• 한국멀티미디어학회논문지
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• 제20권2호
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• pp.115-125
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• 2017

For many stroke patients undergoing rehabilitation therapy, there is a need for indicator for evaluating the body function in paretic and non-paretic regions of stroke patients quantitatively. In this paper, the function of muscles and cells in paretic and non-paretic regions of severe and mild hemiplegic stroke patients was evaluated using multi-channel bioelectrical impedance spectroscopy. The paretic and non-paretic regions of severe and mild stroke patients were quantitatively assessed by using bioelectrical impedance parameters such as prediction marker (PM), phase angle (${\theta}$), characteristic frequency ($f_c$), and bioelectrical impedance vector analysis (BIVA). The mean values of impedance vector were significantly discriminated in all comparisons (severe-paretic, severe-non-paretic, mild-paretic, and mild-non-paretic). The bioelectrical impedance parameters were proved to be a very valuable tool for quantitatively evaluating the paretic and non-paretic regions of hemiplegic stroke patients.

• Physical Therapy Rehabilitation Science
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• 제5권3호
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• pp.143-148
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• 2016

Objective: This study aimed to quantify one of the useful upper extremity movements to evaluate motor control abilities between the groups of people with mild and moderate arm impairments performing a door handling task. Design: Cross-sectional study. Methods: Twenty-one healthy participants and twenty-one persons with chronic stroke (9 mild stroke and 12 moderate stroke) were recruited for this study. Stroke participants were divided into 2 groups based on Fugle-Meyer Assessment scores of 58-65 (mild arm) and 38-57 (moderate arm). All they performed door handling task including the pronation and supination phases 3 times. We measured some movement factors which were reaction time, movement time, hand of peak velocity, hand of movement units to perform door handling task using the three-dimensional motion analysis. Results: The majority of kinematic variables showed significant differences among study groups (p<0.05). The reaction time, total and phase of movement time, hand of peak velocity, the number of movement units discriminated between healthy participants and persons with moderate upper limb stroke (p<0.05). In addition, reaction time, total and phase of movement time, the number of movement units discriminated between those with moderate and mild upper limbs of stroke patients (p<0.05). Conclusions: Three-dimensional kinematic motion analysis in this study was a useful tool for assessing the upper extremity function in different subgroups of people with stroke during the door handling task. These kinematic variables may help clinicians understand the arm movements in door handling task and consist of discriminative therapeutic interventions for stroke patients on upper extremity rehabilitation.

• Journal of Korean Neurosurgical Society
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• 제65권5호
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• pp.665-679
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• 2022

Objective : Patients with mild ischemic stroke experience various sequela and residual symptoms, such as anxious behavior and deficits in movement. Few approaches have been proved to be effective and safe therapeutic approaches for patients with mild ischemic stroke by acute stroke. Sildenafil (SIL), a phosphodiesterase-5 inhibitor (PDE5i), is a known remedy for neurodegenerative disorders and vascular dementia through its angiogenesis and neurogenesis effects. In this study, we investigated the efficacy of PDE5i in the emotional and behavioral abnormalities in rats with mild ischemic stroke. Methods : We divided the rats into four groups as follows (n=20, respectively) : group 1, naïve; group 2, middle cerebral artery occlusion (MCAo30); group 3, MCAo30+SIL-pre; and group 4, MCAo30+SIL-post. In the case of drug administration groups, single dose of PDE5i (sildenafil citrate, 20 mg/kg) was given at 30-minute before and after reperfusion of MCAo in rats. After surgery, we investigated and confirmed the therapeutic effect of sildenafil on histology, immunofluorescence, behavioral assays and neural oscillations. Results : Sildenafil alleviated a neuronal loss and reduced the infarction volume. And results of behavior task and immunofluorescence shown possibility that anti-inflammation process and improve motor deficits sildenafil treatment after mild ischemic stroke. Furthermore, sildenafil treatment attenuated the alteration of theta-frequency rhythm in the CA1 region of the hippocampus, a known neural oscillatory marker for anxiety disorder in rodents, induced by mild ischemic stroke. Conclusion : PDE5i as effective therapeutic agents for anxiety and movement disorders and provide robust preclinical evidence to support the development and use of PDE5i for the treatment of mild ischemic stroke residual disorders.

