• Journal of Medicine and Life Science
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• v.15 no.2
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• pp.72-78
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• 2018

We investigated the effect of KIOM-79, 80% ethanolic extract of herbal prescription isolated from Magnolia officinalis, Pueraria lobate, Glycyrrhiza uralensis, and Euphorbia pekinensis, on streptozotocin-induced diabetes in Sprague-Dawley rats. The rats were treated orally with KIOM-79 (500 mg/kg/day) 1) for 3 days prior to streptozotocin (60 mg/kg, intraperitoneal) injection or 2) for 9 weeks after establishing diabetes model to examine acute and chronic effects on hyperglycemia and biochemical variables, respectively. As a result, KIOM-79 had little effects on hyperglycemic changes in acute model. Sexual comparison, however, showed reduced hyperglycemia in female rats, especially 24 hours after streptozotocin injection with or without KIOM-79 pretreatment. In chronic model, streptozotocin-induced hyperglycemia was well established, but KIOM-79 treatment showed no statistically significant effects on all variables. Thus, based on our findings KIOM-79 might have little effects on streptozotocin-induced insulin-dependent diabetes although it has been known to have hypoglycemic and antidiabetic effects on non-insulin-dependent diabetes models.

• Korean Journal of Pharmacognosy
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• v.37 no.2 s.145
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• pp.103-109
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• 2006

Advanced glycation end products (AGEs) formation plays an important role in the progression of diabetic complications. To develop effective herbal formulations with suppression of diabetic nephropathy, a common complication in diabetic patients, we evaluated inhibitory activities of KIOM-79, a new herbal prescription, on the formation of AGEs using in vitro and in vivo model systems. Effects of KIOM-79 on the expression of AGEs, RAGEs (receptor for Advanced glycation end products), type IV collagen and renal $TGF-{\beta}1$ mRNA was also examined in streptozotocon (STZ)-induced diabetic rats. STZ-induced diabetic rats were treated orally with KIOM-79 (250 and $500\;kg^{-1}$ once a day for 13 weeks). In vitro system KIOM-79 suppressed the formation of AGEs $(18.12\;{\mu}g/ml)$. In STZ-induced diabetic rats showing accumulation of AGE and RAGE, pathological examination revealed that KIOM-79 prevented AGE and RAGE deposition in the kidney. In STZ induced diabetic rats, the expansion of mesangial matrix and the glomerular tufts seemed to be larger than those in normal rats. Howεver, after administration with KIOM-79, mesangial metrix and glomerular volume were decreased, and overexpression of type IV collagen was also decreased. Overexpression of renal $TGF-{\beta}1$ mRNA was inhibited significantly. These results suggest that the KIOM-79 might be an effective herbal prescription to prevent or alleviate the progression of diabetic nephropathy.

• The Journal of Korean Medicine
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• v.32 no.5
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• pp.66-77
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• 2011

Objectives: This study aimed to make preliminary data through the bibliometric analysis of journals registered by national research foundations of Korea for the improvement of traditional Korean medical (TKM) journals. Methods: We collected 4,396 articles from the OASIS database, which is composed of articles published by TKM societies and institutes. First, we analyzed the 'authors by year', 'average authors per article', 'articles by institute' and 'authors by institute' to get the author-related conditions. Second, we analyzed the 'reference type', 'cited times', 'IF with self citation' and 'IF without self citation' to get the citation condition. Results: First, we found that the journal order of total authors was KAOOMP (2362), KOMS (1189), and KAMS (967), and of average authors per article was KAMS (5.29), KOIMS (5.25), and KOMS (4.75). Second, we learned that the journal order of occupied article ratio by high rank institutes was SCMS (92.4%), MAS (90.03%), and KOPS (87.22%) and of occupied author ratio by high rank institutes was KOPMS (96.55%), MAS (95.19%), and SCMS (93.85%). Third, we analyzed the most highly cited reference type by journals and we found that OMCS was books, SCMS was oriental medical journals and the other 10 journals were not oriental medical journals. Finally, we observed that the journal order of self citation ratio was SCMS (16.79%), KMAS (11.77%), and OOGS (11.67%) and also that the IF order was KAMS (0.675), OOGS (0.546), and KAOH (0.430). Conclusions: Through this study we found that TKM research leans too much toward on oriental medical universities, so we insist that TKM R&D institutes must be expanded. We also found that the self citation ratio was high in TKM journals, so the ratio must be decreased to improve the quality of the TKM journals.

• Journal of Information Management
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• v.40 no.3
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• pp.79-97
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• 2009

Thanks to current development of many search engines and web technologies, a new semantic searching technology appears, featuring giving a relevant meaning to the keyword beyond the previous keyword search service. On the wave of advance of various search engines, the enhancement of OASIS offered by KIOM is needed as well. To do this, KIOM examined demographic and sociological analysis on their position, status, and career, the convenience of OASIS, and the value of papers offered in OASIS from members who have ever used it. Furthermore, the importance of each area involved in oriental medicine is also examined in terms of a new direction for OASIS improvement. Based on the result of the user survey, it turned out that not only an automatic search system that can find meaning of chinese character-centered key words but also a Authority-system which can distinguish homonym beyond simple keyword search system should be introduced quickly. Also, we reached the conclusion that it is necessary to interconnect a citation index information on references with laboratory information of the agencies concerned and interconnect major web sites around the world by using Open API. OASIS is the only domestic web site for offering papers that cover oriental medicine. Therefore, if requirements about the site in oriental medical circles are analyzed sufficiently and the problems of its information search system are improved, OASIS is expected to play a critical role in the development of oriental medicine.