• 한국융합학회논문지
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• 제9권8호
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• pp.355-363
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• 2018

본 연구 내용 및 방법은 한국과 미국의 MICE 산업 활성화 정책을 비교, 분석하고 MICE 산업의 세계적 추세와 관련 전문가의견을 내용 분석한 것이다. 이를 통해 향후 우리나라 MICE 산업 발전을 위한 정책방향을 다음과 같이 제시하였다. 미국은 우리나라에 비해 MICE 인프라 규모와 구성 면에서 비교우위를 점하고 있으나, 우리나라는 K-시리즈를 활용한 융 복합 콘텐츠(스토리)를 활용한 MICE 상품개발 전략, 색다른 경험을 제공하는 유니크 베뉴(Unique Venue) 개발과 명소화 정책, 가족 중심적이고 참여자 간 교류 중심적인 MICE 환경 조성, 재미와 엔터테인먼트 요소 강화, '그린 MICE' 정책 강화 및 우리나라의 우수한 의료기술을 활용한 의료관광과 MICE 상품의 연계 등 MICE 산업 활성화 방안을 제시하였다. 이는 향후 우리나라 MICE 산업 발전 정책 수립을 위한 전략적 기반을 제공할 것이다.

• 정보관리연구
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• 제41권1호
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• pp.127-144
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• 2010

최근에 MICE산업에서의 정보공동활용의 중요성이 증가하고 있다. 그러나 MICE산업 전체가 정보제공에 합의할 수 있는 해결책을 제공하는 것은 매우 어려운 상황이다. 따라서 본 연구에서는 MICE 산업에서의 정보공유과정에서 나타나는 주요 문제점들을 분석하고 근거이론에 기초하여 국내 MICE산업에서 연구되지 않았던 패러다임 모델을 개발하고 MICE 정보공유체계의 세부구성안을 제시하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제18권2호
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• pp.183-190
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• 2014

This project's aim was to determine the reserpine-induced gastric ulcer preventive effect of polysaccharide of Larimichthys crocea swim bladder (PLCSB) in ICR mice. The anti-gastric ulcer effects of polysaccharide of Larimichthys crocea swim bladder was evaluated in mice model using morphological test, serum levels assay, cytokine levels assay, tissue contents analysis, reverse transcription-polymerase chain reaction (RT-PCR) analysis and western bolt assay. High concentration (50 mg/kg dose) of PLCSB reduced IFN-${\gamma}$ as compared to low concentration (25 mg/kg dose) and control mice. SS and VIP serum levels of PLCSB treated mice were higher than those of control mice, and MOT and SP serum levels were lower than control mice. Gastric ulcer inhibitory index of PLCSB treatment groups mice were much lower than control mice, and the high concentration treated mice were similar to the ranitidine treated mice. The SOD and GSH-Px activities of PLCSB treated mice were higher than control mice, close to normal mice and ranitidine treated mice. PLCSB treated mice also showed the similar contents of NO and MDA to normal group. By RT-PCR and western blot assay, PLCSB significantly induced inflammation in tissues of mice by downregulating NF-${\kappa}B$, iNOS, and COX-2, and upregulating $I{\kappa}B-{\alpha}$. These results suggest that PLCSB showed a good gastric ulcer preventive effect as the gastric ulcer drug of ranitidine. Polysaccharide of Larimichthys crocea swim bladder may be used as a drug material from marine products.

