• Environmental Mutagens and Carcinogens
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• v.25 no.3
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• pp.97-103
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• 2005

The genotoxic effect of antimalarial drugs amodiaquine (AQ), mefloquine (MQ) and halofantrine (HF) was investigated in.at liver cells using the alkaline comet assay. AQ, MQ and HF at concentrations between $0-1000{\mu}mol/L$ significantly increased DNA strand breaks of rat liver cells dose-dependently. The order of induction of strand breaks was AQ>MQ>HF. The rat liver cells exposed to AQ and HF (200 and 400 ${\mu}mol/L$) and treated with (Fpg) the bacterial DNA repair enzyme that recognizes oxidized purine showed greater DNA damage than those not treated with the enzyme, providing evidence that AQ and HF induced oxidation of purines. Such an effect was not observed when MQ was treated with the enzyme. Treatment of cells with catalase, an enzyme inactivating hydrogen peroxide, decreased significantly the extent of DNA damage induced by AQ, and HF but not the one induced by MQ. Similarly quercetin, an antioxidant flavonoid at $50{\mu}mol/L$ attenuated the extent of the formation of DNA strand breaks by both AQ and HE. Quercetin, however, did not modify the effects of MQ. These results indicate the genotoxicity of AQ, MQ and HF in rat liver cells. In addition, the results suggest that reactive oxygen species may be involved in the formation of DNA lesions induced by AQ and HF and that, free radical scavengers may elicit protective effects against genotoxicity of these antimalarial drugs.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.5
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• pp.56-66
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• 2017

In this study, seismic strengthening performance of RC circular columns reinforced with high ductile PET and hybridized fibers(HF, PET + aramid) strand was experimentally compared and investigated. As a result, the maximum flexural strength and ductility capacity of all reinforced columns were improved than control column and fiber rupture did not occur at the ultimate stage. In addition, the resistive strength and displacement of the PET sheet 25 layers reinforcing column and the HF strand 1 layer reinforcing column were almost similar, so that 1 layer of HF strand showed the same lateral confinement effect as the PET sheet 25 layers. As a result of this experimental study, PET is considered to be suitable as seismic reinforcement material for RC structures in terms of flexural strength and ductility. However, in order to increase the possibility of application in the field, it is necessary to use a prefabricated PET sheet such as HF used in this study. The durability of PET needs investigation in the future.