• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2006년도 6th International Meeting on Information Display
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• pp.956-960
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• 2006

Deep-blue organic light-emitting diodes (OLEDs) with/without ultra-thin LiF layer inserted at the interface between hole-blocking and electron-transporting layers have been fabricated and investigated. The fundamental structures of the OLEDs are ITO/m-MTDATA/NPB/BCP/LiF (with/ without)/ $Alq_3/LiF/Al.Deep$ blue light emission with CIE coordinate of (0.15, 0.11) has been achieved for all devices. Further, by inserting LiF with thickness of 1nm at the interface between BCP and $Alq_3$ layer, the luminous efficiency as well as the power efficiency is much improved compared to that without. The enhancement of electron injection due to insertion of LiF may account for this improvement.

• BMB Reports
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• 제43권4호
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• pp.297-303
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• 2010

In order to demonstrate the potential therapeutic effect of two flavonoids, Baicalein and Wogonin, on suppression of pathological myocardial fibrosis in hypertension, we investigated their in vitro effects on collagen expression in primary cultured cardiac fibroblasts isolated from neonatal normotensive (WKY) and hypertensive (SHR) rats. Our results showed that over-expression of collagen mRNA and protein induced in cardiac fibroblasts by angiotensin (AngII) could be attenuated significantly by both flavonoids at an optimal dosage ($30\;{\mu}M$; P < 0.01). Results of immunoblots showed that expression of 12-LO level, p-ERK/ ERK ratio and MMP-9 in AngII-stimulated SHR cardiac fibroblasts were significantly down-regulated by both flavonoids. Our results show that both Baicalein and Wogonin can suppress collagen deposition in AngII-stimulated SHR and WKY cardiac fibroblasts.

• BMB Reports
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• 제42권1호
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• pp.59-64
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• 2009

Hepatitis B virus (HBV) infection is highly prevalent worldwide. The major challenge for current antiviral treatment is the elevated drug resistance that occurs via rapid viral mutagenesis. In this study, we developed AAV vectors to simultaneously deliver two or three shRNAs targeting different HBV-related genes. These vectors showed markedly better antiviral effects than ones that delivered a single shRNA in vitro. A dual shRNA expression vector (AAV-157i/1694i), which simultaneously expressed two shRNAs targeted the S and X genes of HBV, reduced HBsAg, HBeAg and HBV DNA levels by $87{\pm}4$, $80.3{\pm}2.6$ and $86.2{\pm}7%$ respectively, eight days post-transduction. In a mouse model of prophylactic treatment, HBsAg and HBeAg were reduced to undetectable levels and the serum HBV DNA level was reduced by at least 100 fold. These results indicate that AAV-157i/1694i generates potent anti-HBV effects and that the strategy of constructing multi-shRNA expression vectors may lead to enhanced anti-HBV efficacy and overcome the evading mechanism of the virus and thus the development of drug resistance.

• Archives of Plastic Surgery
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• 제49권1호
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• pp.127-129
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• 2022

• 한국세라믹학회:학술대회논문집
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• 한국세라믹학회 2000년도 추계총회,초청강연,특별강연,연구발표회
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• pp.129.1-129
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• 2000

• 한국세라믹학회:학술대회논문집
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• 한국세라믹학회 2003년도 추계총회 및 연구발표회 초록집
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• pp.163.2-163
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• 2003

• 전기화학회지
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• 제4권4호
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• pp.139-145
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• 2001

