• The Journal of Korean Medicine
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• v.42 no.2
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• pp.98-106
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• 2021

Objectives: The objective of this case report is to find a therapeutic effect of Gyeji-tang in panic disorder patients, based on Shanghanlun provision. Methods: At patient's first visit, we had conducted a medical interview in order to diagnose the physical and mental symptoms of the patient. A questionnaire called BAI had been also used to measure the degree of anxiety in panic disorder. After all the diagnoses had been done, the patient was allowed to take 120cc of Gyeji-tang, three times a day for 25 weeks. 25 weeks later, we conducted a second medical interview to compare with the initial treatment and to evaluate whether his physical and mental symptoms had been decreased or not. Likewise, the patient was asked to fill out the BAI questionnaire to measure the decline of anxiety degree. Results: Based on Shanghanlun provision, the patient with panic disorder due to overwork was diagnosed as Tai-yang-bing. Considering that the patient was having dyspnea, 15th provision of Gyeji-tang was selected and administered for 25 weeks. After 25 weeks, we could have observed that the main physical symptoms such as palpitation, dyspnea, stifling, headache, and fatigue were moderately improved. Moreover, the BAI score, which was evaluated to measaure the degree of anxiety, was also decreased from 49 points to the level of normal condition, 16 points. Conclusions: A 44 year old male patient who suffered from panic disorder due to overwork was allowed to take 15th provision Gyeji-tang for 25 weeks, based on Shanghanlun Provision. In results, the main physical symtpoms including dyspnea, palpitation, stifling, headache, and fatigue, and mental symptom such as extreme anxiety were all effectively improved.

• 대한상한금궤의학회지
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• v.10 no.1
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• pp.69-80
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• 2018

Objective : Patients complaining of dizziness and olfactory hallucination who were diagnosed and treated with the Shanghanlun disease pattern identification diagnostic system were analyzed to report cases. Methods : This is a case report on a patient who has been suffering from Dizziness andolfactory hallucination. According to Diagnostic system based on Shanghanlun provisions, Gyeji-tang was provided. The severity of Dizziness was evaluated by NRS. Results : When analyzing the patient's history and symptoms, it can be found in article No. 42 in Shanghanlun. In the first case, NRS changed from 8 to 2. In the second case, NRS change 8 to 1. Conclusions : Gyeji-tang can be effective in dizziness and olfactory hallucination with the Shanghanlun disease pattern identification diagnostic system.

• Journal of Korean Medical classics
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• v.32 no.1
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• pp.171-189
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• 2019

Objectives : This study analyzes herbs combinations and primary virtues that constitute the prescriptions of Gyeji-tang, Mahwang-tang, and Daecheongryong-tang to effectively analyze medication preparations described in "Shanghanlun" using database, and test the results of the data structure and effectiveness of queries. Methods : This study enters "Sanghanjapbyeongronyeonggudaeseong" as the original text into the database, and even uses one provision as independent knowledge by dividing provisions in accordance with the content. Results : Five tables and 12 queries were created and used for data input and analysis. Using the types of Herbs included in the prescriptions, this study manages to search for the same or supplemented prescriptions, and the primary virtues of the prescriptions were collected and compared. Conclusions : Subject to the combination of herbs and pathology for the prescriptions described in "Shanghanlun" utilizing the database, this study found relevant texts and combinations of herbs and pathologies, and using this, the time required for theoretical research between prescriptions could be shortened.

• Korean Journal of Pharmacognosy
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• v.49 no.1
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• pp.76-83
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• 2018

A traditional herbal formula, Gyeji-tang has been used to treat the early colds, headache, chills, and fever in Asian countries. In this study, we were performed simultaneous determination of the 14 bioactive marker compounds, gallic acid, spinosin, paeoniflorin, albiflorin, liquiritin apioside, liquiritin, 6'''-feruloylspinosin, liquilitigenin, coumarin, cinnmamic acid, benzoylpaeoniflorin, cinnamaldehyde, glycyrrhizin, and 6-gingerol in Gyeji-tang using an ultra-performance liquid chromatography-electrospray ionization-mass spectrometry (UPLC-ESI-MS/MS). Analytical column was used a Waters Acquity UPLC BEH $C_{18}$ analytical column ($2.1{\times}100mm$, $1.7{\mu}m$) and maintained at $45^{\circ}C$ with a flow rate of 0.3 mL/min. The mobile phase consists of 0.1% (v/v) formic acid in water and acetonitrile with gradient elution. The MS analysis was conducted using multiple reaction monitoring in the positive and negative modes by a Waters ACQUITY TQD LC-MS/MS system. The calibration curves of 14 bioactive marker compounds showed linearity with correlation coefficients ${\geq}0.9798$. The limits of detection and quantification values were in the range of 0.11-6.66 ng/mL and 0.34-19.99 ng/mL, respectively. As a result of the analysis using the established LC-MS/MS method, the amounts of tested 14 compounds in the lyophilized Gyeji-tang sample were detected up to $85.7{\mu}g/g$. These results may be useful for quality assessment of a traditional herbal formulas.

