• Journal of the Korean Geotechnical Society
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• v.33 no.10
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• pp.33-47
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• 2017

A self-supported temporary excavation method called IER is normally applicable to excavation depth ranging from 6.0 m to 7.0 m though the method depends on ground condition and overburden load. Combining IER with another method is required in deeper excavation depth in order to maintain the structural stability of the IER. In this study, we performed model tests and 3D FE analysis to check the stability of the IER adopting soil nailing method, and to propose its effective installation method. The lateral displacement of the IER using soil nailing decreased by 92% of that of IER without soil nailing. Optimum design is possible for both economic feasibility and stability when interval spacing and length of soil nails is $1.5m(S_h){\times}0.75m(S_v)$ and 86% of excavation depth, respectively. Excavation depth using IER increases 1.71 times by adopting soil nailing in increment of lateral displacement of IER right before the last excavation stage.

• Journal of the Korean Geotechnical Society
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• v.32 no.12
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• pp.45-57
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• 2016

The Inclined Earth Retaining Structure (IER) is the structure using an integrated system of both front supports and inclined back supports to increase the stability for excavation. The IER is a structurally stable temporary excavation method using the back supports restraining the lateral displacement of the front supports as stabilizing piles. The back supports connected to the front supports significantly reduce the earth pressure acting on both the front wall and the front supports by distributing it to the back supports in order to increase the structural stability. In this study, mechanical behaviors of IER according to the head connection type using fixed- or hinge-connection were found by performing numerical analysis and laboratory model tests in the sandy ground. The maximum lateral displacement of fixed-connection was 88% of that of hinge-connection in the numerical analysis. The lateral displacement of fixed-connection was 7% of that of hinge-connection in the laboratory model test results. Furthermore, the earth pressure of the fixed-connection was 67% of that of the hinge-connection in the shear-strain analysis results of the model ground.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.679-682
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• 2015

Background: Studies indicate the immediate early response gene 3 (IER3) is involved in many biological processes. Recently, it was discovered that IER3 plays an important role in tumorigenesis and tumor progression. Thus it may be a valuable biomarker in tumor. This study was designed to investigate the expression status of IER3 in primary hepatocarcinoma (PHC) and correlation with clinicopathological parameters. Materials and Methods: Real-time PCR was performed to evaluate the expression levels of IER3 in 62 pathologically diagnosed human PHC specimens. Results: A statistically significant association was disclosed between the expression of IER3 and P53 mutant protein (short for P53), Ki-67, EGFR and the biggest diameter, differentiation grade of tumor. Conclusions: This work is the first to shed light on the potential clinical usefulness of IER3, as an efficient tumor biomarker in PHC.

• Journal of the Korean Geotechnical Society
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• v.33 no.10
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• pp.15-24
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• 2017

A self-supported temporary excavation method called Inclined Earth Retaining structure (IER) has been developed by improving an existing excavation method. The stability of the IER was proved with both model tests and field tests. Especially, the results of the model tests proved that the lateral displacement of a model retaining wall was significantly reduced in clay. In this study, the applicability of the IER installed in the soft clay ground is estimated by analyzing survey data collected in the construction field. The results of FE analysis show that the lateral displacement of the IER decreased by 70.9% of that of a single row, self-supported retaining wall using the same number of H-piles. Thus, using the IER method in the soft clay ground will increase the stability of the excavated ground with the effect restraining its lateral displacement. Furthermore, using Deep Cement Mixing (DCM) to the upper half embedded depth of front support is recommended as a subsidiary method of reducing the lateral displacement of IER in the soft clay ground based on FE analysis results.

• Journal of Korean Society for Quality Management
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• v.26 no.1
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• pp.1-10
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• 1998

Su, pp.ier quality plays a major role in the evaluation of su, pp.iers, making it very necessary to develop a proper quality measure useful in selecting su, pp.iers that is able to meet quality specification of the customer. In this paper, we present a measure of the overall quality performance which is a weighted geometric mean of the process capability indices of the quality characteristics of a su, pp.ier. This measure can be used both as a measure of su, pp.ier selection for the customer and as a measure for the self-analysis of the quality performance for the su, pp.ier.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.507-510
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• 2013

Background: More and more research indicate that the immediately early response gene 3 (IER3) is involved inmany biological provesses, such as apoptosis and immunoreaction, as well as viral infection, tumorigenesis and tumour progression. Methods: Here we describe the construction of an eukaryotic expression vector containing IER3 gene and its expression in A549 cells as assessed through fluorescence microscopyand Western-blotting. Results: Fluorescence detection displayed that GFP in cytoplasm was high during 48 and 72 hours post-transfection. In addition, Western blotting showed significant increase in IER3 gene expression in the transfected cells compared with controls. Conclusion: The recombinate plasmid expression vector was constructed successfully, which may provide a basis for further exploration of function of IER3 in lung cancer.

