• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.1147-1150
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• 2013

Background: Cancer diagnostic biomarkers have a wide range of applications that include early detection of oral precancerous lesions and oral squamous cell carcinomas, and assessing the metastatic status of lesions. The interferon stimulated ISG15 gene encodes an ubiquitin-like protein, which conjugates to stabilize activation status of associated proteins. Hence a deregulated expression of ISG15 may promote carcinogenesis. Indeed overexpression of ISG15 has been observed in several cancers and hence it has been proposed as a strong candidate cancer diagnostic biomarker. Given the emerging relationship between malignant transformation and ISG15, we sought to examine the expression pattern of this gene in tumor biopsies of oral squamous cell carcinoma (OSCC) tissues collected from Indian patients. Materials and Methods: Total RNA isolated from thirty oral squamous cell carcinoma tissue biopsy samples were subjected to semi-quantitative RT-PCR with ISG15 specific primers to elucidate the expression level. Results: Of the thirty oral squamous cell carcinomas that were analyzed, ISG15 expression was found in twenty four samples (80%). Twelve samples expressed low level of ISG15, six of them expressed moderately, while the rest of them expressed very high level of ISG15. Conclusions: To the best of our knowledge, the results show for the first time an overexpression of ISG15 in up to 80% of oral squamous cell carcinoma tissues collected from Indian patients. Hence ISG15 may be explored for the possibility of use as a high confidence diagnostic biomarker in oral cancers.

• Transactions of the Korean Society of Automotive Engineers
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• v.21 no.4
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• pp.120-127
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• 2013

Hybrid electric vehicles have applied electric parts for saving fuel consumption and reducing levels of environmental pollution. Electrification of automobiles is indispensable for entering into global market because of enhanced environment restriction. ISG (Integrated Starter & Generator) system is one of main electric parts and can improve fuel efficiency more than other components by using Idle Stop & Go function and regenerative braking system. However, if ISG motor and inverter work under the continuously high load condition, it will make them the decrease of performance and durability. So the ISG motor and inverter need to properly design the cooling system of them. In this study, we suggested the enhancement points by modifying the thermal design of ISG motor and then confirmed the improvement of the cooling performance.

• Proceedings of the KIPE Conference
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• 2002.07a
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• pp.653-656
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• 2002

This paper presents the development of 15G(Integrate Starter Generator). The ISG is the crank shaft mount type and it is installed at tile flywheel. The wide operating range of ISG requires large constant power speed ratio, good overload performance and high efficiency. High saliency ratio permanent magnet motor is developed for the ISG applications and 500A MOSFET inverter is designed to derive the ISG. The characteristic of developed ISG is investigated using the special test-bed for the 42V PowerNet and the detailed results is presented

• Development and Reproduction
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• v.21 no.4
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• pp.371-378
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• 2017

Interferon-stimulated gene 15 (ISG15) is known to interfere with viral replication and infection by limiting the viral infection of cells. Interferon-stimulated gene 15 (ISG15) interferes with viral replication and infectivity by limiting viral infection in cells. It also plays an important role in the immune response. In this study, tissue-specific expression of ISG15 in healthy rock bream samples and spatial and temporal expression analysis of rock bream ISG15 (RbISG15) were performed following rock bream iridovirus (RSIV) infection. RbISG15 expression was significantly higher in the eye, gill, intestine, kidney, liver, muscle, spleen, and stomach, but low in the brain. There were particularly high levels of expression in the liver and muscle. RbISG15 expression was also examined in several tissues and at various times following RSIV infection. ISG15 expression increased within 3 h in the whole body and decreased at 24 h after infection. In addition, temporal expression of several tissues following RSIV infection showed a similar pattern in the muscle, kidney, and spleen, increasing at 3 h and decreasing at 72 h. These results suggest that ISG15 plays an important role in the immune response of rock bream. Overall, this study characterizes the response of RbISG15 following RSIV infection.

• Journal of fish pathology
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• v.23 no.2
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• pp.177-187
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• 2010

The Interferon stimulated gene 15 (ISG15) is strongly induced in many cell types by IFNs, viral infections, and double-stranded RNA (poly I:C). The ISG15 homologue cDNA was isolated from the rock bream LPS stimulated leukocyte cDNA library. The rock bream ISG15 homologue was found to consist of 833 bp encoding 157 amino acid residues. Compared with other known ISG15 peptide sequences, the most conserved regions of the rock bream ISG15 peptide were found to be the tandem ubiquitin-like domains and a C-terminal LRLRGG conjugating motif, characteristic of mammalian and non-mammalian ISG15 proteins. Phylogenetic analysis based on the deduced amino acid sequence revealed a homologous relationship between the ISG15 sequence of rock bream and that of Atlantic salmon, Atlantic cod, northern snake head, black rockfish and olive flounder. The expression of the rock bream ISG15 molecule was induced in the peripheral blood leukocytes (PBLs) from 1 to 24 h following poly I:C stimulation, with a peak at 3 h post-stimulation. The rock bream ISG15 gene was predominantly expressed in the PBLs, spleen and gill.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.796-797
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• 2011