• The Korea Journal of Herbology
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• v.38 no.6
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• pp.53-60
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• 2023

Objectives : The objective of present study was to investigate the vasorelaxant effects of 10 traditional Korean Herbal Prescriptions (KHP) on isolated rat thoracic aorta precontracted with potassium chloride (KCl). Methods : An electric extractor was used to extract KHP in distilled water for 3h. Rat aorta rings were isolated and were precontracted using KCl in organ chambers containing 10 ml Krebs Henseleit (KH) buffer. KHP extracts were added in increasing concentrations (10-1000 ㎍/㎖) to investigate vasorelaxant effects. The vasorelaxant responses induced by KHP were expressed as a percentage in response to contraction generated by KCl. Results : Among the 10 KHP, Gamisoyo-san, Galgeun-tang, Gyeji-tang, Gwakhyangjeonggi-san, Daeyoung-jeon, and Socheongryong-tang showed significant vasorelaxant effect at high concentration. In contrast, Gyejibokryeong-hwan constricted more the aorta rings precontracted by KCl. And Gumiganghwal-tang, Guibi-tang, Saengmaek-san showed no significant effect. Also, rat aorta rings treated with Gyejibokryeong-hwan or Gyeji-tang after pre-relaxation by amlodipine did not cause any significant change. Conclusion : Thus, these results provide the experimental evidence as useful herbal prescriptions for the treatment of hypertension and suggest guidelines in conjunction with other western drugs, including amlodipine.

• Herbal Formula Science
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• v.27 no.4
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• pp.257-267
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• 2019

Objectives: The purpose of this study was to establish experimental evidence for the antimicrobial effects of 51 herbal formulae commonly used in traditional Korean medical institutions. Methods: The antimicrobial activities of herbal formulae were screened using the disc diffusion method against 10 pathogenic microorganisms (Bacillus cereus, Staphylococcus aureus, Listeria monocytogenes, Vibrio parahaemolyticus, Escherichia coli DH5α, E. coli O157, Salmonella enteritidis, Yersinia enterocolitica, Shigella flexneri, and Helicobacter pylori). Of the 51 herbal formulae, 13 herbal formulae with antimicrobial activity were selected and their dose-dependency were confirmed. Results: Nine herbal formulae, including Gyeji-tang, Dangguisu-san, Saengmaek-san, Samul-tang, Ssanghwa-tang, Socheongryong-tang, Yukmijihwang-tang, Jakyakgamcho-tang, and Paljung-san, presented antibacterial activity against B. cereus. The effects of Saengmaek-san and Paljung-san was sustained for 48 hr. On L. monocytogenes, Dangguisu-san and Hyangsapyeongwi-san showed antimicrobial activity, but only Hyangsapyeongwi-san maintained the activity for 48 hr. Thirteen herbal formulae such as Galgeun-tang, Gyeji-tang, Dangguisu-san, Mahwang-tang, Banhasasim-tang, Saengmaek-san, Socheongryong-tang, Yukmijihwang-tang, Jakyakgamcho-tang, Cheonwangbosim-dan, Palmijihwang-tang, Paljung-san, and Hwanglyeonhaedok-tang showed antimicrobial activity against V. parahaemolyticus, and the activity was maintained for 48 hr. The 51 herbal formulae did not show any antimicrobial activity against seven strains such as E. coli DH5α, E. coli O157, S. aureus, S. enteritidis, Y. enterocolitica, S. flexneri, and H. pylori. Conclusions: Nine, two, and thirteen herbal formulae showed antimicrobial activities against B. cereus, L. monocytogenes, and V. parahaemolyticus in a dose-dependent manner, respectively. The results of antimicrobial activity of 51 herbal formulae against 10 microorganisms might be used as the basis for new application of herbal formulae.

