• 한국산학기술학회논문지
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• 제18권2호
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• pp.398-404
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• 2017

본 연구의 목적은 노인 여성의 약화된 천장관절 안정화를 위하여 비탄력 고정식 벨트를 적용하여 균형 능력과 낙상예방에 미치는 영향을 알아보고자 하였다. 노인 여성들은 출산과 폐경으로 천장관절의 약화 및 골반 주위근육들의 약화로 인하여 균형능력의 감소와 낙상위험률이 증가된다. 그러나 이와 관련된 연구는 불충분하다. 연구 대상자들은 실험군과 대조군으로 각각 20명씩 무작위로 배정하였으며, 비탄력 고정식 벨트를 실험군에게 적용한 후 균형 측정기를 사용하여 균형능력과 낙상 위험률을 평가하였다. 또한 비탄력 고정식 벨트를 적용한 실험군에서 하복부근육의 근두께를 초음파기기를 사용하여 실험 전후에 측정하였다. 통계방법은 연구대상자의 일반적 특성을 위하여 독립 t-검정, 균형 및 낙상지수를 위하여 $2{\times}2$ 반복 측정 분산분석 및 근두께를 위하여 짝비교 t-검정을 사용하였다. 두 그룹의 교호작용 효과는 안정성 지수(F1,38=47.24, p=0.001), 퓨리에 지수(F1,38=88.83, p=0.001), 체중분포 지수(F1,38=50.21, p=0.001) 및 낙상 지수(F1,38=21.59, p=0.001)에서 모두 통계적으로 유의하게 나타났다. 또한 비탄력 고정식 벨트를 적용한 결과 실험 후 복횡근(p=0.001)과 내복사근(p=0.001)의 근두께는 통계적으로 유의하게 증가하였다. 노인 여성들의 약화된 천장관절의 강화 및 안정화 방법으로 비탄력 고정식 벨트는 균형 및 낙상 예방에 긍정적이며 용이성, 보편성 및 경제적으로 효과적임을 알 수 있었다.

• 생약학회지
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• 제46권2호
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• pp.167-172
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• 2015

Aleurone layer of Black rice (Oryza sativa L.) is enriched with anthocyanin that could increase bone density. This study was conducted to investigate the osteoporosis-preventing effects of the aleurone layer extract (BRE) on bone loss of ovariectomized (OVX) rats. OVX (or sham-operated) rats were assigned to three groups (n=8 per group): sham operated group (Sham); OVX control group (OVX); OVX-BRE group, OVX rats treated with BRE at 90 mg/kg B.W. The deionized water alone or deionized water with BRE was orally administrated to Sham, OVX or OVX-BRE groups, respectively for 12 weeks. High fat diet with 45 kcal% fat and water were fed to all rats ad libitum. Body weight was significantly decreased in the OVXBRE group compared to the OVX group (p<0.05). The bone mineral density and bone length of tibia were significantly higher in the OVX-BRE group compared to the OVX group and breaking force was significantly higher for the both tibia and femur bones. Serum estradiol concentration and calcium concentration of femur were higher in the OVX-BRE group than those of OVX group. However, serum alkaline phosphatase activity and parathyroid hormone concentration were decreased in the OVXBRE group compared to the OVX group. The results suggest that aleurone layer of Black rice is a potentially useful ingredient to protect against estrogen deficiency or menopause related osteoporosis.

• Journal of Preventive Medicine and Public Health
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• 제43권3호
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• pp.213-221
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• 2010

Objectives: Plasma lipid profiles and Apolipoprotein E (ApoE) are established risk factors for cardiovascular disease (CVD). The knowledge of lipid profile may estimate the potential victims of cardiovascular disease before its initiation and progression and offers the opportunity for primary prevention. The most common ApoE polymorphism has been found to influence plasma lipid concentrations and its correlation with CVD has been extensively investigated in the last decade. Methods: The ApoE polymorphism and its influence on plasma lipid were investigated in healthy woman workers. The information on confounding factors was obtained through a self-administered questionnaire and ApoE polymorphism was investigated using PCR. Results: The relative frequencies of alleles E2, E3 and E4 for the study population (n = 305) were 0.127, 0.750 and 0.121, respectively. ApoE polymorphism was associated with variations in plasma HDL-cholesterol lipid profile. In order to estimate the independent effects of alleles E2 and E4, as compared with E3, on lipid profile, multiple regression was performed after adjustment for confounding variables such as age, BMI, blood pressure, education status, insulin, fasting glucose, HOMA-IR, menopause. ApoE2 had a negative association with HDL cholesterol and ApoE4 had a positive association with LDL cholesterol. Conclusions: This study identified that the ApoE and CVD risk factors contribute to the lipid profiles, similar to other studies. The analysis including dietary intake and other gene in further studies may help to identify clear effects on lipid profiles as risk factor for CVD.

