• Korean Journal of Biological Psychiatry
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• v.11 no.1
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• pp.33-39
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• 2004

Objective:Nitric oxide(NO) has been known to be associated with tolerance and preference to alcohol. It has also been known to affect various alcohol drinking behavior, alcohol withdrawal symptoms and alcohol- induced brain damage. The purpose of this study was to determine the difference, among alcohol dependence group, alcohol drinking group and abstinence group, in serum concentration of nitrite, a stable metabolite of NO, and it's relationship to clinical and biochemical markers of alcoholism. Methods:Forty subjects diagnosed as alcohol dependence according to DSM-IV diagnostic criteria were evaluated for the clinical characteristics and biochemical markers of alcohol dependence including nitrite with their CIWA-Ar scores checked just after admission. Thirty-nine healthy controls were also evaluated, divided into twenty-three alcohol drinking group and sixteen abstinence group. Clinical characteristics were evaluated by CIWA-Ar, CAGE and AUDIT questionnaires. Aspartate aminotransferase(AST), alanine aminotransferase (ALT), gamma glutamyltransferase(GGT) and mean corpuscular volume(MCV) were used as the biochemical markers of alcohol dependence. Serum nitrite concentrations were measured by Griess reaction. Results:1) The concentrations of nitrite in alcohol dependence patients were not different from those in the control subjects. 2) There were no significant association between the nitrite concentrations and the CIWA-Ar scores in alcohol dependence patients. 3) Nitrites are significantly increased in alcohol dependence group and alcohol drinking group compared with abstinence group. Conclusions:These findings suggest that serum nitrite concentration has no relation with alcohol withdrawal symptoms, but alcohol drinking increases serum nitrite concentration influenced by general condition of the body.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.6 no.1
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• pp.19-28
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• 2000

In this experiment, we examined the the effect of Laetrile Oil to the immune system and tried to disclose the anti-cancer mechanism of this. The result is listed as below. 1. After per-os, sub-cutaneous and into the peritoneal injection of Laetrile Oil to the SPF mice, the LD50 is above 5000mg/kg at even group. 2. Mean survival days of mice treated with laetril oil, after S-180 cells transplantation into the peritoneal cavity decreases 1.5 days(-6.8%) compared with the Mean survival days of the control group(22days.) 3. Effects of laetril oil on natural killer cell activity at Effector/Target Cell Ratio with 100:1, 50:1, 10:1 into methotrexate-pretreated mice is like this.: Compared with $29.22\pm12.7\%$ Cytotoxicity of the control group, sample group's Cytotoxicity had $38.83{\pm}12.5%$ of meaningful acrease. At 100:1 Effecr/Target Cell Ratio. At 50:1 Effector/Target Cell Ratio, control group has $20.02{\pm}9.6%$ Cytotoxiciy and sample group had $31.53{\pm}13.4%$ Cytotoxicity. At 25:1 Effector/Target Cell Ratio control group has $13.60{\pm}6.6%$ Cytotoxicity and sample group had $20.81{\pm}9.8%$ Cytotoxicity According to the above results, the Laetrile Oil represents nontotoxic to a SPF mice. non-effective to transplantable Sarcoma 180 tumors, and activaion in NK cell activity.

• The Korean Journal of Community Living Science
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• v.26 no.4
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• pp.761-774
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• 2015

This study examines the dietary life, weight control, perceived body image, self-esteem, and eating disorder of female college students residing in Korea and China. With approval by the IRB of Pusan National University, a survey was conducted in Korea and China. A total of 574 subjects participated in the survey, and they were divided into three groups: 153 Korean female college students residing in Korea (KSK), 180 Chinese female college students residing in Korea (CSK), and 241 Chinese female college students residing in China (CSC). The group of underweight subjects far exceeded the overweight and obese groups, but there was no significant difference (p<0.05). The CSC group showed the highest food intake frequency and eating habit scores, and the KSK group, the lowest (p<0.05). However, the KSK group showed the highest daily life habit score, followed by the CSK and CSC groups, in that order. All groups showed high weight control experience rates mainly for losing weight. In particular, the KSK group showed a much higher rate than the CSC and CSK groups. All groups wanted much thinner body shapes than their actual shapes, resulting in high percentages of body image dissatisfaction. The KSK group showed a higher self-esteem score than the CSC group. The average EAT-26 score was similar across the three groups, but the percentage of eating disorders was much higher in the KSK group than in the CSC and CSK groups.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.5
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• pp.1063-1072
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• 2009

