• Title, Summary, Keyword: Hyperlipidemic

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Regulatory Effects of Cheunggansoyo-san on Pathophysiological Changes Induced by Hyperlipidemic Diets in the Mice

  • Park Kyung-Ho;NamGung Uk;Lee Yong-Koo;Kang Tak-Lim;Kim Dong-Hee
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.19 no.6
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    • pp.1629-1635
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    • 2005
  • Hyperlipidemia is caused by high dietary intake of cholesterol and saturated fats, and is known as a major risk factor for atherosclerosis. In the oriental medicine, Cheunggansoyo-san (CGSYS) has been used for supplementing hematopoietic function and for treating cardiovascular disorders. In the present study, CGSYS was administered into hyperlipidemic mice. Increases in body weight and cholesterol levels induced by hyperlipidemic diets for 6 weeks were significantly inhibited by CGSYS administration. Serum levels of glucose, triglyceride, SGOT, and SGPT values were all decreased by CGSYS treatment compared with hyperlipidemic dietary mice. Moreover, CGSYS decreased LDL-cholesterol, but increased HDL-cholesterol levels in hyperlipidemic mice. Thus, the present results suggest that CGSYS appears to De effective for down-regulating risk factors of hyperlipidemia.

Anti-hyperlipidemic Effect of Shiitake Mushroom Extract in Hyperlipidemic Rats Induced by Poloxamer-407 (고지혈증 동물모델에서 표고버섯 추출물의 항고지혈증 효과)

  • Kim, Gye Yeop;Jung, Hun Woo;Kim, Eun Jung
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.27 no.4
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    • pp.409-415
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    • 2013
  • We attempted to determine the action target of Shiitake mushroom extract with a known anti-hyperlipidemic effect in poloxamer(P) 407-induced hyperlipidemia model. We investigated the anti-hyperlipidemic effects of the water extract from Shiitake mushroom on the progress of high fat diet for 4 weeks. Experimental rats were divided into 5 different experimental groups including an normal group (normal diet; n=10), control group (hyperlipidemia; n=10), Experimental group I (hyperlipidemic rats treated with Shiitake mushroom extract (100 mg/kg, PO), n=10), Experimental group II (hyperlipidemic rats treated with Shiitake mushroom extract (300 mg/kg, PO), n=10), and Experimental group III (hyperlipidemic rats treated with Shiitake mushroom extract (500 mg/kg, PO), n=10). It is to analysis changes in body weight, visceral fat weight, blood lipid profiles, HMG-CoA reductase and histological findings. Body weight and epididymal fat weight was not significantly change in experimental groups (p>0.05). The level of total cholesterol, TG, arthrogenic index, and HMG-CoA reductase were significantly lower in experimental groups than control group (p<0.05). These results suggested that the Shiitake mushroom extract administration may act by inhibitory the release of cholesterol related factors and HMG-CoA from the hepatocyte without liver and kidney cell damage in hyperlipidemia rats.

Effects of Dodam-tang on Cerebral Ischemic Damage of Hyperlipidemic Rats (도담탕(導痰湯)이 고지혈증 흰쥐의 뇌허혈 손상에 미치는 영향)

  • Kim, Kyung-Hun;Kim, Do-Hoon;Kim, Youn-Sub
    • The Korea Journal of Herbology
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    • v.29 no.5
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    • pp.23-30
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    • 2014
  • Objectives : Dodam-tang has been reported to have a control effect against the hyperlipidemia and thrombosis. Based upon these previous reports, this study investigates the effects of Dodam-tang on the cerebral ischemic damage of the hyperlipidemic rats. Methods : Hyperlipidemia was induced by the beef tallow 30% diet for 14 days on Sprague-Dawley rats. Ischemic damage was induced by the middle cerebral artery occlusion (MCAO) for 2 hours with the intraluminal thread method. Then water extract of Dodam-tang was administered daily for 5 days. The effect of Dodam-tang was evaluated with the serum lipids, infarct volume and edema percentage, and immunohistochemical expressions of iNOS, MMP-9, and GFAP in the brain tissue. Results : The obtained results were as follows; Dodam-tang reduced significantly the infarct size in a TTC-stained 5th brain section of the hyperlipidemic MCAO rats. Dodam-tang suppressed the infarct volume of the hyperlipidemic MCAO rats, but not significant statistically. Dodam-tang suppressed the edema percentage of the hyperlipidemic MCAO rats significantly in the brain tissue. Dodam-tang suppressed significantly the iNOS expression in the cerebral penumbra and caudate putamen of the hyperlipidemic MCAO rats. Dodam-tang suppressed significantly the MMP-9 expression in the cerebral penumbra of the hyperlipidemic MCAO rats. Dodam-tang suppressed significantly the GFAP-expressed atrocytes in the cerebral penumbra of the hyperlipidemic MCAO rats. Conclusions : These results suggest that Dodam-tang suppresses the brain edema formation through the suppression of the iNOS, MMP-9 and GFAP, but the neuroprotective effect against the cerebral infarct are not distinct.

