• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.591-598
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• 2012

Aim and background: MicroRNAs (miRNAs) are a class of naturally occurring small noncoding RNAs that regulate gene expression, cell growth, differentiation and apoptosis by targeting mRNAs for translational repression or cleavage. The present study was conducted to study miRNAs in Egyptian breast cancer (BC) and their relation to metastasis, tumor invasion and apoptosis in addition to their association with the ER and PR statuses. Methods: Real Time RT-PCR was performed to identify the miRNA expression level of eight miRNAs and eight metastatic-related genes in 40 breast cancer samples and their adjacent non-neoplastic tissues. The expression levels of each miRNA relative to U6 RNA were determined using the $^{2-{\Delta}}CT$ method. Also, miRNA expression profiles of the BC and their corresponding ANT were evaluated. Results: The BC patients showed an up-regulation in miRNAs (mir-155, mir-10, mir-21 and mir-373) with an upregulation in MMP2, MMp9 and VEGF genes. We found down regulation in mir-17p, mir-126, mir-335, mir-30b and also TIMP3, TMP1 and PDCD4 genes in the cancer tissue compared to the adjacent non-neoplastic tissues. Mir -10b, mir -21, mir-155 and mir373 and the metastatic genes MMP2, MMP9 and VEGF were significantly associated with an increase in tumor size (P < 0.05). No significant difference was observed between any of the studied miRNAs regarding lymph node metastasis. Mir-21 was significantly over-expressed in ER-/PR-cases. Conclusion: Specific miRNAs (mir-10, mir-21, mir-155, mir-373, mir-30b, mir-126, mir-17p, mir-335) are associated with tumor metastasis and other clinical characteristics for BC, facilitating identification of individuals who are at risk.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.49.1-49.1
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• 2013

We present a new galaxy classification scheme in the Wide-field Infrared Survey Explorer (WISE) [$3.4{\mu}m$]-[$12{\mu}m$] color versus $12{\mu}m$ luminosity diagram. In this diagram, galaxies can be classified into three groups in different evolutionary stages. Late-type galaxies are distributed linearly along "MIR star-forming sequence" identified by Hwang et al. (2012). Some early-type galaxies show another sequence at [3.4]-[12] $(AB){\simeq}-2.0$, and we call this 'MIR blue sequence'. They are quiescent systems with old stellar population older than 10 Gyr. Between the MIR star-forming sequence and the MIR blue sequence, some early- and late-type galaxies are sparsely distributed, and we call these galaxies 'MIR green cloud galaxies'. Interestingly, both MIR blue sequence galaxies and MIR green cloud ones lie on the red sequence in the optical color-magnitude diagram. However, MIR green cloud galaxies have lower stellar masses and younger stellar populations (smaller $D_n4000$) than MIR blue sequence galaxies, suggesting that MIR green cloud galaxies are in the transition stage from MIR star-forming sequence galaxies to MIR blue sequence ones. We present differences in various galaxy properties between the three MIR classes using a multi-wavelength data, combined with the WISE and Sloan Digital Sky Survey Data Release 10, of local (0.03 < z < 0.07) galaxies.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.48.1-48.1
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• 2014

We investigate the evolution of galaxies in mid-infrared (MIR) $[3.4{\mu}m]-[12{\mu}m]$ color versus $12{\mu}$ luminosity diagram using Wide-field Infrared Survey Explorer data for member galaxies of the A2199 supercluster at $z{\simeq}0.03$. In the MIR color-luminosity diagram, we classify galaxies into three MIR classes: MIR blue cloud (massive, quiescent and mostly early-type), MIR star-forming sequence (mostly late-type), and MIR green valley galaxies. Both MIR green valley galaxies and MIR blue cloud galaxies are optically red sequence populations, and there is no significant difference in star formation rates and stellar masses between them. We compare cumulative distribution functions of surface galaxy number density and of cluster/group-centric distance between three MIR classes. However, when considering only early-type galaxies, the difference between MIR blue cloud galaxies and MIR green valley galaxies disappears. In contrast, the intermediate trend of MIR green valley galaxies is still found for late-type galaxies. We discuss our results concerning the difference of evolution between early- and late-type galaxies and the connection to environment.