Membranous nephropathy(MN) is the most common cause of adult nephrotic syndrome worldwide. But treatment of MN is not defined. This study was to evaluate the effects of Lonicerae Flos Extract(LFE) on the MN induced by cBSA in mice. Mice were divided into 4 groups. The first group named for 'Normal' was injected with a saline solution. The second group named 'Control' treated with cBSA(10 mg/kg i.p) only. The third group named 'LFE-250', treated with cBSA(10 mg/kg i.p) and LFE(250 mg/kg, p.o). The fourth group named 'LFE-500'treated with cBSA(10 mg/kg i.p) and LFE(500 mg/kg, p.o). After cBSA and LFE treatment for 4 weeks, we measured change of body weight, 24hrs proteinuria, serum albumin, total cholesterol, triglyceride, BUN, creatinine, TNF-$\alpha$, IL-6, IL-$1{\beta}$, IL-10, IFN-$\gamma$, IgA, IgM and IgG levels. The morphologic changes of renal glomeruli were also observed with a light microscope. The levels of 24 hrs proteinuria, total cholesterol, IgG , IgM, IgA, IL-6 were significantly decreased in both LFE groups. The level of triglyceride, IL-$1{\beta}$ was significantly decreased in LFE-500 group. The level of Albumin was significantly increased in LFE-250 group. The level of TNF-$\alpha$, IFN-$\gamma$ were significantly decreased in LFE-250 group. The mRNA expression of IL-$1{\beta}$ in splenocytes was consideraly decreased in LFE-500 group. In histological findings of kidney tissue, thickening of GBM decreased in both LFE groups. This study shows that the LFE might be effective for treatment of MN. More clinical data and studies are to be done for efficient application.

• The Journal of Korean Physical Therapy
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• v.23 no.5
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• pp.65-72
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• 2011

Purpose: The intention of this study was to investigate the effects of modified constraint-induced movement therapy (mCIMT) with bilateral arm training (BAT) on the motor performance and daily activity performance of individuals with chronic hemiparetic stroke. Methods: Sixteen subjects one year after stroke participated in this study with a control group; the pretest-posttest method was used. The subjects were randomly allocated into two groups: combination of bilateral arm training and modified constraint-induced movement therapy (n=8), and modified constraint-induced movement therapy (n=8). The mCIMT group received therapy for 90 minutes in 3 sessions per week over a period of 4 weeks. The patients receiving a combination of mCIMT and BAT were treated for the same period and frequency. The results were evaluated using the Fugl-Meyer Assessment, Action Research Arm Test (ARAT), and Motor Activity Log-Amount of Use, and Quality of Movement (MAL-AOU, QOM) assessment tools. Results: The Fugl-Meyer Assessment showed that hand and wrist performance improved significantly more in the mCIMT group than in the Combination group (p<0.05). Result from the ARAT assessment showed greater scores for gross movement in the combined group than in the mCIMT group (p<0.05). The MAL-AOU showed that there was greater improvement in the combined group than in the mCIMT group (p<0.05). Conclusion: The forced use of the more affected side can be important for the enhancement of upper extremity performance for chronic hemiparetic stroke patients during their daily activities.

• Physical Therapy Rehabilitation Science
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• v.8 no.4
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• pp.202-209
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• 2019

Objective: The purpose of this study was to evaluate the effects of temporomandibular joint and cervical vertebra treatment in persons with tension-type headaches on pain, tenderness, and functional improvement. Design: Three-group pretest-posttest design. Methods: Subjects with tension-type headaches were divided into the temporomandibular joint and cervical vertebra treatment group (n=11), temporomandibular joint treatment group (n=11), and cervical vertebra treatment group (n=11), and pre- and post-evaluation was performed. The temporomandibular joint treatment group underwent compression massage and joint ply of the muscles around the temporomandibular joint. The cervical vertebra group received deep tendon massage and Myofascial Release of the cervical muscles. The temporomandibular joint and cervical vertebra treatment group performed both types of treatment. Treatment was performed for 50 minutes, three times a week for 4 weeks. Measurement tools included the Korean version of the short form-McGill Pain Questionnaire (SF-MPQ, K), Headache Impact test-6 (HIT-6), Neck Disability Index (NDI), and the Digital Algometer FPX25. Results: The groups showed significant differences in SF-MPQ, HIT-6 test, NDI, and Alogometer FPX25 test scores before and after intervention (p<0.05). The differences between the groups were most significant in the group that received treatment of the temporomandibular joint and cervical vertebra (p<0.05). Conclusions: In this study, the treatment of the temporomandibular joint and cervical vertebra was shown to be effective for improving pain, quality of life, and cervical vertebra in persons with tension-type headaches. This data may be helpful in identifying treatment techniques for tension-type headaches in the future.

