• 제목, 요약, 키워드: Immunoglobulin

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정주 면역글로불린을 투여 받은 길랑-바레 증후군 환자에서 치료효과와 예후에 영향을 주는 인자들에 관한 연구 (Therapeutic Outcomes and Prognostic Factors in Guillain-Barre Syndrome Treated with Intravenous Immunoglobulin)

  • 이지영;조중양;김성훈;이광우
    • Annals of Clinical Neurophysiology
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    • v.6 no.2
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    • pp.92-97
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    • 2004
  • Background: There were several studies comparing prognostic factors in Guillain-Barre syndrome treated with intravenous immunoglobulin and plasmapheresis. However, there were controversies in what were significant factors and there were few studies so far comparing the therapeutic outcomes in patients treated with immunoglobulin. This study was aimed to determine the prognostic factors which affected the therapeutic outcome of Guillain-Barre syndrome treated with intravenous immunoglobulin. Method: We retrospectively reviewed the medical records of patients with Guillain-Barre syndrome admitted to our hospital between January 1999 and March 2004. All patients were treated with intravenous immunoglobulin. Outcome and prognosis were followed up after four weeks using the overall disability sum score. Results: Thirty-six patients were enrolled in this study. According to the clinical and electrophysiological findings, 17 patients were AIDP, 10 were axonal forms, two were mixed and seven had electrophysiologically no evidence of abnormalities. At a follow-up of four weeks, disabilities at the nadir (p<0.001) and admission (P<0.012), initial manifestations of bulbar symptom (P<0.024) and electrodiagnostic features (P<0.013) were significantly correlated with outcome in patients treated with intravenous immunoglobulin. But only disabilities at the nadir (P<0.033) and electrodiagnostic features (P<0.018) were significant in the multivariate logistic regression analysis. Conclusion: Among the patient treated with intravenous immunoglobulin, the outcomes were significantly different according to the neurological status at the nadir. Therefore early diagnosis, administration of intravenous immunoglobulin and preventing complications during acute stages are essential to minimize neurological deficit and shorten the periods of recovery.

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타액의 수소이온 농도, 점도, 세균 및 면역글로블린 A에 관한 연구 (A Study on pH, Viscosity, Microorganisms and Immunoglobulin A of the Saliva)

  • Jin-Woo Sohn;Sung-Woo Lee
    • Journal of Oral Medicine and Pain
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    • v.17 no.2
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    • pp.87-97
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    • 1992
  • The purpose of this study is to investigate the age-and sex-related changes in the pH of resting saliva, viscosity, microorganisms and immunoglobulin A of stimulated whole saliva, and to investigate their correlations. The 120 healthy subjects were included in this study and the author used cone-and plate digital viscometer for viscosity, MSB agar for Streptococcus mutans, SL Rogosa agar for lactobacilli, and single radial immunodiffusion technique for immunoglobulinA. The obtained results were as follows : 1. There was no significant difference in pH, viscosity, Streptococcus mutans lactobacilli and immunoglobulin A of the saliva between males and females. 2. The viscosity values of stimulated whole saliva showed the increasing pattern with aging. 3. DMFS (or dmfs) rate was not correlated with pH, viscosity, Streptococcus mutans, lactobacilli and immunoglobulin A of the saliva. 4. There was a significant difference in the concentration of immunoglobulin A between the group under 10 and groups above 10. 5. The viscosity values of stimulated whole saliva showed the increasing pattern with decreasing of the number of Streptococcus mutans.

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치근단 병소에서 면역글로불린의 분포에 관한 연구 (A QUANTITATIVE ANALYSIS OF THE IMMUNOGLOBULIN CONTAINING CELLS IN PERIAPICAL LESIONS OF THE HUMAN TEETH)

  • 조수진;윤태철;박동수
    • Restorative Dentistry and Endodontics
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    • v.20 no.1
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    • pp.55-70
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    • 1995
  • Periapical lesions develop as a result of immunopathologic response to irritants from infected root canal systems. Removal of these irritants from the root canal system and sealing the root canal space may induce he31ing of the periapical lesions. 83 periapical lesions diagnosed as periapical abscess, periapical granuloma, chronic nonspecific inflammation, fibrosis and periapical Cyst were evaluated for the distribution of immunoglobulin containing cells. The influence of the state of root canal treatment on the distribution of immunoglobulin containing cells has evaluated. All lesions were divided into a group with no treatment, a group with canal enlargement, a group filled with gutta percha, and a group filled with Vitapex(calcium hydroxide). The distribution of immunoglobulin-containing cells according to the presence of pain and fistula was also evaluated. The following results were obtained. 1. Statistically significant difference in the distribution of immunoglobulin-containing cells among periapical abscess, periapical granuloma, chronic nonspecific inflammation/fibrosis and periapical cyst were found.(Kruskal-Wallis analysis, P<0.05) The number of immunoglobulin-containing cells in fibrosis was remarkably lower than that of periapical abscess, granuloma and cyst. 2. IgM and IgA containing cells were predominantly observed in periapical abscesses and periapical cysts, respectively. 3. All periapical lesions showed a large number of IgG containing cells followed by IgM, IgA and IgE containing cells. 4. There was a decrease in all Ig-containing cells in the group with canal filling compared to groups without treatment or with enlargement. That is, there is a decrease in Ig-containing cells as treatment progresses. 5. No significant correlation existed between the presence of pain and fistula and the distribution of immunoglobulin containing cells in periapical lesions.(t-test) Results appear to support that immune response are actively involved in the development and progress in periapical lesions. The fact that distribution of immunoglobulins differ according to the state of endodontic treatment suggests that root canal treatment may alter the humoral immune response of the periapical lesions.

