• 제목/요약/키워드: K-group

검색결과 65,544건 처리시간 0.08초

Effect of FC-GT Supplement on Body Fat and Lipid Metabolism in Rats

  • Woo, Myoung-Nam;Jeon, Seon-Min;Kim, Hye-Jin;Yeo, Ji-Young;Ha, Tae-Youl;Choi, Myung-Sook
    • Nutritional Sciences
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    • 제9권4호
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    • pp.248-258
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    • 2006
  • The objective of this study was to investigate the effects of supplementation of an antiobese functional formula (FC-GT) on body weight and lipid metabolism in rats fed a high-fat diet. Three groups of male Sprague-Dawley rats were fed different diets for 6 weeks: normal control (NC), high-fat (HF), and high-fat supplemented with powdered antiobese functional formula (FC-GT) (5% wt/wt) groups. Although body weight was not significantly different among the groups, relative weights of epididymal and perirenal white adipose tissues were significantly lower in the FC-GT group than in the HF group. FC-GT supplementation significantly lowered the plasma total cholesterol and triglyceride concentrations, whereas it elevated the ratio of HDL-C/total-C and improved the atherogenic index. Hepatic cholesterol and triglyceride concentrations were significantly lowered in the FC-GT group compared to the HF group. The accumulation of hepatic lipid droplets and the epididymal white adipocyte size of the FC-GT group were diminished compared to the HF group. Hepatic HMG-CoA reductase activity was significantly lower in the FC-GT group than in the HF group. Plasma GPT activity was significantly lowered in the FC-GT group compared to the HF group. Additionally, fecal weight was significantly increased in the FC-GT group than in the HF group. In addition, contents of fecal triglyceride and cholesterol were significantly higher in the FC-GT group compared to the other groups. The antioxidant activities of hepatic SOD, CAT, and GR were significantly increased in the FC-GT group compared to the HF group. Hepatic mARS and plasma mARS levels were significantly lowered in the FC-GT group compared to the NC group. Accordingly, we conclude that supplementation of FC-GT improves plasma and hepatic lipid levels in high-fat fed rats.

F93-A: A Inhibitor of Farnesyl Protein Transferase from Aspergillus fumigatus KL93

  • Kwon, Byoung-Mog;Lee, Seung-Ho;Jeong, Tae-Sook;Kim, Sung-Uk;Son, Kwang-Hee;Park, Diol;Kim, Young-Kook;Nam, Ji-Youn;Bok, Song-Hae
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 1995년도 춘계학술대회
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    • pp.66-66
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    • 1995
  • Mutated forms of the ras oncogenes are associated with about 30% of human tumors. The ras genes encode 21KDa proteins, called p21 or Ras, that are associated with the plasma membrane. FPTase is a dimeric enzyme that catalyses the transfer of the farnesyl group from farnesyl pyrophosphate onto cysteine 186 at the C-terminus of the Ras protein. This is mandatory process for triggering ras oncogene toward tumor formation. Therefore, selective inhibitors of FPTase have the potential to be used as antitumorgenic agents.

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High Speed and Sensitive X-ray Analysis System with Automated Aberration Correction Scanning Transmission Electron Microscope

  • Inada, Hiromi;Hirayama, Yoichi;Tamura, Keiji;Terauchi, Daisuke;Namekawa, Ryoji;Shichiji, Takeharu;Sato, Takahiro;Suzuki, Yuya;Ohtsu, Yoshihiro;Watanabe, Keitaro;Konno, Mitsuru;Tanaka, Hiroyuki;Saito, Koichiro;Shimoyama, Wataru;Nakamura, Kuniyasu;Kaji, Kazutoshi;Hashimoto, Takahito
    • Applied Microscopy
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    • 제45권1호
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    • pp.1-8
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    • 2015
  • We have developed a new HD-2700 (Hitachi High-Technologies Corp., Japan) scanning transmission electron microscope (STEM) that includes an automatic aberration correction function, and a large-solid-angle energy-dispersive X-ray spectroscopy detector that enables high-resolution and sensitive analysis. For observation with atomic resolution, using spherical-aberration-corrected STEM, in order that satisfactory performance of the device can be achieved readily, and within a short time, irrespective of the operator's skill level, a spherical-aberration-correction device with an automatic aberration-correction function was developed. This automatic aberration-correction function carries out the entire correction-related process (aberration measurement, selection and correction) automatically, with automatic selection of the aberrations that require correction, and automatic measurement of the appropriate corrections.