• Journal of the Korean Magnetics Society
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• v.8 no.1
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• pp.21-26
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• 1998

The temperature dependence of the magnetoimpedance (MI) effect is important both for scientific study and for thermal stability of MI sensor. We have performed the measurement of MI effect in amorphous $Co_{66}Fe_1Ni_1B_{14}Si_{15}$ (Metglas 2714 A) ribbon from a cryogenic chamber where the temperature of the sample can vary from 10 K to 300 K. The ac current was fixed at 10 mA for all measured frequencies ranging from 100 KHz to 10 MHz. The magnetoimpedance ratio (MIR) was revealed the drastic increment as a function of MIR (T) = MIR (0) exp(cT$^2$) where c is a constant. The measured MIR values at room temperature are usually 2-3 times larger than the data measured at 10 K for all measured frequencies. However, the shapes of the MIR curves are remained. This result shows the potential application of the MI effect for a temperature sensor. The frequency dependence of MIR has shown the typical tendency where the maximum values of MIR are increasing ans also the shapes of MIR curves are getting broader as the measured frequency increases.

• Journal of Information Processing Systems
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• v.14 no.1
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• pp.32-55
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• 2018

The digitization of music has seen a considerable increase in audience size from a few localized listeners to a wider range of global listeners. At the same time, the digitization brings the challenge of smoothly retrieving music from large databases. To deal with this challenge, many systems which support the smooth retrieval of musical data have been developed. At the computational level, a query music piece is compared with the rest of the music pieces in the database. These systems, music information retrieval (MIR systems), work for various applications such as general music retrieval, plagiarism detection, music recommendation, and musicology. This paper mainly addresses two parts of the MIR research area. First, it presents a general overview of MIR, which will examine the history of MIR, the functionality of MIR, application areas of MIR, and the components of MIR. Second, we will investigate music similarity measurement methods, where we provide a comparative analysis of state of the art methods. The scope of this paper focuses on comparative analysis of the accuracy and efficiency of a few key MIR systems. These analyses help in understanding the current and future challenges associated with the field of MIR systems and music similarity measures.

• Korean Journal of Remote Sensing
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• v.35 no.6_4
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• pp.1391-1401
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• 2019

The KOMPSAT-3A is a high-resolution optical satellite launched in 2015 by Korea Aerospace Research Institute (KARI). KOMPSAT-3A provides Panchromatic (PAN-0.55 m), Multispectral (MS-2.2 m), and Mid-wavelength infrared (MIR_OR-5.5 m) image. However, due to security or military problems, MIR_OR image with 5.5m spatial resolution are provided down sampled at 33 m spatial resolution (MIR_rd). In this study, we propose spatial sharpening method to improve the spatial resolution of MIR_rd image (33 m) using virtual High Frequency (HF) image and optimal fusion factor. Using MS image and MIR_rd image, we generated virtual high resolution (5.5 m) MIR_OR^fus image and then compared them to actual high-resolution MIR_OR image. The test results show that the proposed method merges the spatial resolution of MS image and the spectral information of MIR_rd image efficiently.