본 연구에서는 리튬전지내 양극 재료로서 리튬철계 산화물을 제조하여 전극재료의 다양한 조성에 따른 전기화학적 특성을 고찰하고자 하였다 출발 물질인 $FeCl_3-6H_2O,\; NaOH,\;LiOH$를 혼합하여 저온으로 가열하여 층상의 $LiFeO_2$를 합성하였으며 출발 물질의 조성비를 바꾸어 그 영향을 조사하였다. 그 결과 NaOH의 첨가량이 증가할수록 전극의 용량은 감소하나 효율 및 용량의 감소율은 작아짐을 알 수 있었다. $NaOH/FeCl_3/LiOH$의 중량비를 2/1/7로 조성하여 합성하였을 때 가장 큰 용량을 보였으나 효율은 30회 순환 후 급격히 감소하였다. 층상의 $LiFeO_2$ 양극을 사용한 리튬 전지의 충방전 실험을 수행한 결과 이 셀은 1.5-4.5V의 범위에서 가역적임을 알 수 있었다 CPR방법을 사용하여 1M $LiPF_6/EC/DEC$ 전해질에서 확산계수를 측정하였다. 확산계수는 0.5$10^{-11}cm^2/s$임을 알 수 있었다.

• 한국전기전자재료학회논문지
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• 제21권11호
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• pp.1029-1035
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• 2008

$LiNi_{1/3}Co_{1/3}Mn_{1/3}O_2$ cathode materials prepared from different precursors in lithium rechargeable batteries were characterized by various analytical methods. $LiNi_{1/3}Co_{1/3}Mn_{1/3}O_2$ powders were synthesized by using solid-state reaction method and their physical and chemical properties were analyzed by XRD, SEM, particle size analyzer and TCP-AES. These materials showed different crystallinity, particle size, surface morphology and chemical composition. Also, the charge/discharge cycling of $LiNi_{1/3}Co_{1/3}Mn_{1/3}O_2$ electrodes was carried out under various cut-off voltages and it showed different behaviors. It was found that the electrochemical cyclability of $LiNi_{1/3}Co_{1/3}Mn_{1/3}O_2$ was strongly related to its crystallinity.

• 대한공간정보학회지
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• 제14권2호
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• pp.33-42
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• 2006

최근 LiDAR데이터를 이용한 3차원 위치 정보와 지표면 속성정보를 취득하는 연구가 많이 진행되고 있다. LiDAR 데이터는 높은 위치정확도를 지니며, 데이터의 취득시 바로 지상좌표를 취득함으로써 좌표의 변환이 필요 없기 때문에 좀더 빠르게 데이터를 처리할 수 있는 장점을 가지고 있다. 본 연구에서는 LiDAR 데이터만을 이용하여 수치지도의 가장 많은 부분을 차지하는 도로, 건물, 등고선을 제작하여, 기존 수치지도와 정확도를 비교함으로서 LiDAR 데이터만을 이용한 수치지도제작의 가능성을 평가하였다.

• IMMUNE NETWORK
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• 제14권3호
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• pp.138-148
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• 2014

MicroRNAs (miRNAs) are endogenous small RNA molecules best known for their function in post-transcriptional gene regulation. Immunologically, miRNA regulates the differentiation and function of immune cells and its malfunction contributes to the development of various autoimmune diseases including systemic lupus erythematosus (SLE). Over the last decade, accumulating researches provide evidence for the connection between dysregulated miRNA network and autoimmunity. Interruption of miRNA biogenesis machinery contributes to the abnormal T and B cell development and particularly a reduced suppressive function of regulatory T cells, leading to systemic autoimmune diseases. Additionally, multiple factors under autoimmune conditions interfere with miRNA generation via key miRNA processing enzymes, thus further skewing the miRNA expression profile. Indeed, several independent miRNA profiling studies reported significant differences between SLE patients and healthy controls. Despite the lack of a consistent expression pattern on individual dysregulated miRNAs in SLE among these studies, the aberrant expression of distinct groups of miRNAs causes overlapping functional outcomes including perturbed type I interferon signalling cascade, DNA hypomethylation and hyperactivation of T and B cells. The impact of specific miRNA-mediated regulation on function of major immune cells in lupus is also discussed. Although research on the clinical application of miRNAs is still immature, through an integrated approach with advances in next generation sequencing, novel tools in bioinformatics database analysis and new in vitro and in vivo models for functional evaluation, the diagnostic and therapeutic potentials of miRNAs may bring to fruition in the future.