesion patients were evaluated by comparing to the literature reports. Results : There were additive deactivated regions according to intracranial lesions : fusiform gyrus in cavernous hemangioma; lateral occipital gyrus in meningioma; crus cerebri in hemangiopericytoma; globus pallidus, lateral occipital gyrus, caudate nucleus, fusiform gyrus, lingual gyrus, claustrum, substantia nigra, subthalamic nucleus in GBM; fusiform gyrus in metastatic brain tumors. Conclusion : There is increasing interest in human brain function using fMRI. The authors report the brain function migrations and changes that occur in patients with intracranial lesions.

• Proceedings of the KSPS conference
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• 2005.11a
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• pp.137-140
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• 2005

In this study we investigated the cognitive neuropsychological characteristics and the underlying mechanism in a letter-by-letter reading dyslexic patient after cerebral infarct of left posterior cerebral artery using fMRl, The results of cognitive neuropsychological assesment are visual perception was appropriate, and semantic categorization, picture naming and picture-word matching tasks were above83% correct, respectively. However, she was very poor in lexical decision task. The selective reading impairment is thought to result from the disruption of the left occipitotemporal region included fusiform gyrus. In fMRl results, the activation level increase din the right occipitotemporal region included fusiform gyrus compared with normal group in compensation for left impairment and more increased in pseudo word reading task than word reading on account of familiarity.

• 한국HCI학회:학술대회논문집
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• 2008.02b
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• pp.501-506
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• 2008

본 연구에서는 가상현실을 이용한 단서노출치료가 흡연자의 니코틴 갈망수준을 감소시키는지를 알아보았다. 이를 위하여 8명의 흡연청소년을 대상으로 6회기의 가상환경 단서노출치료를 실시하였다. 또한 단서노출치료 실시전과 후에 흡연관련 사진과 중립사진을 제시하는 동안 참가자들의 뇌를 기능성 자기공명영상장치(fMRI)로 측정하였다. 그 결과 단서노출실시 전에는 prefrontal cortex(PFC), Anterior cingulate gyrus(ACC) 영역을 비롯한 7개의 영역이 활성화되었고, 단서노출치료 후에는 right middle frontal gyrus, right uncus, left medial frontal gyrus, right fusiform gyrus, 그리고 right superior frontal gyrus 영역이 활성화되었다. 단서노출치료 전과 후의 비교에 서는 PFC가 관찰되었다. 본 연구의 결과로 흡연자의 흡연 갈망은 감소되었으며, 가상현실단서노출치료는 흡연자들 뿐 아니라 여러 물질의존자들의 치료에 유용한 방법이 될 것이라는 것을 시사한다.

• Korean Journal of Cognitive Science
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• v.18 no.2
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• pp.139-157
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• 2007

We compared brain activation areas during participants drawn from contrasting two college majors performed intentionality detection (known as the basic mechanism of theory of mind) task using fMRI. The main purpose of this study was to identify whether individual differences are present in intentionality detection or not. In psychology major, the left inferior frontal gyrus, the fusiform gyrus, the superior temporal gyrus and the right fusiform gyrus, the supramarginal gyrus were activated. In engineering major, the inferior parietal lobule and the superior parietal lobule were found. This result suggests that according to participants' major, different brain areas were activated. The relations between performance of the intentionality detection task and the individual variants of participants were discussed.

• Anxiety and mood
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• v.10 no.2
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• pp.143-150
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• 2014

Objective : The subgenual cingulate cortex, a part of default-mode network, has been known to playa key role in the pathophysiology of depression. The previous studies have reported abnormal functional connectivity between the subgenual cingulate cortex and other brain regions in the patients with depression. The goal of this shldy was to explore the resting-state functional connectivity of the subgenual cingulate cortex between the patients with depression and healthy subjects. Methods : Twenty patients with major depression and age- and sex-matched 20 healthy subjects underwent 5-minute resting state fMRI scans. The functional connectivity map in each subject was acquired using seed-based correlation analysis with the seed located in the subgenual cingulate cortex (Talairach coordinates; x=-10, y=5, z=-10). The functional connectivity maps were calculated using AFNI and compared between the patient and healthy subject group via two-sample T-test using 3dttest++ in AFNI package. Results : Functional connectivity was decreased between the subgenual cingulate cortex and both sides of fusiform gyrus in depressed subjects. Connectivity was also decreased between the subgenual cingulate cortex and the left cerebellum in the patient group. There was no correlation between the severity of depression and the degree of functional connectivity between the subgenual cingulate cortex and the regions showing decreased functional connectivity. Conclusion : Decreased resting-state functional connectivity between the subgenual cingulate cortex and both sides of fusiform gyrus, and decreased connectivity between the subgenual cingulate cortex and the left cerebellum found in the patients with major depression in comparison to the healthy subjects might be related to abnormal emotional and cognitive processing of depressed patients.

