• Journal of Preventive Medicine and Public Health
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• v.43 no.2
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• pp.125-130
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• 2010

Objectives: The current study was performed to assess the distribution of intraocular pressure (IOP) and its association with metabolic syndrome (MS) in a community. Methods: We measured IOP and MS components from 446 adults, age 20 or more years old, who reside in a community in Kyunggi Province, South Korea. We compared the level of IOP according to the number of metabolic abnormalities and between normal and abnormal metabolic components. Linear regression analyses were used to determine the relationship between IOP and metabolic components. Results: No significant difference in IOP (mean${\pm}$SE) was found between men ($12.24{\pm}2.42$) and women ($12.55{\pm}2.41$ mmHg, p > 0.1), while IOP of men tended to decrease as age increased (p for trend < 0.01). After adjusting for age, IOP of subjects with abdominal obesity in men and high blood pressure in women were significantly higher than those without abdominal obesity or high blood pressure (p < 0.05). Female subjects with MS showed significantly higher IOP than those without MS. Participants with more metabolic disturbances tended to have a greater IOP elevation with a linear trend after adjusting for age and sex. In the univariate regression analysis, age and waist circumference were significantly associated with IOP in men, but systolic and diastolic blood pressure were associated with IOP in women. In final multiple regression model, age, systolic blood pressure, and triglyceride were associated with IOP in women, and age in men. Conclusions: These findings suggest that MS and its components may be important determinants of elevated IOP.

• Journal of Veterinary Clinics
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• v.19 no.4
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• pp.415-417
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• 2002

To investigate the diurnal change of intraocular pressures(IOP) and compare of $Tono-pen^{XL}$ and Schi$\emptyset$tz tonometer, we measured the IOP in clinically normal eyes of dogs. To estimate the diurnal change of IOP, the measurements of IOP were taken with $Tono-pen^{XL}$ in 44 normal canine eyes. Two physicians measured the IOP through the central cornea and limbal cornea. To compare of two tonometers, a physician measured the IOP with both $Tono-pen^{XL}$ and Schi$\emptyset$tz (7.5 g) tonometer in 23 clinically normal eyes of dogs. Mean of lOP was 26.51 $\pm$ 6.91 mmHg and IOP was highest as 30.65 mmHg at a.m. 10, but not significantly different within physicians and corneal regions (p > 0.05). Correlation coefficient within two tonometers was too low.

• Journal of Preventive Medicine and Public Health
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• v.44 no.4
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• pp.157-166
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• 2011

Objectives: This study was conducted to show the intraocular pressure (IOP) distribution and the factors affecting IOP in subjects with type 2 diabetes mellitus (DM) in India. Methods: We measured the anthropometric and biochemical parameters for confirmed type 2 DM patients. A comprehensive ocular examination was performed for 1377 subjects aged > 40 years and residing in Chennai. Results: A significant difference in IOP (mean ${\pm}$ standard deviation) was found between men and women ($14.6{\pm}2.9$ and $15.0{\pm}2.8$ mmHg, p = 0.005). A significantly elevated IOP was observed among smokers, subjects with systemic hypertension and women with clinically significant macular edema (CSME). After a univariate analysis, factors associated significantly with higher IOP were elevated systolic blood pressure, elevated resting pulse rate and thicker central corneal thickness (CCT). In women, elevated glycosylated hemoglobin was associated with a higher IOP. After adjusting for all variables, the elevated resting pulse rate and CCT were found to be associated with a higher IOP. Conclusions: Systemic hypertension, smoking, pulse rate and CCT were associated with elevated intraocular pressure in type 2 DM. Women with type 2 DM, especially those with CSME, were more prone to have an elevated IOP.