하이브리드 자동차의 Integrated Starter & Generator (ISG)는 기동 시 높은 토크를 발생시키면서 진동과 소음을 동반한다. 이러한 진동 및 소음은 차량의 품질 확보를 위하여 최소화 시켜야 할 필요가 있다. 본 논문에서는 매입형 영구자석 동기 전동기로 설계된 ISG의 진동 및 소음 저감에 관한 연구에 대하여 다룬다. ISG의 진동 및 소음 저감을 위하여 회전자 코어의 형상 최적설계, 슬롯 수 변경설계 그리고 회전자의 step skew를 적용시켜 각각의 설계방법이 ISG의 진동 및 소음에 미치는 영향을 해석과 실험을 통해 검증하였다.

• Journal of Korean Society of Transportation
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• v.32 no.5
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• pp.421-430
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• 2014

The greenhouse gas emission generated by idling vehicles is a critical issue in the greenhouse gas reduction from the transportation sector. Recently, the mandatory application of the Idle Stop and Go (ISG) for buses, trucks and taxis is in the process of legislation. Focusing on the regulation is about to apply to passenger cars, this study analyzed the quantitative economic effects of the ISG installation by passenger car types in Seoul metropolitan area to support proper policy making. The benefit cost ratio of ISG installation on commercial passenger car of Seoul is the most effective, calculated as 8.55. Accordingly, the amount of 660 liters (per year per vehicle) of fuel and 1,606 kg (per year per vehicle) of $CO_2$ could be reduced. The results of this study might be used as an index for judgment of policy such as determining appropriate subsidy for ISG installation on passenger cars.

• Transactions of the Korean Society of Automotive Engineers
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• v.13 no.3
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• pp.1-9
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• 2005

In this paper, an operation algorithm and a performance simulator are developed for a 42-volt ISG vehiclewhich consists of 5 kW ISG, 2500cc IC engine, torque converter and 4 speed automatic transmission. Modularapproach using MATLAB Simulink is used to construct a dynamic model of the vehicle powertrain which is obtainedfrom each component such as engine, battery, ISG, torque converter, etc.. An operation strategy for a 42-volt ISG vehicle including the function such as engine idle stop and regenerative braking is proposed. Performance simulator is developed based on the dynamic models of the powertrain. It is found from the simulation results that fuel economy can be improved as much as 6 percent for FTP75 driving cycle mostly owing to the engine idle stop.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.1
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• pp.59-64
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• 2014

Integrated Starter Generator (ISG) system improves the fuel economy of hybrid electric vehicles by using idle stop and go function, and regenerative braking system. To obtain the high performance and durability of ISG motor under continuously high load condition, the motor needs to properly design the cooling system (cooling fan and cooling structure). In this study, we suggested the enhanced design by modifying the thermal design of the ISG motor and then analyzed the improvement of the cooling performance under high-speed condition and generating mode by CFD simulation. The temperatures at the coil and the magnet of the enhanced model were decreased by about $4^{\circ}C$ and $6^{\circ}C$, respectively, compared to those of the conventional model. Therefore, we verified the cooling performance enhancement of the novel thermal design in the case of core loss increment due to the higher speed condition.

• Journal of Magnetics
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• v.20 no.2
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• pp.148-154
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• 2015

48-V ISG (Integrated Starter Generator) system has attracted attention to improve the fuel efficiency of ICE (Internal Combustion Engine) vehicle. One of the key components that significantly affects the cost and performance of the 48-V ISG system is the motor. In an ISG motor, the core and copper loss make the motor efficiency change because the motor has a broad driving operated range and more diverse driving modes compared with other motors. When designing an ISG motor, the selection of an electrical steel sheet is important, because the electrical steel sheet directly influences the efficiency of the motor. In this paper, the efficiency of the ISG motor, considering core loss and copper loss, is analyzed by testing different types of electrical steel sheets with respect to the driving speed range and mode. Using the results of a finite element method (FEM) analysis, a method to select the electrical steel sheet is proposed. This method considers the cost of the steel sheet and the efficiency according to driving mode frequency during the design process of the motor. A wound rotor synchronous machine (WRSM) was applied to the ISG motor in this study.