• 동의생리병리학회지
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• 제19권6호
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• pp.1599-1603
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• 2005

The study was designed to investigate the effects of Leonuri herba extract (LHE) on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determine the mechanism of action of LHE. The results in normal rats were as follows, LHE significantly increased rCBF in a dose-dependent manner, and MABP did not change in a dose-dependent manner. This results were suggested that LHE significantly increased rCBF by dilating pial arterial diameter. The LHE-induced increase in rCBF was significantly inhibited by Pretreatment with indomethacin(1 mg/kg, i.p.), an inhibitor of cyclooxygenase, and was significantly inhibited by methylene blue($10{\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase. The LHE-induced MABP did not change by pretreatment with indomethacin but was significantly inhibited by methylene blue. This results were suggested that the mechanism of LHE was mediated by cyclooxygenase.

• Ocean and Polar Research
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• 제44권1호
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• pp.29-38
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• 2022

Halophytes are plants that live in harsh environments in coastal regions and are known for their diverse chemical compositions. Limonium tetragonum, a halophyte endemic to Korean shores, is known for its bioactive compounds and is utilized in folk medicine. In this study L. tetragonum extract (LHE) was used to determine and evaluate its anti-osteoporotic properties. Pre-adipocyte and pre-osteoblasts were induced to differentiate along with LHE treatment, and their differentiation was evaluated using differentiation markers. LHE treatment decreased lipid accumulation in 3T3-L1 preadipocytes during adipogenesis. Results indicated that the LHE treatment also decreased the levels of key adipogenic transcription factors: PPARγ, SREBP1c, and C/EBPα. Enhancing osteoblastogenesis by LHE treatment was confirmed in osteoblastogenesis-induced MC3T3-E1 pre-osteoblasts. Cells treated with LHE resulted in increased calcification and alkaline phosphatase (ALP) activity compared with osteoblasts without LHE treatment. Pro-osteogenic and anti-adipogenic effects were also confirmed in D1 murine mesenchymal stromal cells which are capable of differentiation into both adipocytes and osteoblasts. LHE hindered adipogenesis and enhanced osteoblastogenesis in D1 MSCs in a similar fashion. In conclusion, L. tetragonum is believed to possess the potential to be utilized as a nutraceutical ingredient against osteoporotic conditions.

• 한방안이비인후피부과학회지
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• 제30권4호
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• pp.49-61
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• 2017

Objectives : In order to find out the whitening effects of Leonuri Herba, this study was designed to identify the effects and the action mechanism of LHE(Leonuri Herba extract) on Malignant melanoma cell lines. Methods : After treating LHE on the B16F10 cell-Malignant melanoma cell line-, the cell survival rate, melanin biosynthesis rate, intra&extracellular tyrosinase activity rate, SOD-like activity, tyrosinase mRNA gene expression were investigated. The results were compared with control group without LHE treatment or with positive control group treated with whitening efficacy substance. Results : B16F10 cell survival rate, melanin biosynthesis rate, and intra&extracellular tyrosinase activity were significantly inhibited depending on the concentration of treated LHE. Melanin biosynthesis rate and tyrosinase activity rate were also decreased when ${\alpha}-MSH$ was combined with LHE. In addition, the SOD-like activity was increased in a concentration-dependent manner in the treatment with the LHE, indicating signigicant activity at high concentrations, and the tyrosinase mRNA gene expression was decreased in both the LHE-treated group, the LHE and ${\alpha}-MSH-treated$ group. Conclusions : LHE seems to inhibit melanin synthesis through inhibition of tyrosinase activity and inhibition of tyrosinase mRNA gene expression. It also has the effect of promoting SOD-like activity and may be used clinically as a skin whitening agent in the future.

• 한국정보처리학회논문지
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• 제5권1호
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• pp.86-96
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• 1998

객체 지향 설계 모델에서 클래스 계층구조는 소프트웨어 재사용성과 복잡한 시스템 설계시에 효율적이다. 본 논문에서는 래피드 프로토타입핑 기법을 사용한 객체 지향 클래스 계층 구조 설계 방법을 제시한다. 이 방법은 객체 모델링 단계에서 식별된 클래스들을 새로운 분류 방법을 사용하여 관계성 식별과 유사성을 측정한다. 여기에는 클래스의 속성과 메소드의 측정이 요구된다. 하나의 설계 모듈인 클래스 계층구조는 대화식으로 반복적인 작업을 통하여 생성되며, 각 모듈은 참조 관계, 상속 관계, 복합 관계로 구성된다. 이들 정보는 구형 및 프로그램 유지보수시에 도움을 주기 위하여 테이블에 저장하여 클래스 관계성을 그래프로 표현하고 노드클래스를 아이콘화 하였다. 따라서 새로운 클래스 추가 및 삭제 작업이 용이하여 클래스 계층 구조 재구성과 설계정보 재사용시에 효율적이다. 본 논문에서 제시하는 방법은 프로토타입 시스템으로 뿐만 아니라 실제 시스템에 최종 전환할 수 있기 때문에 시스템 분석, 설계, 구현의 능률을 높일 수 있다.