• Food Science and Biotechnology
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• v.18 no.5
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• pp.1118-1123
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• 2009

Event-specific real-time polymerase chain reaction (PCR) detection method for genetically modified (GM) maize MIR604 was developed based on integration junction sequences between the host plant genome and the integrated transgene. In this study, 2 primer pairs and probes were designed for specific amplification of 100 and 111 bp DNA fragments from the zSSIIb gene (the maize endogenous reference gene) and MIR604. The quantitative method was validated using 3 certified reference materials (CRMs) with levels of 0.1, 1, and 10% MIR604. The method was also assayed with 14 different plants and other GM maize. No amplification signal was observed in real-time PCR assays with any of the species tested other than MIR604 maize. As a result, the bias from the true value and the relative deviation for MIR604 was within the range from 0 to 9%. Precision, expressed as relative standard deviation (RSD), varied from 2.7 to 10% for MIR604. Limits of detections (LODs) of qualitative and quantitative methods were all 0.1%. These results indicated that the event-specific quantitative PCR detection system for MIR604 is accurate and useful.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4323-4326
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• 2016

Background: The cancer mortality-to-incidence ratio (MIR) has been established as an important measure of health disparities in local and global circumstances. Past work has corroborated a linkage between the colorectal cancer MIR and the World Health Organization (WHO) Health System ranking. The literature further documents many Asian countries having incomplete cancer registries and a lack of comprehensive colorectal cancer screening guidelines. Materials and Methods: The colorectal cancer MIR values for 23 Asian countries were calculated from data obtained from the 2012 GLOBOCAN database. The 2000 World Health Organization (WHO) Health System rankings were used as a proxy for health system infrastructure and responsiveness. A regression equation was calculated with the MIR as the dependent variable and the WHO Health System ranking as the independent variable. Predicted MIR values were next calculated based on the regression results. Actual MIR values that exceeded 0.20 from the predicted MIR were removed as 'divergent' points. The regression equation was then re-plotted. Goodness-of-fit for both regressions was assessed by the R-squared test. Results: Asian countries have a relatively wide colorectal cancer MIR range, from a minimum of 0.24 to a maximum of 0.86. For the full dataset, the adjusted R-squared value for this regression was 0.53. The equation was then used to calculate a predicted MIR, whereby two data points were identified as 'divergent' and removed. The adjusted R-squared for the edited dataset increased to 0.66. Conclusions: Asian countries have a marked range in their colorectal cancer MIR values and there is a strong correlationwith the WHO Health System ranking. These results corroborate the contribution of the MIR as a potentially robust tool in monitoring changes in colorectal cancer care for Asian nations.

• Journal of Microbiology and Biotechnology
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• v.31 no.10
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• pp.1331-1342
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• 2021

In this study, we evaluated the mechanism of long non-coding RNA MIR22 host gene (LncRNA MIR22HG) in osteosarcoma cells. Forty-eight paired osteosarcoma and adjacent tissues samples were collected and the bioinformatic analyses were performed. Target genes and potential binding sites of MIR22HG, microRNA (miR)-629-5p and tet methylcytosine dioxygenase 3 (TET3) were predicted by Starbase and TargetScan V7.2 and confirmed by dual-luciferase reporter assay. Cell Counting Kit-8, colony formation and flow cytometry assays were utilized to determine the viability, proliferation and apoptosis of transfected osteosarcoma cells. Pearson's analysis was introduced for the correlation analysis between MIR22HG and miR-629-5p in osteosarcoma tissue. Relative expressions of MIR22HG, miR-629-5p and TET3 were measured by quantitative real-time polymerase chain reaction or Western blot. MiR-629-5p could competitively bind with and was negatively correlated with MIR22HG, the latter of which was evidenced by the high expression of miR-629-5p and low expression of MIR22HG in osteosarcoma tissues. Overexpressed MIR22HG repressed the viability and proliferation but enhanced apoptosis of osteosarcoma cells, which was reversed by miR-629-5p upregulation. TET3 was the target gene of miR-629-5p, and the promotive effects of upregulated miR-629-5p on the viability and proliferation as well as its repressive effect on apoptosis were abrogated via overexpressed TET3. To sum up, overexpressed MIR22HG inhibits the viability and proliferation of osteosarcoma cells, which was achieved via regulation of the miR-629-5p/TET3 axis.

• 대한치주과학회:학술대회논문집
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• 2007.11a
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• pp.78-78
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• 2007