• Nutrition Research and Practice
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• v.1 no.3
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• pp.195-199
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• 2007

Inositol hexaphosphate ($IP_6$) is a major constituent of most cereals, legumes, nuts, oil seeds and soybean. Previous studies reported the anticancer effect of $IP_6$ and suggested that co-treatment of $IP_6$ with inositol may enhance anticancer effect of $IP_6$. Although the anticancer effect of $IP_6$ has been intensively studied, the combinational effect of $IP_6$ and inositol and involved mechanisms are not well understood so far. In the present study, we investigated the effect of $IP_6$ and myo-inositol (MI) on cell cycle regulation and apoptosis using PC3 prostate cancer cell lines. When cell, were co-treated with $IP_6$ and MI, the extent of cell growth inhibition was significantly increased than that by $IP_6$ alone. To identify the effect of $IP_6$ and MI on apoptosis, the activity of caspase-3 was measured. The caspase-3 activity was significantly increased when cells were treated with either $IP_6$ alone or both $IP_6$ and MI, with no significant enhancement by co-treatment. To investigate the effect of $IP_6$ and MI of cell cycle arrest, we measured p21 mRNA expression in PC3 cells and observed significant increase in p21 mRNA by $IP_6$. But synergistic regulation by co-treatment with $IP_6$ and MI was not observed. In addition, there was no significant effect by co-treatment compared to $IP_6$ treatment on the regulation of cell cycle progression although $IP_6$ significantly changed cell cycle distribution in the presence of MI or not. Therefore, these findings support that $IP_6$ has anticancer function by induction of apoptosis and regulation of cell cycle. However, synergistic effect by MI on cell cycle regulation and apoptosis was not observed in PC3 prostate cancer cells.

• Proceedings of the Korea Information Processing Society Conference
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• 2002.04b
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• pp.1459-1462
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• 2002

3GPP(Third Generation Partnership Project)와 3GPP2 등의 국제 표준화 기구에서는 초기 IMT-2000 망 구조로부터 All IP 망으로 진화할 것으로 예상하고 있다. 이에 본 논문에서는3GPP와 3GPP2를 중심으로 All IP 망의 기존에 제시된 All IP 망의 진화 시나리오를 분석하고, 이를 바탕으로 기존 PSTN/ISDN 연동, VoIP, Mobile IP 등과 같은 새로운 기술, 기존회선 모드 단말기 수용 등을 고려한 All IP 진화 시나리오에 따른 단계별 망 구조를 제시한다.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.6A
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• pp.558-564
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• 2007

3G Long Term Evolution, which aims for various mobile multimedia service provision by enhanced wireless interface, proposes VoIP-based voice service through a Packet Switching (PS) domain. As delay and loss-sensitive VoIP traffic flows through the PS domain, more challenging technical difficulties are expected than in Circuit Switching (CS) domain based VoIP services. Moreover, since 3G LTE, which adopts the OFDM as its physical layer, introduces Physical Resource Block (PRB) as a unit for transmission resources, new types of resource management schemes are needed. This paper proposes a PRB scheduling algorithm of MAC layer for VoIP service in 3G LTE and shows the simulation results. The proposed algorithm has two key parts; dynamic activation of VoIP priority mode to satisfy VoIP QoS requirements and adaptive adjustment of the priority mode duration in order to minimize the degradation of resource utilization.

• Development and Reproduction
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• v.23 no.1
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• pp.1-9
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• 2019

The ability of oocytes to undergo normal fertilization and embryo development is acquired during oocyte maturation which is transition from the germinal vesicle stage (GV), germinal vesicle breakdown (GVBD) to metaphase of meiosis II (MII). Part of this process includes redistribution of inositol 1, 4, 5-triphosphate receptor (IP3R), a predominant $Ca^{2+}$ channel on the endoplasmic reticulum membrane. Type 1 IP3R (IP3R1) is expressed in mouse oocytes dominantly. At GV stage, IP3R1 are arranged as a network throughout the cytoplasm with minute accumulation around the nucleus. At MII stage, IP3R1 diffuses to the entire cytoplasm in a more reticular manner, and obvious clusters of IP3R1 are observed at the cortex of the egg. This structural reorganization provides acquisition of $[Ca^{2+}]_i$ oscillatory activity during fertilization. In this review, general properties of IP3R1 in somatic cells and mammalian oocyte are introduced.

