• Biomolecules & Therapeutics
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• v.10 no.4
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• pp.236-239
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• 2002

The goal of this study was to evaluate the antidiarrheal efficacy of $Lacteol^{TM}$-loperamide combination against the mouse model of secretory diarrhea. Secretory dirrhea was induced in mice by p.o. administration of castor oil (0.3 ml). Antidirrheal effects of $Lacteol^{TM}$-loperamide combination were compared with each individual component. $Lacteol^{TM}$-loperamide combination was the most potent among these agents, eliminating diarrhea in 100% of mice at a dose 1360/4 mg/kg (Lacteol/loperamide, respectively). In this study, we also measured changes of bodyweight as another indicator of the dirrhea, based on the assumption that lower bodyweight loss represented reduced fecal passage. The bodyweight loss of $Lacteol^{TM}$-loperamide combination administered group was 4 times lower than that of vehicle control. These findings indicate that $Lacteol^{TM}$-loperamide combination may be more potent than individual component in its antidiarrheal action, so we are going to challenge this combination for further study and clinical evaluation.

• The Journal of the Korea institute of electronic communication sciences
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• v.17 no.2
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• pp.237-244
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• 2022

We measured the clutter loss (CL) and building entry loss (BEL) of signals in a low-rise high-density suburban environment. Three propagation models for BEL, CL, and a combination of BEL and CL were measured in the selected environment. We then derived the figures when the BEL was combined with the CL. At the two frequencies, the measured value of combination of BEL and CL is 27.55 dB and 26.12dB, respectively, and the differences between the measured value and the sum were -4.19 dB and 5.82 dB. Considering that the measurement was performed inside a building, such a difference seems to be small. Therefore, when BEL and CL were measured separately and summed, and then combined and summed, differences of -4.19 dB and 5.82 dB were apparent. This this result can be referenced when similar case of a propagation model was analyzed.

• KIPS Transactions on Software and Data Engineering
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• v.9 no.2
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• pp.61-68
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• 2020

E-sports has grown steadily in recent years and has become a popular sport in the world. In this paper, we propose a win-loss prediction model of League of Legends at the start of the game. In League of Legends, the combination of a champion statistics of the team that is made through each player's selection affects the win-loss of the game. The proposed model is a deep learning model based on Bidirectional LSTM embedding which considers a combination of champion statistics for each team without any domain knowledge. Compared with other prediction models, the highest prediction accuracy of 58.07% was evaluated in the proposed model considering a combination of champion statistics for each team.

• Proceedings of the KIEE Conference
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• 2006.10d
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• pp.71-73
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• 2006

AC loss on variation of external magnetic field is a very important factor in development of power applications. In this paper, we measured and compared AC loss of hybrid-multi stacked wire made of the combination of 1G wires and 2G wires and uniform-multi-stacked wire made of one type of wires, 1G wires or 2G wires. Measurement was performed using by the linked-picked coil method. As results, as the number of wires increase, AC loss per unit volume of both stacked wires in low external magnetic field is reduced. Also AC loss of 2G slacked wire is higher than that of 1G wire. AC loss per unit length of 2G stacked wire is less than that of 1G stacked wire. And AC loss of hybrid-multi stacked wire made of the combination of 1G wires and 2G wires was between uniform-multi-stacked wire made of 1G wires and 2G wires.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.49 no.4
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• pp.208-213
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• 2023

Objectives: Orthognathic surgery is a corrective intervention for maxillofacial deformities. Bleeding is a major concern for oral and maxillofacial surgeons. Various agents, such as hemocoagulase, tranexamic acid, and aprotinin have been developed to reduce intraoperative bleeding and transfusion requirements. Therefore, in this study we aimed to investigate the effects of hemocoagulase and tranexamic acid, as well as their simultaneous use, to reduce bleeding during orthognathic surgery. Patients and Methods: This retrospective study included patients who had undergone simultaneous orthognathic surgery of the maxilla and mandible between January 2013 and September 2022 and were classified into three groups based on drugs administered: hemocoagulase (Botropase), tranexamic acid, and a combination of both drugs. We recorded patient age, sex, weight, blood loss, and duration of surgery. Red blood cell (RBC), hemoglobin, hematocrit, and platelet levels were measured before, immediately after, and one day after surgery. Results: No statistically significant differences were found in blood loss, RBC, hemoglobin, hematocrit, or platelet levels between any of the groups. There were no differences in the drug effects between Le Fort I and bilateral mandibular sagittal split osteotomies, with or without double genioplasty. However, there were significant reductions in RBC, hemoglobin, hematocrit, and platelet levels during genioplasty. Conclusion: Tranexamic acid, hemocoagulase, and their combination had similar efficacy in patients who underwent Le Fort I and bilateral mandibular sagittal split osteotomies with and without genioplasty.