• Clinical and Experimental Reproductive Medicine
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• 제24권2호
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• pp.167-177
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• 1997

Oocyte donation program developed to reach the pregnancy in those patients suffering from premature ovarian failure or surgery induced menopause, particularly in their reproductive age. With technical advances and popularity of ART (assisted reproductive technology), the indication of oocyte donation program extended to low responders, and even to naturally menopaused patients that has led them quite successfully to getting in pregnancy. The purpose of this study was to evaluate which one is involved in the decline of fertility between the oocyte and uterine factor. One hundred five cycles of oocyte donation program were performed in 84 patients from Jan., 1993 to Dec., 1996. Oocytes were donated from healthy, young, fertile anonymous donors or relatives or infertile patients with supernumerary oocytes. The study population was divided into 3 groups according to the age of recipients. Group 1 was less than 35 years old, Group 2 was between 35 to 39 years old, and Group 3 was more than 39 years old. The results were as follows: The mean age of oocyte donor was $31.5{\pm}3.3$ (range; 25-36). The mean concentration of basal serum FSH and peak serum estradiol were not different among groups. The mean number of oocytes retrieved from donors, embryos transferred to recipients, and fertilization rate were not different among groups. The clinical pregnancy rate was 37.3% in Group 1, 31.6% in Group 2, and 31.6% in Group 3, respectively. The spontaneous abortion rate was 16.0% in Group 1, 16.7% in Group 2, and 16.7 in Group 3, respectively. The multiple pregnancy rate was 20.0% in Group 1, 16.7% in Group 2, 16,7% in Group 3, respectively, The implantation rate was 11.3% in Group 1, 10.3% in Group 2 and 10.0% in Group 3, respectively. All of the pregnancy outcomes were not different statistically among groups. In conclusion, endometrial receptivity does not seem to be impaired as age increases with transfer of good quality embryos and adequate endometrial preparation.

• 대한한방부인과학회지
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• 제25권4호
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• pp.1-11
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• 2012

Objectives: Osteoporosis, which occurs after menopause, is a kind of metabolic bone disorder. It develops when the bone mass begins to decrease radically, and its main symptoms are bone fracture and height-shortening. This thesis aims at what effects the Cuscutae Semen Extract(CSE) has on the prevention of osteoporosis in SD-rat that is caused by ovariectomy. Methods: The 24 female white rats, after removing their ovaries, were divided into the Normals, the Control group, and the CSE administrated group. For the next 8 weeks, distilled water to the normals and the control, and the CSE(45.9 mg/100 g) to the CSE administrated group were given in the mouths of them. After 8 weeks the rats were sacrificed. Weight, albumin, aspartate aminotransferase, alanine aminotransferase, total-cholesterol, triglyceride, phosphorus, calcium, tetraiodothyronine, estradiol, the weight of the femur, the amount of tibia ash, the area of trabecular bone, and the thickness of trabecular bone were measured. Results: The serum analysis shows that the calcium and phosphorous of the CSE administrated group significantly increased compared to that of the control group. Aspartate aminotransferase, alkalinephosphatase, total cholesterol, tetraiodothyronine of CSE group were decreased, but not so significant. Albumin, alanine aminotransferase, triglyceride and estradiol of the group showed the tendency to increase, but the significance wasn't admitted. Regarding the variation of bone, the femur weight and the ash content of tibia, CSE group was more increased than the control group but the significance wasn't admitted. The histological observation shows that the trabecular thickness was more increased than the control group, and trabecular area increased significantly compared to those of the control group. The number of osteoclast and osteoblast area of the CSE groups decreased significantly compared to those of the control group. Conclusions: From the result of the above study, CSE should be effective for the osteoporosis cure and precaution and deeper study through bedside and clinical demonstration is much needed from now on.