Anti-hyperlipidemic Effects of Cordyceps militaris Hot-Water Extract (동충하초 열수추출액의 항고지혈증 효과에 관한 연구)

  • Kim, Han-Soo;Kim, Min-A;Jang, Seong-Ho;Lee, Won-Ki;Ryu, Jae-Young;Lee, Chun-Sik
    • Journal of Environmental Science International
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    • v.21 no.7
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    • pp.875-881
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    • 2012
  • This study was performed to observe the effects of the feeding physiological activity substance in Cordyceps militaris hot-water extract intake on the improvement of lipid components and metabolic enzyme activities in the serum of dietary hyperlipidemic rats (SD strain, male) fed the experimental diets for 5 weeks. The concentrations of cholesterol (total cholesterol, ${\beta}$-lipoprotein, LDL-cholesterol, free cholesterol and cholesteryl ester), atherosclerotic index, triglyceride (TG), phospholipid (PL) and blood glucose in sera were remarkably lower in the Cordyceps militaris extract intake group than in the hyperlipidemic rats. In the ratio of HDL-cholesterol concentration was higher percentage in the Cordyceps militaris extract intake group than in the hyperlipidemic rats. The activities aminotransferase (AST, ALT) in sera were rather lower in the Cordyceps militaris extract administration than in the hyperlipidemic rats. From the above research, Cordyceps militaris extract were effective on the improvement of the lipid compositions in sera of dietary hyperlipidemic rats.

Effect of Taurine on Hyperlipidemic Rats Fed Cholesterol and Vitamin $D_2$ containing Diet (콜레스테롤과 비타민 $D_2$ 첨가 사료로 유도된 흰쥐의 고지혈증에 대한 Taurine의 효과)

  • Lee, Eun-Bang;Kim, Ok-Kyung;Jung, Chun-Sik;Kim, Ju-Sun
    • YAKHAK HOEJI
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    • v.41 no.4
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    • pp.512-517
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    • 1997
  • Antihyperlipidemic effect of taurine was investigated in the hyperlipidemic rats induced by feeding a diet supplemented with cholesterol (1.5% in diet), vitamin $D_2$(1.25 million IU/kg of diet) and cholic acid (0.5% in diet). The rats were fed the diet containing 1% and 3% of taurine for 8 weeks. The contents of the cholesterol and triglycerides in the serum and liver of the hyperlipidemic rats were increased as compared with those of the control group. Feeding taurine resulted in decreases in total cholesterol and triglyceride levels. The HDL-cholesterol level in serum was decreased in the hyperlipidemic rats, but by administration of taurine its level was increased. In the aorta of the animals, total cholesterol and triglycerides contents were reduced significantly by treatment with taurine. The contents of calcium in the heart of hyperlipidemic rats were greatly increased as compared with those of the control group. Treatment of taurine produced significant decreases in calcium contents in the heart muscle of the animals. These results showed that the hyperlipidemic states in this model of rats were reversed by treatment of taurine.

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Effects of Cardiotonic Pills (CP) on Serum Lipid Level in Hyperlipidemic Rats (심적환이 고지혈증 흰쥐의 혈중 지질 변화에 미치는 영향)

