• 한국식품영양학회지
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• 제25권4호
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• pp.1016-1022
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• 2012

In order to investigate the effects of 70% EtOH extract obtained from Hovenia dulcis Thunberg on enzymes relating reactive oxygen intermediate, cancer-stricken animals induced by DEN (N,N-diethylnitrosamine) were recovered by administering the extract of Hovenia dulcis Thunberg. It showed that there was no effect on the generation of superoxide radical by the extract of Hovenia dulcis Thunberg. However, considering the increase of the activity of Cu, Zn-SOD and Mn-SOD in the tested animal class, the extract of Hovenia dulcis Thunberg could participate directly in removing of superoxides. The experimented-animals treated with the extract of Hovenia dulcis Thunberg showed an increase in the activity of the enzymes, catalase and glutathione peroxidase, which can eliminate hydrogen peroxide pertained in liver tissue. The extract of Hovenia dulcis Thunberg seemed to have some factors that accelerate the oxidation. Also, the extract of Hovenia dulcis Thunberg showed effects on the enzymes relating to the active oxygen toxicity which could be an indicator of aging and body toxicity.

• 대한의생명과학회지
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• 제11권4호
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• pp.533-538
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• 2005

This investigation was performed to study the antioxidant activities of Hovenia dulcis THUNBER var. koreana Nakai fruits extracts and the effect of Hovenia dulcis fruits extracts on glucose, lipid metabolism in diabetic rats. DPPH free radical scavanging activitiy and superoxide anion radical Scavenging of Hovenia dulcis fruits $80\%$ methanol extracts were $0.06\pm0.002mg$ polyphrnol/ml and $0.l2\pm0.00lmg$ polyphmol/ml, respectively. Hovenia dulcis fruits $80\%$ methanol extracts were partitioned into hexan, dichloro methane, ethyl acetate and butanol, successively. Ethyl acetate fraction were good antioxidant activity. Streptozotocin (45 mg/kg body weight, i.p.) induced diabetic rats showed a significant increases of plasma glucose, triglyceride and total cholesterol. Concomitantly significant decrease of plasma high density lipoprotein. Glutathione level were decrease in cytosol of liver. Lipid peroxide were increase in microsome of liver. Group 1 and 2 were treated with Hovenia dulcis fruits ethyl acetate extracts 50 mg/kg body weight and 20mg/kg body weight for 24 days, individually. Group land 2 rats showed decreased plasma glucose, triglyceride, total cholesterol and lipide peroxide in microsome of liver tissue of rats, and increased plasma high density lipoprotein and glutathione in cytosol of liver tissue rats. The result suggest that Hovenia dulcis THUNBER var. koreana Nakai fruits extracts may effectively normalize the impaired antioxiants status in streptozotocin induced diabetic rats. Hovenia dulcis fruits ethyl acetate extracts were used to improve the imbalance between free radicals and antioxidant system due to the diabetes.

• 한국식품영양과학회지
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• 제44권11호
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• pp.1599-1606
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• 2015