• Herbal Formula Science
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• v.29 no.2
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• pp.93-103
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• 2021

Objectives : This study was conducted to evaluate the Intraocular pressure (IOP) and retina neuroprotective effect of Acer palmatum thumb. extract in glaucoma of DBA2/J mice vivo model. Methods : The amount of change in intraocular pressure(IOP) was measured every two weeks for 30 weeks in the DBA2/J glaucoma animal model. The increased IOP were regrouping into drug treatment groups. EW and EE (1, 2 mg/㎖)extract was eye drop administered twice per day for 8 weeks. After administration of the extract, IOP was measured every 1 week at a fixed time for 8 weeks, and protein expression levels and serological changes related to retinal function were investigated. Results : The DBA2/J mice were IOP increased as time dependent, resulting in damage to the retinal function protein related in glaucoma animal model. However, administration of extracts from Leaves of Acer palmatum thumb. prevented an increase IOP, increased for Brn3α, PKCα, and OPN1SW. Additionally, the experssion of Aterocyte maker, GFAP was decreased in DBA2/J mice. Conclusions : These results demonstrate that both IOP and age can be considered in studies using DBA2/J mice and suggest that the extracts from Leaves of Acer palmatum thumb. regulating of IOP and expression of proteins related to retinal function.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.4
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• pp.905-912
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• 2011

Interaocular pressure (IOP) sensor and external coil to detect the resonance frequency of the IOP sensor are designed and implemented using MEMS technology. The IOP sensor is designed using 3-D electromagnetic (EM) simulation. The resonance frequency of IOP sensor needs to be lower than that of the external coil. Additionally, the resonance frequency of the IOP sensor needs to be located near the resonance frequency of the coil to get the sufficient amplitude of phase variation. The frequency where the phase peak appears must be constant according to the distance between the IOP sensor and the external coil. From the measurement results, we demonstrated that the designed IOP sensor has the same resonance frequency with various distances between the IOP sensor and the coil.

• Yonsei Medical Journal
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• v.59 no.9
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• pp.1115-1122
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• 2018

Purpose: To investigate biomechanical properties of the cornea using a dynamic Scheimpflug analyzer according to age. Materials and Methods: In this prospective, cross-sectional, observational study, participants underwent ophthalmic investigations including corneal biomechanical properties, keratometric values, intraocular pressure (IOP), and manifest refraction spherical equivalent (MRSE). We determined the relationship of biomechanical parameters and ocular/systemic variables (participant's age, MRSE, IOP, and mean keratometric values) by piecewise regression analysis, association of biomechanical parameters with variables by Spearman's correlation and stepwise multiple regression analyses, and reference intervals (RI) by the bootstrap method. Results: This study included 217 eyes of 118 participants (20-81 years of age). Piecewise regression analysis between Corvis-central corneal thickness (CCT) and participant's age revealed that the optimal cut-off value of age was 45 years. No clear breakpoints were detected between the corneal biomechanical parameters and MRSE, IOP, and mean keratometric values. Corneal velocity, deformation amplitude, radius, maximal concave power, Corvis-CCT, and Corvis-IOP exhibited correlations with IOP, regardless of age (all ages, 20-44 years, and over 44 years). With smaller deformation amplitude and corneal velocity as well as increased CorvisIOP and Corvis-CCT, IOP became significantly increased. We provided the results of determination of confidence interval from RI data using bootstrap method in three separate age groups (all ages, 20-44 years, and over 44 years). Conclusion: We demonstrated multiple corneal biomechanical parameters according to age, and reported that the corneal biomechanical parameters are influenced by IOP.

• Journal of The Korean Ophthalmological Society
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• v.59 no.12
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• pp.1166-1172
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• 2018

Purpose: To investigate the efficacy, and identify predictors of success of selective laser trabeculoplasty (SLT) in open-angle glaucoma (OAG) patients after adjusting for intraocular pressure (IOP) changes in the untreated fellow eye. Methods: This retrospective chart review included 52 eyes of 52 OAG patients who underwent SLT in one eye and were followed-up for at least 1 year after the procedure. The IOP was measured before the treatment, at 1, 2, and 3 months posttreatment, and every 3 months thereafter. To account for the possible influence of IOP fluctuations on laser outcomes, post-laser IOP values of the treated eye of each patient were also analyzed, after adjusting for IOP changes in the untreated fellow eye. Success was defined as an IOP decrease ${\geq}20%$ of the pretreatment IOP. The success rate was determined based on Kaplan-Meier survival analysis and factors predictive of success were analyzed using the Cox proportional hazard model. Results: The mean pretreatment IOP was $23.17{\pm}6.96mmHg$. The mean IOP reduction was $5.59{\pm}4.78mmHg$ (29.7%) and the success rate was 65.4% at 1 year. The adjusted mean IOP reduction was $4.70{\pm}4.67mmHg$ (23.9%) and the adjusted success rate was 53.9%. Pretreatment IOP was associated with SLT success; the higher the pretreatment IOP, the greater the post-laser IOP reduction (p = 0.025). Age and mean deviation index did not show a significant association with SLT success (p = 0.066 and p = 0.464, respectively). Conclusions: SLT is a safe and effective alternative method of IOP reduction in OAG patients. Herein, pretreatment IOP was the only factor significantly associated with SLT success. IOP fluctuations of the untreated eye should be considered for a better understanding of the impact of treatment.

