• 제목/요약/키워드: Liver Tissue

검색결과 1,821건 처리시간 0.029초

Histologic Alterations in the Liver of Black Bengal Goats Infected with Fasciola gigantica

  • Howlader, M.M.R.;Huq, M.M.
    • Asian-Australasian Journal of Animal Sciences
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    • 제10권1호
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    • pp.114-117
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    • 1997
  • A total of 77 Black Bengal goats (67 females and 10 males) of 3.5 to 5.0 years old between 18 and 20 kg liveweights were used in this study. The whole liver with gall-bladder from respective carcass was collected at slaughter following fecal and postmortem examinations. Tissue sections of all lobes of each liver were prepared and stained with hematoxylin and eosin following a standard procedure. Results confirmed the presence of flukes surrounded by fibrous capsule in the liver. All the animals were suffering from chronic Fasciola gigantica infections. The blood vessels in most of the liver tissue were thickened due to proliferation of fibrous tissue around them. Focal infiltration of lymphocytes in the lobules, patches of focal accumulation of neutrophils and eosinophils were found in all the liver tissue. Proliferations of new bile ductules in the hepatic trinity around the bile ducts that were clogged by the flukes were also observed in most tissue sections.

녹용이 cholesterol 투여가토의 간조긱및 각장기에 미치는 영향 (The effects of deer horn on the liver and other organs of cholesterol adminstered rabbits.)

  • 용재익
    • 약학회지
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    • 제8권1호
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    • pp.12-29
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    • 1964
  • The oral administration of deer horn extract was proved to cause a considerable amelioration to the impairment of hepatic oxidative phosphorylation and to the decrease of ATP content in liver tissue induced by cholesterol ingestion. Deer horn extract was shown to accelerate considerably incorporation of acetate-1-C$^{14}$ into cholesterol in liver tissue and it tends to restore a decrease of GOT activity of liver tissue, caused by cholesterol administration. Histological examination showed that deer horn extract had a remarkable preventive effect against fatty infiltration of organs such as liver, heart, spleen, and adrenal gland of cholesterol given rabbits.

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Altered lipid metabolism as a predisposing factor for liver metastasis in MASLD

  • So Jung Kim;Jeongeun Hyun
    • Molecules and Cells
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    • 제47권2호
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    • pp.100010.1-100010.12
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    • 2024
  • Recently, the incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing due to the high prevalence of metabolic conditions, such as obesity and type 2 diabetes mellitus. Steatotic liver is a hotspot for cancer metastasis in MASLD. Altered lipid metabolism, a hallmark of MASLD, remodels the tissue microenvironment, making it conducive to the growth of metastatic liver cancer. Tumors exacerbate the dysregulation of hepatic metabolism by releasing extracellular vesicles and particles into the liver. Altered lipid metabolism influences the proliferation, differentiation, and functions of immune cells, contributing to the formation of an immunosuppressive and metastasis-prone liver microenvironment in MASLD. This review discusses the mechanisms by which the steatotic liver promotes liver metastasis progression, focusing on its role in fostering an immunosuppressive microenvironment in MASLD. Furthermore, this review highlights lipid metabolism manipulation strategies for the therapeutic management of metastatic liver cancer.

피부화상이 피부 및 간에 미치는 영향 (Effect of Skin Burn on the Skin and Liver)

  • 남철현;서현규;황태연;최현임;이동호
    • 대한물리치료과학회지
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    • 제8권2호
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    • pp.1091-1097
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    • 2001
  • The main experiments was investigated the skin tissue damage changing for the skin bum having influence on the skin and the liver and also observed the radical liver weight, ALT in the serum, the fluctuating of AST for the skin bum causing to the liver damage. Anatomically the edema formation of skin after thermal injury was showed, and skin bum increased liver weight (% of body weight, p<0.05) and the activity of serum aniline aminotrasferase (p<0.05), and also histologically induced wes of epidermal layer, protein degeneration of connective tissue, local hemorrhage and degeneration of glandular epithelium in the skin tissue. Liver tissue showed the evidences of postbum damage, they were sinusoidal dilatation, cell swelling, infiltration of inflammatory cells.