• Anxiety and mood
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• v.18 no.2
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• pp.39-47
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• 2022

Objective : This study investigated brain functional connectivity in male firefighters who showed subclinical post-traumatic stress disorder (PTSD) symptoms. Methods : We compared the data of 17 firefighters who were not diagnosed with PTSD and 18 healthy controls who had no trauma exposure. The following instruments were applied to assess psychiatric symptoms: Korean version of the Post-traumatic stress disorder Checklist for DSM-5 (PCL-5-K), Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI). For all subjects, functional magnetic resonance imaging was performed, and functional connectivity was compared between the two groups (family-wise error-corrected p<0.05). Additionally, correlations between psychiatric symptoms and functional connectivity were explored. Results : The following connectivity was higher than that of healthy controls: 1) the central opercular cortex-superior temporal gyrus, 2) planum polare-parahippocampal gyrus, 3) angular gyrus-amygdala, and 4) temporal fusiform cortex-parahippocampal gyrus. The functional connectivity of 1) the lateral occipital cortex-inferior temporal gyrus, 2) superior parietal lobule-caudate, and 3) middle temporal gyrus-thalamus were lower in firefighters. In firefighters, the connectivity of the planum polare-parahippocampal gyrus showed a negative correlation with the severity of arousal symptoms (rho=-0.586, p=0.013). The connectivity of the middle temporal gyrus-thalamus showed a positive correlation with the severity of intrusion (rho=0.552, p=0.022) and arousal symptoms (rho=0.619, p=0.008). The connectivity of the temporal fusiform cortex-parahippocampal gyrus was negatively correlated with intrusion (rho=-0.491, p=0.045) and arousal (rho=-0.579, p=0.015). Conclusion : Our results indicate that the brain functional connectivity is associated with occupational trauma exposure in firefighters without PTSD. Therefore, this study provides evidence that close monitoring and early intervention are important for firefighters with traumatic experience even at a subthreshold level.

• Progress in Medical Physics
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• v.16 no.1
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• pp.32-38
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• 2005

Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with schizophrenia. The purpose of this study was to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Ten patients with schizophrenia were recruited along with matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the performance of a 1-back working memory paradigm using images of neutral faces as mnemonic content. The patient group performed the tasks with reduced accuracy. Group analysis revealed that left fusiform gyrus, right superior frontal gyrus, bilateral middle frontal gyri/insula, left middle temporal gyrus, precuneus and vermis of cerebellum and showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in lateral prefrontal cortex and parietal lobule was observed from the patient group, all in the right hemisphere. A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2002.05a
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• pp.231-235
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• 2002

본 논문에서는 전문 안무가와 일반인들을 대상으로, 현대적 스타일의 독무와 임의적으로 움직이는 육면체를 제시할 때의 두뇌 활동 양상을 fMRI를 통하여 알아보았다. 피험자들은 총 8명으로 구성되었으며, 4명은 안무 전문가들, 4명은 동일한 연령대의 일반인들이었다. 피험자들은 시각 자극으로 제시되는 춤동작과 다양하게 변화하는 단순한 육면체의 움직임을 아무런 반응 없이 보는 과제를 수행하였다. 두 피험자 그룹 모두에서 육면체의 움직임보다 무용을 응시할 때 occipital cortex에서 더 큰 활성화를 보였고, 특히 좌측 STS와 angular gyrus사이의 경계선 영역, 그리고 좌측 fusiform gyrus에서는 안무가들이 무용을 볼 때 일반인들보다 더 높은 활성화를 나타내었다. STS/angular gyrus와 fusiform gyrus가 시각 자극의 의미 표상을 이해하는데 관련이 있고, angular gyrus가 사전적 의미 해석에 있어 중계적 역할을 하는 곳이며, fusiform gyrus는 사물을 지각하는데 있어서 보조 역할을 맡고 있다는 논의를 바탕으로, 무용가들은 그들이 지니고 있는 안무에 대한 전문적인 소견과 지식을 이용하여 몸의 움직임을 분석할 수 있고, 또 그것에서부터 어떠한 상징적인 의미까지 끌어내어 결과적으로 의미 추출의 과정에서 두뇌의 semantic network를 활성화시킨다고 볼 수 있다.