• The Journal of Korean Physical Therapy
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• 제28권5호
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• pp.334-340
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• 2016

Purpose: This study was conducted to investigate the effects of skater exercise on cardiopulmonary fitness and balance function in patients with mild chronic stroke. Methods: A total of ten chronic stroke patients with mild neurologic deficits were recruited. The participants were divided into two groups, a skater exercise (n=5) and a control group (n=5). Skater exercise was performed by physical therapists in the experimental group, whereas patients in the control group conducted self-exercise. One session of the intervention was carried out for 30 minutes, three times per week for eight weeks. Cardiopulmonary function, falling index, and Euro-Quality of Life-5 Dimension (EQ-5D) were measured before and after the intervention. Results: No side effects were reported during and after skater exercise intervention. The peak aerobic capacity, falling index, and EQ-5D improved significantly in the experimental group compared with the control group after eight weeks of skater exercise (p=0.002, p=0.010, and p=0.006). Significant relationships were identified between the change in EQ-5D and peak aerobic capacity (R2=0.75, p=0.002)/falling index (R2=0.65, p=0.002). Conclusion: Skater exercise was an effective physical therapy to improve cardiopulmonary fitness and balance function in patients with mild chronic stroke.

• 대한한의학회지
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• 제22권3호
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• pp.119-128
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• 2001

Objectives: Daechu (Dazhui: GV 14 (Governor Vessel))-point is located between the spinous process of the 7th cervical vertebra and that of the 1st thoracic vertebra. GV 14 has been used to treat high fever, neck pain, common cold, headache and so on. Fever may badly affect the improvement of stroke patients, so we investigated whether wet-cupping at GV 14 had effects on fever. Methods: In this study, 100 stroke patients were studied from Nov. 1999 to Oct. 2000. They were divided into the Sample group (n=49) and Control group (n=5l). The Sample group (n=49) was divided into Sample-Severe (n=2l), Sample-Mild (n=12), and Sample-Normal groups (n=16) and the Control group (n=5l) was divided into Control-Severe (n=8) and Control-Mild (n=43). We checked body temperature 6 times (just before treatment, after 30 ruin., 60, 90, 120 (2 hrs.), and 240 ruin. (4 hrs.)) in the Sample group and 3 times (just before treatment, after 120 min. (2 hrs.), and 240 ruin. (4 hrs.)) in the Control group. Results: In comparison with fever between before treatment and after 2 and 4 hours in each group, fever in the Sample subgroups decreased significantly in all cases, fever in the Control subgroups didn't decrease significantly in most cases except fever after 4 hours in the Control-Mild group. In comparison with fever differences between the Sample and Control group, fever of the Sample group more significantly decreased than that of the Control group in all comparisons. In comparison with fever among sample subgroups, fever of the Sample-Severe group decreased more than that of the Sample-Mild group but it was not significant. Conclusions: This study suggested that wet-cupping at GV 14 has significant effects on fever in stroke patients. We hope that this treatment will be used more widely as an emergent treatment.

• 약학회지
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• 제53권5호
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• pp.265-273
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• 2009

The aims of this study are to conduct meta-analysis for obtaining pooled estimates of the utility weight for stroke and to explore the study design characteristics that determine the utility weight for stroke. Medline (Pubmed), CEA Registry (Tufts Medical Center), and KERIS (Korea Education & Research Information Service) were searched to find out the literature that reported quality of life with stroke. Patient characteristics, utility weights and standard errors were extracted and stratified by severity, study method, respondent and country. All estimates were measured on a 0 to 1 scale with 0 representing the death and 1 representing the perfect health. The pooled estimates of the utility weight were 0.627 for total stroke, 0.756 for mild stroke, 0.631 for moderate stroke, and 0.389 for severe stroke (p=0.0001). Non-patients showed significantly lower utility weights than patients for severe (p=0.0122) stroke.

• Advances in Traditional Medicine
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• 제7권5호
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• pp.494-500
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• 2008

Ginseng has been traditionally used to recover vital energy from Qi deficiency in oriental countries. Recent reports suggested that ginseng could regulate blood pressure (BP), but much controversy still remain. Therefore, we intended to assess the anti-hypertensive effect of some ginseng species on Koreans and Chinese. This is a randomized, double blinded controlled clinical trial. The study subjects were recruited from the mild hypertensive patients who belonged prehypertension(120/80 to 139/89 mmHg) and stage I hypertension (140/90 to 159/99 mmHg) in Korea and China. After assigning the subjects into a Korean, a Chinese, and an American ginseng group by randomization, we prescribed ginseng with the dose of 4.5 g per a day for 4 w. To assess the anti-hypertensive effect, we compared the mean of systolic and diastolic BP between before and after ginseng medication by 24 h Ambulatory Blood Pressure Monitor (24 h ABPM). We also monitored adverse effect and laboratory findings to secure the subjects' safety. There were 64 subjects treated with Korean ginseng, 58 treated with Chinese ginseng, and 64 treated with American ginseng. All of the ginseng species reduced subjects' BP. Especially, Korean and Chinese ginseng showed more excellent effects. The secondary analysis on the subjects' nationality revealed that all of the ginseng species showed more significant anti-hypertensive effect in Chinese than in Koreans. We suggest ginseng could be useful for mild hypertension regardless of its species. And it would be safe within the dosage of 4.5 g per a day.

