• Herbal Formula Science
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• v.32 no.1
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• pp.11-28
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• 2024

Objectives : GunRyeong-Tang(GRT) is a traditional herbal prescription that combines Oryeongsan and Sagunja-tang. This study employed network analysis methods on the components of GRT and target genes related to diabetes complications to predict the improvement effects of GRT on diabetes complications. Methods : The collection of active compounds of GRT and related target genes involved the utilization of public databases and the PubChem database. We selected diabetes complication-related genes using GeneCards and confirmed their correlation through comparative analysis with the target genes of GRT. We constructed a network using Cytoscape 3.9.1 and conducted topological analysis. To predict the mechanism, we performed functional enrichment analysis based on Gene Ontology (GO) biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Results : Through network analysis, 234 active compounds and 1361 related genes were collected from GRT. A total of 9,136 genes related to diabetes complications were collected, and 1,039 target genes overlapping with the components of GRT were identified. The core genes of this network were TP53, INS, AKT1, ALB, and EGFR. In addition, GRT significantly reduced the H9c2 cell size and the expression of myocardial hypertrophy biomarkers (ANP, BNP), which were increased by high glucose (HG). Conclusions : Through this study, we were able to predict the activity and mechanism of action of GRT on diabetes and diabetic complications, and confirmed the potential of GRT as a treatment for diabetes complications through the effect of GRT on improving myocardial hypertrophy for diabetic cardiomyopathy.

• Resources Recycling
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• v.14 no.4 s.66
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• pp.22-33
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• 2005

Four sheet-shaped and one soft-shaped self-sealing waterproof materials were prepared to recycle some GRT(Ground Rubber Tires). Their physical properties were tested to consider characteristics of them. The self-sealing waterproof materials were consisted of GRT/super absorbent polymer(SAP)/binder and mold by a hot press after mixing with a batch-typed internal mixer. The average size of GRT particles was -40 mesh, SAPs were commercial GE-500F and poly(AM-SAS-AA) prepared in this work. Binders were PU. EVA, LDPE, SBR, and poly(2-EHA). And PU film was attached to improve the properties of waterproof materials. Characteristics of self-sealing waterproof materials consisted of by GRT/GE-500F/EV-600/PU film and GRT/GE-500F/SBR(vulcanization)/PU film among the developed self-sealing waterproof materials were similar to the commercial products. And properties of the soft-shaped self-sealing waterproof materials consisted of by GRT/GE-500F/Po1y(2-EHA) and CRT/Poly(AM-SAS-AA)/poly(2-EHA) were improved within from four times to twenty times compared to the one oi the commercial products.

• Proceedings of the IEEK Conference
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• 2001.10a
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• pp.236-239
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• 2001

In this study, the compound materials of GRT/plastics (HDPE, LLDPE, LDPE, PP and PS) were developed. Their tensile strength, strain at yield and flexural modulus according to the change in CRT content were measured. And, the physical properties of the compound materials that the GRT content was changed in the waste vinyl HDPE and pure HDPE were measured, compared and analyzed. If tile GRT is added to PE plastics, the physical properties were superior to those of PP and PS, and in the case of HDPE, the waste vinyl HDPE had superior physical properties by the GRT content to the pure HDPE.

• Proceedings of the KSR Conference
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• 2008.11b
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• pp.679-686
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• 2008

There has been an increasing demand of introducing innovative public transport modes meriting high flexibilities of a bus mode along with on-time accuracy and quality environment-friendliness of a rail mode, as it is considered to significantly contribute to reducing huge social expenditures on the traffic congestion and environmental pollution agenda, and to be an alternative solution to better the urban transport problems. In order to comply with the need, Seoul Municipal Government has recently decided to build up GRT system of a new concept in Nangok area in Seoul, the first in its kind in Korea. The concession has been awarded to Seoul Metro. This thesis will study and benchmark similar systems abroad under operation, and further review necessary requirements overall which would secure full readiness for the operation of Nangok GRT system.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.2
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• pp.57.1-57.1
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• 2021

K-SIM (KASI-Simulation) research project is dedicated to develop new numerical techniques in order to theoretically study galaxy formation and evolution. As the first step of the K-SIM, to model tidal stripping of galaxies with a very high resolution in a fully cosmological context, we invented the Galaxy Replacement Technique (GRT) that is very efficient and fast. The high resolution allows us to accurately resolve the tidal stripping process and well describe the formation of ultra-low surface brightness features in the galaxy cluster (㎶ < 32 mag/arcsec^2), such as the intra-cluster light, shells and tidal streams. I'll introduce how the GRT is designed and which science topics in low-surface brightness regime can be visited using the GRT.

