• The Journal of the Korea Contents Association
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• v.11 no.3
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• pp.271-280
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• 2011

Heart Rate Variability (HRV) analysis is a convenient tool to assess Myocardial Ischemia (MI). The analysis methods of HRV can be divided into time domain and frequency domain analysis. This paper uses wavelet transform as frequency domain analysis in contrast to time domain analysis in short term HRV analysis. ST-T and normal episodes are collected from the European ST-T database and the MIT-BIH Normal Sinus Rhythm database, respectively. An episode can be divided into several segments, each of which is formed by 32 successive RR intervals. Eighteen HRV features are extracted from each segment by the time and frequency domain analysis. To diagnose MI, the Neural Network with Weighted Fuzzy Membership functions (NEWFM) is used with the extracted 18 features. The results show that the average accuracy from time and frequency domain features is 75.29% and 80.93%, respectively.

• Journal of Electrical Engineering and Technology
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• v.3 no.4
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• pp.576-583
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• 2008

In this study, we attempt to design a real-time autonomic nervous system(ANS) evaluation system usable during exercise using heart instantaneous frequency(HIF). Although heart rate variability(HRV) is considered to be a representative signal widely used ANS evaluation system, the R-peak detection process must be included to obtain an HRV signal, which involves a high sampling frequency and interpolation process. In particular, it cannot accurately evaluate the ANS using HRV signals during exercise because it is difficult to detect the R-peak of electrocardiogram(ECG) signals with exposure to many noises during exercise. Therefore, in this study, we develop the ground for a system that can analyze an ANS in real-time by using the HIF signal circumventing the problem of the HRV signal during exercise. First, we compare the HRV and HIF signals in order to prove that the HIF signal is more efficient for ANS analysis than HRV signals during exercise. Further, we performed real-time ANS analysis using HIF and confirmed that the exerciser's ANS variation experiences massive surges at points of acceleration and deceleration of the treadmill(similar to HRV).

• The Journal of Korean Medicine
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• v.28 no.2 s.70
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• pp.80-92
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• 2007

Objectives : Functional dyspepsia (FD) is one of the most common gastrointestinal diseases. Nevertheless, there are many unknown mechanisms of autonomic functioning in FD patients. This study was designed to investigate the relationship between FD and biosignals from heart rate variability (HRV) and Yangdorak diagnosis. Methods : 32 patients (22 female, 10 male; mean age 40) and 32 healthy volunteers (21 female, 11 malemean; age 38) participated in this study. First gastrointestinal symptoms rating scale (GSRS) was assessed by questionnaires in both groups to evaluate the types of gastrointestinal symptoms. Second, HRV and Yangdorak diagnosis were measured in both groups. Results : 1. The FD group in this study mainly had the complaint of 'bloating' symptoms. 2. There was statistically no significant difference between Yangdorak (total average and 24 acupoints) and HRV values except logarithmic low-frequency band (lnLF) and total power (TP) in frequency domain. 3. There was statistically no significant relationship between HRV and Yangdorak in either group. However, most Yangdorak values were positively related with some HRV values (low-frequency, low-frequency/high-frequency ratio and high-frequency, etc) in the control group. Conclusions : FD patients had relatively lesser sympathetic domain than healthy subjects, indicated by decreased lnLF and TP. Particularly, there were positive relationships and significant differences between Yangdorak and HRV in young healthy subjects. This suggests that biosignals from HRV may be a useful method that can differentiate FD from healthy state in those of young age.

• Journal of Oriental Neuropsychiatry
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• v.15 no.1
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• pp.197-209
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• 2004

Objectives : The purpose of this case-control research was to investigate the effects of acupuncture stimulation on autonomic nervous system for patients with HRV and to find out relationship with anti-stress effects. Methods : The study group consists of 24 patients with self-recognition of stress as the case group, and 20 normal person as the control group by similar age. We measured HRV of case and control groups before acupuncture stimulation, prick acupuncture in Hegu(LI4), Taichong(Liv3), Shenme(H7), Neiguan(P6), Zusanli(S36). After treating for 20 minutes, measurement values of HRV and PSV were compared for pre-acupuncture and post-acupuncture. Results : 1. LF norm, HF norm, LF/HF between the case and control groups were significant different in HRV before acupuncture stimulation in the 1st experiment. 2. HRT, SDNN, SDSD, LF norm, HF norm, and LF/HF of the case group were significant different in HRV after acupuncture stimulation in the 1st experiment. HRT of the case group was significantly different in HRV after acupuncture stimulation in the 1st experiment. 3. LF norm, HF norm, LF/HF of the case group were significant different between the 1st and 2nd experiment in HRV before acupuncture stimulation. 4. LF norm, HF norm, and LF/HF were significant different between the 1st and 2nd experiment in HRV of patients whose symptoms improved. But HRV of patients whose symptoms unimproved didn't show significant difference. Conclusion : The results suggest that acupuncture stimulation is associated with changed activity in the sympathetic and parasympathetic nervous system. Measurement values of HRV is suitable to estimate the activity of automatic nervous system.