• Journal of Yeungnam Medical Science
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• v.7 no.1
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• pp.39-50
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• 1990

The one event on signalling mechanism is the cleavage by adenyl cyclase of ATP into second messenger, cyclic AMP. The other transfer system of inositol metabolism. it is widely recognized that hydrolysis of the minor membrane lipid phosphoinositide bisphosphate($PIP_2$) initiated by occupation of certain receptors and catalyzed by phospholipase C, lead to toe generation of the two intracellular messengers, inositol triphosphate($IP_3$) and diacylglycerol(DG). $IP_3$ is converted to inositol tetrakisphosphate($IP_4$) by $IP_3$ kinase. In the present study, it is that purification of calmodulin is used by phenyl-Sepharose CL-4B chromatography. it's molecular weigh, 17.000 in SDS-polyacrylamide gel electrophoresis. In order to observe the affinity between calmodulin (CaM)-Affigel 15 and $IP_3$ kinase, and isolated $IP_3$ kinase, was applied in CaM-Affigel with $Ca^{2+}$ equilibirum buffer and EGTA equilibirum buffer. We compared with binding and elution effect of $IP_3$ kinase in several condition of buffer. In affinity of binding. $Ca^{2+}$ equilibrium buffer was in the most proper condition. and elution, CaM/$Ca^{2+}$ buffer(CE1 10.36, CE2 12. 76pM/min/mg of protein) was effected much more than EGTA buffer(E2 1.48, E3 2.43pM/min/mg of protein), but CaM/$Ca^{2+}$ stimulate the activity of $IP_3$ kinase. And then, several detergents such as sodium deoxycholate, tween 20. cholic acid, polyethylene glycol, chaps were applied. The 0.2% chaps buffer(E2 23.19, E3 8.05pM/min/mg of protein) was the most effective in elution of $IP_3$ kinase.

• Journal of the Korea Society of Computer and Information
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• v.27 no.9
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• pp.113-120
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• 2022

In this paper, we analyze the feasibility of the IP spoofing attack exploiting null security algorithms in 5G networks based on 3GPP standard specifications. According to 3GPP standard specifications, the initial Registration Request message is not protected by encryption and integrity. The IP spoofing attack exploits the vulnerability that allows a malicious gNB (next generation Node B) to modify the contents of the initial Registration Request message of a victim UE (User Equipment) before forwarding it to AMF (Access and Mobility Management Function). If the attack succeeds, the victim UE is disconnected from the 5G network and a malicious UE gets Internet services, while the 5G operator will charge the victim UE. In this paper, we analyze the feasibility of the IP spoofing attack by analyzing whether each signaling message composing the attack conforms to the 3GPP Rel-17 standard specifications. As a result of the analysis, it is determined that the IP spoofing attack is not feasible in the 5G system implemented according to the 3GPP Rel-17 standard specifications.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.1
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• pp.31-36
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• 2012

The receptor activator of NF-${\kappa}B$ ligand (RANKL) signal is an activator of tumor necrosis factor receptor-associated factor 6 (TRAF6), which leads to the activation of NF-${\kappa}B$ and other signal transduction pathways essential for osteoclastogenesis, such as $Ca^{2+}$ signaling. However, the intracellular levels of inositol 1,4,5-trisphosphate ($IP_3$) and $IP_3$-mediated cellular function of RANKL during osteoclastogenesis are not known. In the present study, we determined the levels of $IP_3$ and evaluated $IP_3$-mediated osteoclast differentiation and osteoclast activity by RANKL treatment of mouse leukemic macrophage cells (RAW 264.7) and mouse bone marrow-derived monocyte/macrophage precursor cells (BMMs). During osteoclastogenesis, the expression levels of $Ca^{2+}$ signaling proteins such as $IP_3$ receptors ($IP_3Rs$), plasma membrane $Ca^{2+}$ ATPase, and sarco/endoplasmic reticulum $Ca^{2+}$ ATPase type2 did not change by RANKL treatment for up to 6 days in both cell types. At 24 h after RANKL treatment, a higher steady-state level of $IP_3$ was observed in RAW264.7 cells transfected with green fluorescent protein (GFP)-tagged pleckstrin homology (PH) domains of phospholipase C (PLC) ${\delta}$, a probe specifically detecting intracellular $IP_3$ levels. In BMMs, the inhibition of PLC with U73122 [a specific inhibitor of phospholipase C (PLC)[ and of $IP_3Rs$ with 2-aminoethoxydiphenyl borate (2APB; a non-specific inhibitor of $IP_3Rs$) inhibited the generation of RANKL-induced multinucleated cells and decreased the bone-resorption rate in dentin slice, respectively. These results suggest that intracellular $IP_3$ levels and the $IP_3$-mediated signaling pathway play an important role in RANKL-induced osteoclastogenesis.