• Journal of Korean Medicine for Obesity Research
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• v.18 no.1
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• pp.1-9
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• 2018

Objectives: The objective of this study was to assess the safety of 'Gamitaeeumjowee-tang' by analyzing adverse events in weight loss program in combination with 'Gamitaeeumjowee-tang' and low-calorie diet. Methods: A retrospective review of adverse events in weight loss program in combination with 'Gamitaeeumjowee-tang' and low-calorie diet from the electronic medical chart (n=124) between June 2015 and December 2016 was conducted. Three Korean Medicine Doctors (KMDs) reviewed adverse events for two times, during week 2 to 4 and at week 10, after starting weight loss program. Adverse events were evaluated in terms of causality, severity and system-organ classes. Also, agreement among the three KMDs was made through further discussion in case of disagreement after independent review. Results: The overall rate of adverse events was 37.1% during week 2 to 4 and 16.9% at week 10. For causality of adverse events using the World Health Organization-Uppsala Monitoring Centre causality categories, 52.2% were evaluated 'possible' at week 2-4 and 57.1% were evaluated 'unlikely' at week 10. All symptoms were evaluated as 'mild' by LDS scale. Nausea (15, 12.1%) was the most frequent adverse event at week 2-4 and dizziness (6, 4.8%) was the most common at week 10. Conclusions: Adverse events decreased over time. There were no serious adverse events and none of the subjects were dropped due to adverse events. Continuous study is needed to prove the safety of 'Gamitaeeumjowee-tang' for treating obesity.

• The Journal of the Acoustical Society of Korea
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• v.41 no.1
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• pp.38-44
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• 2022

Speech enhancement is performed to improve intelligibility and quality of the noise-corrupted speech. In this paper, speech enhancement performance was compared using different loss functions in time and frequency domains. This study proposes a combination of loss functions to utilize advantage of each domain by considering both the details of spectrum and the speech waveform. In our study, Scale Invariant-Source to Noise Ratio (SI-SNR) is used for the time domain loss function, and Mean Squared Error (MSE) is used for the frequency domain, which is calculated over the complex-valued spectrum and magnitude spectrum. The phase loss is obtained using the sin function. Speech enhancement result is evaluated using Source-to-Distortion Ratio (SDR), Perceptual Evaluation of Speech Quality (PESQ), and Short-Time Objective Intelligibility (STOI). In order to confirm the result of speech enhancement, resulting spectrograms are also compared. The experimental results over the TIMIT database show the highest performance when using combination of SI-SNR and magnitude loss functions.

• Proceedings of the KIEE Conference
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• 1998.07c
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• pp.1076-1078
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• 1998

This paper proposes a new approach for calculating frequency and duration by using the moment matching technique. Two separate expressions are derived, one for the loss of load expectation(LOLE) and the other for the loss of load frequency(LOLF). These expressions are combination of exponentials and are therefore easily integrable and can be readily evaluated. The proposed approach is quite comparable of with the other methods at the aspect of accuracy and efficiency.

• Herbal Formula Science
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• v.18 no.2
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• pp.167-182
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• 2010

Cervi parvum cornu (Deer Antler) and Carthami tinctorii fructus (Also known as Carthami seed) are widely used for treating osteoporosis and rheumatoid arthritis. In this study, We found out that the water extract of Cervi parvum cornu(WECPC), Carthami tinctorii fructus(WECTF) and their combination have effects of suppressing the RANKL-induced osteoclast differentiation. We assayed mRNA expression levels of NFATc1, c-Fos, TRAP and GAPDHS from bone marrow macrophages(BMMs) by means of RT-PCR. Similarly, the protein expression levels of NFATc1, c-Fos, MAPKs and $\beta$-actin in cell lysates were analyzed by means of Western blotting. then we determined the anti-osteoporotic effects of WECPC, WECTF and their combination using Lipopolysaccharide (LPS)-induced bone-loss mouse. WECPC, WECTF and their combination showed remarkable inhibition on RANKL-treated osteoclast differentiation without cytotoxicity. WECPC suppressed degradation of I-${\kappa}B$. WECPC, WECTF and their combination down-regulated the induction of c-Fos and NFATc1 by RANKL. Lastly, in vivo data showed that WECPC, WECTF and their combination rescued the bone erosion by LPS treatment. Thus, these results demonstrate that WECPC, WECTF and their combination can be efficacious remedies for bone-loss diseases such as osteoporosis and rheumatoid arthritis.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.9
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• pp.1228-1233
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• 2013

In this paper, design of Wound Rotor Synchronous Motor(WRSM) for Integrated Starter and Generator(ISG) is performed based on Finite Element Analysis(FEA). WRSM can control not only magnitude and phase of armature current, but also field current. Thus, various control methods can be considered. Since driving characteristic of WRSM depends greatly on the control method, characteristic analysis accoding to possible driving current combination is reguired. Especially in high speed region, the control method that reduces unnecessary d-axis current by reducing field current is possible, which is similar to field weakening control. By the current combination reducing field and d-axis current, the design minimizing copper loss to increase efficiency on identical driving point is possible. In this paper, high efficient WRSM is designed applying the current combination which can minimize copper loss on each driving point.