• Title/Summary/Keyword: Knee osteoarthritis

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A Systematic Review of Herbal Medicine Treatment for Knee Osteoarthritis (퇴행성 슬관절염의 한약제제 치료에 대한 체계적 문헌고찰)

  • Kim, Ji-Hoon;Yoon, Young-Suk;Lee, Won-Jun;Ko, Hong-Je;Kim, Seon-Jong
    • Journal of Korean Medicine Rehabilitation
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    • v.29 no.4
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    • pp.47-60
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    • 2019
  • Objectives This study reviewed recent clinical research trends regarding the effectiveness of herbal medicine treatments for knee osteoarthritis. Methods We reviewed 4 different online databases (PubMed, China National Knowledge Infrastructure [CNKI], National Digital Science Library [NDSL], Oriental Medicine Advanced Searching Integrated System [OASIS]) from January 1, 2015 to August 31, 2019. Results Thirty-two randomized controlled trial papers were selected in this review. Most of them were conducted during 12 weeks, used Western Ontario and Mcmaster Universities Arthritis Index. In 22 of the papers, the effectiveness in the intervention groups was significantly higher than that in the control groups statistically (p<0.05). 5 studies reported intervention group was not inferior to the control group. Conclusions Most of studies showed herbal medicine treatments were statistically effective to knee osteoarthritis. More scientific and systematic clinical studies should be actively conducted in the future, and the results of this study could be used as basic data in the future clinical studies on herbal medicine treatment for knee osteoarthritis.

Apo-1/Fas (CD95) Gene Polymorphism in Korean Knee Osteoarthritis Patients (한국인 무릎 골 관절염 환자들의 임상 양상과 Apo-1/Fas (CD95) 유전자 다형성과의 상관관계에 관한 연구)

  • Hong, Seung-Jae;Yang, Hyung-In;Yim, Sung-Vin;Chung, Joo-Ho;Jung, Young-Ok;Kim, Ho-Youn
    • IMMUNE NETWORK
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    • v.3 no.2
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    • pp.145-149
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    • 2003
  • Background: Apoptosis has been implicated in pathogenesis of various disease. Apo-1/Fas (CD95) is one of the main pathway of apoptosis. To examine the possible relationship between Apo-1/Fas (CD95) and primary knee osteoarthritis, MvaI restriction length polymorphism (RFLP) in human Apo-1/Fas (CD95) gene was assessed. Methods: Genotype and allele frequencies in promoter region in the Apo-1/Fas (CD95) gene were studied by PCR-RFLP in 226 Korean controls and 148 Korean patients with primary knee osteoarthritis. Results: No statistically significant difference in the genotypic distribution and allelic frequencies was found between the control and the knee oateoarthritis patients. But in the severe grade (grade 3, 4) Kellgren-Lawrence score patients, the frequency of $MvaI^*1$ (G) allele was significantly decreased (P=0.0392) and the of $MvaI^*2$ (A) allele frequency was significantly increased (P=0.0473) compared to the normal controls. Conclusion: Apo-1/Fas (CD95) gene polymorphism is a part a determinant factor of severity in knee osteoarthritis, the patients with $MvaI^*2$ (A) allele is more severe radiologic progression. Further substantiation studies are needed in larger patient samples and various other apoptosis related genes to elucidate the mechanism of osteoarthritis, including the Fas ligand gene analysis.

Case Series Study about the Effect of Korean Medicine Treatment Including Chuna Manual Therapy on Knee Osteoarthritis (슬관절 추나치료를 비롯한 한의치료의 슬관절염 치료 효과에 대한 환자군 연구)

