• Health Policy and Management
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• v.29 no.1
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• pp.19-26
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• 2019

Background: The purpose of this study was to evaluate the effectiveness and the level of self-management support on the Metabolic Syndrome Management Program at public health centers in Seoul metropolitan city. Methods: The effectiveness on the Metabolic Syndrome Management Program were analyzed using secondary data from 1,312 community residents who were receiving program. The level of self-management support on Metabolic Syndrome Management Program was evaluated using an 'Assessment of Primary Care Resources and Supports for Chronic Disease Self-Management' from four public health centers. Results: The effectiveness on the Metabolic Syndrome Management Program was showed that decreased smoking (p= 0.044) and drinking (p< 0.001), and increased healthy dietary habit (p< 0.001) in health behaviors. It was showed that decreased triglyceride (p= 0.002) and increased high-density lipoprotein cholesterol (p< 0.001) in clinical indicators. The level of self-management support on Metabolic Syndrome Management Program was 98.1 points and it meaned that implementation is done in an organized and consistent manner using a team approach. There was difference in the level of self-management support by public health centers (p= 0.003). Conclusion: The Metabolic Syndrome Management Program in public health centers was effective, and level of self-management support was done as organizational level, but patient input and mental health were insufficient.

• Korean Journal of Clinical Laboratory Science
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• v.44 no.2
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• pp.86-96
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• 2012

The high sensitivity C-reactive protein (hs-CRP) as one of the typical acute phase reactants is used for predictive factor of the cardiovascular disease and diabetes mellitus. In addition, there are claims that must be included as factors of metabolic syndrome. This research examined the relationship between the concentration of hs-CRP in blood and risk factors of the metabolic syndrome by gender, and the rates of metabolic syndrome depending on the hs-CRP level based on the general public who took the comprehensive medical check-up at Chonbuk National University Hospital in the Jeonbuk province. The subjects aged 17-87 years were participated, and 2,000 people were included as the final subjects except the persons with more than 10 mg/L of the hs-CRP of blood level. The hs-CRP concentrations increased according to the number of risk factors of metabolic syndrome in both men and women. In regards to the risk ratio of metabolic syndrome based on hs-CRP level in blood according to gender, the risk ratio increased by 3.07 times in male and 4.55 times in female intermediate risk group and 3.60 times in male and 6.15 times in female high risk group compared to hs-CRP low risk group. As a result, there was a proportional relation between hs-CRP level and the occurrence of metabolic syndrome, and it occurs more frequently among women than men.

• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.5
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• pp.425-431
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• 2005

The systems-level analysis of microbes with myriad of heterologous data generated by omics technologies has been applied to improve our understanding of cellular function and physiology and consequently to enhance production of various bioproducts. At the heart of this revolution resides in silico genome-scale metabolic model, In order to fully exploit the power of genome-scale model, a systematic approach employing user-friendly software is required. Metabolic flux analysis of genome-scale metabolic network is becoming widely employed to quantify the flux distribution and validate model-driven hypotheses. Here we describe the development of an upgraded MetaFluxNet which allows (1) construction of metabolic models connected to metabolic databases, (2) calculation of fluxes by metabolic flux analysis, (3) comparative flux analysis with flux-profile visualization, (4) the use of metabolic flux analysis markup language to enable models to be exchanged efficiently, and (5) the exporting of data from constraints-based flux analysis into various formats. MetaFluxNet also allows cellular physiology to be predicted and strategies for strain improvement to be developed from genome-based information on flux distributions. This integrated software environment promises to enhance our understanding on metabolic network at a whole organism level and to establish novel strategies for improving the properties of organisms for various biotechnological applications.