• 한국군사과학기술학회지
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• 제7권3호
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• pp.101-109
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• 2004

Image enhancement for Infrared imaging system is mainly based on the global histogram equalization. The global histogram equalization(GHE) is a method in which each pixel is equalized by using a whole histogram of an image. GHE is speedy and effective for real-time imaging system but its method fails to enhance the fine details. On the other hand, the basic local histogram equalization(LHE) method uses sliding a window and. the pixels under the window region are equalized over the whole output dynamic range. The LHE is adequate to enhance the fine details. But this method is computationally slow and noises are over-enhanced. So various local histogram equalization methods have been already presented to overcome these problems of LHE. In this paper, a new regional dynamic range histogram equalization (RDRHE) is presented. RDRHE improves the equalization quality while reducing the computational burden.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1996년도 춘계학술대회 논문집
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• pp.178-184
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• 1996

Electrical properties such as surface flashover discharge and discharge degradations of insulating materials for superconducting cable have been investigated. It is found that the surface voltage is proportional to /$\^$0.7/(/: discharge length) in LHe(Liquid Helium). V-t characteristic LHe were a n=5.5 that was less than liquid N$_2$. After applied AC voltage, the surface condition of polymer films were observed non-eroded area and eroded area. The eroded area is depending on the applied voltage. In case of LHe, the crack was observed.

• E2M - 전기 전자와 첨단 소재
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• 제9권9호
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• pp.942-948
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• 1996

Electrical properties such as surface flashover discharge and discharge degradations of insulating materials for superconducting cable have been investigated. It is found that the surface voltage is proportional to $l^{0.7}$ (l: discharge length) in liquid helium (LHe). V-t characteristic in LHe was a n=5.5 that was less than liquid nitrogen (L $N_{2}$). After applied AC voltage, the surface condition of polymer films was observed non-eroded areas and eroded areas. The eroded area is depending on the applied voltage. In case of LHe, the crack was observed.d.

• Progress in Superconductivity
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• 제11권2호
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• pp.152-157
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• 2010

We have fabricated the low noise liquid helium(LHe) dewar with a different shape of thermal shield to apply the 64-channel SQUID(Superconducting Quantum Interference Device) gradiometer. The first shape of thermal shield was made of an aluminum plate with a wide width of 100 mm slit and the other shape was modified with a narrow width of 20 mm slit. The two types of dewars were estimated by comparing the thermal noise and the signal-to-noise ratio(SNR) of magnetocardiography(MCG) using the $1^{st}$ order SQUID gradiometer system cooled each dewar. The white noise was different as a point of the dewar. The noise was increased as close as the edge of dewar, and also increased at the thermal shield with the more wide width slit. The white noise of the dewar with thermal shield of 100 mm slit was 6.5 fT/$Hz^{1/2}$ at the center of dewar and 25 fT/$Hz^{1/2}$ at the edge, and the white noise of the other one was 3.5 - 7 fT/$Hz^{1/2}$. We measured the MCG using 64-channel SQUID gradiometer cooled at each LHe dewar and compared the SNR of MCG signal. The SNR was improved of 10 times at the LHe dewar with a modified thermal shield.

• 동의생리병리학회지
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• 제21권3호
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• pp.611-616
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• 2007

The study was designed to investigate the effects of Leonuri herba extract (LHE) on the change of regional cerebral blood flow (rCBT and cytokines production (IL-1${\beta}$, TNF-${\alpha}$, IL-10, TGF-${\beta}$) in ischemic rats. The results were as follows : The rCBF was significantly and stably increased by LHE (10 mg/kg, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. In cytokine production of serum by drawing from femoral arterial blood at 1 hr after middle cerebral arterial occlusion, experimental group (LHE 10 mg/kg treated group) was significantly decreased IL-l${\beta}$ production, and increased TGF-${\beta}$ production compared with control group. In cytokine production of serum by drawing from femoral arterial blood at 1 hr after reperfusion, experimental group was significantly decreased IL-1${\beta}$ production compared with control group. IL-10 and TGF-${\beta}$ production of sample group were significantly increased compared with control group. These results suggested that LHE was significantly and stably increased regional cerebral blood flow by inhibited IL-1${\beta}$ production, and accelerated IL-10 and TGF-${\beta}$ production.

• Progress in Superconductivity
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• 제11권1호
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• pp.78-82
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• 2009

We have fabricated a helmet type magnetoencephalogrphy(MEG) with a $1^{st}$ order gradiometer in vacuum to improve the signal-to-noise ratio(SNR) and the boil-off rate of liquid helium(LHe). The axial type first-order gradiometer was fabricated with a double relaxation oscillation SQUID(DROS) sensor which was directly connected with a pickup coil. The neck space of LHe dewar was made to be smaller than that of a conventional dewar, but the LHe boil-off ratio appeared to increase. To reduce the temperature of low Tc SQUID sensor and pickup coil to 9 K, a metal shield made of, such as copper, brass or aluminum, have been usually used for thermal transmission. But the metal shield exhibited high thermal noise and eddy current fluctuation. We quantified the thermal noise and the eddy current fluctuation of metal. In this experiment, we used the bobbin which was made of an alumina to wind Nb superconductive wire for pickup coil and the average noise of coil-in-vacuum type MEG system was $3.5fT/Hz^{1/2}$. Finally, we measured the auditory evoked signal to prove the reliability of coil-in-vacuum type MEG system.