• Title/Summary/Keyword: MPEQ

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Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [11C]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5)

  • Kim, Ji Young;Son, Myung-Hee;Choi, Kihang;Baek, Du-Jong;Ko, Min Kyung;Lim, Eun Jeong;Pae, Ae Nim;Keum, Gyochang;Lee, Jae Kyun;Cho, Yong Seo;Choo, Hyunah;Lee, Youn Woo;Moon, Byung Seok;Lee, Byung Cheol;Lee, Ho-Young;Min, Sun-Joon
    • Bulletin of the Korean Chemical Society
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    • v.35 no.8
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    • pp.2304-2310
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    • 2014

  • The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [$^{11}C$]MPEQ 3 proved that accumulation of [$^{11}C$]MPEQ 3 in rat brain was correlated to the localization of the mGluR5.

  • https://doi.org/10.5012/bkcs.2014.35.8.2304 인용 PDF KSCI KPUBS HTML