  • Seo, Ji Yeon;Song, Kwang chan;Moon, Young Ju;Lee, Ji Yun;Jeon, Hyun A
    • The Journal of Korea CHUNA Manual Medicine for Spine and Nerves
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    • v.13 no.2
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    • pp.97-108
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    • 2018
  • Objectives : The purpose of this research is to find out the effect of Korean Medicine Treatment Including Chuna Manual Therapy with on patients who were diagnosed as Knee Osteoarthritis. Methods : Chuna Manual Therapy was proceeded on 4 patients who received treatment at ${\bigcirc}{\bigcirc}$ Korean Medicine Hospital from Februrary, 2018 to September, 2018. In addition, We also kept a record of NRS, EQ-5D and WOMAC on the day of admission and discharge to find out the differences between initial and final figures. Results : As a result, Chuna Manual Therapy showed a significant effect on alleviating pain on patients with Knee Osteoarthritis. There was a significant decrease in NRS, WOMAC scores. Not only did the scores of NRS and WOMAC decrease significantly, but also the figures of EQ-5D increased significantly as well. Conclusions : This research suggests Korean Medicine Treatment Including Chuna Manual Therapy could be a remedy for Knee Osteoarthritis.

Effect of a Physical Activity Promoting Program Based on the IMB Model on Obese-Metabolic Health Outcomes among Obese Older Adults with Knee Osteoarthritis (슬관절염 비만노인을 위한 IMB 모델 기반 신체활동 증진 프로그램의 효과)

  • Kim, Jung-Suk;Kim, Chun-Ja
    • Journal of Korean Academy of Nursing
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    • v.50 no.2
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    • pp.271-285
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    • 2020
  • Purpose: This study examined the effects of a physical activity promoting program based on the Information-Motivation-Behavioral Skills (IMB) model on physical activity and health outcomes among obese older adults with knee osteoarthritis. Methods: This study utilized a randomized controlled trial with a convenience sample of 75 obese older adults with knee osteoarthritis in a university hospital. The older adults in the intervention group participated in a 12-week program involving weekly group sessions and monitoring calls with education booklets and video clips for exercise dances, while those in the control group received an usual care. Outcomes were measured using self-report questionnaires, anthropometrics, and blood analyses. The intervention effects were analyzed using Mann-Whitney U test and ANCOVA. Results: The mean age of participants was 74.9 years with 84.0% women. The intervention group at 12 weeks showed significantly greater improvements in self-efficacy for physical activity (F=81.92, p<.001), physical activity amounts (Z=-2.21, p=.044), knee joint function (F=15.88, p<.001), and health-related quality of life (F=14.89, p<.001) compared to the control group. Among obese-metabolic outcomes, the intervention group at 12 weeks showed a significant decrease in visceral fat mass (F=7.57, p=.008) and improvement in high-density level cholesterol (F=9.51, p=.003) compared to the control group. Conclusion: Study findings support the need for an IMB based physical activity program for promoting physical activity, knee function and health outcomes in obese older adults with knee osteoarthritis. Longitudinal studies are warranted to confirm the persistence of obese-metabolic effects in clinical settings.

Thread-Embedding Therapy for Knee Osteoarthritis

  • Roh, Jeong-Du
    • Journal of Acupuncture Research
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    • v.37 no.1
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    • pp.64-67
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    • 2020
  • The aim of this study was to investigate the efficacy of thread-embedding therapy for the treatment of knee osteoarthritis. There were 20 patients treated with thread-embedding therapy at various acupoints on the muscles around the knee. Gender, age, location, morbidity period, numeric rating scale (NRS), Western Ontario and McMaster Universities (WOMAC) index, improvement result, side effects, and patient's satisfaction were investigated. After the treatment, the NRS score (z = -4.07, p < 0.001) and WOMAC (p < 0.001) indices decreased in most patients. The NRS score decreased by more than 2 points in 95% of the patients. The WOMAC index decreased by 6-12 points. There were no serious side effects, although bruising, pain, and edema were observed. Overall, 85% of the patients felt satisfied with the thread-embedding therapy. These findings suggested that thread-embedding therapy was effective and may be used widely for knee osteoarthritis.