• Korean Journal of Health Education and Promotion
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• v.30 no.1
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• pp.83-93
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• 2013

Objectives: The objective of this study was to assess the gender differences in the relationship between alcohol use behaviors and the risk of metabolic syndrome among Korean adult population. Methods: Data from the Korean National Health and Nutrition Examination Survey (5th, 2010) was analyzed. Using the Alcohol Use Disorders Identification Test, subjects were classified into 4 groups including non-drinking, low-risk drinking, medium-level alcohol problem, and high-level alcohol problem group. Metabolic syndrome and its components were compared among the alcohol behavior groups by gender. Results: The odds ratio vs. non-drinking group for metabolic syndrome was significantly higher in male medium and high-level alcohol problem group. In female, high-level alcohol problem group showed significantly higher odds ratio for metabolic syndrome. Blood pressure and HDL-cholesterol were likely to be higher with the excessive drinking behaviors in both men and woman. Triglyceride level in men was significantly higher in the medium and high-level alcohol problem group than non-drinking group. Although fasting glucose level did not show differences among drinking groups, the odd ratios vs. non-drinking group for the hyperglycemia (${\geq}$ 100mg/dl) were significantly higher in female drinking groups. Conclusions: Problematic alcohol drinking is likely to increase the risk of metabolic syndrome in Korean adults.

• BMB Reports
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• v.49 no.7
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• pp.388-393
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• 2016

Although brown adipose tissue is important with regard to energy balance, the molecular mechanism of brown adipocyte differentiation has not been extensively studied. Specifically, regulation factors at the level of protein modification are largely unknown. In this study, we examine the changes in the expression level of enzymes which are involved in protein lysine methylation during brown adipocyte differentiation. Several enzymes, in this case SUV420H2, PRDM9, MLL3 and JHDM1D, were found to be up-regulated. On the other hand, Set7/9 was significantly down-regulated. In the case of SUV420H2, the expression level increased sharply during brown adipocyte differentiation, whereas the expression of SUV420H2 was marginally enhanced during the white adipocyte differentiation. The knock-down of SUV420H2 caused the suppression of brown adipocyte differentiation, as compared to a scrambled control. These results suggest that SUV420H2, a methyltransferase, is involved in brown adipocyte differentiation, and that the methylation of protein lysine is important in brown adipocyte differentiation.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.10 no.2
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• pp.171-180
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• 2003

Purpose: The purpose of this study was to investigate the relationship of self-efficacy, knowledge about the disease, and self-care behavior to the metabolic level in patients with NIDDM. Method: Data were collected from March 15 to April 15, 2001. Participants in the study were 48 patients with NIDDM who were seen regularly at the endocrinology out-patient department of Gwangju Christian Hospital. The data were collected through individual interviews and patient blood samples. The data were analyzed with SPSS/PC+, using t-test, ANOVA, Pearson correlation coefficients and Cronbach's Alpha. Result: 1. The mean score for self-efficacy was $71.37{\pm}15.56$, knowledge $15.00{\pm}2.84$, self-care behavior $63.18{\pm}13.10$. The mean score for HbAlc level was $7.66{\pm}1.77%$, HDL cholesterol level, $46.22{\pm}13.04 mg/dl$ and total cholesterol level, $187.93{\pm}41.45 mg/dl$. 2. There was a significant difference between patients with a spouse and those without one (t=-2.08, p=0.042), in knowledge according to level of obesity (t=5.14, p=0.010), duration of illness (t=3.22, p=0.031) and presence of complications related to diabetes (t=-2.58, p= 0.013). There were no significant differences in self-care behavior, but there were significant differences in sugar metabolic level according to sex (t=-2.02, p=0.050). 3. The correlation between diabetic patients' self-efficacy, knowledge and self-care behaviour and metabolic control was significantly related only to self-efficacy and self-care behavior (r=.692, p=0.000). Conclusion: It is necessary to improve self-efficacy, knowledge, and self-care behavior for patients with NIDDM by using nursing intervention programs to promote and maintain metabolic control.

• Journal of Korean Biological Nursing Science
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• v.13 no.2
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• pp.134-141
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• 2011

Purpose: Although the risk factors of metabolic syndrome have been extensively studied, the association between osteoporosis and metabolic syndrome has remained unclear in Korean elderly women. Yet to be determined are the effect of risk factors of metabolic syndrome on osteoporosis in these subjects. The purpose of this study was to investigate how the risk factors of metabolic syndrome affect the bone mineral density in Korean elderly women. Methods: One hundred twenty one elderly women from a community center in Seoul elderly welfare center participated in this study. A structured questionnare was used to assess their demographics and lifestyles. Participants' anthropometric information was also obtained by measuring heights, weights, and waist circumferences. The blood samples were also obtained to measure blood glucoses and blood lipids. Bone mineral density was measured with the use of ultra sono. Results: The prevalence of metabolic syndrome in our subjects was 58%. In multivariate regression analysis, fasting plasma glucose level (p=.036) and triglycerides (p=.006) were significant factors predicting bone mineral density after adjusting age and other factors of metabolic syndrome. In age-adjusted analysis, women with metabolic syndrome had significantly higher bone mineral density as compared to those without metabolic syndrome (p=.026). Conclusion: Bone mineral density among elderly Korean women is associated with the level of blood glucose and triglycerides.