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간내의 비정상 조직 검출을 위한 감쇠계수 추정 (Estimation of Attenuation Coefficient for Detection of Abnormal Tissue in Liver)

  • 최홍호;홍승홍
    • 대한의용생체공학회:의공학회지
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    • 제6권2호
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    • pp.43-52
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    • 1985
  • In this paper, the depth and attenuation coefficient are estimated from the mutilayered liver tissue which contained a inhomogeneous one using reflected ultrasonic signals and the abnormal one is detected quantitatively. Regarding a liver tissue as several reflectors, we analyzed each one by the frequency spectral difference method and discussed its attenuation characteristics. For the verification of this method, the liver pantom and acryle are used. And also we proved the usefulness through the experiment.

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Digital Spectrum 분석방법을 이용한 조직특성 변수에 관한 연구 (Ultrasonic Tissue Characterization by Digital Spectrum Analysis Technique)

  • 곽철은;민병구
    • 대한의용생체공학회:의공학회지
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    • 제5권1호
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    • pp.55-62
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    • 1984
  • A digital spectrum analysis technique was used to estimate the tissue characteristic parameters (transmission velocity and attenuation coefficient) in the phantom study and the human liver's ultrasound scanning. The soft tissue equivalent phantom was made with the combination materials of agar, water, powdered graphite, and n-propyl alcohol. In the human study, twenty five normal subjects and three patients with liver diseases were studied using the ultrasonic reflection signals and the spectrum analysis method The following results were obtained; 1. The soft tissue-equivalent materical could be produced with various acoustic parameters by changing the composition amount of the powdered graphite and n-propyl alcohol. 2. Attenuation coefficients of normal human liver tissue were estimated to be 0. 36 dB/cm MHz$\pm$0.11. In patients with liver disese, tile attenuation coefficients were shown to be different from the above normal values.

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산양의 Liver cirrhosis 발생보고 (Liver Cirrhosis of Korean Native Goat in Korea : A Case Report)

  • 민병만;박경애;김환균;조용성;김성열;구찬희;정운익;김홍집
    • 한국동물위생학회지
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    • 제16권1호
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    • pp.57-64
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    • 1993
  • This survey was performed to report rare outbreak of liver cirrhosis in Korean native goat (KNG) which was died of Yangpyeong's goat farm on Feb. 1992. The examination for the KNG was carried out by clinical signs, necropsy and various lab-oratory test including parasitic, bacterial and histological test. The KNG looked jaundice, ascite, hemorrhage of lumen, abomasum and intestine, and brownish smooth cirrhotic liver at necropsy. Histological examination for liver revealed considerable proliferation of connective tissue and piecemeal necrosis which was caused by chronic active inflammation in interlobules and intralobules. There were atrophic micro and macro nodules which were sur-rounded by connective tissue. The lobular structure lack almost all central vein. The portal areas appearred proliferation of bile ducts, blood vessels and connective tissues. These connective tissue infiltrated heavily with plasma cells, Iymphocytes and histocytes. Histological examination for brain proved to be hepatic encephalopathy by virture of congestion and edema in cerebral medullary. From these results were demonstrated miked nodular, active, postnecrotic liver cirrhosis.

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카드뮴 급성폭로에 의한 Metallothionein 생성과 독성작용 (Induction of Metallothionein and Toxicity in Acute Cadmium Intoxicated Rat)

  • 민경준;박정덕;홍연표;장임원
    • Journal of Preventive Medicine and Public Health
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    • 제26권2호
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    • pp.231-250
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    • 1993
  • Thirty five male Sprague-Dawley rats were treated with cadmium chloride solution ranging from 0.2 to 3.2mg $CdCl_2/kg$ by intravenous single injection. At 48 hours after administration of cadmium, total cadmium, MT bound cadmium and histopathologic finding in liver, kidney, lung, heart, testis, metallothionein in liver, kidney and total cadmium in bleed were examined. Tissue cadmium concentration was highest in liver, followed by in kidney, heart, lung and testis. Cadmium bound to rnetallothionein (MT-Cd) and ratio of MT-Cd to total cadmium were increased in liver and kidney dependently of cadmium exposure dose, but not significantly changed in other organs. On histopathologic finding, the most susceptible organ was heart in considering cadmium exposed dose, but testis in considering cadmium concentration. Blood cadmium concentration was increased with dose-dependent pattern, and significantly correlated with tissue cadmium concentration, so that we may estimate tissue cadmium concentration by measurement of blood cadmium concentration. Metallothionein in liver and kidney was increased with dose-dependent pattern, higher in liver than in kidney, and was significantly correlated with tissue cadmium concentration. However, metallothionein induction efficiency of tissue cadmium(${\mu}g\;MT/{\mu}g\;Cd$) was eater in liver than in kidney, and reverse to tissue concentration or exposed dose of cadmium.