• 한국가축번식학회지
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• 제14권3호
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• pp.191-197
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• 1990

The transgenic mice were produced by microinjection of human growth hormone gene fused with mouse metallothionein Ⅰ promoter. They were mated with momal mice by backcross or brother-sister mating. The reproduction efficiencies of female and male n the FO transgenic mice were 17.6%(3/17 mice) and 31.2%(5/16 mice), respectively, and were very lower than that in normal mice(85.7% and 100%, respectively). Interestingly, a few of female transgenic mice were fertile which was different from the previous reports. Of 6 fertile transgenic mice, 2 mice were identified as mosaic type by the reduced frequency of genetic transmission to successive generation below Mendelian levle and the enhanced copy numbers of transgene in progeny mice compared with the transgenic parent. In the group of F1, F2, F3 transgenic mice the reproduction efficiencies of males were gradually improved, whereas females were absolutely infertile. It was consequently shown that the transgenic mice expressing human growth hormone gene were frequently infertile, but the genotypic and phenotypic characteristics of the fertile transgenic mice were normally passed on to the progeny through herm line. Therefore it must be considered wheter or not the products of foreign DNA introduced into animals will detrimentally affect their physiological aspects.

• 한국식품영양과학회지
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• 제27권1호
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• pp.163-167
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• 1998

Anticarcinogenic activity of astaxanthin-contatining egg yolk(designate AEY) was investigated for mouse ascites carcinogenesis induced by mouse Sarcoma-180(S-180) cells. Female ICR mice(8mice/treatment, 7∼8weeks of age, 25±1g) were injected, i.p. with S-180 cells(1×107cell/ml PBS). Two days later, each mouse was given 0.1ml PBS containing AEY(10, 25 or 50ug/g body weight) or control egg yolk (CEY; 50ug/g body weight) every other day for 7 times. Control mice were only given 0.1ml S-180 cells and 0.1ml PBS. Mice treated with 25ug/g body weight of AEY showed 24.8 days of life, which was equivalent to 138% of control mice's life(180.0 dyas). Based on dose-dependant experiment of AFY, mice treated with 10ug/g body weight showed slightly longer life(19.4 days) relative to mice treated with control mice, and mice treated with 50ug/g body weight exhibited 21.9 days of life. Mice treated with any dose of AEY exhibited longer life than mice with CEY 50ug/g body weight. Body weight of mice treated with AEY was reduced relative to that of control mice CEY-treated mice. These results suggest than AEY inhibits the carcinogenesis of mouse ascites induced by S-180 cells.

• 지식경영연구
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• 제20권2호
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• pp.43-58
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• 2019

The main purpose of this study is to empirically investigate determinants affecting MICE quality, which then affects to loyalty. In particular, this study focuses on variables in the exhibition and event experiences of the MICE participants. The proposed research includes four variables representing the exhibitions and event experiences (affective, intellectual, behavioral, relational experience), two MICE qualities (commitment, satisfaction), and MICE loyalty. The results of this study reveal that four proposed variables (affective, intellectual, behavioral and relational experience) have a positive impact on two MICE qualities (commitment and satisfaction). Furthermore, the study found that commitment and satisfaction positively influence MICE loyalty. The findings of the study would provide theoretical and practical implications of exhibition and event experiences, quality and loyalty of MICE.

• 국제지역연구
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• 제12권3호
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• pp.269-291
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• 2008

비즈니스 성격의 회의, 인센티브관광, 컨벤션, 전시를 아우르는 MICE산업은 수익성이 낮은 우리나라 관광구조를 개선시키기 위해 육성할 필요가 높은 산업으로 제시되고 있다. 이를 위해 개선이 요구되는 발전요인과 정부 및 전담기구의 역할, MICE산업의 파급효과 간 관계를 전문가들의 인식을 바탕으로 파악해 보았다. 그 결과, MICE산업 발전요인으로 마케팅요인과 인적자원 육성 요인이 제시되었으며, MICE 산업의 파급효과는 경제적 효과와 국가홍보 효과요인으로 압축되었다. 요인들 간의 구조모형분석결과, 여러 가지 시사점을 도출할 수 있었다. MICE 발전의 마케팅요인은 정부의 역할에 유의한 영향을 끼친 반면, 전담기구의 역할과는 유의한 영향관계를 보이지 않았다. 반면, 인적자원 육성요인은 정부와 전담기구의 역할 모두에 유의한 영향관계를 가지는 것으로 분석되었다. 그리고, 정부의 역할은 전담기구의 역할에 유의한 영향관계에 있으며, 정부의 역할과 전담기구의 역할은 MICE산업의 경제적 효과와 국가홍보의 효과에 모두 유의한 영향을 주는 것으로 나타났다.