• Korean Journal of Health Education and Promotion
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• v.29 no.5
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• pp.61-75
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• 2012

Objectives: A great number of the elderly are not aware of having metabolic syndrome, and this pattern differs among regions of the nation. This issue is particularly important for the elderly people with chronic diseases. This study was conducted in order to identify the prevalence, predicting factors of perception and exercise behaviors of among the elderly population. Methods: Using data from the 2009 Korean Community Health Survey, we employed two-level logistic regression models to determine whether individual and community factors are associated with perception and exercise behaviors among the elderly population. Results: Results from weighted two-level logistic regression analyses indicated the individual-level factors of smoking, education level, health center education, community exercise program participation and unmet needs in men, and marital status (being separated), health center education women predicted the elders' perception. As for the community-level predictors, higher smoking and living in regions with high suicide rates significantly predicted the elders' perception and exercise behaviors of metabolic syndrome. Conclusions: These findings demonstrate that education according to stage would increase the perception and motivation toward healthier behavior particularly for the elderly with lower perception levels of metabolic syndrome.

• Journal of Sasang Constitutional Medicine
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• v.21 no.3
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• pp.122-130
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• 2009

1. Objectives: The objective of this study is to investigate the relationship between adiponectin and metabolic syndrome according to Sasang Constitution. 2. Methods: Six hundred sixty six participants were included in this cohort study. Sex, age, BMI(Body Mass Index), smoking, drinking, adiponectin level and Metabolic syndrome components were considerd. Sasang constitutional diagnosis was carried out by a sasang constitutional specialist using photos, questionnaires and PSSC(Phonetic System for Sasang Classification). 3. Results: In binary logistic analysis after adjustment of age, sex, BMI, smoking, drinking, adiponectin level and sasang constitution were related with Metabolic syndrome. 4. Conclusions: We suggest that adiponectin and sasang constitution are the important biomarker in Metabolic syndorme.

• Journal of Korean society of Dental Hygiene
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• v.12 no.3
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• pp.597-609
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• 2012

Objectives : The purpose of this study was to determine the influence of workers health behaviorals, oral health behaviorals and metabolic syndrome risk factors on oral health and to identify the relationship between these. and then, a basis data propose for integrative health promotion programs development and effective Management measures. Methods : The subjects were 4,600 workers working at a industrial place in North Gyeongsang Province, data were collected from July 13, 2010 to September 12, 2010. using the results of the subjects medical check-ups and Oral examinations, this study was performed. collected data included workers general characteristics, job characteristics, and smoking, drinking, exercise behavior as lifestyle factors, and waist measurement, fasting blood sugar level, systolic blood pressure, diastolic blood pressure, the level of Triglyceride and HDL-cholesterol as metabolic syndrome risk factor indicator. Data were analyzed by descriptive statistics, chi-square test, correlation analysis, logistic regression using SPSS 18.0. Results : In results of the subjects medical check-ups, 14.1% were above the criterion value of waist measurement, 2.5% fasting blood sugar level, 8.5% hypertension, 16.8% Triglyceride level and 4.0% HDL-cholesterol respectively. according to oral examination results, showing that 43.3% inflammation of the gums. The inflammation of the gums was correlated with gender, age, dental clinic visit, scaling management, smoking, exercise behavior and high triglyceride level and hypertension of metabolic syndrome risk factor indicators. In addition, this result was statistically significant. Conclusions : Based on this study, the workers health should be managed actively and effectively by using periodical workers health check-ups. At a corporate level, the institutional supports were achieved and arranged for activation of regular oral health education programs, and the prevention plan of metabolic syndrome were needed for changing exercise behavior by conducting suitable exercise programs.