The Effects of a Self-Management Program on Physical Function and Quality of Life of Patients with Knee Osteoarthritis (자가관리프로그램이 슬관절염환자의 신체기능 및 삶의 질에 미치는 영향)

  • Cheon Eui Young
    • Journal of Korean Academy of Nursing
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    • v.35 no.3
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    • pp.514-525
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    • 2005
  • Purpose: This study was to examine the effects of a Self-management program on physical function and quality of life of women with knee osteoarthritis. Method: The participants for this study, who had knee osteoarthritis, were recruited from an arthritis clinic, at a university hospital located in S city, Korea between February 16, 2004 and June IS, 2004. Seventeen subjects in the control group received no intervention and 18 subjects in for experimental group received an individual Self-management program. The self-management program consisted of dietary education and home-based exercise; walking and resistance exercise. The subjects performed this program 5 times per week during 8 weeks and recorded a diary for diet and exercise. In order to verify the effects of the Self-management program, physical function and Quality of life as a dependent variable were measured at three points in time: before, week4 and week8 after the interventions. Result: There were significant increases on physical function (F=5.08, p=.002) and significant interaction effects (F=7.42, p=.002) in the intervention group over the three measurement points in time. In addition, there were significant increases on quality of life (F=8.08, p=.002) and significant interaction effects (F=4.89, p=.016) in the intervention group over the three measurement points in time. Conclusion: This study revealed that a Self-management program can be used as an efficient nursing intervention for women with knee osteoarthritis.

A Pilot Study to Evaluate the Reliability of Pattern Identification Tool for Knee Osteoarthritis and to Analyze Correlation between Pattern Identification Tool and Knee Range of Motion, Visual Analog Scale and Western Ontario & Mcmaster Universities Osteoarthritis Index (퇴행성 무릎관절염 변증도구의 신뢰도 평가 및 무릎 ROM, VAS, WOMAC과의 상관관계에 대한 탐색적 연구)

  • Oh, Seung-Joon;Jang, Eunsu;Oh, Young-Seon;Kang, Wee-chang;Lee, Eun-Jung;Jung, In Chul
    • Journal of Korean Medicine Rehabilitation
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    • v.29 no.3
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    • pp.113-128
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    • 2019
  • Objectives To evaluate the pattern identification tool for knee osteoarthritis and to investigate the relationship between pattern identification tool and knee ROM (range of motion), VAS (visual analog scale) and WOMAC (Western Ontario & McMaster Universities osteoarthritis index). Methods We studied 50 patients who are diagnosed as degenerative osteoarthritis. With one patient dropping out, total of 49 patient went through pattern identification tool. Re-test of the pattern identification tool was implemented after about a week. The reliability was analyzed by calculating ICC (intraclass correlation coefficient). Also, reliability of each pattern identification score was calculated along with influence factor and correlation between knee ROM, VAS and WOMAC. Results Reliability of the pattern identification tool was evaluated as 'poor agreement beyond chance' with ICC value of 0.396. Reliablility of each pattern identification score was calculated and four out of five were measured 'good' with one 'moderate' reliability. Two of inter-item consistency were 'good', two were 'acceptable' and one was 'questionable'. Correlation between each pattern identification and knee ROM showed 'clear negative linear relationship' with two patterns. VAS showed 'clear positivie linear relationship' with all five patterns. WOMAC showed 'positivie linear relationship' with all five patterns. Conclusions According to the results, pattern identification tool for knee osteoarthritis seems to have meaningful relationship with other agnedas. Also, further research is needed to develop the tool.

Effects of Auricular Acupressure on Joint Pain, Range of Motion, and Sleep in the Elderly with Knee Osteoarthritis (이압요법이 퇴행성 슬관절염 노인의 관절 통증, 관절 가동범위 및 수면에 미치는 효과)