• The Journal of Korean Obstetrics and Gynecology
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• v.35 no.3
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• pp.122-136
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• 2022

Objectives: The aim of this study is to investigate Heart Rate Variability (HRV) characteristics of patients with primary dysmenorrhea at the menstrual phase. Methods: 7 databases (Pubmed, Cochrane library, CNKI, RISS, KISS, OASIS, ScienceON) were searched for eligible studies published before 2021 December. The studies comparing HRV between patients with primary dysmenorrhea and controls were included. A random-effects model was used to evaluate differences of HRV parameters between patients with primary dysmenorrhea and controls. Results: 4 articles were included in this review based on inclusion and exclusion criteria. SDNN (Standard deviation of NN intervals), RMSSD (Square root of the mean squared difference of successive NN intervals), mean PR (Mean of pulse rate), LF (Low frequency), HF (High frequency), was the most frequently used as HRV parameters. RMSSD was significantly lower in patients with primary dysmenorrhea than controls. There was no statistically significant difference of other HRV parameters between patients with primary dysmenorrhea and controls. Conclusions: This study suggests that parasympathetic activity and overall functions of autonomic nervous system might be decreased in patients with primary dysmenorrhea at the menstrual phase. In the future, well-designed clinical studies using HRV and additional meta-analysis should be conducted to obtain a wealth of information about HRV characteristics of patients with primary dysmenorrhea.

• Journal of Korean Biological Nursing Science
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• v.21 no.3
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• pp.178-187
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• 2019

Purpose: The purpose of this study was to investigate how college students' perceived stress, cognitive stress, and somatization affect their heart rate variability (HRV). Methods: This study is a cross-sectional survey research on 191 university students, registered at the G University. The perceived stress scale (PSS) and cognitive stress response scale, were used to assess level of stress. The somatization symptom scale of the Symptom Check List 90 (SCL-90), was used to assess level of somatization caused by stress. To assess heart rate variability (HRV), we conducted a five-minute test using a pulse wave analyzer, to analyze short-term HRV. Results: The SCL-90 somatization score had relatively high positive correlation (p< .001) with cognitive stress, but low positive correlation (p< .001) with perceived stress. Cognitive stress response had low negative correlation (p< .001) with 1nSDNN and 1nRMSSD among HRV parameters. Perceived stress was not correlated with HRV. Multiple regression analysis showed that variables of perceived stress, cognitive stress, and somatization symptoms, could not explain HRV. By contrast, one of the HRV indicators, 1nSDNN, was affected by age, gender, and aggressive-hostile thought, the latter being a subscale of the cognitive stress response scale. Conclusion: This study suggests that stress evaluation for people in early adulthood will be more effective, if the evaluation examines cognitive stress and heart rate variability.

• Journal of Pharmacopuncture
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• v.12 no.3
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• pp.31-40
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• 2009

Objective : This study was to investigate the effects of distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture on autonomic nervous system with Heart Rate Variability(HRV). Purpose of the trial was to observe what influence distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture have on the autonomic nervous system. Methods : 60 healthy male volunteers were divided into three groups which consist of two experimental groups such as Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture, and a control group. Study design was a randomized, placebo-controlled, double-blind clinical trial. 20 subjects in experimental group were injected distilled Cervi Pantotrichum Cornu Pharmacopuncture at $GB_{21}$(Kyonjong), 20 subjects in other experimental group were injected distilled Zizyphi Spinosi Semen Pharmacopuncture and 20 subjects in control group were injected Normal Saline at $GB_{21}$(Kyonjong). One volunteer of each groups were excluded from analysis because of error during measuring HRV. At the end of the study 57 volunteers completed HRV analysis. HRV was measured by QECG-3:LXC3203(LAXTHA Inc. Korea) at P0, P1, P2, P3, P4, P5 and P6 and its time-course dependent change in each group was analyzed using paired t-test, and the difference of HRV fluctuation among two experimental group and a control was evaluated by one way ANOVA(p<0.05). Results : A. Time Domain Analysis 1. Analysis of Mean HRV, SDNN and Complexity After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, Mean HRV was significantly decreased only at 20 minutes after injection. SDNN was significantly increased from 15 minute after injection. Complexity was significantly decreased only at 15 minute after injection. After injection of distilled Zizyphi Spinosi Semen Pharmacopuncture, Complexity was significantly decreased at 10, 15 and 30 minutes after injection. 2. Analysis of HRV index, pNN50 After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, pNN50 was significantly decreased at 15, 20 and 25 minutes after injection. Compared with Normal Saline injection, distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture showed significant difference on HRV index and pNN50 at 5 minutes after injection. B. Frequency Domain Analysis 1. Analysis of Ln(TP), Ln(VLF) After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, Ln(TP) was significantly increased at 15 and 30 minutes after injection. Ln(VLF) was significantly increased at 10, 15 and 30 minutes after injection. After injection of distilled Zizyphi Spinosi Semen Pharmacopuncture, Ln(VLF) was significantly increased only at 30 minutes after injection. Compared with Normal Saline injection, distilled Cervi Pantotrichum Cornu Pharmacopuncture showed significant difference on Ln(TP) after 5 minutes of injection. Conclusions : Our results suggest that Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture in healthy adult man tend to activate the autonomic nervous system and sympathetic nervous system compared to Normal Saline within normal range.