• Journal of dental hygiene science
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• v.19 no.4
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• pp.254-260
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• 2019

Background: The primary aims of periodontal disease treatment is to remove dental plaque and calculus, the main causes of tooth loss, and restore periodontal tissue destroyed by inflammation. Periodontal disease treatment should also help maintain the alveolar bone, alleviate inflammation, and promote periodontal ligament cell proliferation, which is essential for tissue regeneration. Conventional antibiotics and anti-inflammatories have adverse side effects, especially during long-term use, so there is a need for adjunct treatment agents derived from natural products. The purpose of this study was to investigate whether the herbal flavone baicalein has the osteogenic activity under inflammatory conditions, and assess the involvement of osteoblast immediate early response 3 (IER3) expression. Methods: Human osteoblastic MG-63 cells were cultured with the pro-inflammatory cytokines tumor necrosis factor α and interleukin 1β in the presence and absence of baicalein. Proliferation was assessed using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay, and expression of IER3 mRNA was assessed using real-time polymerase chain reaction. The expression of IER3 protein levels and activation of associated signal transduction pathways were assessed using western blotting. Results: Baicalein increased IER3 mRNA and protein expression synergistically. In addition, baicalein reversed the suppression of cell proliferation, and the downregulation of osteogenic transcription factor runt-related transcription factor 2 and osterix induced by pro-inflammatory cytokines. Baicalein also upregulated the phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK 1/2). The upregulation of IER3 by pro-inflammatory cytokines was blocked by pretreatment with inhibitors of AKT, p38, JNK, and ERK 1/2. Conclusion: Baicalein mitigates the deleterious responses of osteoblasts to pro-inflammatory cytokines. Further, IER3 enhanced the effect of baicalein via activation of AKT, p38, JNK, and ERK pathways.

• Journal of the Korean Geotechnical Society
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• v.29 no.6
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• pp.63-75
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• 2013

Inclined Earth Retaining Structure Method (IER Method), was developed in order to improve the mechanical properties of the existing earth retaining method. IER consists of two supports, which are front and back supports. In the IER method, back support is very effective for the reduction of the earth pressure acting on the front support. In this study, the effects of back support and fixing conditions of lower ends of supports are analysed by laboratory model tests in clay. The test results show that back support reduces the Leteral displacement of IER effectively, and according to the results the effect of interval and fixing condition of back support was analysed.

• Convergence Security Journal
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• v.22 no.5
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• pp.95-105
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• 2022

The Army, Navy, and Air Force are making various efforts to develop a weapon system that incorporates the 4th industrial revolution technology so that it can be used in multi-domain operations. In order to effectively demonstrate the integrated combat power through the weapon system to which the new technology is applied, it is necessary to establish a network environment in which each weapon system can transmit and receive information smoothly. For this, it is essential to analyze the Information Exchange Requirement(IER) of each weapon system, but many IER analysis studies did not sufficiently reflect the various considerations of the actual tactical network. Therefore, this study closely analyzes the research methods and results of the existing information exchange requirements analysis studies. In IER analysis, the size of the message itself, the size of the network protocol header, the transmission/reception structure of the tactical network, the information distribution process, and the message occurrence frequency. In order to be able to use it for future IER prediction, we present a technique for calculating the information exchange requirement as a probability distribution using the Poisson distribution and the probability generating function. In order to prove the validity of this technique, the results of the probability distribution calculation using the message list and network topology samples are compared with the simulation results using Network Simulator 2.

• Journal of dental hygiene science
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• v.19 no.3
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• pp.198-204
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• 2019

Background: Oxidative stress is a known to be associated with in the pathogenesis of many inflammatory diseases, including periodontitis. Ursolic acid is a pentacyclic triterpenoid with has antimicrobial, antioxidative, and anticancer properties. However, the role of ursolic acid in the regulating of osteogenesis remains undetermined. This study was aimed to elucidate the crucial osteogenic effects of ursolic acid and its ability to inhibit oxidative stress by targeting the immediate early response 3 (IER3)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Methods: Cell proliferation was determined using water-soluble tetrazolium salt assay, cell differentiation was evaluated by alkaline phosphatase (ALP) activity, and formation of calcium nodules was detected using alizarin red S stain. Generation of reactive oxygen species (ROS) was determined using by DCFH-DA fluorescence dye in hydrogen peroxide ($H_2O_2$)-treated MG-63 cells. Expression levels of IER3, Nrf2, and heme oxygenase-1 (HO-1) were analyzed using western blot analysis. Results: Our results showed that ursolic acid up-regulated the proliferation of osteoblasts without any cytotoxic effects, and promoted ALP activity and mineralization. $H_2O_2$-induced ROS generation was found to be significantly inhibited on treatment with ursolic acid. Furthermore, in $H_2O_2$-treated cells, the expression of the early response genes: IER3, Nrf2, and Nrf2-related phase II enzyme (HO-1) was enhanced in the presence of ursolic acid. Conclusion: The key findings of the present study elucidate the protective effects of ursolic acid against oxidative stress conditions in osteoblasts via the IER3/Nrf2 pathway. Thus, ursolic acid may be developed as a preventative and therapeutic agent for mineral homeostasis and inflammatory diseases caused due to oxidative injury.