  • Kim, Hyung-Woo;Kwon, Tae-Woo;Jung, Sun;Cho, Su-In;Kim, Young-Gyun;Bong, Seung-Jeon
    • The Korea Journal of Herbology
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    • v.23 no.2
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    • pp.145-150
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    • 2008
  • Objectives : SimJeok-Hwan (CP, Cardiotonic Pills) is the traditional remedy to treat patients with coronary arteriosclerosis, angina pectoris and hyperlipidemia. This study was designed to investigate the effects of CP on changes in serum cholesterol levels in hyperlipidemic rats. Methods : In this study, we investigated the effects of CP on changes in body weights, food and water uptake, fasting blood glucose, total cholesterols, HDL-cholesterol, and triglyceride in hyperlipidemic rats. Results : In our results, body weights of hyperlipidemic rats induced by high fat diet did not changed, and treatment with CP did not affect body weights in hyperlipidemic rats. For experimental period, food and water uptake in CP administered group were the same as those in hyperlipidemic control group. In this experiment, treatment with CP decreased total cholesterol and triglyceride in serum which elevated by high fat diet respectively. Conclusions : These results suggest that CP is useful to treat patients with disease related to hyperlipidemia because CP can decrease cholesterol in serum

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Effects of Polygoni Multiflori Radix on Cerebral Ischemia of Hyperlipidemic Rats. (하수오가 고지혈증 흰쥐의 허혈성 뇌손상에 미치는 영향)

  • Lee Young-Hyo;Lee Won-Chul
    • The Journal of Korean Medicine
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    • v.26 no.3
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    • pp.146-161
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    • 2005
  • Objectives : This study investigated neuroprotective effects of Polygoni Multiflori Radix on cerebral ischemia of hyperlipidemic rats. Methods : Effects of Polygoni Multiflori Radix were evaluated with changes of infarct size after He focal cerebral ischemia induced by the middle cerebral artery occlusion, changes of pyramidal neurons and expressions of Bax and Bcl-2 apoptosis regulating factors after global cerebral ischemia, and changes of serum lipid revels after cerebral ischemia. Results & Conclusions : Results obtained were as follows; 1. Polygoni Multiflori Radix did net reduce the focal cerebral infarct size induced by the middle cerebral artery occlusion under both hyperlipidemic and normal-lipid conditions. 2. Polygoni Multiflori Radix significantly reduced the increase of neuronal cell death in CAl region of hippocampus induced by the global cerebral ischemia under both hyperlipidemic and normal-lipid conditions. 3. Polygoni Multiflori Radix significantly reduced the increase of Bax expression in the CAl region of the hippocampus induced by global cerebral ischemia under both hyperlipidemic and normal-lipid conditions. 4. Polygoni Multiflori Radix significantly increased Bc1-2 expression in the CA1 region of the hippocampus after global cerebral ischemia under normal-lipid condition, but was not effective on that under hyperlipidemic condition. 5. Polygoni Multiflori Radix was not effective on serum total-cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride levels under normal-lipid conditions, irrespective of focal cerebral infarct or global cerebral ischemia. 6. Polygoni Multiflori Radix significantly reduced the increase of serum total-cholesterol and triglyceride levels, and increased serum LDL-cholesterol level under hyperlipidemic conditions, irrespective of foc31 cerebral infarct or global cerebral ischemia.

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Effects of Green and Black Korean Teas on Lipid Metabolism in Diet-Induced Hyperlipidemic Rats (한국산 녹차와 홍차가 고지혈증 유도 쥐에 있어서 혈청 지질 대사에 미치는 영향)

  • Jung, Young-Hee;Han, Sung-Hee;Shin, Mee-Kyung
    • Journal of the East Asian Society of Dietary Life
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    • v.16 no.5
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    • pp.550-558
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    • 2006
  • The study investigated the serum lipid metabolism and enzyme activities of Korean teas for their preventative activity against chronic disease and obesity. Male Sprague-Dawley rats were raised for 8 weeks on four experimental diets: normal diet, hyperlipidemic diet, and hyperlipidemic diet to which green and black teas (2% each) were added. Various biological actions, including lipid metabolism and enzyme activities of the serum, were investigated. Diet-induced, hyperlipidemic rats fed with green and black teas, showed significant decrease in food efficiency ratio, triglyceride, total lipid, and phospholipid compared to control, i.e. the normal and diet-induced, hyperlipidemic rats. Total cholesterol, LDL-cholesterol, Al(atherogenic index), LHR, VLDL-cholesterol, ester-cholesterol, and free-cholesterol also showed a significant decrease. However, there was no significant difference between the tea-fed, diet-induced, hyperlipidemic dieted groups. HDL-cholesterol concentration was increased significantly in the tea-dieted and normal groups compared to the control. There was a little difference in lipase activity between the normal and control groups, although green and black tea-dieted experimental groups were both increased compared to the control. The contents of total lipid, triglycerides, and total cholesterol were decreased in the normal and experimental groups compared to the control. The GOT, GPT, ALP and LDH serum enzyme activities of the experimental groups were significantly reduced compared to those of the control groups.

