• Korean Journal of Oriental Medicine
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• v.9 no.2
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• pp.121-130
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• 2003

The goal of this study is construction and efficacy evaluation of MPC-25 (Magnetic Pain Control-25), a medical device using magnetic stimulation. MPC-25 consists of a main body containing power supply and control module and a bed containing magnetic core and coil. In distinction from electric pain control medical devices, magnetic pain control system is non-contact, so the patients need not take off their clothes to be treated. High amplitude current pulses are applied to a magnetic coil and induce time varying magnetic field generating eddy current in a conductor like human body. Clinical efficacy test was performed in patients suffering from musculoskeletal pain of lumbar, shoulder and joint. Degree of pain before and after treatment for 30 minutes was compared using Visual Analogous Scale. As a result, 14 cases out of 20 showed decreased pain perception, so the rate of efficacy is 70%. Reduction of pain perception was statistically significant (P=0.001 by Wilcoxon Signed Rank Test).

• Proceedings of the KSMRM Conference
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• 2000.11a
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• pp.44-44
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• 2000

• Proceedings of the Korean Magnestics Society Conference
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• 2014.11a
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• pp.155-157
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• 2014

• Journal of the Korea Society of Computer and Information
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• v.21 no.12
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• pp.11-18
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• 2016

Magnetic resonance image (MRI) is widely used in brain research field and medical image. Especially, non-invasive brain activation acquired image technique, which is functional magnetic resonance image (fMRI) is used in brain study. In this study, we investigate brain activation occurred by LED light stimulation. For investigate of brain activation in experimental small animal, we used high magnetic field 9.4T MRI. Experimental small animal is Balb/c mouse, method of fMRI is using echo planar image (EPI). EPI method spend more less time than any other MRI method. For this reason, however, EPI data has low contrast. Due to the low contrast, image pre-processing is very hard and inaccuracy. In this study, we planned the study protocol, which is called block design in fMRI research field. The block designed has 8 LED light stimulation session and 8 rest session. All block is consist of 6 EPI images and acquired 1 slice of EPI image is 16 second. During the light session, we occurred LED light stimulation for 1 minutes 36 seconds. During the rest session, we do not occurred light stimulation and remain the light off state for 1 minutes 36 seconds. This session repeat the all over the EPI scan time, so the total spend time of EPI scan has almost 26 minutes. After acquired EPI data, we performed the analysis of this image data. In this study, we analysis of EPI data using statistical parametric map (SPM) software and performed image pre-processing such as realignment, co-registration, normalization, smoothing of EPI data. The pre-processing of fMRI data have to segmented using this software. However this method has 3 different method which is Gaussian nonparametric, warped modulate, and tissue probability map. In this study we performed the this 3 different method and compared how they can change the result of fMRI analysis results. The result of this study show that LED light stimulation was activate superior colliculus region in mouse brain. And the most higher activated value of segmentation method was using tissue probability map. this study may help to improve brain activation study using EPI and SPM analysis.

• Journal of Yeungnam Medical Science
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• v.11 no.2
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• pp.248-261
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• 1994

This study was undertaken to evaluate the clinical usefulness of magnetic motor evoked potential (MEP) in the diagnosis of stroke and predicting the motor improvement following stroke. The cortical, cervical and lumbar stimulations were performed in the case of 24 healthy controls and 24 ischemic stroke patients. The central motor conduction time (CMCT) was represented by the difference of latency to a target muscle between after transcranial stimulation and after cervical or lumbar stimulation. There was no case showing no response in controls. But in 11 out of 24 ischemic patients, we could not get cortical MEP. Mean CMCT of abductor pollicis brevis muscle was not significantly different in controls and stroke patients in whom MEPs were recorded. There were significant differences between mean CMCT of normal controls and that of stroke patients showing MEPs in AH Muscle. MEP Results from testing the stroke patients were correlated with site of lesion, degree of motor weakness and motor improvement after 1 to 2 months. These results suggest that magnetic MEP is easy and useful in electrophysiological test of central motor pathway and is useful indicator for representing the motor weakness and predicting the motor outcome in acute ischemic stroke patients.

• Journal of information and communication convergence engineering
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• v.6 no.4
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• pp.411-416
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• 2008

When compose magnetic field curer by belt and band style and need by magnetic field ripple last month, produce self-discipline roof. Bred in muscle disease (lumbago, backbone disease, corpulence) back. Result that study, manufactured various variableness band style - magnetic field probe firstly. Can establish self-discipline treatment pulse price by disease secondly. Could seek correct variableness band punishment, - magnetic field probe relationship implementation and property in waist, and so on, shoulder, neck, arm, leg, ankle, wrist etc. by third. Could find variableness band style energy value that need in-magnetic field Probe's treatment by fourth. This research could design pulse of self-discipline in band form and apply each according to disease.

