• Title/Summary/Keyword: Medical laboratory science

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Transgene Expression of Biologically Active Human Follicle-Stimulating Hormone in Milk and Histological Analysis

  • Myoung-Ok Kim;Kil-Soo Kim;Eun-Ju Lee;Sung-Hyun Kim;Jun-Hong Park;Kyoungin-Cho;Boo-Kyung Jung;Hee-Chul Kim;Sol-ha Hwang
    • Proceedings of the KSAR Conference
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    • 2004.06a
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    • pp.214-214
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    • 2004
  • Follicle stimulating hormone (FSH) is a pituitary glycoprotein composed of two post translationally modified subunits, which must properly assemble to be biologically active. We developed a transgenic (TG) mouse model that overexpresses the human Follicle-Stimulating hormone (FSH) -subunit under the bovine -casein promoter, displaying in females an excessive levels express in mammary gland. (omitted)

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Production of Human Keratinocyte 14 Promoter Driven EC-SOD Transgenic Mice

  • Kim, Sung-Hyun;Lee, Tae-Hoon;Kim, Kil-Soo;Lee, Eun-Ju;Kim, Myoung-Ok;Park, Jun-Hong;Cho, Kyoung-In;Jung, Boo-Kyung;Kim, Hee-Chul;Hwang, Sol-Ha;Lee, Hoon-Taek;Ryoo, Zae-Young
    • Proceedings of the KSAR Conference
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    • 2004.06a
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    • pp.222-222
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    • 2004
  • Superoxide dismutases are key antioxidant enzymes in metabolism of reactive oxygen species. Three different isoforms of SOD exist in mammals. The extracellular SOD (EC-SOD) is the most recently discovered SOD family member. This isoform is a copper- and zinc-containing enzyme like Cu/Zn-SOD and a homotetrameric glycoprotein with a molecular weight of about 165 kDa in mouse. (omitted)

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Obtainment and Characterization of Brain Tumor Cell Using Vasopressin-SV40 T Ag Transgenic Mouse

  • Kim, Sung-Hyun;Lee, Eun-Ju;Kim, Myoung-Li;Park, Jun-Hong;Cho, Kyoungin;Jung, Boo-Kyung;Kim, Hee-Chul;Hwnag, Sol-Ha;Lee, Hoon-Taek;Ryoo, Zae-Young
    • Proceedings of the Korean Society of Developmental Biology Conference
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    • 2003.10a
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    • pp.105-105
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    • 2003
  • In previous reports, pVPSV.IGR2.1 transgenic mouse were described that brain tumor and lymphoma by reason of Vasopressin-SV40 T antigen. In this study, we produced pVPSV.IGR3.6 transgenic mouse that used pVPSV.IGR3.6 vector. Expression of transgene was vary different in transgenic mouse. We obtained 6 transgenic mouse line, moreover they had died at the age of 2-6 weeks without transmitting the transgene to their offspring, and had tumorigenesis on same location with pVPSV.IGR2.1 transgenic mouse. Only a founder mouse was investigated for expression of fusion gene. Here we extended this transgenic approach to the study of tumor progression. From the mouse, we confirmed brain tumor cell, after then cultured for investigate characterization. In this report, we demonstrate that reduction of survival rate in transgenic mouse fused vasopressin gene length, acquisition of brain tumor cell, composition with astrocyte cells and neuronal cells. Finally, cells had no change with increase of passage.

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A Study on the Development of Academic Classification System for Biomedical Laboratory Science (임상병리검사학의 학문분류체계 개발을 위한 연구)

  • Koo, Bon-Kyeong
    • Korean Journal of Clinical Laboratory Science
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    • v.49 no.4
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    • pp.477-488
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    • 2017
  • This study presents a discussion on the biomedical laboratory science (formally clinical laboratory science or medical laboratory science) with the identity of biomedical laboratory science, as well as the academic classification system for systematic approach. The field of biomedical laboratory science is not registered in the academic research area classification system of the National Research Foundation of Korea. Since the inception of the first department of biomedical laboratory science in 1963, about 52 departments were since established. Despite the scientific identity, biomedical laboratory science have not been acknowledged professionally in most institutions. Observing the academic research area classification, the physical therapy, occupational therapy, and dental hygiene science are systematically classified and approved the identities by the authorities. This study is freshly academic area classification system of the biomedical laboratory science. The contents of this study are summarized as follows. The medical laboratory technologist's discipline is considered within the medical and science category, clinical pathology in class, and biomedical laboratory science in division. Sections of biomedical laboratory science include hematology, transfusionology, immunology, biochemistry, microbiology, parasitology, science, molecular biology, histology, cytology, cardiopulmonary physiology, and neurophysiology.

Produce a Novel Breast Cancer Disease Model with Test-off System

  • Park, Jun-Hong;Lee, Eun-Ju;Kim, Myoung-Ok;Kim, Sung-Hyun;Park, Jung-Ok;Cho, Kyong-In;Park, Hum-Dai;Ryoo, Zae-Young
    • Proceedings of the KSAR Conference
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    • 2002.06a
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    • pp.93-93
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    • 2002
  • The utility of transgenic animal for studying the function of a particular gene in the breast system has been limited because transgenic typically occurs constitutively throughout development and in most tissue. So we use the inducible gene expression system. Several inducible gene expression system have been developed in vitro in recent years to overcome limitation with transgenic mice. (omitted)

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Evidance that Two Mouse Deafness Mutation, Cir and Sr, are Allelic

  • Cho, Kyung-In;Lee, Eun-Ju;Kim, Myoung-Ok;Kim, Sung-Hyun;Park, Jun-Hong;Park, Jung-Ok;Ryoo, Zae-Young
    • Proceedings of the KSAR Conference
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    • 2002.06a
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    • pp.68-68
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    • 2002
  • Positional cloning of hereditary deafness genes is a direct approach to identify molecules and mechanisms underlying auditory function. Nowadays many deafness genes are newly identified by finding the locus for the causative genes. Mutations at many different loci in humans and mice are known to cause hearing impairment. Mouse mutants exhibiting deafness may be useful in identifying some of genes involved. (omitted)

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