• Journal of the Korean Applied Science and Technology
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• v.21 no.1
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• pp.31-36
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• 2004

Liquid crystalline phases were formed from acylglutamate; polyglyceryl-10 myristate and glycerine mixture and they were used as a base material for preparing an O/W emulsion. When an oil phase is added into the liquid crystalline phases, it was inserted into the dispersed liquid crystal droplets rather than stayed outside the liquid crystals, which can be known by the fact that the size of liquid crystal droplets increases with the increasing oil phase content. Along with the increase in the droplet size, the complex modulus increases from 100 to 350 pascals and the loss angle decreases from 60 to 24 degrees, from which it can be known that the increase in the internal phase volume results in the increase in the elastic property of oil in liquid crystalline-phases (O/LC). When the water phase was lastly added into the O/LC phase, the emulsification occurred to form a O/W emulsion and the averaged particle size of the O/W emulsion changes from 22.5nm to 538nm with the addition of water phase. The results from the droplet size measurements and stability tests under accelerated conditions such as high temperature show that the obtained O/W emulsion is very consistent with time.

• Applied Chemistry for Engineering
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• v.4 no.1
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• pp.196-203
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• 1993

Emulsions were prepared with the inversion emulsification method which adopted the agent-in-oil method-dissolving the mixed surfactants composed of the glycerin monostearate, polyoxyethylene(100) monostearate, and polyoxyethylene(20) sorbitan monostearate into mixtures of liquid paraffin and beeswax, and adding the aqueous solution of propylene glycol, gradually-and then their phases and viscosities behaviors in the emulsifying process were investigated. The fine and homogeneous o/w emulsions were formed in the HLB region (HLB 10.1~12.3), showing liquid crystalline phase and white gel phase in the emulsifying process. The phase inversion steps in the emulsifying process appeared as follows, i.e., oil continuous phase${\rightarrow}$liquid crystalline phase${\rightarrow}$white gel phase${\rightarrow}$o/w emulsion. Shear rate-shear stress curves of the prepared emulsions had the yield values which pointed out the existence of inner structure between emulsion particles, and the hysteresis loop which showed that the inner structure wasbroken irreversibly by the shear. The area of hystersis loop, an index of breakdown of inner structure, was increased with the decreasing of the HLB value of emulsifier, Shear time-shear stress curves showed the time dependence of plastic viscosity, and the relaxation time in time thinning behavior(${\lambda}$) indicated that the stability of emulsions prepared with the inversion emulsification method was decreased with the increasing of HLB values of emulsifier and was higher than that of emulsions prepared by homomixer.

• Applied Chemistry for Engineering
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• v.8 no.3
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• pp.473-481
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• 1997

Enhanced videomicroscopy was used to observe the dynamic behavior which occurred when water containing pure nonionic surfactant was carefully contacted with equal volumes of polar oils such as oleyl alcohol and oleic acid at various temperatures. A key component of the system is a vertical-stage microscope which provides for stable interfaces by locating the oil above the denser aqueous phase. This arrangement allowed intermediate phases formed at the surface of contact to be clearly observed, as well as any spontaneous emulsification which developed. Contacting experiments with $C_{12}E_5$ as the surfactant and with pure oleyl alcohol and oleic acid soils showed little activity below the cloud point but vigorous activity at higher temperatures including formation of an intermediate lamellar liquid crystalline phase. Diffusion path theory, which allows prediction of spontaneous emulsification resulting from diffusion and of intermediate phase formation during contacting processes, was used to understand the dynamic behavior seen during contacting experiments. Tentative diffusion paths for the contacting experiments with pure oleyl alcohol were presented with the aid of a partial phase diagram of the oleyl alcohol-water-$C_{12}E_5$ system.

• Journal of the Korean Applied Science and Technology
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• v.37 no.3
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• pp.484-495
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• 2020

This study is a mixed surfactant (MimicLipid-MSM1000) that forms the same structure as that of the stratum corneum, sucrose distearate, polyglyceryl-2 dioleate, fermented squalane, ergosterol, 10-hydroxystearic acid, mixture consisting of was synthesized. When using 2~5 wt% of this mixed surfactant, it was possible to make an artificial skin mimetic that forms a multi-layer lamellar structure of 5~30 layers. An emulsion was prepared using this mixed surfactant, and a multi-layered lamellar phase was formed and analyzed mechanically. The appearance of this surfactant was a light brown hard wax, the hydrophilic lipophilic balance (HLB) was 12.53, the critical parameter value was 0.987, and the acid value was 0.13. Stability according to pH change was also stable in acidic (3.8), neutral (7.2) and alkaline (10.8). The particle size of the liquid crystal was found to be the most stable maltese cross lamellar crystalline droplet at 5~25mm. The size of the emulsified particles according to the change in the speed of the homo agitator is 2500 rpm (17.9mm±2.6mm), 3500rpm (12.5mm±2.1mm), 4500rpm (6.2mm±1.8mm) particles were formed. Liquid crystal forming particles were observed through a polarization microscope, and the formation structure of the liquid crystal was precisely analyzed with a scanning electron microscope (cryo-SEM). As an application field, it is expected that it will be widely applicable to the development of various prescriptions, such as various skin care cosmetics, makeup care cosmetics, and scalp protection cosmetics, by using a skin-mimicking surfactant.