만성 피로증후군과 특발성 만성 피로에 대한 침 치료 효과: 무작위 대조 예비 임상연구 (Acupuncture for Chronic Fatigue Syndrome and Idiopathic Chronic Fatigue: a Pilot Randomized Controlled Trial)

  • 김정은;강경원;김애란;김주희;김태훈;박효주;신미숙;이민희;이상훈;이승훈;정소영;정희정;홍권의;최선미
    • Journal of Acupuncture Research
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    • 제29권5호
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    • pp.109-118
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    • 2012
  • Objectives : The aim of this study was to evaluate the effectiveness and safety of acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue. Methods : A randomized, controlled pilot trial was conducted. Twenty-four participants were randomized into one of the two groups: an acupuncture group(n=12) and wait-list group(n=12). The treatment group received 12 sessions of acupuncture over 4 weeks. Eight points($GV_{20}$; bilateral GB20, $BL_{11}$, $BL_{13}$, $BL_{15}$, $BL_{18}$, $BL_{20}$, and $BL_{23}$) were selected for needling. The control group did not receive acupuncture treatment during study period and follow-up were done in the $5^{th}$ and $9^{th}$ weeks after randomization in both groups. The primary outcome was fatigue severity scale(FSS) and the secondary outcomes included a short form of stress response inventory(SRI-short form), beck depression inventory(BDI), and insomnia severity index(ISI). Safety was assessed at every visit. Results : There were statistically significant differences in the between group values of FSS at $5^{th}$ weeks after randomization(p=0.0002), SRI-short form, BDI, and ISI at $5^{th}$, $9^{th}$ weeks after randomization(p<0.01). There were no adverse events. Conclusions : The results suggest that acupuncture is associated with benefits on the short-term outcomes in chronic fatigue syndrome and idiopathic chronic fatigue.

하악골 신장술에서 압축자극을 통한 골 재생방식에 대한 생체 역학적 평가 (BIOMECHANICAL EVALUATION ON BONE REGENERATION IN MANDIBULAR DISTRACTION OSTEOGENESIS COMBINED WITH COMPRESSION STIMULATION)

  • 허준;김욱규;황대석;김용덕;신상훈;정인교;김철훈;윤석영
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • 제33권5호
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    • pp.470-478
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    • 2007
  • The purpose of this study was to investigate the clinical, biomechanical, and histologic changes in new distraction osteogenesis(DO) technique combined with a compression stimulation in accordance to different compression-distraction force ratio. 23 adult male rabbits underwent open-osteotomy at the mandibular body area and a external distraction device was applied. In the control group of 8 rabbits, only a 8 mm of distraction was performed by conventional DO technique. In an experimental group of 15 rabbits, a distraction followed by a compression force was performed according to the ratio of compression-distraction suggested by authors. The rate of experimental group I was set up as a 2 mm compression versus 10 mm distraction and the rate of experimental group II was set up as a 3 mm compression versus 11 mm distraction. All the rabbits were sacrificed for a gross finding, biomechanical, histomorphometric and histologic findings at the time of 55 days from the operation day. The results were as follows: 1. On the gross findings, because all rabbits had a sufficient healing time, every distracted new bone had good bone quality and we could not find any difference among all three groups. 2. In the histologic findings, rapid bone maturation(wide lamellar bone formation in the cancellous and cortical bone areas) was observed in two experimental groups compared to the control group. 3. On the bone density tests, the experimental group II showed higher bone density than the other experimental group and control group(control group-$0,2906g/cm^2$, experimental group I-$0.2961g/cm^2$, experimental group II-$0.3328g/cm^2$). 4. On the biomechanical tests, the experimental group II had significantly higher bone microhardness than the other experimental group and control group(control group-252.7 MPa, experimental group I-263.5 MPa, experimental group II-426.0 MPa). 5. On the microhardness tests, when we compared the hardness ratio of distracted bone versus normal bone, we could find experimental group II had significantly higher hardness ratio than the other experimental group and control group(control group-0.47, experimental group I-0.575, experimental group II-0.80). From this study, we could deduce that the modified distraction osteogenesis method with a compression stimulation might improve the quality of bone regeneration and shorten the consolidation period in comparison with conventional distraction osteogenesis techniques.