• 대한상한금궤의학회지
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• v.10 no.1
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• pp.37-45
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• 2018

Objective : The purpose of this paper is to report the improvement of a patient who had a postpartum disease treated with herb medication based on Shanghanlun provisions. Methods : According to 'Disease Pattern Identification Diagnostic System based on Shanghanlun Provisions', the patient was diagnosed with TaeYang-byung, number 12 provision, and was administered herb medication for 4 months. Visual Analogue Scale(VAS) was used to estimate the patient's status. Results : The VAS changed 10 to 0. These results suggest that cold pain and weakness in the legs have improved. Conclusions : The patient had an experience of miscarriage 3 times and finally got a baby but with postpartum disease. She treated with the herb medication for 4 months and the outcome was found effective and economical due to the diagnostic system based on Shanghanlun provisions.

• The Journal of Korean Medicine
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• v.41 no.2
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• pp.1-8
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• 2020

Objectives: To establish the expiration date of herbal decoction pouch, the change in antimicrobial activities was measured according to storage temperature and period. Methods: Five herbal formulas, Gyeji-tang, Jakyakgamcho-tang, Saengmaek-san, Paljung-san, and Dangguisu-san, with antimicrobial activity were selected from 51 herbal formulas commonly used in traditional Korean medical institutions. Five herbal formula decoction pouches were prepared and stored at room temperature (RT) or 4℃ from 0 to 12 weeks to evaluate the antimicrobial activity against Bacillus cereus, Listeria monocytogenes, or Vibrio parahaemolyticus. The antimicrobial activities were evaluated by the disk diffusion method (disk size: 10 mm). Results: The decoction pouches of Gyeji-tang and Jakyakgamcho-tang maintained antimicrobial activity against V. parahaemolyticus from week 0 (14 mm) to week 12 (14 mm) at both temperatures. Saengmaek-san pouch had antimicrobial activities against V. parahaemolyticus and B. cereus from week 0 (19 mm and 20 mm) to week 12 (both 18 mm), respectively. At RT and 4℃, the antimicrobial activity of Paljung-san pouch was maintained week 0 (17 mm) to week 12 (both 13 mm) against B. cereus. Against L. monocytogenes, the antimicrobial activity of Dangguisu-san pouch showed 27 mm at week 0 and 23 mm (RT) and 24 mm (4℃) at week 12, respectively. Conclusion: According to increase of the storage duration, the antimicrobial activities of 5 herbal formula decoction pouches decreased slightly but remained up to 12 weeks. These results can be used as important data to establish the expiration date of herbal formula decoction pouches.

• The Journal of Internal Korean Medicine
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• v.43 no.5
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• pp.1006-1017
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• 2022

Objectives: This study examined a clinical case of a recurrent polyarticular gout patient treated with Korean medicine. Methods: The patient was treated with Korean medicine (Gyejigagye-tang, Soshiho-tang-gami, Gyejigajakyak-tang, acupuncture, and moxibustion), Western medicine, and rehabilitative therapy. Their effects were evaluated using the Visual Analog Scale. Results: After receiving Korean medical treatment for two admission periods, the Visual Analog Scale score for joint pain improved or disappeared. Moreover, Korean medicine was able to manage the symptoms of the gout patient. Conclusions: Proper Korean medicine treatment could be effective in improving the symptoms of recurrent polyarticular gout pain.

• Herbal Formula Science
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• v.27 no.1
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• pp.65-71
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• 2019

Objective : This study aims to diversify interpretation of formulas from "Onbyungjobyun" by analyzing various formulas from "Onbyungjobyun" as basic formulas. Method : This study found herbal communities of combination by analyzing herbal combinations based on network analysis of formulas from "Onbyungjobyun", and has analyzed each community of combination as basic formulas. Result : The results of network analysis showed a total of 3 herbal communities of combination; first was medicinal herbs from Eungyo-san(銀翹散), Jeungaek-tang(增液湯), Bokmaek-tang(復脈湯), Gyeji-tang(桂枝湯), Sogeonjung-tang (小建中湯) series; second was medicinal herbs from Angungwoohwang-hwan(安宮牛黃丸); third was medicinal herbs from Baekho-tang(白虎湯), Jaseol-dan(紫雪丹), Sayeok-tang(四逆湯) series. Conclusion : The formulas from "Onbyungjobyun" are consisted of herbal communities of combination; that treat warm-heat pathogen and supplies yin essence or yang qi; treat reverse transmission to the pericardium(逆傳心包); and treat heat in the qi phase in Onbyeong and cold-dampness in the middle energizer.