• Elastomers and Composites
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• v.43 no.2
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• pp.72-81
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• 2008

Nowadays, modifying asphalt to improve the resistancy of plastic deformation or rutting on roads has been drawing attention. In this study, asphalts were modified with modifying agents and ground rubber from waste tire (GRT), and the effects of modifier and GRT on the properties of asphalt were analyzed. The Marshall stability of modified asphalt was increased by 98% and the tensile strength increased by 43% compared to straight asphalt. GRT played an important role in enhancing these properties. Viscosity tests, penetration tests and TMA analysis showed the deformation resistancy of modified asphalt. IR and GPC tests indicated that asphalt and modifier have similar chemical structures to each other, and chemical bonding between asphalt and modifier have occurred so that the molecular size lengthened.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.29.2-29.2
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• 2021

Intracluster light (ICL) is composed of the stars diffused throughout the galaxy cluster but does not bound to any galaxy. The ICL is a ubiquitous feature of galaxy clusters and occupies a significant fraction of the total stellar mass in the cluster. Therefore, the ICL components are believed to help understand the formation and evolution of the clusters. However, in the numerical study, one needs to perform the high-resolution cosmological hydrodynamic simulations, which require an expensive calculation, to trace these low-surface brightness structures (LSB). Here, we introduce the Galaxy Replacement Technique (GRT) that focuses on implementing the gravitational evolution of the diffused ICL structures without the expensive baryonic physics. The GRT reproduces the ICL structures by a multi-resolution cosmological N-body re-simulation using a full merger tree of the cluster from a low-resolution DM-only cosmological simulation and an abundance matching model. Using the GRT, we show the preliminary results about the evolution of the ICL in the on-going simulations for the various clusters.

• Journal of Korean Society of Water and Wastewater
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• v.25 no.6
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• pp.815-824
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• 2011

In this study, a non-thermal plasma system was employed to simultaneously remove odorous compounds and organic sludge. The system consisted of two reactors; the first one was the non-thermal plasma reactor where ozone was produced by the plasma reaction and the ozone oxidized hydrogen sulfide, the model odorous compound, and then the ozone-laden gas stream was introduced to the second reactor where wasted sludge was disintegrated and solubilized by ozone oxidation. In this study, the gas retention time (GRT) and the hydraulic retention time (HRT) were changed in the two-reactor system, and the effects of GRT and HRT on reduction efficiencies of odor and sludge were determined. As the GRT increased, the ozone concentration increased resulting in an increasing efficiency of hydrogen sulfide removal. However, the overall ozone loading rate to the second sludge reactor was the same at any GRT, which resulted in an insignificant change in sludge reduction rate. When HRTs in the sludge reactor were 1, 2, 4 hours, the sludge reduction rates were approximately 30% during the four-hour operation, while the rate increased to 70% at the HRT of 6 hours. Nevertheless, at HRTs greater than 4 hours, the solubilization efficiency was not proportionally increased with increasing specific input energy, indicating that an appropriate sludge retention time needs to be applied to achieve effective solubilization efficiencies at a minimal power consumption for the non-thermal plasma reaction.