동일연령군에서 크기 선별에 따른 넙치(Paralichthys olivaceus) 성장, 사료효율 및 생존율의 비교 (Effect of Size Grading on Growth, Feed Efficiency and Survival in Olive Flounder (Paralichthys olivaceus))

  • 김종현;김현철;이정호;노재구;이미숙;김경길
    • 한국양식학회지
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    • 제18권3호
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    • pp.154-159
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    • 2005
  • 동일연령군의 넙치 치어를 개체 크기별 4개의 group (small group, 체중 $1.3{\pm}0.23g;$ medium group, 체중 $3.1{\pm}0.45g;$ large group, 체중 $4.9{\pm}0.57g;$ ungraded group, 체중 $3.3{\pm}1.66g$)으로 나누어 8주동안 사육하면서 크기 선별이 어류의 성장, 사료효율 및 생존율에 미치는 영향을 조사하였다. 실험종료시 체중의 분포에 따른 소형 개체(체중 10 g)의 빈도는 크기 선별한 small group에 비해 ungraded group에서 매우 높게 나타났다. 실험 전기간동안의 일일성장률은 small group 및 large group에서 각각 최고치 및 최저치를 보였으며, medium group과 선별 group (small group; medium group; large group)의 pooled data는 ungraded group에 비해 높은 수치의 일일성장률을 나타내었다. (P<0.05). 사료섭취율은 ungraded group이 medium group 및 선별 group의 pooled data에 비해 높았던 반면, 사료효율에 있어서는 ungraded group이 이들에 비해 낮게 나타났다(P<0.05). 그리고 ungraded group의 생존율은 93.3%로 99.3% 이상으로 나타난 다른 실험구들에 비해 유의적으로 낮게 나타났다(P<0.05). 결론적으로 크기가 작은 넙치는 큰 넙치가 없는 곳에서 유의하게 빠른 성장과 높은 생존율을 나타내었다. 따라서 크기 선별은 넙치 치어(체중 1-5 g)의 성장과 생존율을 향상시키기 위해서 중요한 작업이 될 수 있다.

Vibrio parahaemolyticus에 대한 황금추출물의 항균활성 (Antimicrobial Activities of Scutellariae Radix Extract against Vibrio parahaemolyticus)

  • 조성환;김영록
    • 한국식품영양과학회지
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    • 제31권3호
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    • pp.534-538
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    • 2002
  • 식품 가물로부터 분리.동정 된 V. parahaemolyticus에 대하여 황금추출물의 항균력을 검토하였다. 바지락 72건 가검물 중에서 66건(91.7%)이 양성으로서 높은 검출율을 보였다. 슬라이드 응집법으로 혈청형을 확인한 결과 분리 된 V. parahaemolyticus 66균주 중에서 혈청형을 결정할 수 없는 UT(untypeable) K-group이 46균주로서 69.7%였으며, 확인된 혈청형 중에서는 serotype K-I group이 7균주로서 10.6%의 검출율을 나타내었고, K-IV group 5균주(7.6%), K-II, V, VII group이 각각 2균주(3.0%)이 었으며, K-VI, VIII group 1균주(1.5%)의 순으로 분리되었고, K-III와 IX group 혈청형은 검출되지 않았다. 식품에 있어서 생육관계를 조사하기 위하여 시판되는 바지락을 시료로 분리균주들을 각각 접종한 다음35$^{\circ}C$에서 120시간동안 배양하여 얻은 생육곡선에서 V. parahemolyticus균주들 모두가 유도기, 대수기, 정지기, 사멸기를 거치는 전형적인 S자 모양의 생육곡선을 보였다. 식품에 대한 황금추출물의 항균작용을 알아보기 위하여 시판되는 바지락을 시료로 하여 증기 멸균한 후, 동량의 멸균생리식염수를 넣고 황금추출물의 농도가 0, 500, 1000, 5000 ppm (mg/kg)이 되도록 균질화시킨 시료에 분리균주들을 각각 접종한 다음, 35$^{\circ}C$에서 48시간 동안 배양하여 얻은 생육저해곡선에서 V. parahaemolyticus 균주들 모두가 유도기를 거친 다음인 6시간이 경과된 후 황금추출물의 농도에 따라 시험균주의 균수 차이를 보였고, 식품중의 Vibrio parahaemolyticus에 있어서 생육이 억제되는 황금추출물 유효저해농도는 1000ppm이었다. 세포형태변화를 관찰하기 위한 투과형전자현미경(TEM) 상에서 황금추출물 처리로 인한 V. parahaemolyticus균주들의 세포막기능의 파괴로 세포내용물들이 용출된 것을 볼 수 있었다.