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구강궤양 환자의 타액내 면역 글로블린 A의 농도 (Salivary Immunoglobulin A Concentrations in Patients with Oral Ulcer)

  • Geun-Chun Ryu;Chang-Lyuk Yoon
    • Journal of Oral Medicine and Pain
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    • v.19 no.1
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    • pp.117-124
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    • 1994
  • Parotid and whole saliva were collected from 27 healthy adults, from 25 years of age to 30, and from 27 patients with oral ulcer, from 23 years of age to 61. The amount of each Salivary immunoglobulin A was measured by single radial immunodiffusion (SRID) technique. Results were as follows : 1. There was no significant difference between the normal group and the disease group in the concentration of immunoglobulin A in whole saliva. 2. The concentration of immunoglobulin A in parotid saliva of the normal group was higher than the disease group and the difference was statistically significant between the two groups. (p<0.01) 3. The concentration of immunoglobulin A of the parotid saliva in both groups was higher than that of the whole saliva.

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자원봉사활동과 시험이 포함된 교과과정이 일 간호전문대학생의 자아존중감, 건강증진 생활양식과 Immunoglobulin에 미치는 영향 (The Effect of Curriculum with Volutary Activity of Midterm Examination on Self-esteem, Health-promoting Lifestyle and Immunoglobulin in Nursing College Student.)

  • 김민정
    • 대한간호
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    • v.37 no.1
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    • pp.81-97
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    • 1998
  • The purpose of this study was to identify the effect of voluntary activity or midterm examination on self-esteem, health-promoting lifestyle, immunoglobulin in Nursing college student. Voluntary activity provides positive emotion(higher score of self-esteem) and midterm examination provides high level stress to students. Emotion and stress affect immune system. Seventy-five and seventy-eight subjects were assigned to voluntary activity and midterm examination group. In analyzing data, paired and unpaired t-tests and ANCOVA were used. The results were as following : 1.1 Self-esteem of after-voluntary activity was increased significantly than before-voluntary activity. 1.2 Health-promoting lifestyle of after-voluntary activity was not increased significantly than before- voluntary activity. 1.3 Immunoglobulin of after-voluntary activity was not increased significantly than before-voluntary activity. 2.1 Self-esteem of after-midterm examination was not decreased significantly than before-midterm examination. 2.2 Health-promoting lifestyle of after-midterm examination was decreased significantly .than before-midterm examination. 2.3 Immunoglobulin of after-midterm examination was not decreased significantly than before-midterm examination. 3.1 Self-esteem of voluntary activity group and midterm examination group was not different significantly. 3.2 Health-promoting lifestyle of voluntary activity group and midterm examination group was different significantly. 3.3 Immunoglobulin of voluntary activity group and midterm examination group was not different significantly.

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중년기 여성의 웃음치료가 웃음지수, Cortisol 및 면역글로불린에 미치는 효과 (Effects on the Laughter Score, Cortisol and Immunoglobulin of Laughter Therapy in Middle Aged Women)

  • 차미연;홍해숙
    • Journal of Korean Biological Nursing Science
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    • v.15 no.4
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    • pp.230-236
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    • 2013
  • Purpose: In this study, the effects of laughter therapy on a laughter index, cortisol and immunoglobulin of middle aged women were examined. Methods: A quasi-experimental nonequivalent control group pre/post-test design were used. The participants (n=54) included 27 in the experimental group and 27 in the control group. The data were collected from February through March of 2013. The experimental group participated in laughter therapy for 40 minutes per session, five times a week for a period of 2 weeks. The tool was used to measure pre/post-test laughter index, cortisol and immunoglobulin of middle aged women. Results: The results showed that laughter therapy was effective in increasing the laughter index (p<.001), and immunoglobulin IgA (p<.001), IgG (p<.001), and IgM (p=.010). Also, the stress hormone, cortisol of middle aged women decreased but non-significantly (p=.158). Conclusion: The result of the study indicates that laughter therapy may have an influence on nursing intervention and treatment effects to improve the laughter index and immunoglobulin of middle aged women.