본 연구는 헛개나무(Hovenia dulcis Thunb.) 함량을 달리한 모주를 제조한 후 관능검사를 통해 최종 레시피를 선정하였으며, 개발 모주를 실험군, 일반 모주를 대조군으로 하여 일반성분, 이화학적 특성 및 항산화 활성을 측정하였다. 생리활성 검증을 위한 동물실험은 6개의 군[증류수섭취군(NC), 알코올섭취군(EC), 알코올+일반 모주 저농도섭취군(MCL), 알코올+일반 모주 고농도섭취군(MCH), 알코올+헛개나무 모주 저농도섭취군(MDL), 알코올+헛개나무 모주 고농도섭취군(MDH)]으로 나눠 실시하였다. 헛개나무 모주의 일반성분 분석 결과 수분 86.77 g/100 g, 탄수화물 11.86 g/100 g을 함유한 것으로 측정되었다. 이화학적 분석결과 수율 60%, pH 4.91, 산도 0.28%, 당도 $12.63^{\circ}Brix$, 환원당 68.97 mg/mL, 알코올 농도 0.1%, 알코올 밀도 $0.998g/cm^3$로 측정되었으며 대조군과 유의적인 차이는 없었다. SOD 활성은 헛개나무 모주가 대조군에 비해 유의적으로 높게 측정되었다. 헛개나무 모주를 실험동물(ICR mice)에게 4주 동안 투여한 결과 혈중 중성지방은 알코올섭취군(EC)에 비해 헛개나무 모주 저농도섭취군(MDL), 헛개나무 모주 고농도섭취군(MDH)에서 낮은 경향을 보였고, 혈중 총 콜레스테롤은 알코올섭취군(EC)에 비해 헛개나무 모주 저농도섭취군(MDL), 헛개나무 모주 고농도섭취군(MDH)에서 유의적으로 낮았다. HDL-콜레스테롤은 알코올섭취군(EC)에 비해 헛개나무 모주 저농도섭취군(MDL), 헛개나무 모주 고농도섭취군(MDH)에서 유의적으로 높았다. 간 중 중성지방은 에탄올섭취군(EC)과 비교하여 일반 모주 저농도섭취군(MCL)과 헛개나무 모주 저농도섭취군(MDL)에서 유의적으로 낮았다. 이상의 결과로 본 연구는 헛개나무 모주를 개발하고, 개발된 모주의 일반성분, 이화학적 특성, 항산화 활성 및 체내 지질 수준을 확인하였으며, 이를 통해 헛개나무를 이용한 모주가 무알코올 음료 및 건강기능성 식품 소재로써 활용 가능한 것으로 사료된다.

• 동아시아식생활학회지
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• 제21권4호
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• pp.520-525
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• 2011

This experiment was conducted to evaluate the quality characteristics of soybean Dasik containing different amounts of Hovenia dulcis Thunb. extract, and the results were as follows. In general components, the contents of moisture and crude protein increased with an increased amount of Hovenia dulcis Thunb. extract, whereas the crude fat content showed a tendency to decrease. The ash content was, however, not significantly different. In chromacity, the value of L, lightness, constantly decreased with an increase in the amount of added extract, whereas the a and b values increased. The hardness and gumminess decreased with an increase in the amount of extract added, whereas the springiness, cohesiveness, and chewiness increased. In sensory evaluation, the Dasik added with 20% of Hovenia dulcis Thunb. extract showed the highest score, and was evaluated as the best formulation for overall acceptability.

• 약학회지
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• 제48권3호
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• pp.213-217
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• 2004

For the determination of glutathione S-transferase activity, a new method was established by using HPLC system. Moreover, amount of enzyme for a optimum reaction was determined by a comparative study with a variety concentration of enzyme. Using a established method, activity of glutathione S-transferase that is alcohol metabolizing enzyme was investigated on the fruit of Hovenia dulcis Thunb. As the result of experiment, EtOH and $H_2O$ extracts of the fruit of Hovenia dulcis Thunb showed visible a synergistic effect of glutathione S-transferase activity. On a continuous experiment, EtOH and $H_2O$ extracts of the fruit of Hovenia dulcis Thunb showed alcohol decomposition activity on the in vivo test using rat. These results suggest that the fruit of Hovenia dulcis Thunb may be useful in the prevention of hangover.

• The Korean Journal of Ecology
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• 제25권1호
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• pp.33-39
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• 2002

Objectives of this study are to make clear the vegetation structure of Hovenia dulcis community in the Korean Peninsula over ten mountains including 17 plots. The results were summarized as follows. Habitat of the community indicated that elevation ranged from 115 meter to 720 meter at the sea level, slope aspect in nearly all directions, bare rock from 0 to 90 percent, slope degree from 10$^{\circ}$ to 40$^{\circ}$, topography from valley to middle slope, the height of tree layer from 8m to 22m, the diameter at breast height from 12cm to 59cm and coverage from 65% to 95$\%$$\%$

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2003년도 생물공학의 동향(XIII)
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• pp.626-629
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• 2003