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.1
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• pp.131-135
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• 2008

Purpose: To measure and quantify the factors of intraocular pressure (IOP) variation for normal Korean youth. Methods: The IOP of normal youth 805 persons (male: 367, female: 438) were measured as a function of time and quantity for fixation, reclining posture, hard blinking, drinking water, drinking hard liquor, tobacco and coffee by using non-contact tonometer (AT555, Reichert Co.). In the case of fixation, reclining posture and hard blinking, the intraocular pressure of right and left eye were measured for 6 males and 6 females every 10 minutes during 30 minute. In the case of water, liquor, tobacco and coffee, the measurement for 4 or 5 groups (6 persons/ group) having similar IOP were done for the IOP variation of right eye. Results: The mean IOP was 15.2 mmHg for males and 15.8 mmHg for females (slightly higher than male's), respectively and the 99% of those were in the range of the normal IOP. The measured IOP was increased by fixation, reclining posture and hard blinking with males and females. The gradient of increasing slope was 0.15/0.13/0.07/0.08, 0.09/0.08/0.08/0.08 and 0.19/0.08/0.26/0.31, respectively. The IOP variation was elevated by drinking water (especially in the case of 1000 ml) and lowered in proportion to the amount of drinking by hard liquor. Cigarette smoking was associated with rise in intra ocular pressure, but was not shown a definite relation. And coffee had virtually no effect. Conclusions: Fixation, reclining posture, hard blinking and Tobacco caused a transient increase in IOP, but alcohol elicited a slight reduction in IOP overall.

• Journal of Korean Ophthalmic Optics Society
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• v.11 no.2
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• pp.91-97
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• 2006

The intraocular pressure for Korean youth were measured by using tonometer (AT555-Reichert). The relative frequency distributions of intraocular pressures have been studied for samples of 1,027 persons(475 males, 552 females). The most commonly recorded IOP for both men and women was around 14.5mmHg and 17.5mmHg, respectively. They were in the range of 7 to 23mmHg(males) and 7 to 22mmHg(females). The median pressure(cumulative frequency=0.5%) is 13.0~16.5mmHg for males and 16.5~18.5mmHg for females, so the values for females are slightly higher than males. The mean pressure is 15.2mmHg for males and 15.8mmHg for females, respectively. The 98% of population was in the range of the normal IOP. There are long-term diurnal variation in mean intraocular pressure and the IOP was decreased as a function of time from morning to night. The measured IOP was affected by several factors: exercise made to decrease the IOP and tight collars, dark places and posture of decubitus position got to elevate the IOP.

• Journal of Veterinary Clinics
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• v.30 no.2
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• pp.95-99
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• 2013

This study was performed to evaluate the seasonal variation of intraocular pressure (IOP) values in normal Sapsaree dogs. Sapsaree dogs (n = 474) clinically free from ophthalmic disease were included in this study, and both eyes were examined in each dog. An applanation tonometer (Tonopen$^{(R)}$ XL) was used to measure IOP values in both eyes. Data obtained from both eyes were stratified by factors thought to affect IOP values including age, gender, hair coat type as well as season of measurement. The IOP results were compared by ANCOVA to verify the effect each factor had on IOP, and an ANOVA test followed by a Bonferroni post hoc test was used for further analysis. The overall mean ${\pm}$ SD IOP value was $19.1{\pm}3.7$ mmHg (range: 8 to 28 mmHg) in the present study. Only seasonal variation showed a significant effect (P < 0.001), on IOP values. IOP values measured in winter ($20.4{\pm}3.4$ mmHg) and summer ($17.1{\pm}3.6$ mmHg) were significantly higher and lower, respectively, than those measured in other seasons. These results suggest a seasonal variation has a significant effect on the IOP of normal dogs. This may prompt further research and possible modification of current veterinary ophthalmic references.