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The Effect of Herbal Formula KH-204 on Erectile Dysfunction in Hyperlipidemic Rat (고지혈증 흰쥐에서 생약제제 KH-204의 발기부전 치료연구)

  • Lee, Eun-Jeong;Kim, Hee-Seok;Sohn, Dong-Wan;Kim, Sae-Woong;Cho, Yong-Hyun;Hwang, Sung-Wan;Hwang, Sung-Yeoun
    • Korean Journal of Pharmacognosy
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    • v.38 no.1
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    • pp.50-55
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    • 2007
  • This study was designed to investigate the effects KH-204 on erectile dysfunction in hyperlipidemic rat. KH-204 has been evaluated antihyperlipidemic and antierectile dysfunction effects on experimental hyperlipidemic rats induced by high fat diet. After oral administration of the water extract KH-204 (50, 100, 200, 300 mg/kg) to hyperlipidemic rats for 8 weeks, the variables including body weight, total cholesterol, HDL and LDL levels in serum, the expression of eNOS and nNOS in penis were measured. And erectile function was determined by measurement of intracavernosal pressure (ICP) and maximal arterial pressure (MAP) after electrical stimulation of the cavernosal nerve. Oral administration of KH-204 significantly inhibited the increases of serum total cholesterol and LDL-cholesterol levels and the decreased of serum HDL-cholesterol levels in hyperlipidemic rats induced by high fat diet. The penile expression level of the two enzyme (eNOS, nNOS) were increased significantly after oral administration of the KH-204 50 mg/kg. Erectile function after 10 volts stimulation was significantly decreased in the hyperlipidemic rat compared with the normal rat, but increased in KH-204 group compared with hyperlipidemic group. These results suggest that KH-204 is effective for erectile dysfunction in hyperlipidemia.

Cerebral Blood Flow as Measured by TCD in Hyperlipidemic Group (TCD를 이용한 정상군과 고지혈증군의 혈류측정에 관한 비교연구)

  • Park, Sun-Mi;Kim, Young-Kyun;Kwon, Jung-Nam;Shin, Woo-Jin;Son, Yeon-Hui;Jeong, Hyun-Yun;Han, Hyun-Young;Park, Ga-Young
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.23 no.6
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    • pp.1513-1520
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    • 2009
  • The purpose of this study was to compare cerebral blood flow between hyperlipidemic patient group and normal healthy aldult group using transcranial doppler ultrasonography(TCD). I investigated cerebral blood flow of 63 hyperlipidemic patients and 42 healthy adults. To evaluate the cerebral blood flow, I measured the systolic peak velocity(Vs) and mean flow velocity(Vm) of the milddle cerebral artery(MCA), anterior cerebral artery(ACA), posterior cerebral artery(PCA), basilar artery(BA), internal carotid artery(ICA) in the two groups using TCD. In normal healthy adults, subjects showed a decerease in Vs and Vm with advancing in age. There was a significant difference in the Vm of ICA. There was no significant differences in the Vm of ACA and ICA. In normal healthy adults, females showed high velocities of all examined vessel. There was a significant difference in the Vs of ICA. There was a significant differences in the Vm of MCA and ICA. Normal healthy adults higher than hyperlipidemic patients in the Vs of MCA, ACA, PCA. There was no significant difference in the Vs of all exmined vessels. Hyperlipidemic patientsincrease higher than normal healthy adults in the Vm of ACA. There was a significant difference in the Vs of BA. In the patients aged under 50's, normal healthy adults higher than hyperlipidemic patients in the Vs and Vm except BA. But there was no significant difference in all exmined vessels. In the patients aged over 50's, hyperlipidemic patients higher than normal healthy adults in all examined vessel expect PCA. There was a significant difference in the Vs of BA and ICA. And hyperlipidemic patients higher than that normal healthy adults in all exmined vessels. There was a significant difference in BA and ICA. In this study, visible differences in blood flow between hyperlipidemic patient group and normal healthy aldult group were shown. However, these results do not come up to the previous values that were reported and known worldwide.