• Journal of the Korean Applied Science and Technology
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• v.34 no.3
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• pp.545-554
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• 2017

This study is concerned with the stability of liquid crystal forming emulsifier with localized depend on change of pH using liquid crystal forming agent of advanced company. The liquid crystal emulsifying agent was localized using Sugar Crystal-LC (bio-tech Co., Ltd., Korea), and comparative samples were measured by using Nikkomulese-LC (Nikko Camicarls, Japan) and Alacel-LC (Croda Camicarls, UK). Liquid crystal formation was confirmed microscopically to show the formation of liquid crystal structure at acidic (pH=4.2), neutral (pH=7.0) and alkaline (pH=11.7). The particles of the liquid crystal were observed with a polarizing microscope according to the stirring speed. The stirring time was all the same for 3 minutes with a homo-mixer, and the stirring speed was increased to 2500 rpm, 3500 rpm and 4500 rpm to observe the liquid crystal state. As a result, it was found that the Korean surfactant was more stable and clear liquid crystal structure was formed than the two foreign acids. In the case of the UK in acid zone, the emulsion particle size was uniform and unstable. In the case of Japanese surfactant, it has similar structure and performance to those of localized Korean. It was found that Korean surfactant had superior emulsifying performance in acid zone compared with foreign products. It is possible to develop various formulations such as liquid crystal cream, lotion, eye cream, etc. using Sugar Crystal-LC emulsifier as an application cosmetic field, and it is expected that it can be widely applied as emulsifying technology for skin care external application in the pharmaceutical industry and the pharmaceutical industry as well as the cosmetics industry.

• Proceedings of the SCSK Conference
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• 2003.09b
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• pp.330-342
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• 2003

The formation of emulsions and micelles in water/ceramide PC104/CholE $O_{20}$/C$_{16}$E $O_{20}$ and water/ceramide PC104/CholE $O_{20}$ mixtures was investigated through the phase behavior studies. The phase diagrams showed the existence of micelle and emulsion regions in both systems. The mixed surfactant system (CholE $O_{20}$/C$_{16}$E $O_{20}$) showed the wider micellar and emulsion regions than the single surfactant system (CholE $O_{20}$). From FT-IR measurements, it was found that the polyoxyethylene (POE) groups of surfactants formed the hydrogen bonds with amido carbonyl group in ceramide PC104. This result indicated that the hydrophilic part (EO) of surfactants could stabilize the lamellar structure and emulsion of ceramide PC104. The mixed surfactant system (CholE $O_{20}$/C$_{16}$E $O_{20}$) resulted in the smaller emulsion droplet size due to the effect of curvature at the interface, thus further increasing emulsion stability. With the penetration of $C_{16}$E $O_{20}$into the interfacial layer of surfactants in emulsion, the curvature of the interface might be altered for the formation of smaller emulsion droplets. The mixed surfactant system could incorporate up to 4 wt. % of ceramide PC104 into emulsion more than single surfactant system.ystem.m.

• Nutrition Research and Practice
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• v.15 no.5
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• pp.541-554
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• 2021

BACKGROUND/OBJECTIVES: Isoflavones (ISFs) are effective in preventing bone loss, but not effective enough to prevent osteoporosis. Mixtures of soy ISF and lecithin (LCT) were prepared and characterized in an attempt to improve the bone loss. MATERIALS/METHODS: The daidzein (DZ) and genistein (GN) solubility in soy ISF were measured using liquid chromatography-mass spectrometry. The change in the crystalline characteristics of soy ISF in LCT was evaluated using X-ray diffraction analysis. Pharmacokinetic studies were conducted to evaluate and compare ISF bioavailability. Animal studies with ovariectomized (OVX) mice were carried out to estimate the effects on bone loss. The Student's t-test was used to evaluate statistical significance. RESULTS: The solubility of DZ and GN in LCT was 125.6 and 9.7 mg/L, respectively, which were approximately 25 and 7 times higher, respectively, than those in water. The bioavailability determined by the area under the curve of DZ for the oral administration (400 mg/kg) of soy ISF alone and the soy ISF-LCT mixture was 13.19 and 16.09 ㎍·h/mL, respectively. The bone mineral density of OVX mice given soy ISF-LCT mixtures at ISF doses of 60 and 100 mg/kg daily was 0.189 ± 0.020 and 0.194 ± 0.010 g/mm³, respectively, whereas that of mice given 100 mg/kg soy ISF was 0.172 ± 0.028 g/mm³. The number of osteoclasts per bone perimeter was reduced by the simultaneous administration of soy ISF and LCT. CONCLUSIONS: The effect of preventing bone loss and osteoclast formation by ingesting soy ISF and LCT at the same time was superior to soy ISF alone as the bioavailability of ISF may have been improved by the emulsification and solvation of LCT. These results suggest the possibility of using the combination of soy ISF and LCT to prevent osteoporosis.