• 대한의생명과학회지
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• 제21권2호
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• pp.51-59
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• 2015

A humanized mice (hu-mice) model is extremely valuable to verify human cell activity in vivo condition and is regarded as an important tool in examining multimodal therapies and drug screening in tumor biology. Moreover, hu-mice models that simply received human $CD34^+$ blood cells and tissue transplants are also overwhelmingly useful in immunology and stem cell biology. Because generated hu-mice harboring a human immune system have displayed phenotype of human $CD45^+$ hematopoietic cells and when played partly with functional immune network, it could be used to evaluate human cell properties in vivo. Although the hu-mice model does not completely recapitulate human condition, it is a key methodological factor in studying human hematological malignancies with impaired immune cells. Also, an advanced humanized leukemic mice (hu-leukemic-mice) model has been developed by improving immunodeficient mice. In this review, we briefly described the history of development on immunodeficient SCID strain mice for hu-and hu-leukemic-mice model for immunologic and tumor microenviromental study while inferring the potential benefits of hu-leukemic-mice in cancer biology.

• 대한수의학회지
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• 제34권4호
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• pp.653-664
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• 1994

This study was carried out to investigate diabetic renal changes in cyclophosphamide(CY) treated nonobese diabetic(NOD) mice and to develop animal model of diabetic human nephropathy. The 8-week-old NOD and ICR mice were injected with cyclophosphamide intraperitoneally at 200mg/kg body weight and compared the chemical effects on these mice with the non-treated NOD and ICR mice respectively. The renal glomeruli in ICR, cyclophosphamide-treated ICR(ICR+CY), NOD and cyclophosphamide-treated NOD(NOD+CY) mice were observed by the light and electron microscopes. The results obtained were summarized as follows ; 1. Spontaneous incidences of diabetes mellitus in NOD mice were significantly promoted by dosing with cyclophosphamide. 2. Glomerulohypertrophy, proliferation of mesangium, partial thickening of glomerular basement membrane, and partial fusion of pedicels of podocyte were observed in NOD mice and NOD+CY mice. These changes were not observed in both ICR mice and ICR+CY mice. 3. The diabetic nephropathy observed in NOD+CY mice was more severe than that of non-treated NOD mice.

• Journal of Nutrition and Health
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• 제21권2호
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• pp.113-121
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• 1988

The purpose of this study was to investigate the effects of dietary zinc on immune response in mice. Weanling male mice was placed individually in stainless steel cages and fed a zinc dificient diet and control diet. All mice were given deionized water ad libitum. The introduction of extraneous zinc was minimized in all cage by washing feed jars and water bottles sequentially with 4mM EDTA and conc-nitiric acid followed by deionized water. After 4 and 5 weeks of the diets, mice were immunized with lx 106 Naegleria fowleri intraperitoneally. Mice were weighed once a week. The results from this study are summarized as followed ; 1) Mice fed the zinc dificient diet showed growth retardation. After 3 weeks of diets, mean body weight of zinc deficient mice was 21.4g and that of control was 25.0g. This difference is singnificant statistically (p<0.01). The more time passed, the more remarkable difference was found. 2) The weigth of organs were measured on liver, kidney, spleen, thymus, heart, lung, brain. Difference in weight were observed only in liver and spleen. 3) Proliferative response of spleen cells of zinc deficient mice to con A was lower than that of control mice after one week on immunization(p<0.005). 4) Stimulation index was lower in zinc deficient mice to phytohemagglutinin after two weeks on immunization (p<0.05). 5) Blastogenesis of speen cells of zinc deficient mice to Naegleria fowleric lysate was lower after 10 days on immunization (p<0.05). 6) Immunoglobulin G antribody titers of zinc deficient mice sera by ELISA was lowered to control mice after 5 weeks on immunization (p<0.005).