• Investigative Magnetic Resonance Imaging
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• v.25 no.4
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• pp.218-228
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• 2021

Due to their high degree of freedom to transfer and acquire light, fiber optics can be used in the presence of strong magnetic fields. Hence, optical sensing and imaging based on fiber optics can be integrated with magnetic resonance imaging (MRI) diagnostic systems to acquire valuable information on biological tissues and organs based on a magnetic field. In this article, we explored the combination of MRI and optical sensing/imaging techniques by classifying them into the following topics: 1) functional near-infrared spectroscopy with functional MRI for brain studies and brain disease diagnoses, 2) integration of fiber-optic molecular imaging and optogenetic stimulation with MRI, and 3) optical therapeutic applications with an MRI guidance system. Through these investigations, we believe that a combination of MRI and optical sensing/imaging techniques can be employed as both research methods for multidisciplinary studies and clinical diagnostic/therapeutic devices.

• Journal of Radiation Protection and Research
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• v.40 no.4
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• pp.277-282
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• 2015

This study was to investigate the effects of the hot compress pack on alleviating local muscular discomfort, stiffness in limbs as well as the chronic pains such as migraine in terms of hemodynamics. In this study, the hot compress band was put on the neck and the local physiological change on the stimulation site and the cranial blood circulation change were examined. We recruited healthy volunteers (n=8, mean age: 32.13 (4.61)), who participated in the magnetic resonance imaging (MRI) study. Local skin color and temperature were measured for the local effect of the hot compress band and the changes of intra-cranial and extra-cranial blood vessels were examined with MR angiography (MRA) images. The skin temperature increased from $36.4^{\circ}C$ at the rest condition to $36.7^{\circ}C$ and $37.1^{\circ}C$ after 15 min and 30 min stimulation, respectively. The change of the extra-cranial blood vessels between pre-stimulation and post-stimulation of 30 min was significantly increased (+38.8%), while the change of the intra-cranial blood vessels was negligible. In this study, we demonstrated that the hot compress band on the neck yielded the increase of local skin temperature on the stimulation site and it made an effect on the extracranial circulation. In conclusion, the stimulation with a hot compress could facilitate the blood circulation, causing to relieve the muscular discomfort, stiffness in limbs as well as the chronic pains such as migraine.

• Investigative Magnetic Resonance Imaging
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• v.3 no.1
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• pp.47-52
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• 1999

Purpose : The purpose of this study was aimed to evaluate the BOLD(blood oxygen level dependent) contrast fMRI(functional MR imaging) in the occipital lobe and to compare with the metabolic changes based on H MRS (MR spectroscopy) and MRSI (MR spectroscopic imaging) before and after visual stimulation Materials and Methods : Healthy human volunteers (eight males and two females with 24-30 year age) participated in this study. All of the BOLD fMRI were acquired on a 1.5T MR with EPI during supervised visual stimulation in the occipital lobe. The red flicker with 8Hz was used for visual stimulation. After imaging acquisition, the MR images were transferred into unix workstation and processed with acquired from the same location based on the activation map. MRSI (magnetic resonance spectroscopic imaging) was also acquired to analyze the lactate changes before and after stimulation. Results : The activation maps were successfully produced by BOLD effect due to visual stimulation. NAA (N-acetyle aspartate)/Cr (creatine) ratio varied only from $1.79{\pm}0.28{\;}to{\;}1.88{\pm}0.20$ in activation area before and after stimulation. However, the signal intensity of lactate was elevated $9.48{\pm}4.38$ times higher than before activation. Lactate metabolite images were consistent with the activation maps. Conclusion : The BOLD contrast fMRI is enough sensitive to detect the activated area in human brain during the visual stimulation. Lactate metabolite map presents the evidence of lactate elevation on the same area of activation.

• Journal of electromagnetic engineering and science
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• v.18 no.1
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• pp.70-72
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• 2018

We propose a microwave signal generation system for brain stimulation. The existing brain stimulation system uses a signal of several tens of kHz, and the magnetic field distribution is wide. Microwave is used to locally limit the distribution of the electromagnetic field and to change the action potential of the cell with less power. The switch modulates the microwave signal to obtain a pulse envelope. The action potential of the cell can be controlled to the excitation/inhibition state by adjusting the repetition frequency. These results are confirmed by measuring the cell potential of the mouse brain.