• 한국임상약학회지
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• 제31권3호
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• pp.180-187
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• 2021

Objective: We investigated arthralgia and myalgia associated with the use of oral bisphosphonate (BP) by conducting a survey of patient. Methods: The pharmacists conducted a survey between 1 Oct 2019 and 30 Sep 2020 among patients who were dispensed BP in community pharmacies to assess their demographic and medical characteristics, and their experiences with, and process for pain. Logistic regression analyses were performed to find the risk factors associated with the pain, and the odds ratios (OR) and 95% confidence intervals (CI) were determined. Results: A total of 160 patients who used BP participated in the survey (74 [46.3%] used risedronate; 61 [38.1%] used alendronate; 23 [14.4%] used ibandronate), and 20 (12.5%) of them experienced pain. Significant statistical differences of the characteristics between patients who experienced pain or not were observed regarding menopause, and parity. Compared with women who had one or two parity, women who had more than three parity were associated with the decreased risk of pain (OR, 0.24; 95% CI, 0.04-0.98). Moreover, steady exercise was associated with the decreased risk of pain compared to less exercise (OR, 0.37; 95% CI, 0.14-0.98). Conclusion: Our findings suggest that the risk of pain in BP-treated patients might be different regarding the different ingredients of BP, and dosing frequency. This survey highlights a need for a further safety research to understand the factors influencing the pain associated with the BP treatment.

• 한국융합학회논문지
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• 제10권2호
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• pp.339-347
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• 2019

본 연구는 G시에 소재한 D와 S 조선소에 근무하는 폐경 후기 여성 근로자 268명을 대상으로 2017년 11월 1일부터 11월 30일까지 설문조사를 실시하였다. 심뇌혈관질환 발병 위험인자 유무에 따라 심뇌혈관질환 발병 위험군과 건강군으로 분류하여 이들 두 군 간의 일반적 특성, 심뇌혈관질환 예방관련 지식, 태도, 건강행위 이행 정도 및 관계를 비교 분석하였다. 건강군과 발병 위험군에서 통계적으로 유의한 차이가 있었던 변수는 연령(F=92.239, p<.001), 동거유형($x^2=20.056$, p<.001), 소득수준($x^2=39.023$, p<.001), 주당 근무시간(F=32.217, p<.001), 근무년수(F=12.310, p=.001), 심뇌혈관질환 가족력($x^2=233.442$, p<.001), 주관적 건강상태($x^2=19.058$, p=.001)였다. 두 군에서 심뇌혈관질환 예방관련 지식 정도(F=2.679, p=.008)와 건강행위 이행 정도(F=4.339, p<.001)가 유의한 차이가 있었다. 심뇌혈관질환 예방관련 건강행위 이행 정도의 관계에서 건강군은 지식이 정적 상관관계를 보였고(r=.348, p<.001), 발병 위험군은 지식(r=.279, p=.002)과 태도(r=.194, p=.030)가 정적 상관관계를 보였다. 이를 바탕으로 심뇌혈관질환 발병에 취약한 집단의 특성을 고려한 중재 프로그램의 개발 및 적용이 필요할 것으로 사료된다.

• 대한한방부인과학회지
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• 제32권2호
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• pp.29-49
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• 2019

Objectives: This study was a methodological study to verify the reliability and validity and to make a diagnosis of a diagnostic tool for climacteric and postmenopausal syndrome pattern identification (CaPSPI). Methods: This study was conducted from June 1, 2018 to October 18, 2018 with ${{\bigcirc}{\bigcirc}}$ University Korean Medicine Hospital IRB's approval (2018-3). To make a diagnosis using CaPSPI, we decided the cut-points for the tool. Three professors of ${{\bigcirc}{\bigcirc}}$Korean Medical University conducted pattern identification diagnosis. The result is marked from 0 to 3, 0 is 'No', 1 is 'Slightly Yes', 2 is 'Yes' and 3 is 'Very Yes'. And if two or more professors' diagnoses are the same, we took the diagnoses as a diagnostic criteria. The decision of pattern by three experts converted to 0-1 scores in two ways. In "method 1", if the diagnosis was zero points, the score was 0 (have no such identification), and the rest was 1 (have such identification). In "method 2", if the diagnosis was zero or 1 point, the score was 0, and the rest was 1. After that, intraclass correlation was calculated for experts agreement. And logistic regression was conducted. A response variable was the results of the experts' diagnosis and an explanatory variable was the results of the pattern identification diagnostic tool. Results: The diagnosis of the three experts showed excellent concordance of more than 0.794 and showed a significant correlation with the diagnostic tool. Both 'Method 1' and 'Method 2' showed statistically significant effects with the diagnosis of 3 experts and the results of the diagnostic tool. The frequency of cumulative pattern identification diagnosis in 'Method 1' and 'Method 2' were found to be 578 occasions and 203 occasions, respectively. The average number of pattern held by participants in 'Method 1' and 'Method 2' were found to be 5.26 and 1.85, respectively. In both "Method 1" and "Method 2," the yield frequency of liver qi depression was the highest, and the frequency of kidney yin deficiency and liver-kidney yin deficiency was relatively high. Conclusions: Based on the above results, it is thought that, in diagnosis using CaPSPI of menopausal women, 'method 1' could be used for the health diagnosis and prevention, 'method 2' could be used for the pattern diagnosis. On the conclusion, CaPSPI is thought to be available for pattern diagnosis of menopause women.