  • Jang, Minjin;Lim, Yun-Mi;Park, Hyojung
    • Journal of Korean Academy of Community Health Nursing
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    • v.30 no.1
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    • pp.79-89
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    • 2019
  • Purpose: The purpose of this paper is to determine effects of auricular acupressure on knee pain, range of motion, and sleep in the elderly with knee osteoarthritis. Methods: This is an experimental study designed with randomization and single-blind in a placebo-control approach. The subjects included the elderly with knee osteoarthritis who were using an elderly welfare facility. In each of the groups, 28 subjects were assigned. For the experimental group, auricular acupressure was applied to five pressure points related to the pain caused by osteoarthritis and sleep. In the case of the placebo-control group, auricular acupressure was applied to other five points than the former. The intervention lasted eight weeks. In order to examine intervention effects of auricular acupressure, joint pain, Pressure Pain Thresholds (PPTs), and extension and flexion range of motion (ROM) were measured weekly. As for the preand post-examinations, pain, sleep quality, and the time-by-sleep stage of the patients with knee osteoarthritis were measured. Results: The VAS scores in the experimental group with auricular acupressure significantly decreased through time (p<.001) and WOMAC also significantly decreased (p<.01) compared with the placebo-control group. However, there were no significant differences in PPTs. The flexion (p<.01) and extension (p<.001) ROMs measured for eight weeks improved over time. Meanwhile, sleep quality improved significantly after the intervention termination (p<.01), but there was no significant difference found in the time-by-sleep stage. Conclusion: Auricular acupressure applied for eight weeks was found to be effective in reducing joint pain, improving knee ROM, and improving sleep quality in patients with degenerative knee arthritis.

Research Trends on the Treatment of Knee Osteoarthritis in Korean Medicine (퇴행성 슬관절염의 한의학적 치료에 관한 연구동향)

  • Yoh, Sang-Bum;Sul, Jae-Uk;Shin, Mi-Sook
    • Korean Journal of Acupuncture
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    • v.28 no.1
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    • pp.139-155
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    • 2011
  • Objectives : To research trends of studies on treatments of knee osteoarthritis in Korean medicine. Methods : Domestic theses, published from 2000 to 2010, mentioning the treatments of knee osteoarthritis in Korean medicine were reviewed and analyzed. This study researched 79 theses and classified again according to the fields of the treatment. Results : The results were obtained as below ; 1. Studies on pharmacoacupuncture account for 41% of the total (32cases/79cases). The target of treatments had changed from pain alleviation and anti-inflammation to cartilage-protection since 2006. 2. Herbal Drug, Bee Venom, Cervi Cornu Parvum pharmacoacupuncture, Taping Therapy and Tai-Chi Exercise program were more effective than others. Moreover research on exercise program such as Tai-Chi has been increasing. 3. Some Herbal Drug (Glycyrrhizae Radix, Angelicae Gigantis Radix, Achyrantis Radix, Paeoniae Radix, Eucommiae Cortex and so on) were mainly used to investigate the effect on cartilage protection, pain relief and anti-inflammation in laboratory test. 4. Acupuncture including individualized, local acupoints and constitution acupuncture were effective than others in pain alleviation and symptom relief. 5. Pharmacoacupuncture Bee Venom were effective in recovery of joint function and pain relief while Buthus martensii Karsch, Homnis Placenta and Cervi Cornu Parvum were effective in cartilage protection and recovery. 6. Moxibustion was efficient to reduce joint pain and partly increase ROM (range of motion) of knee joint, but was not efficient to recover the function of knee joint. Conclusions : These results indicate that research trends on knee osteoarthritis were changed from symptomatic treatment (pain alleviation and anti-inflammation) to conservative treatment (cartilage protection and recovery).

Acute Pseudoseptic Inflammatory Local Reactions after Intra-articular Hyaluronic Acid Injections in Patients with Knee Osteoarthritis (퇴행성 슬관절염 환자에서 관절 내 Hyaluronic Acid 주입 후 발생한 비감염성 급성 염증반응 2예)

  • Lee, Jun Yong;Nahm, Francis Sahngun;Park, Soo Young;Lim, Kyoung Hoon;Park, Chan Do;Lee, Seung Jun;Kim, Yong Chul;Lee, Sang Chul
    • The Korean Journal of Pain
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    • v.22 no.2
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    • pp.191-194
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    • 2009
  • Knee osteoarthritis is a common, but difficult problem to manage in primary care. Intra-articular hyaluronic acid injection has recently been frequently used for treating knee osteoarthritis. The adverse local reactions, except septic arthritis, following intra-articular hyaluronic acid injections are generally transient and not severe. Pseudoseptic arthritis is an extreme form of inflammatory arthritis that is not due to bacterial infection and it is important to distinguish this from true septic arthritis. In this article, we report 2 cases of acute pseudoseptic local reactions after intra-articular hyaluronic acid injections in patients with knee osteoarthritis.