사상체질음성분석기(PSSC)를 통한 한국인 소아 ${\cdot}$ 청소년의 체질별 음성특성연구 - 단문을 중심으로 - (A Study on the Characteristics of the Korean Juvenile Sound According to Sasang Constitution using PSSC with a Sentence)

  • 허재범;정운기;최민기;전종원;김달래;유준상
    • 사상체질의학회지
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    • 제19권2호
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    • pp.40-52
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    • 2007
  • 1. Objectives and Methods The purpose of this study was to objectify the diagnosis of Sasang Constitution. 63 Male Juvenile's and 151 Female Juvenile's sentences were analyzed into 73 factors like Pitch, APQ, Shimmer, Octave and Energy, etc. Juvenile's sentences were classified into 6 categories: total Male Juvenile group, under 12 years old Male Juvenile grout, over 13 years old Male Juvenile group, total Female Juvenile group, under 12 years old Female Juvenile group and over 13 years old Female Juvenile group. 2. Results 1) In Total Male Juvenile group, there were no significant differences among constitutional groups in APQ and Octave segment. Taeumin's Center freq.(3) was significantly high compared with Soyangin group. Soeumin's Center freq.(5) was significantly high compared with Soyangin and Taeumin groups. Taeumin's Octave3 Shimmer was significantly high compared with Soeumin group. Soeumin's Octave6 Shimmer was significantly high compared with Taeumin group. Solyangin's D# Tot E was significantly high compared with Taeumin group. 2) In Under 12 years old Male Juvenile group, there were on significantly among constitutional groups in Pitch, APQ, Octave and Energy segment. Taeumin's Octave3 Shimmer and G Shimmer(1) were significantly high compared with Soeumin group. 3) In Over 13 years old Male Juvenile group, there were no signigicant differences among constitutional groups in Pitch, APQ and Shimmer segment. Soyangin's and Soeumin's Octave6 were significantly high compared with Taeumin group. Soyangin's $0k{\sim}2k$ Total Sum, $0k{\sim}2k$ Dev., $2k{\sim}4k$ Total Sum, $2k{\sim}4k$ Dev., A Dev.(1), D# Dev.(1) and G# Dev.(1) were significantly high compared with Taeumin group. Soyangin's and Soeumin's G# Tot E were significantly high compared with Taeumin group. 4) In Total Female Juvenile group, there were no significant differences among constitutional groups in Pitch and APQ segment. Soeumin's Octave4 Shimmer was significantly high compared with Soyangin group. Soyangin's Octave6 was significantly high compared with Soeumin group. Solyangin's 2k-4k Total Sum and B Tot E were significantly high compared with Soeumin group. 5) In Under 12 years old Female Juvenile group, there were no significant differences among constitutional groups in APQ and Energy segment. Soeumin's and Taeumin's Center Pitch and Pitch were significantly high compared with Soyangin group. Soyangin's Center freq.(1) and Center freq.(7) were significantly high compared with Soeumin and Taeeunin groups. Soyangin's and Taeumin's B Shimmer(1) and F# Shimmer(1) were significantly high compared with Soeumin group. Soeumin's D Shimmer(1) was significantly high compared with Soyangin group. Taeumin's and Soeumin's G# Shimmer(1) were significantly high compared with Soyangin group. Soyangin's and Taeumin's Octave2 were significantly high compared with Soeumin group. 6) In Over 13 years old Female Juvenile group, there were no significant differences among constitutional groups in Pitch, APQ and Octave segment. Soeumin's Octave4 Shimmer was significantly high compared with Soyangin group. Soyangin's B Dev.(1) and F Dev.(1) were significantly high compared with Soeumin group. 3. Conclusions In juvenile groups, some sound factors are regarded as useful. PSSC are thought to be the objertive way to diagnose the Consitution and more participants are needed to get more efficiencies using PSSC.

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순기활혈탕(順氣活血湯)이 고지혈증(高脂血症)에 미치는 영향(影響) (Study on the Effect of SGHHT on Hyperlipidemia)

  • 이기서;강탁림;남궁욱;김동희
    • 혜화의학회지
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    • 제13권2호
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    • pp.97-107
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    • 2004
  • As a long-term goal for the development of new prescriptions for hyperlipidemia, SGHHT was examined in the present study using a rat model in which the hyperlipidemia was induced. The major parameters related to lipid metabolism were investigated and the key findings are summarized below. 1. The body weight of hyperlipidemia-induced rats began to show lower body weight beginning one week after SGHHT treatment compared to non-treated control group animals. 2. Cholesterol levels showed a significant decrease beginning three weeks after SGHHT treatment, compared to hyperlipidemia-induced control group. 3. Total cholesterol levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 4. Glucose levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 5. Triglyceride levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group.6. SGOT levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group whereas there was no significant change in SGPT levels. 7. HDL-cholesterol levels were significantly increased in SGHHT- treated animal group compared to the hyperlipidemia-induced control group. 8. LDL-cholesterol levels were significantly decreased in SGHHT-treated animal group compared to the hyperlidemia-induced control group.

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