• 한국엔터테인먼트산업학회논문지
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• 제13권8호
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• pp.603-610
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• 2019

본 연구는 휴대용 전산화 인지훈련 시스템이 경도 인지손상이 있는 뇌졸중 환자의 시지각에 미치는 효과를 알고자 하였다. 재활병원에 입원 중인 경도인지손상이 있는 12명의 뇌졸중 환자가 본 연구에 참여하였다. 모든 대상자들은 실험군과 대조군으로 6명씩 할당되었다. 모든 대상자들은 실험군 또는 대조군의 훈련을 하루 30분, 주 5회, 4주 동안 수행하였다. 실험군은 휴대용 전산화 인지훈련 시스템을 실시하였으며, 대조군은 보편적인 인지훈련을 수행하였다. 시지각을 측정하기 위하여, MVPT-3(Motor-Free Visual Perception-3)을 측정하였다. 연구 결과, 두 군은 중재 전과 후로 MVPT-3 total score에서 유의한 향상을 보였다(p<.05). 두 군 간 변화량 비교에서 실험군은 대조군보다 MVPT-3 total score와 visual short-term memory of sub-item of MVPT-3에서 유의하게 더 큰 향상을 보였다(p<.05). 이러한 결과는 휴대용 전산화 인지훈련 시스템이 경도인지손상이 있는 뇌졸중 환자의 시지각 능력 향상에 긍정적인 효과를 이끌어 낼 수 있는 중재방법이 될 수 있음을 시사한다.

• 대한핵의학회지
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• 제16권2호
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• pp.29-36
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• 1982

Quantification of the regurgitation amount is important before and after valvular replacement surgery. Until now cardiac catheterization with cineventriculography, echocardiography have been used to measure the regurgitation amount, but also have many limitations. EKG gated cardiac blood pool scan provides a simple, non-invasive -method for quantify the regurgitation amount. By calculating the ratio of left ventricular to right ventricular stroke counts (stroke volume ratio) in gated bood pool scan, we measured the left ventricular regurgitation amount in 28 cases of valvular regurgitation and 25 cases of normal group. 1. Stroke volume ratio was higher in cases of valvular regurgitation $(2.11{\pm}0.58)$ than in cases of normal control $(1.15{\pm}0.31)$. (p<0.01). 2. Stroke volume ratio was classified by regurgitation grade using X-ray cineventriculography. In grades of mild regurgitation $(Grade\;I{\sim}II)$, stroke volume ratio was $2.02{\pm}0.29$, and in grades of severe regurgitation $(Grade\;III{\sim}IV)$, stroke volume ratio was $2.55{\pm}0.34$, so stroke volume ratio was well correlated with the grade of X-ray cineventriculography. 3. Stroke volume ratio was classfied by functional class made in New York Heart Association. In classes of mild regurgitation $(class\;I{\sim}II)$, stroke volume ratio was $2.08{\pm}0.26$, and in classes of severe regurgitation $(class\;III{\sim}IV)$, stroke volume ratio was $2.55{\pm}0.38$, Stroke volume ratio well represented the functional class. 4. After aortic and mitral valve replacement in 28 patients, the stroke volume ratio, decreased from $2.11{\pm}0.58\;to\;1.06{\pm}0.26$. Gated blood pool scan provides a noninvasive method of qnantifying valvular regurgitation and assessing the result of surgical interventions.

• Investigative Magnetic Resonance Imaging
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• 제24권3호
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• pp.174-177
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• 2020

Multiple studies have established that mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) exhibits reversible diffusion restriction in the white matter, including the splenium. There have been a few previous reports of the change in fractional anisotropy (FA) of MERS cases. Herein, we report the longitudinal changes in axial and radial diffusivity (AD and RD), and FA in a 15-year-old boy patient with MERS. Our case demonstrated that a MERS lesion had a significant drop of AD in the early period and gradual recovery. On the contrary, RD did not show any significant change.