• Title/Summary/Keyword: Haloform reaction

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Synthesis of Polyamides Containing N-Methylpyrrole and N-Methylimidazole and Their Anticancer Activity

  • Yuan, Gu;Xiao, Junhua;Huang, Weiqiang;Tang, Feili;Zhou, Yawei
    • Archives of Pharmacal Research
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    • v.25 no.5
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    • pp.585-589
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    • 2002
  • Three hairpin polyamides were designed and synthesized by a haloform reaction and DCC/HOBt coupling reaction without amino protection and deprotection. Their anticancer activity were investigated with three kinds of cell lines-hepatic carcinoma, lung carcinoma and gastric carcinoma, and the values of $IC_{50}$ were at range of $10^{-7}~10^{-8}M$.