• Anxiety and mood
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• v.2 no.2
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• pp.101-107
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• 2006

Object : Since autonomic nerve system dysfunction was known as the mechanism of panic disorder, many researchers used heart rate variability (HRV) as means of measuring autonomic nerve function of patients with panic disorder. We aimed to examine the effect of paroxetine medication for 3 months on symptom improvement and change of heart rate variability of the patients with panic disorder. Methods : The subjects were patients with panic disorder who visited the psychiatric outpatient clinic of Samsung Medical Center in Seoul. We included panic disorder patients who were aged from 20 to 50 and in normal BMI range (from 18 to 30) to minimize the effect of age and weight on HRV data. We excluded the patients with EKG abnormalities, hypertension or other major psychiatric disorders. They took 20-40 mg paroxetine medication a day for 3 months. Alprazolam was used only during the first month to control the acute panic symptoms and was tapered off after that. We measured the acute panic inventory (API), Hamilton rating scale for anxiety and depression (HAM-A & HAM-D), Spielberger state-trait anxiety inventory (STAIS, STAIT), and Beck depression inventory (BDI) in order to assess clinical improvement of the patients. And we measured time and frequency domain HRV in the resting, standing and cognitive stress states to assess the change of HRV. All measurements were done before and after paroxetine treatment. Result : After paroxetine medication, patients showed significant improvement in all psychiatric scales. In time domain of HRV, standard deviations of all R-R intervals (SDNN) were significantly increased in all states. In frequency domain of HRV, the ratio of high frequency to total power (HF/TP) in the standing state was significantly increased. Conclusion : After 3 months paroxetine medication, panic disorder patients showed significant clinical improvement and change in HRV data such as SDNN in all states and HF/TP ratio in the standing state. This result suggests that paroxetine medication is effective for the improvement of autonomic nerve system dysfunction in panic disorder patients.

• Journal of information and communication convergence engineering
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• v.11 no.3
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• pp.216-222
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• 2013

It is known that blood circulation in human body causes the skin tone to change concurrently with heartbeats. A number of apps have been developed to measure the heartbeat using smartphone camera; however, no any further analysis is performed. In this paper we propose an algorithm that detects heartbeats from the phone's camera and further extracts the heart rate variability (HRV). We compare the HRV extracted from the camera with the HRV extracted from the electrocardiogram. We estimated a number of commonly used HRV characteristics and compared them. Our results show that smartphone camera leads to slightly overestimated characteristics although the difference in extracted HRV signals is negligible. As a consequence we suggest that a smartphone camera can be employed in a quick heart diagnosis and diagnosis of autonomic nervous system.

• Clinical and Experimental Pediatrics
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• v.59 no.11
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• pp.432-439
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• 2016

Asthma is recognized as a complex disease resulting from interactions between multiple genetic and environmental factors. Accumulating evidence suggests that respiratory viral infections in early life constitute a major environmental risk factor for the development of childhood asthma. Respiratory viral infections have also been recognized as the most common cause of asthma exacerbation. The advent of molecular diagnostics to detect respiratory viruses has provided new insights into the role of human rhinovirus (HRV) infections in the pathogenesis of asthma. However, it is still unclear whether HRV infections cause asthma or if wheezing with HRV infection is simply a predictor of childhood asthma. Recent clinical and experimental studies have identified plausible pathways by which HRV infection could cause asthma, particularly in a susceptible host, and exacerbate disease. Airway epithelial cells, the primary site of infection and replication of HRV, play a key role in these processes. Details regarding the role of genetic factors, including ORMDL3, are beginning to emerge. This review discusses recent clinical and experimental evidence for the role of HRV infection in the development and exacerbation of childhood asthma and the potential underlying mechanisms that have been proposed.