• The Journal of Korean Medicine
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• v.23 no.2
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• pp.211-224
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• 2002

Background and Objective : In order to investigate the effects of Gilgyunglwedok-tang (GRT) on antitumor activity and antimetastatic activity, studies were done experimentally. Materials and Methods : Experimental studies were perfonned for the cytotoxic effect on BALB/c mouse lung fibroblast cells, the proliferating effect of splenic lymphocyte, the expression of CD3e/CD4, CD3e/CD8, and B220 in peripheral blood mononuclear cells (PBMCs), the cytotoxic effect on A549, SK-OV-3, SK-MEL-2, MCF-7 cells, the inhibitory effect on the activity of DNA topoisomerase I, the T/C% in ICR mice bearing S-180, the inhibitory effect of Cell adhesive of A549 Cells and SK-OY-3 Cells to complex extracellular matrix, the inhibitory effect on lung colonies, the change of lung tissue, the antiangiogenic activity, and the effect on MMP-2 and MMP-9 gene expression in the RT1080 cell line. Results and Conclusion : The results were obtained as follows : 1. In the cytotoxic effect on BALB/C mouse lung fibroblast Cell, GHT didn't show the significant cytotoxic effect on BALB/C mouse lung fibroblast cell compared to the control group. 2. In thymidine uptake assay, GHT showed the significant proliferating effect of splenic lymphocyte in proportion to the concentration. 3. In the expression of CD3e/CD4, CD3e/CD8, and B220 in peripheral blood mononuclea cells (PBMCs) of mice, GRT had no significant change to the normal group in CD4. However, GRT showed an increase to the normal group in CD8 and GHT in the only $1\mu\textrm{g}/ml$ category showed an increase to the normal group in B220. 4. In the cytotoxic effect of GRT on A549, SK-OY-3, SK-MEL-2 and MCF-7 cells, there was no significant cytotoxic effect compared to the control group. 5. In the inhibitory effect on the activity of DNA topoisomerase I, GHT in the $10\mu\textrm{g}/ml$ category showed the inhibitory effect on the activity of DNA topoisomerase I in proportion to the concentration. 6. In the T/C% in ICRmice bearing S-180, GHTtreated group showed 123.7% of T/C% compared to the control group. 7. In the inhibitory effect of cell adhesive of A549 Cells and SK-OV-3 Cells to complex extracellular matrix, GRT in the only $100\mu\textrm{g}/ml$ category showed the significant inhibitory effect compared to the control group. 8. In the inhibitory effect on lung colonies, GHT showed the significant inhibitory effect on lung colonies compared to the control group. 9. In the change of lung tissue, GHT showed a significant decrease of lung cancer growth, interalveolar fibrosis and hyaline material compared to the control group. In the development of lymphocyte around lung cancer cells and lung parenchymal, GHT showed the significant inducement efficacy compared to the control group. 10. In CAM assay, the antiangiogenic activity of GHT showed 30%. 11. In the effect on MMP-2 and MMP-9 gene expression in the RT1080 cell line, GHT had no significant inhibitory effect on MMP-2 and MMP-9 gene expression compared to the control group. According to the above results, it could be suggested that GHT has an antitumor activity and antimetastatic activity.

• The Journal of Korean Society for Radiation Therapy
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• v.26 no.2
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• pp.363-368
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• 2014

Purpose : The aim of this study was to appraise properties for radiation therapy techniques and effectiveness of time and economy to a patient in the case of applying flattening filter-free (3F) and flattening filter (2F) beam to the radiation therapy. Materials and Methods : Alderson rando phantom was scanned for computed tomography image. Treatment plans for intensity modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT) and stereotactic body radiation therapy (SBRT) with 3F and 2F beam were designed for prostate cancer. To evaluate the differences between the 3F and 2F beam, total monitor units (MUs), beam on time (BOT) and gantry rotation time (GRT) were used and measured with $TrueBeam^{TM}$ STx and Surveillance And Measurement (SAM) 940 detector was used for photoneutron emitted by using 3F and 2F. To assess temporal and economical aspect for a patient, total treatment periods and medical fees were estimated. Results : In using 3F beam, total MUs in IMRT plan increased the highest up to 34.0% and in the test of BOT, GRT and photoneutron, the values in SBRT plan decreased the lowest 39.8, 38.6 and 48.1%, respectively. In the temporal and economical aspect, there were no differences between 3F and 2F beam in all of plans and the results showed that 10 days and 169,560 won was lowest in SBRT plan. Conclusion : According as the results, total MUs increased by using 3F beam than 2F beam but BOT, GRT and photoneutron decreased. From above the results, using 3F beam can decrease intra-fraction setup error and risk of radiation-induced secondary malignancy. But, using 3F beam did not make the benefits of temporal and economical aspect for a patient with the radiation therapy.