다양한 HPLC Column에서의 IgY(Immunoglobulin Yolk) 분리특성 (Separation Characteristics of IgY (Immunoglobulin Yolk) in Various HPLC Columns)

  • 송성문;김인호
    • Korean Chemical Engineering Research
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    • v.50 no.4
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    • pp.659-665
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    • 2012
  • 동물 혈청 중의 IgG (Immunoglobulin G)에 해당되는 난황에 포함된 면역 단백질 IgY (Immunoglobulin Yolk)는 식품 단백질로 장내 면역 물질로 중요하다. IgY를 정제하기 위해 신선란의 노른자에 카리지난이나 아라빅검을 전처리 물질로 사용하였다. 전처리 후 FPLC (Fast Protein Liquid chromatography)의 DEAE (Diethylaminoethyl) Sepharose 칼럼에서 이온교환법에 의해 불순물을 제거하여 IgY를 얻고, GF HPLC (Gel Filtration High Performance Liquid Chromatography)로 IgY의 분자량을 측정하고 표준 IgY와 비교하여 IgY 단백질을 동정하였다. GF HPLC에서 IgY의 다양성을 발견하였고 IgY 단백질 군의 다양성을 IE HPLC (Ion Exchange High Performance Liquid Chromatography)에서 AX, CX, SCX 칼럼을 사용하여 pH, NaCl 농도를 바꾸어 조사하였다. AX를 사용하여 0.5M NaCl, pH=8 조건에서 3개의 IgY 피크를 분리하였고, SCX를 이용했을 때 0.5M NaCl, pH=5 조건에서도 3개의 IgY 피크를 분리할 수 있었다.

Treatment of Henoch-Sch$\ddot{o}$nlein Purpura with Intravenous Immunoglobulin

  • ;;;;박용훈
    • Yeungnam University Journal of Medicine
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    • v.18 no.2
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    • pp.246-252
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    • 2001
  • 고용량 스테로이드 충격 요법에 반응하지 않는 심한 복통과 신생검에서 50% 이상 반월체 형성이 되는 알레르기성 자반증 산염 환자의 치료를 위하여 고용량 정맥용 면역 글로불린을 투여하여 복부 증상이 조기 회복되었으며 이후 혈뇨와 단백뇨도 호전되었다. 그러므로 복부 증상과 선장 침범이 스테로이드 치료야 반응하지 않는 알레르기성 자반증 환자의 경우에 정맥용 면역 글로블린 치료가 고려되어야 할 것으로 사료된다.

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고정식 교정 장치물 장착후 타액내 미생물과 면역 글로블린 A의 변화 (A Longitudinal Study on Salivary Microorgnisms and Immunoglobulin A after Delivery of Fixed Orthodontic Appliances)

  • 이현경;이광호;이승우
    • Journal of Oral Medicine and Pain
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    • v.23 no.2
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    • pp.109-117
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    • 1998
  • Fixed orthodontic appliances for the treatment of malocclusion has iatrogenic side effect such as demineralization of enamel, gingivitix and gingival hyperplasia. The purpose of this study is to longitudinally investigate the salivary microorganisms and immunoglobulin A after delivery of fixed orthodontic appliances for 10 months. Eight orthodontic patients were included in this study and the author has investigated the numbers of general bacteria, Streptococcus mutans Staphylococcus aureus and concentration of immunoglobulin A from unstimulated whole saliva. The author examined these parameters at prebracketing, 1 month after, 4 months after, 7 months after and 10 months after delivery of fixed orthodontic appliances. The obtained results were as follows : There were significant increases in the number of salivary general bacteria, Streptococcus mutans and Staphylococcus aureus after delivery of fixed orthodontic appliances The numbers of general bacteria were significantly increased at 1 month after (p<005), 4 months after (p<0.05), 7 months after (p<0.01), compared with prebracketing. However it showed no difference at 10 month after compared with 7 months after bracketing. The Numbers of Staphylococcus aureus were significantly increased at 1 month after (p<0.05), 4 months after(p<0.01), 7 month(p<0.01), compared with prebracketing. However it showed decreasing pattern at 10 months after compared with 7 months after bracketing. There was no significant difference in the concentration of immunoglobulin A after delivery of fixed orthodontic appliances.

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Predictors and management of intravenous immunoglobulin-resistant Kawasaki disease

  • Song, Min Seob
    • Clinical and Experimental Pediatrics
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    • v.62 no.4
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    • pp.119-123
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    • 2019
  • Kawasaki disease (KD) is a systemic vasculitis that mainly affects younger children. Intravenous immunoglobulin (IVIG) resistant cases are at increasing risk for coronary artery complications. The strategy on prediction of potential nonresponders and treatment of IVIG-resistant patients is now controversial. In this review the definition and predictors of IVIG-resistant KD and current evidence to guide management are discussed.