헛개나무 열매, 잎 및 줄기를 부위별로 열수 추출한 추출액의 알코올 분해 효과를 관찰한 결과 6hr인 경우, 헛개열매의 알코올 분해 효과가 38% 증가하였고 6hr 이후에는 평형에 도달함을 알 수 있었다. $D-galactosamine(600{\mu}g/kg)/LPS(60{\mu}g/kg)$와 $CCl_4(1.0m{\ell}/kg)$를 처리한 후 헛개열매 열수 추출물을 투여한 결과 간 기능 수치인 AST, ALT 및 LDH 값이 상당히 감소함을 알 수 있었다. 급성독성 시험과 아급성독성 시험에서도 헛개열매 추출물이 안정한 물질로 작용하는 것을 알 수 있었다.

• 한국축산식품학회지
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• 제40권2호
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• pp.221-230
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• 2020

The aim of this study was to evaluate the antioxidant and antibacterial activity of Hovenia (Hovenia dulcis) monofloral honey produced in Korea. To produce Hovenia monofloral honey, Hovenia trees were surrounded by a net house, and honeybees were breed there over a 20-day period. Hovenia monofloral honey contained more than 95% of Hovenia pollen and showed physicochemical properties in agreement with the international honey standard (Codex). The total phenolic and flavonoid contents of Hovenia monofloral honey ranged from a 24.82-27.00 mg gallic acid equivalent/100 g honey and a 0.41-0.46 mg quercetin equivalent/100 g honey, respectively. In addition, to evaluate the functional properties of Hovenia monofloral honey, the antioxidant activity of Hovenia monofloral honey was estimated by using the 1,1-diphenyl-2-picrylhydrazyl radical and the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging assay. Furthermore, Hovenia monofloral honey showed an antibacterial activity against foodborne gram positive (Listeria monocytogenes and Staphylococcus aureus) and gram negative bacteria (Salmonella Typhimurium and Escherichia coli O157:H7).

• 한국임상수의학회지
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• 제27권4호
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• pp.366-373
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• 2010

Diabetes mellitus (DM) is one of the highest morbidity and mortality diseases and is a state of increased oxidative stress. This study was carried out to evaluate anti-oxidant activities of Hovenia dulcis Thunberg in streptozotocin (STZ)-induced diabetic rats. Eighty Sprague-Dawley rats, 6 week-old, were divided into 3 groups at 12hours after STZ induction; Diabetic control group (DW per os DC group), Glibencliamide group (5 mg/kg glibenclimide per os, GLI group) and Hovenia dulcis group (100 mg/kg Hovenia dulcis Thunberg water extract per os HDT group). Normal control group (NC group) was just injected with DW instead of STZ. On day 5, superoxide dismutase (SOD) and catalase activities of HDT group were significantly (P < 0.05) increased compared with DC group and glutathione peroxidase activities of HDT group was more increased than DC group but there was no significant difference.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2009년도 추계학술대회
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• pp.1087-1090
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• 2009

본 연구는 약용식물로부터 항균활성 물질을 찾기 위하여 Glycyrrhiza uralensis, Dryopteris crassirhizoma, Dictamnus albus, Paeonia lactiflora, Angelica dahurica, Spirodela polyrhiza, Cimicifuga heracleifolia, Bupleurum falcatum, Magnolia kobus, Artemisia princeps, Arctium lappa, Aster tataricus, Hovenia dulcis, Citrus unshiu, Asparagus cochinchinensis, Gardenia jasminoides, Smilax china, Hovenia dulcis, Prunus sargentii, Scutellaria baicalensis등의 약용식물을 사용하였다. 총 20종류의 약용식물로부터 에탄올 추출물을 분리하여 Agrobacterium tumefaciens에 대한 항균활성을 조사하였다. Glycyrrhiza uralensis, Dryopteris crassirhizoma, Cimicifuga heracleifolia, Bupleurum falcatum,의 추출물이 Agrobacterium tumefaciens에 대한 항균활성을 나타냈다.