• Applied Chemistry for Engineering
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• v.28 no.2
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• pp.230-236
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• 2017

We synthesized liquid crystalline polymers containing isosorbide group as a cholesteric derivative and methylene group for controlling the transition temperature to the liquid crystal phase. Effects of the concentration of the isosorbide group and the position of the methylene group on the properties of the liquid crystalline polymer were investigated. Among all the synthesized polymers, polymers (MnHI-x) with a methylene group in the main chain showed higher melting transition temperature and thermal stability than those (SnBI-x) with a methylene group in the side chain. All the synthesized polymers showed an enantiotropic liquid crystal phase. The polymers having 10 mol% isosorbide as a cholesteric liquid crystal phase derivative showed nematic phase, and those having 20 mol% or more isosorbide showed a cholesteric or chiral smectic phase. Thus, we can conclude that the isosorbide group plays a role as a cholesteric liquid crystal phase derivative.

• The Journal of Korean Physical Therapy
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• v.18 no.1
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• pp.53-64
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• 2006

Purpose: The present study purposed to examine the effects of massage and stretching on the recovery of muscle contraction force for muscle fatigue caused by sustained isometric contraction. Methods: The subjects of this study Were 64 healthy men and women (women: 30, men: 34). They Were divided into massage group (23), stretching group (21) and rest group (20), and using Biodex System we observed the pattern of changes in maximal voluntary contraction force (MVC) after causing muscle fatigue in quadriceps femoris muscle through sustained isometric contraction. Results: We measured the point of fatigue occurrence by sustained isometric contraction with 50% MVC and changes in isometric contraction force at 0, 10, 20 and 30 minutes after fatigue and compared them according to gender and treatment group. Conclusion: 1. According to the result of measuring the point of time when fatigue occurred, a difference was observed in time to task failure between men and women. It was significantly longer in women. 2. By gender, MVC changed significantly in all time frames in women, but it showed significant increases only at 10 minutes after fatigue in men. 3. In the comparison of MVC among the treatment groups, it showed significant differences among the groups at 10 minutes after fatigue. 4. In the comparison of changes in MVC among the time frames for each group, the rest group showed significant differences in MVC between 0 and 10 minutes after fatigue and between 20 and 30 minutes after fatigue. The massage group showed significant differences in MVC between 0 and 10 minutes after fatigue and between 10 and 20 minutes after fatigue. The stretching group showed a significant difference in MVC between 10 and 20 minutes after fatigue and between 20 and 30 minutes after fatigue.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.4
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• pp.557-565
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• 2012

The purpose of this study was to examine the effect of acupuncture on trunk flexors compared with trunk extensors in patients with chronic low back pain. The experimental group was treated with acupuncture on trunk flexors. The control group was treated with acupuncture on trunk extensors. Acupuncture treatment was performed 12 sessions over the course of 6 weeks. Volunteers who satisfied the requirements were enrolled in the study. Chronic low back pain was evaluated based on the VAS for bothersomeness, VAS for pain intensity at every treatment and 8, 12 and 24 weeks after starting the treatments, and ODI, SF-36 and BDI before and after treatments and 8, 12 and 24 weeks after starting the treatments. The VAS score for bothersomeness significantly decreased after treatment for up to 24 weeks after starting the treatments in both group (p<0.05). The VAS score for bothersomeness in the experimental group decreased more rapidly than that of the control group with statistical significance (p<0.05). The VAS score for pain intensity, ODI, SF-36 and BDI significantly improved after treatment for up to 24 weeks after starting the treatments in both group (p<0.05). The VAS score for pain intensity, ODI, SF-36 and BDI in the experimental group showed more rapid improvement than those of the control group. But, there were no statistical significances. Treating trunk flexors using acupuncture was more effective in decreasing the degree of bothersomeness caused by chronic low back pain than treating trunk extensors with acupuncture. There is a need to perform further studies.

• Journal of the Korean Society of Physical Medicine
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• v.7 no.4
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• pp.401-409
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• 2012

PURPOSE: The purpose of this study is to assess the difference in the effect of provision of feedback on knowledge of performance and knowledge of result in the training using somesthetic video game aimed at enhancement of balance of hemiparalysis patients due to stroke. METHODS: 20 stroke patients participated in the study. The participants were randomly divided into 2 groups, namely, the knowledge of performance feedback group (KP group, n=10) and the knowledge of result feedback group (KR group, n=10). Both groups received somesthetic video game training 5 times (30 minutes each) a week for total of 4 weeks. The KP group received feedback on the patterns of movement in execution of somesthetic video game. The KR group received feedback on the scores acquired following execution of somesthetic video game. Verification of the significance of the data was performed through paired t-test and independent t-test. RESULTS: Both groups displayed significant reduction in the movement of center of pressure (COP) and Timed up and Go (TUG), and significant increase in the Berg Balance Scale (BBS) following the training. Although the movement of COP was reduced for the KP group in comparison to the KR group, it was not statistically significant, and there was significant reduction in TUG and significant increase in BBS. CONCLUSION: The above results illustrate that provision of feedback on knowledge of performance is more effective than feedback on knowledge of result in somesthetic video game training for the purpose of enhancement of balance in stroke patients. Therefore, provision of feedback on knowledge of performance is necessary in somesthetic video game training for stroke patients.