• Journal of the Korea Convergence Society
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• v.3 no.3
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• pp.7-12
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• 2012

mVoIP (mobile Voice over Internet Protocol) service is a technology to transmit voice data through an IP network using mobile device. mVoIP provides various supplementary services with low communication cost. It can maximize the availability and efficiency by using IP-based network resources. In addition, the users can use voice call service at any time and in any place, as long as they can access the Internet on mobile device easily. However, SIP on mobile device is exposed to IP-based attacks and threats. Observed cyber threats to SIP services include wiretapping, denial of service, and service misuse, VoIP spam which are also applicable to existing IP-based networks. These attacks are also applicable to SIP and continuously cause problems. In this study, we analysis the threat and vulnerability on mVoIP service and propose several possible attack scenarios on existing mobile VoIP devices. Based on a proposed analysis and vulnerability test mechanism, we can construct more enhanced SIP security mechanism and stable mobile VoIP service framework after eliminating its vulnerability on mobile telephony system.

• Electronics and Telecommunications Trends
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• v.19 no.6 s.90
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• pp.66-73
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• 2004

2004년도 정보통신부의 IT839 전략에 따르면 8대 신규 서비스로 인터넷 전화(VoIP)와 3대 첨단 인프라로 광대역 통합망(BcN)을 선정한 바 있다. 이에 본 고에서는 9대 신성장동력에서 공동으로 활용하기 위한 VoIP와 BcN을 연계한 기술 동향을 설명한다. SIP 와 H. 323에 의한 VoIP 서비스가 제공되면서 네트워크 구조 변화가 시작되었다. 유선 네트워크, 무선 이동통신 네트워크, 인터넷 등을 통합하는 유무선 통합네트워크(BcN)는 VoIP 기술로 구축될 것이다. 본 고의 구성으로는 VoIP 기술 특성을 설명하고, VoIP 표준 동향을 분석한 후에 앞으로 구축될 BcN VoIP 의 발전 방향에 대하여 설명한다. VoIP 기술은 회선 정합및 인터넷 정합 기술과 H. 323, SIP, MEGACO 등의 프로토콜 기술과 VoIP 품질을 결정하는 코덱 기술이있다. VoIP 표준은 IETF에서 제정한 SIP를 중심으로 네트워크 특성을 고려하여 3GPP, 3GPP2, ITU에서개발하고 있다. BcN VoIP 는 기존의 VoIP 기술을 발전시켜 음성 품질이 오디오 수준으로 향상되고, 유선과 무선, 방송이 통합되는 제어 기술과 연계하여 실시간 멀티미디어 서비스를 제공할 것이다.

• Journal of IKEEE
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• v.5 no.1 s.8
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• pp.8-15
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• 2001

This paper remarks IETF based requirements for IP/UDP/RTP header compression issued in 3GPP2 All IP Ad Hoc Meeting and protocol stacks of the next generation mobile station. All IP Network, for real time application such as Voice over IP (VoIP) multimedia services based on 3GPP2 3G cdma2000. Frames for various protocols expected in the All IP network Mobile Station (MS) are explained with several figures including the bit-for-bit notation of header format based on IETF draft of Robust Header Compression Working Group (ROHC). Especially, this paper includes problems of IS-707 Radio Link Protocol (RLP) for header compression which will be expected to modify in All IP network MS's medium access layer to accommodate real time packet data service[1]. And also, since PPP has also many problems in header compression and mobility aspects in MS protocol stacks for 3G cdma2000 packet data network based on Mobile IP (PN-4286)[2], we introduce the problem of solution for header compression of PPP. Finally. we suggest the guidelines for All IP network MS header compression about expected protocol stacks, radio resource efficiency and performance.