• 산업진흥연구
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• 제6권3호
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• pp.25-35
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• 2021

중년여성은 갱년기와 노화, 과다한 역할로 인해 다양한 심리적·신체적 스트레스로 긴장을 경험하며, 이것이 수면장애로 이어지는 경우가 많다. 그러나 이와 연관된 연구는 미비한 실정이다. 이에 수면장애를 경험하는 중년여성이 건강을 도모할 수 있도록 긴장이완을 돕는 싱잉볼의 효과성에 대한 연구 필요성이 제기된다. 이에 본 연구는 2019년 2월부터 2020년 4월까지 수면장애의 어려움을 호소하는 중년여성 중 피츠버그 수면의 질 평가 측정점수가 5점 이상인 4명을 선정하여 싱잉볼 체험을 40분 실시하고 심층 인터뷰 내용을 토대로 한 Giorgi의 현상학적 연구방법으로 진행하였다. 본 연구의 결과를 토대로 도출한 결론은 다음과 같다. 연구 결과 참여자들의 싱잉볼 체험을 통해 518개의 구성의미와 15개의 의미단위, 7개의 하위요소, 2개의 주제군을 도출해 내었다. 첫째, 싱잉볼 경험 시 신체적 경험으로는 통증과 이완 경험, 심리적 경험으로는 마음이완과 긍정심리 경험, 심상적 경험으로는 이미지와 색깔 경험을 하였다. 둘째, 싱잉볼 경험 이후 연구 참여자들이 느낀 신체적 변화는 신체이완, 신체증상, 신체활력 증가였으며 심리적 변화는 불안감소, 유쾌함과 긍정심리 증가였다. 행동적 변화는 행동 느긋해짐, 활동량의 증가였고 수면변화로 인한 수면개선의 효과가 두드러지게 나타났다. 본 연구에서 싱잉볼은 수면장애를 경험하는 중년여성의 긴장이완에 심리적·신체적으로 긍정적인 효과가 있음을 확인하였고, 스트레스와 긴장으로 인한 수면장애로 고통 받는 중년여성들과 현대인들에게 유용한 도구인 싱잉볼을 활용하여 양질의 삶을 살아가도록 돕는데 그 의의를 둔다.

• 한국식품영양학회지
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• 제33권6호
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• pp.655-665
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• 2020

In this study, chemical information on a total of 20 individual compounds was constructed to identify isoflavones from the previous reports related with used parts(seeds, leaves, stems, pods) and products of soybean(Glycine max L.). Through constructed library and UPLC-DAD-QToF/MS analysis, a total of 19 individual isoflavones including aglycones, glucosides, acetylglucosides and malonylglucosides as major compounds was identified and quantified from 14 selected soybean seeds. Among them, genistein 7-O-(2"-O-apiosyl)glucoside and genistein 7-O-(6"-O-apiosyl)glucoside(ambocin) were identified tentatively as novel compounds in soybean seeds. Besides, among malonylglucosides, glycitein 4'-O-(6"-O-malonyl)glucoside was estimated for the first time. Total isoflavone contents were distributed from 240.21 to 445.21(mg/100 g, dry matter) and 7-O-6"-O-malonylglucosides were composed of 77.8% on total isoflavone as well as genistein derivatives were confirmed as major class. It was considered importantly that the development of isoflavone-rich varieties was necessary to strengthen their effects such as anti-inflammation, anti-cancer and menopause mitigation. The qualitative and quantitative data presented precisely in this study could be help to select and breed isoflavone-rich varieties. Furthermore, their basic isoflavone profile is expected to be applied to estimate the change of isoflavone conjugates on bioavailability after soy food supplements.