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두뇌 조직의 $\alpha$-Tocopherol에 관한 연구 - I. Saponification 과정 유무에 의한 뇌조직, 간조직 및 혈청 $\alpha$-Tocopherol농도의 비교연구 - (Studies on Concentration of $\alpha$-Tocophero in Rat Tissue and Serum - I. Effect of Saponification on Concentration of $\alpha$-Tocopherol in Rat Brain, Liver and Serum -)

  • 박연희
    • Journal of Nutrition and Health
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    • 제23권2호
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    • pp.108-114
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    • 1990
  • The concentrations of $\alpha$-tocopherol in the brain, liver, and serum were studied with and without saponification process between control and vitamin E supplemented rats. Young rats, 80-120g body weight, were fed control and vitamin E supplemented diets, ad libitum, for four weeks. $\alpha$-Tocopherol concentrations were determined by high pressure liquid chromatography. The $\alpha$-tocopherol concentration per wet weight base in the brain tissue was significantly lower than that in the liver. Vitamin E supplementation had no effect on brain $\alpha$-tocopherol levels in contrast to the significant increase in lover $\alpha$-tocopherol concentration with and without saponification is significantly greater in the brain than in the liver or serum. Further study is needed to clarify the nature of interaction or /and binding between $\alpha$-tocopherol and the complex membrane system in brain tissue. It can be speculated from this and other studies that the metabolism and the nature of interaction of $\alpha$-tocopherol with the complex membrane system in brain tissue rich in polyunsaturated fatty acids seems different from that in liver tissue or serum.

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수종(數種)의 한약재(韓藥材) 전탕액(煎湯液)이 동물 간조직내 항섬유효능검색에 관한 실험적 연구 (The Studies on Search of Antifibrotic Effect by Several Herbs Extract in Rat Liver Tissue)

  • 서동진;이춘우;김홍기;이기남
    • 대한예방한의학회지
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    • 제5권1호
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    • pp.116-133
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    • 2001
  • Antifibrotic drugs could be delayed or inhibited massive collagen deposition in liver tissue or inhibited collagen synthesis. we investigated antifibrotic effects by several herbs(Schisnadra chinensis, Ganoderma japonicum, Sedum sarmentosum, Alisma canaliculatum, Plantago asiatica) extract with observations of collagen accumulation in liver tissue and collagen synthesis in sera. Rats were used for experimental animal that were devided 3 groups(sham control, BDL/S, BDL/S-ER). Rats were operated for inducing liver fibrosis(cirrhosis) by bile duct obstruction. Several herbs were prepared by water extraction and were applicated p. o. $3ml/day$ during 4 weeks. After observation period, rats were sacrificed and liver tissue and sera were collected. In result, the mortality of rats was 35% in BDL/S group and 20% in BDL/S-ER The color of bile juice in BDL/S-ER was bright yellow and murky yellow in BDL/S group. The significantly lower weight of liver($16.21g{\pm}5.3,\;20.58{\pm}2.4$) and spleen($1.96g{\pm}0.96,\;3.93{\pm}0.21$) were shown in BDL/S-ER than that of BDL/S(p<0.05) group. The value of collagen in liver tissue(25.7%) in BDL/S-ER was observed significantly lower than that of BDL/S group (Tab. 2). AST. ALT, ALP, t-bilirubin, BUN levels were low in BDL/S-ER as compared with those of BDL/S group, but the significance was not proven. The trichrome stained liver tissue in BDL/S-ER group was observed mild bile duct proliferation and fibrosis compared with BDL/S group. In conclusion, natural products inhibited new collagen synthesis and delayed massive collagen deposition in liver tissue, so that they have noticeable antifibrotic effects in experimental liver fibrosis(cirrhosis).

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